LOCUS       NM_032311               3362 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DNA polymerase delta interacting protein 3 (POLDIP3),
            transcript variant 1, mRNA.
ACCESSION   NM_032311
VERSION     NM_032311.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3362)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3362)
  AUTHORS   Bjorkman,A., Johansen,S.L., Lin,L., Schertzer,M., Kanellis,D.C.,
            Katsori,A.M., Christensen,S.T., Luo,Y., Andersen,J.S.,
            Elsasser,S.J., Londono-Vallejo,A., Bartek,J. and Schou,K.B.
  TITLE     Human RTEL1 associates with Poldip3 to facilitate responses to
            replication stress and R-loop resolution
  JOURNAL   Genes Dev 34 (15-16), 1065-1074 (2020)
   PUBMED   32561545
  REMARK    GeneRIF: Human RTEL1 associates with Poldip3 to facilitate
            responses to replication stress and R-loop resolution.
REFERENCE   3  (bases 1 to 3362)
  AUTHORS   Wang,X., Zhang,S., Zheng,R., Yue,F., Lin,S.H., Rahmeh,A.A.,
            Lee,E.Y., Zhang,Z. and Lee,M.Y.
  TITLE     PDIP46 (DNA polymerase delta interacting protein 46) is an
            activating factor for human DNA polymerase delta
  JOURNAL   Oncotarget 7 (5), 6294-6313 (2016)
   PUBMED   26819372
  REMARK    GeneRIF: Altered expression of PDIP46 or its mutation may affect
            Pol delta functions in vivo, and thereby be a nexus for altered
            genomic stability.
REFERENCE   4  (bases 1 to 3362)
  AUTHORS   Suzuki,H., Shibagaki,Y., Hattori,S. and Matsuoka,M.
  TITLE     Nuclear TDP-43 causes neuronal toxicity by escaping from the
            inhibitory regulation by hnRNPs
  JOURNAL   Hum Mol Genet 24 (6), 1513-1527 (2015)
   PUBMED   25378556
  REMARK    GeneRIF: hnRNP-U inhibits TDP-43-mediated alterations in splicing
            of POLDIP3 mRNA.
REFERENCE   5  (bases 1 to 3362)
  AUTHORS   Kroczynska,B., Mehrotra,S., Majchrzak-Kita,B., Arslan,A.D.,
            Altman,J.K., Stein,B.L., McMahon,B., Kozlowski,P., Kahle,P.J.,
            Eklund,E.A., Fish,E.N. and Platanias,L.C.
  TITLE     Regulatory effects of SKAR in interferon alpha signaling and its
            role in the generation of type I IFN responses
  JOURNAL   Proc Natl Acad Sci U S A 111 (31), 11377-11382 (2014)
   PUBMED   25049393
  REMARK    GeneRIF: these findings establish critical and essential roles for
            SKAR in the regulation of mRNA translation of IFN-sensitive genes
            and induction of IFN-alpha biological responses.
REFERENCE   6  (bases 1 to 3362)
  AUTHORS   Dufu,K., Livingstone,M.J., Seebacher,J., Gygi,S.P., Wilson,S.A. and
            Reed,R.
  TITLE     ATP is required for interactions between UAP56 and two conserved
            mRNA export proteins, Aly and CIP29, to assemble the TREX complex
  JOURNAL   Genes Dev 24 (18), 2043-2053 (2010)
   PUBMED   20844015
REFERENCE   7  (bases 1 to 3362)
  AUTHORS   Ma,X.M., Yoon,S.O., Richardson,C.J., Julich,K. and Blenis,J.
  TITLE     SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced
            translation efficiency of spliced mRNAs
  JOURNAL   Cell 133 (2), 303-313 (2008)
   PUBMED   18423201
  REMARK    GeneRIF: SKAR-mediated recruitment of activated S6K1 to newly
            processed mRNPs serves as a conduit between mTOR checkpoint
            signaling and the pioneer round of translation when cells exist in
            conditions supportive of protein synthesis.
REFERENCE   8  (bases 1 to 3362)
  AUTHORS   Smyk,A., Szuminska,M., Uniewicz,K.A., Graves,L.M. and Kozlowski,P.
  TITLE     Human enhancer of rudimentary is a molecular partner of
            PDIP46/SKAR, a protein interacting with DNA polymerase delta and
            S6K1 and regulating cell growth
  JOURNAL   FEBS J 273 (20), 4728-4741 (2006)
   PUBMED   16984396
  REMARK    GeneRIF: This study showed that PDIP46 aka SKAR, a protein
            possessing one RNA recognition motif (RRM) and being a protein
            partner of both the p50 subunit of DNA polymerase delta and p70
            ribosomal protein S6 kinase 1 (S6K1).
REFERENCE   9  (bases 1 to 3362)
  AUTHORS   Richardson,C.J., Broenstrup,M., Fingar,D.C., Julich,K.,
            Ballif,B.A., Gygi,S. and Blenis,J.
  TITLE     SKAR is a specific target of S6 kinase 1 in cell growth control
  JOURNAL   Curr Biol 14 (17), 1540-1549 (2004)
   PUBMED   15341740
  REMARK    GeneRIF: SKAR is a specific target of S6K1 and regulates cell
            growth.
REFERENCE   10 (bases 1 to 3362)
  AUTHORS   Liu,L., Rodriguez-Belmonte,E.M., Mazloum,N., Xie,B. and Lee,M.Y.
  TITLE     Identification of a novel protein, PDIP38, that interacts with the
            p50 subunit of DNA polymerase delta and proliferating cell nuclear
            antigen
  JOURNAL   J Biol Chem 278 (12), 10041-10047 (2003)
   PUBMED   12522211
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC368557.1 and AL160111.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032311.4.
            
            Summary: This gene encodes an RRM (RNA recognition
            motif)-containing protein that participates in the regulation of
            translation by recruiting ribosomal protein S6 kinase beta-1 to
            mRNAs. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024626.1, BC095411.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252115.10/ ENSP00000252115.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DC368557.1         80-82
            4-3362              AL160111.1         1-3359
FEATURES             Location/Qualifiers
     source          1..3362
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..3362
                     /gene="POLDIP3"
                     /gene_synonym="PDIP3; PDIP46; SKAR"
                     /note="DNA polymerase delta interacting protein 3"
                     /db_xref="GeneID:84271"
                     /db_xref="HGNC:HGNC:23782"
                     /db_xref="MIM:611520"
     exon            1..85
                     /gene="POLDIP3"
                     /gene_synonym="PDIP3; PDIP46; SKAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1292
                     /gene="POLDIP3"
                     /gene_synonym="PDIP3; PDIP46; SKAR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     polymerase delta-interacting protein 3; polymerase
                     (DNA-directed), delta interacting protein 3; S6K1
                     Aly/REF-like target; RNA-binding protein P46; polymerase
                     (DNA) delta interacting protein 3; 46 kDa DNA polymerase
                     delta interaction protein"
                     /codon_start=1
                     /product="polymerase delta-interacting protein 3 isoform
                     1"
                     /protein_id="NP_115687.2"
                     /db_xref="CCDS:CCDS14038.1"
                     /db_xref="GeneID:84271"
                     /db_xref="HGNC:HGNC:23782"
                     /db_xref="MIM:611520"
                     /translation="MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQS
                     TRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGKVQDAREMLNSRK
                     QQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQVPQQKAMAPL
                     HPHPAGMRINVVNNHQAKQNLYDLDEDDDGIASVPTKQMKFAASGGFLHHMAGLSSSK
                     LSMSKALPLTKVVQNDAYTAPALPSSIRTKALTNMSRTLVNKEEPPKELPAAEPVLSP
                     LEGTKMTVNNLHPRVTEEDIVELFCVCGALKRARLVHPGVAEVVFVKKDDAITAYKKY
                     NNRCLDGQPMKCNLHMNGNVITSDQPILLRLSDSPSMKKESELPRRVNSASSSNPPAE
                     VDPDTILKALFKSSGASVTTQPTEFKIKL"
     exon            86..476
                     /gene="POLDIP3"
                     /gene_synonym="PDIP3; PDIP46; SKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            477..563
                     /gene="POLDIP3"
                     /gene_synonym="PDIP3; PDIP46; SKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            564..659
                     /gene="POLDIP3"
                     /gene_synonym="PDIP3; PDIP46; SKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            660..839
                     /gene="POLDIP3"
                     /gene_synonym="PDIP3; PDIP46; SKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            840..917
                     /gene="POLDIP3"
                     /gene_synonym="PDIP3; PDIP46; SKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1047
                     /gene="POLDIP3"
                     /gene_synonym="PDIP3; PDIP46; SKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1114
                     /gene="POLDIP3"
                     /gene_synonym="PDIP3; PDIP46; SKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..3362
                     /gene="POLDIP3"
                     /gene_synonym="PDIP3; PDIP46; SKAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3342..3347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLDIP3"
                     /gene_synonym="PDIP3; PDIP46; SKAR"
                     /note="hexamer: AATAAA"
     polyA_site      3362
                     /gene="POLDIP3"
                     /gene_synonym="PDIP3; PDIP46; SKAR"
                     /note="major polyA site"
ORIGIN      
        1 gctttcggct tgctcggcgg agcaagatgg cggacatctc cctggacgaa ctcatcagga
       61 agcgcggggc ggcggcgaaa ggacggctta atgccagacc gggagttgga ggtgtccgat
      121 ctcgagttgg gatccagcaa ggccttctca gccagtcaac acgcacagcc accttccagc
      181 agagatttga tgcccggcag aagattggcc tctcagatgc ccggctcaaa ctgggagtca
      241 aggatgcccg ggagaagctt ttgcagaaag atgcccgatt tcgaatcaaa gggaaagtgc
      301 aggatgccag agagatgttg aactctcgca agcagcagac cacggtgccc cagaagcccc
      361 gccaggttgc tgatgcccgg gagaagatca gcttgaagag gagttcccct gctgccttca
      421 taaacccacc cattgggaca gtgacccctg ctctgaagct caccaaaacc atccaggttc
      481 cacagcagaa agccatggca ccacttcatc cccatcctgc cggaatgaga atcaatgttg
      541 tcaataacca ccaggccaaa cagaatttat atgacctgga tgaagatgat gatggtatag
      601 cttccgttcc tactaaacag atgaagtttg cagcctcagg cggctttctc caccacatgg
      661 ctgggctaag cagttccaag ctttccatgt ccaaggccct ccctctcacc aaagtggttc
      721 agaatgatgc atacacagct cctgctctcc cttcctctat tcgaacaaaa gccttgacca
      781 acatgtcccg gacactggtg aacaaggaag aaccccccaa agagctgcca gctgctgagc
      841 ctgttctcag cccattggaa ggcaccaaga tgactgtgaa taatctgcac cctcgagtca
      901 ctgaggagga cattgttgag cttttctgtg tgtgtggggc cctcaagcga gctcgactgg
      961 tccatcctgg ggtagcggag gtggtgtttg tgaaaaagga cgatgccatc accgcatata
     1021 agaagtacaa caaccggtgt ctggacgggc agccgatgaa gtgcaacctt cacatgaatg
     1081 ggaatgttat cacctcagac cagcccatcc tgctgcggct gagtgacagc ccatcaatga
     1141 aaaaggagag cgagctgcct cgcagggtga actctgcctc ctcctccaac ccccctgccg
     1201 aagtggaccc tgacaccatc ctgaaggcac tcttcaagtc ctcaggggcc tctgtgacca
     1261 cgcagcccac agaattcaaa atcaagcttt gagcagggga gtgaggcagc cagaagtggg
     1321 ggcagaggag ggtggctctg tttccccaag gcaaagctta tgaccaatgg gccatcggac
     1381 tggagacccc tgattgtggg aagggttgcc agggataaag agcttcctca ctggatggga
     1441 cccgcctttc tgtgttgtgt tctgccctgt gctcttctct ctacgttaac gtttcctgta
     1501 gtatgtttct tcatctcatc gccaaggtag gcttgtgttt ttcagtgtgt gcctccccga
     1561 gcctcagccc caagctgatt tcttatctgg aaatggtaca ctgaattctc tgggtggctt
     1621 tcttgtggcc ccatgggatg cagcgtgggg gctgtctgaa ggaccctgct ttttccaggg
     1681 gccgaggggc tgcctttcct ttgtgtgtat taagcttttc aaacaatgga ggggatggag
     1741 agccctggtg tcctgacggg agccaggtcg gcctgagagc tgtgccgctc ctctgtcttg
     1801 tcagtggagg tgcctgggtg gggagcaggt ctcaggcctc ttgtcctctc cccagtggct
     1861 ccaggcctca ctagtggcaa gggcaggatg aggctgcacc gctgggaaga gtctatctaa
     1921 gctcttggct tggagtcccg tgtcgtctcc acccagagga agttctccag agttcacctt
     1981 tcccttttcc ttgagttgtg ctgaatgccc caccccagct ctctttccct tctgggtgtc
     2041 tttgctggga gggggctgtg ttgtgagccc tcccggttct cacctcgcct ggcacttaac
     2101 cacaccctgg ttttgtgtag ccgccagctc tcttctggtt gggcctttga aaggctcagc
     2161 ctcccattgt gcagtgcttg ggtttggagc ttatttgaat ggaagaggtc agtttgttcc
     2221 tggctctcca tttctggcct cagttgtcta caggacagtg gtcagggatg cctggaggca
     2281 tatatccagc tgccaccaag gggcactgtt tgttcccact tatgtgagtg accccatcca
     2341 tccatgacca gaggattatt ttcctgcctt ggcagaggag gaggagtcaa gggagcaggg
     2401 cagctctacc aggcaaggtg tttccccagc ataggcgcag acagttggga cgaaacttca
     2461 gagcccaggc agtccctgaa tgaccaggcc agtgttgtca ctgagtggtc ccctgctggt
     2521 tgggagtgaa gagaatccag gctggcagag ctggagccag ttggggagca cggttctggg
     2581 agctctgcaa aatcagtagc aagtgctgga aaaggcacat gccgaagata ctcaagagct
     2641 cccaagattt gcttgaggct agcccagtga aaaaaaccag agactcatgt ttccaggggt
     2701 cagtctgtca ggcaggaagg acccaggatt tgaacccagc ttcagtgtgc aggctctgag
     2761 gctgcccagg acgggaaagt ccaaggaagg ggcctggtgg tgctccactt gcagttcttt
     2821 aaagaatgct gctttttatt ctcctaaccc tttcaagtgg gtgcagactt ctcgttagca
     2881 gctggaagac attcctccca cacttttccc ttcctggccc aagagagcat ccagaaggca
     2941 gtaggacctg gtttttcagg tactgggagc cgggggctca ctgcttgcac tgtgcttagg
     3001 gtagggatgg taaatatcct ccctgcatgg ctttatcctc cctctcatcc caaagcaggt
     3061 atcttctggt tgtcacagag tttcattgag tccagctgca gccacgtggc catctggagc
     3121 tggtgctata ggtgaccatc tggtacattg aggggacctg tttgcctcct ccactctata
     3181 agcagtcatc ttgggagacc gggaggagaa ggtggtgggc tagtcctgtg tcctcctcca
     3241 cttcccatgc ctctatgtta cccatctgtg tctcctgtgc agaaggagag gaaggggcat
     3301 taagagatga agggtgatta tgtattactt atccatttct gaataaacat ttgttattcc
     3361 ta
//
