LOCUS       NM_015584               2670 bp    mRNA    linear   PRI 19-DEC-2024
DEFINITION  Homo sapiens DNA polymerase delta interacting protein 2 (POLDIP2),
            transcript variant 1, mRNA.
ACCESSION   NM_015584
VERSION     NM_015584.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2670)
  AUTHORS   Nguyen,T., Urrutia-Cabrera,D., Wang,L., Lees,J.G., Wang,J.H.,
            Hung,S.S.C., Hewitt,A.W., Edwards,T.L., McLenachan,S., Chen,F.K.,
            Lim,S.Y., Luu,C.D., Guymer,R. and Wong,R.C.B.
  TITLE     Knockout of AMD-associated gene POLDIP2 reduces mitochondrial
            superoxide in human retinal pigment epithelial cells
  JOURNAL   Aging (Albany NY) 15 (6), 1713-1733 (2023)
   PUBMED   36795578
  REMARK    GeneRIF: Knockout of AMD-associated gene POLDIP2 reduces
            mitochondrial superoxide in human retinal pigment epithelial cells.
REFERENCE   2  (bases 1 to 2670)
  AUTHORS   Paredes,F., Williams,H.C., Suster,I., Tejos,M., Fuentealba,R.,
            Bogan,B., Holden,C.M. and San Martin,A.
  TITLE     Metabolic regulation of the proteasome under hypoxia by Poldip2
            controls fibrotic signaling in vascular smooth muscle cells
  JOURNAL   Free Radic Biol Med 195, 283-297 (2023)
   PUBMED   36596387
  REMARK    GeneRIF: Metabolic regulation of the proteasome under hypoxia by
            Poldip2 controls fibrotic signaling in vascular smooth muscle
            cells.
REFERENCE   3  (bases 1 to 2670)
  AUTHORS   Dolmatova,E.V., Forrester,S.J., Wang,K., Ou,Z., Williams,H.C.,
            Joseph,G., Kumar,S., Valdivia,A., Kowalczyk,A.P., Qu,H., Jo,H.,
            Lassegue,B., Hernandes,M.S. and Griendling,K.K.
  TITLE     Endothelial Poldip2 regulates sepsis-induced lung injury via Rho
            pathway activation
  JOURNAL   Cardiovasc Res 118 (11), 2506-2518 (2022)
   PUBMED   34528082
  REMARK    GeneRIF: Endothelial Poldip2 regulates sepsis-induced lung injury
            via Rho pathway activation.
REFERENCE   4  (bases 1 to 2670)
  AUTHORS   Wang,Y., Ding,Z., Tu,Y., Wu,X., Zhang,W., Ji,S., Shen,J., Zhang,L.,
            Wu,H. and Fei,G.
  TITLE     Poldip2/Nox4 Mediates Lipopolysaccharide-Induced Oxidative Stress
            and Inflammation in Human Lung Epithelial Cells
  JOURNAL   Mediators Inflamm 2022, 6666022 (2022)
   PUBMED   35140544
  REMARK    GeneRIF: Poldip2/Nox4 Mediates Lipopolysaccharide-Induced Oxidative
            Stress and Inflammation in Human Lung Epithelial Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2670)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 2670)
  AUTHORS   Cheng,X., Kanki,T., Fukuoh,A., Ohgaki,K., Takeya,R., Aoki,Y.,
            Hamasaki,N. and Kang,D.
  TITLE     PDIP38 associates with proteins constituting the mitochondrial DNA
            nucleoid
  JOURNAL   J Biochem 138 (6), 673-678 (2005)
   PUBMED   16428295
  REMARK    GeneRIF: PDIP38 is located in the mitochondrial matrix. TFAM and
            mitochondrial single-stranded DNA binding protein (mtSSB) are
            co-immunoprecipitated with PDIP38
REFERENCE   7  (bases 1 to 2670)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   8  (bases 1 to 2670)
  AUTHORS   Xie,B., Li,H., Wang,Q., Xie,S., Rahmeh,A., Dai,W. and Lee,M.Y.
  TITLE     Further characterization of human DNA polymerase delta interacting
            protein 38
  JOURNAL   J Biol Chem 280 (23), 22375-22384 (2005)
   PUBMED   15811854
  REMARK    GeneRIF: PDIP38 might play a role in the pol delta-mediated viral
            DNA replication
REFERENCE   9  (bases 1 to 2670)
  AUTHORS   Liu,L., Rodriguez-Belmonte,E.M., Mazloum,N., Xie,B. and Lee,M.Y.
  TITLE     Identification of a novel protein, PDIP38, that interacts with the
            p50 subunit of DNA polymerase delta and proliferating cell nuclear
            antigen
  JOURNAL   J Biol Chem 278 (12), 10041-10047 (2003)
   PUBMED   12522211
REFERENCE   10 (bases 1 to 2670)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY130221.1, BC000655.2,
            BM809398.1 and BG150599.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015584.4.
            
            Summary: This gene encodes a protein that interacts with the DNA
            polymerase delta p50 subunit, as well as with proliferating cell
            nuclear antigen. The encoded protein maybe play a role in the
            ability of the replication fork to bypass DNA lesions. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018864.2, AF077203.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000540200.6/ ENSP00000475924.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                HY130221.1         64-109
            47-2122             BC000655.2         1-2076
            2123-2476           BM809398.1         400-753
            2477-2670           BG150599.1         248-441
FEATURES             Location/Qualifiers
     source          1..2670
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..2670
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /note="DNA polymerase delta interacting protein 2"
                     /db_xref="GeneID:26073"
                     /db_xref="HGNC:HGNC:23781"
                     /db_xref="MIM:611519"
     exon            1..240
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1186
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /note="isoform 1 is encoded by transcript variant 1;
                     polymerase delta interacting protein 38; polymerase
                     delta-interacting protein 2; 38 kDa DNA polymerase delta
                     interaction protein; polymerase (DNA-directed), delta
                     interacting protein 2; polymerase (DNA) delta interacting
                     protein 2"
                     /codon_start=1
                     /product="polymerase delta-interacting protein 2 isoform
                     1"
                     /protein_id="NP_056399.1"
                     /db_xref="CCDS:CCDS74018.1"
                     /db_xref="GeneID:26073"
                     /db_xref="HGNC:HGNC:23781"
                     /db_xref="MIM:611519"
                     /translation="MAACTARRALAVGSRWWSRSLTGARWPRPLCAAAGAGAFSPAST
                     TTTRRHLSSRNRPEGKVLETVGVFEVPKQNGKYETGQLFLHSIFGYRGVVLFPWQARL
                     YDRDVASAAPEKAENPAGHGSKEVKGKTHTYYQVLIDARDCPHISQRSQTEAVTFLAN
                     HDDSRALYAIPGLDYVSHEDILPYTSTDQVPIQHELFERFLLYDQTKAPPFVARETLR
                     AWQEKNHPWLELSDVHRETTENIRVTVIPFYMGMREAQNSHVYWWRYCIRLENLDSDV
                     VQLRERHWRIFSLSGTLETVRGRGVVGREPVLSKEQPAFQYSSHVSLQASSGHMWGTF
                     RFERPDGSHFDVRIPPFSLESNKDEKTPPSGLHW"
     exon            241..322
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            323..420
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            421..517
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            518..593
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            594..701
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            702..838
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            839..865
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            866..991
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1071
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..2670
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2100..2105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /note="hexamer: ATTAAA"
     polyA_site      2122
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /note="major polyA site"
     polyA_site      2514
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
     regulatory      2652..2657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
                     /note="hexamer: ATTAAA"
     polyA_site      2670
                     /gene="POLDIP2"
                     /gene_synonym="p38; PDIP38"
ORIGIN      
        1 agtgtgggac tggggcggaa cgccgcccgg ccgcgggtcg ggctctgtgt cagcagccgg
       61 gcgggcgctc gggcgggaca tggcagcctg tacagcccgg cgggccctgg ccgtgggcag
      121 ccgctggtgg tcccggtcgc tgactggggc ccggtggcca aggccgctct gtgcggcggc
      181 cggagctgga gccttctcgc cagcgtcgac cacgacgacg cggaggcacc tctcgtcccg
      241 aaaccgacca gagggcaaag tgttggagac agttggtgtg tttgaggtgc caaaacagaa
      301 tggaaaatat gagaccgggc agcttttcct tcatagcatt tttggctacc gaggtgtcgt
      361 cctgtttccc tggcaggcca gactgtatga ccgggatgtg gcttctgcag ctccagaaaa
      421 agcagagaac cctgctggcc atggctccaa ggaggtgaaa ggcaaaactc acacttacta
      481 tcaggtgctg attgatgctc gtgactgccc acatatatct cagagatctc agacagaagc
      541 tgtgaccttc ttggctaacc atgatgacag tcgggccctc tatgccatcc caggcttgga
      601 ctatgtcagc catgaagaca tcctccccta cacctccact gatcaggttc ccatccaaca
      661 tgaactcttt gaaagatttc ttctgtatga ccagacaaaa gcacctcctt ttgtggctcg
      721 ggagacgcta agggcctggc aagagaagaa tcacccctgg ctggagctct ccgatgttca
      781 tcgggaaaca actgagaaca tacgtgtcac tgtcatcccc ttctacatgg gcatgaggga
      841 agcccagaat tcccacgtgt actggtggcg ctactgtatc cgtttggaga accttgacag
      901 tgatgtggta cagctccggg agcggcactg gaggatattc agtctctctg gcaccttgga
      961 gacagtgcga ggccgagggg tagtgggcag ggaaccagtg ttatccaagg agcagcctgc
     1021 gttccagtat agcagccacg tctcgctgca ggcttccagt gggcacatgt ggggcacgtt
     1081 ccgctttgaa agacctgatg gctcccactt tgatgttcgg attcctccct tctccctgga
     1141 aagcaataaa gatgagaaga caccaccctc aggccttcac tggtaggcca gctgaggccc
     1201 caagtgccca ggcttggtca ccgggaagaa caactctcat cccacaattg ctgcagaact
     1261 cttctctccc catcatgggc cacagtgggt ctcttaattt gattgtgggg ttctttttgt
     1321 ggggaggggt ggtataactt ttcttcagaa gacccatgtg ggacacctcc aaggctggcc
     1381 tcctcataag ccctgcctac accatgttcc agtaaacctc tccaccaagg aactgtgttc
     1441 agctgccaca ggcctggagg agtttcctgg cctgtcacgt gaggtttgat cagtaaacca
     1501 gtgcacgctt ggccaccctt gccatttctg ctcccagagt ctcaggctcc ccttctgacc
     1561 cagtgtgcgc ccttgactgc tttctttgct gcccttccag ggagctgccc ccctggtagg
     1621 gcatgtgcct gtttccctct cagcctggag gctggctgga catctcctag ggtcactgtg
     1681 cctctcagct agttggcggg ggtgctggac tggactcttg ttcactttac cttctgccaa
     1741 atgcagagag ggaggccagt gtcagggtcg gagtggcctg gctcttagca ctgaccgacc
     1801 attgccattt ctggcctcgc taggcccagg agaggaggga ggcaagccag tcgggtttcc
     1861 tggagcaatg ggtgtgccag ccctcagcat gactctgcca agcatccaga ccacaaatgc
     1921 aggaatttgg ctgaggagca gctttaggta tggattgatg actaagtcaa gctacttcct
     1981 gagcttctct cagatttcca agagccagag atgaattgtg ctgcatcttg ccccaattct
     2041 taggatttct tttcctccgc cactgcagtg attgttagag gtagttttct tgaattaata
     2101 ttaaatcaca gttccagccc ttgttattct tgtccttagt cctccagggg gagctggggt
     2161 tgcagggcaa cagtacagtc gcgcttacga cctggctaga acacaaggtc agatgataaa
     2221 cagaagcaca ggaactcagc ccatggccgc aagctggtca aggcctgctc actgtaaaca
     2281 tggctctgta ccattgagtt taacacaatt ttattagaaa ttagtgtttg cttccatcac
     2341 ttatgctgag caaccaaata ttacagttat gtgataaagg aaaaattctt tcctgcccag
     2401 gacctgcgcc atcctttagg ccgaccttgg tcacatacca aattcaataa aacccaatac
     2461 tggcctgtgt tgttaacagc aggctgccag gtttctcaga aactgacaag aaaatctgac
     2521 cttcatccat actttgttta cttacccctg ggctgcttgg agttgaaaaa tgcacacagc
     2581 caagagttgc tttctgaata gggctggaaa ctttcaaaga aaacccccaa acttttaagt
     2641 cacaaagtct gattaaagaa gctaagatca
//
