LOCUS       NM_015100               6655 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens pogo transposable element derived with ZNF domain
            (POGZ), transcript variant 1, mRNA.
ACCESSION   NM_015100
VERSION     NM_015100.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6655)
  AUTHORS   Marquezini,B.P., Moyses-Oliveira,M., Kloster,A., Cunha,L.,
            Deconto,T.B., Mosini,A.C., Guerreiro,P., Paschalidis,M.,
            Adami,L.N.G., Andersen,M.L. and Tufik,S.
  TITLE     Exploring the molecular pathways linking sleep phenotypes and
            POGZ-associated neurodevelopmental disorder
  JOURNAL   J Med Genet 61 (6), 586-589 (2024)
   PUBMED   38350721
  REMARK    GeneRIF: Exploring the molecular pathways linking sleep phenotypes
            and POGZ-associated neurodevelopmental disorder.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6655)
  AUTHORS   Siouda,M., Dujardin,A.D., Dekeyzer,B., Schaeffer,L. and Mulligan,P.
  TITLE     Chromodomain on Y-like 2 (CDYL2) implicated in mitosis and genome
            stability regulation via interaction with CHAMP1 and POGZ
  JOURNAL   Cell Mol Life Sci 80 (2), 47 (2023)
   PUBMED   36658409
  REMARK    GeneRIF: Chromodomain on Y-like 2 (CDYL2) implicated in mitosis and
            genome stability regulation via interaction with CHAMP1 and POGZ.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6655)
  AUTHORS   Deng,L., Mojica-Perez,S.P., Azaria,R.D., Schultz,M., Parent,J.M.
            and Niu,W.
  TITLE     Loss of POGZ alters neural differentiation of human embryonic stem
            cells
  JOURNAL   Mol Cell Neurosci 120, 103727 (2022)
   PUBMED   35367590
  REMARK    GeneRIF: Loss of POGZ alters neural differentiation of human
            embryonic stem cells.
REFERENCE   4  (bases 1 to 6655)
  AUTHORS   Nagy,D., Verheyen,S., Wigby,K.M., Borovikov,A., Sharkov,A.,
            Slegesky,V., Larson,A., Fagerberg,C., Brasch-Andersen,C.,
            Kibaek,M., Bader,I., Hernan,R., High,F.A., Chung,W.K.,
            Schieving,J.H., Behunova,J., Smogavec,M., Laccone,F.,
            Witsch-Baumgartner,M., Zobel,J., Duba,H.C. and Weis,D.
  TITLE     Genotype-Phenotype Comparison in POGZ-Related Neurodevelopmental
            Disorders by Using Clinical Scoring
  JOURNAL   Genes (Basel) 13 (1), 154 (2022)
   PUBMED   35052493
  REMARK    GeneRIF: Genotype-Phenotype Comparison in POGZ-Related
            Neurodevelopmental Disorders by Using Clinical Scoring.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6655)
  AUTHORS   Vermeulen,M., Eberl,H.C., Matarese,F., Marks,H., Denissov,S.,
            Butter,F., Lee,K.K., Olsen,J.V., Hyman,A.A., Stunnenberg,H.G. and
            Mann,M.
  TITLE     Quantitative interaction proteomics and genome-wide profiling of
            epigenetic histone marks and their readers
  JOURNAL   Cell 142 (6), 967-980 (2010)
   PUBMED   20850016
REFERENCE   6  (bases 1 to 6655)
  AUTHORS   Nozawa,R.S., Nagao,K., Masuda,H.T., Iwasaki,O., Hirota,T.,
            Nozaki,N., Kimura,H. and Obuse,C.
  TITLE     Human POGZ modulates dissociation of HP1alpha from mitotic
            chromosome arms through Aurora B activation
  JOURNAL   Nat Cell Biol 12 (7), 719-727 (2010)
   PUBMED   20562864
  REMARK    GeneRIF: The results reveal POGZ as an essential protein that links
            HP1alpha dissociation with Aurora B kinase activation during
            mitosis.
REFERENCE   7  (bases 1 to 6655)
  AUTHORS   Loyola,A., Tagami,H., Bonaldi,T., Roche,D., Quivy,J.P., Imhof,A.,
            Nakatani,Y., Dent,S.Y. and Almouzni,G.
  TITLE     The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for
            Suv39-mediated K9me3 in pericentric heterochromatin
  JOURNAL   EMBO Rep 10 (7), 769-775 (2009)
   PUBMED   19498464
REFERENCE   8  (bases 1 to 6655)
  AUTHORS   Bartholomeeusen,K., Christ,F., Hendrix,J., Rain,J.C., Emiliani,S.,
            Benarous,R., Debyser,Z., Gijsbers,R. and De Rijck,J.
  TITLE     Lens epithelium-derived growth factor/p75 interacts with the
            transposase-derived DDE domain of PogZ
  JOURNAL   J Biol Chem 284 (17), 11467-11477 (2009)
   PUBMED   19244240
  REMARK    GeneRIF: LEDGF/p75 has a role in DDE domain protein function and
            interacts with the transposase-derived DDE domain of PogZ
REFERENCE   9  (bases 1 to 6655)
  AUTHORS   Assia Batzir,N., White,J. and Sutton,V.R.
  TITLE     White-Sutton Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   34529370
REFERENCE   10 (bases 1 to 6655)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Hugh Robertson. The reference sequence was
            derived from AL589764.19, BX537838.1, AJ242979.1, AB007930.1 and
            BX649163.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015100.3.
            
            Summary: The protein encoded by this gene appears to be a zinc
            finger protein containing a transposase domain at the C-terminus.
            This protein was found to interact with the transcription factor
            SP1 in a yeast two-hybrid system. Alternatively spliced transcript
            variants encoding distinct isoforms have been observed. [provided
            by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537838.1, SRR11853567.1915.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271715.7/ ENSP00000271715.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL589764.19        77064-77092         c
            30-338              BX537838.1         2-310
            339-339             AJ242979.1         301-301
            340-2803            BX537838.1         312-2775
            2804-4606           AB007930.1         2297-4099
            4607-4607           AL589764.19        22370-22370         c
            4608-6655           BX649163.1         4413-6460
FEATURES             Location/Qualifiers
     source          1..6655
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..6655
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /note="pogo transposable element derived with ZNF domain"
                     /db_xref="GeneID:23126"
                     /db_xref="HGNC:HGNC:18801"
                     /db_xref="MIM:614787"
     exon            1..343
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            344..468
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..4577
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 280E; putative protein product of
                     Nbla00003; zinc finger protein 635; pogo transposable
                     element with ZNF domain"
                     /codon_start=1
                     /product="pogo transposable element with ZNF domain
                     isoform 1"
                     /protein_id="NP_055915.2"
                     /db_xref="CCDS:CCDS997.1"
                     /db_xref="GeneID:23126"
                     /db_xref="HGNC:HGNC:18801"
                     /db_xref="MIM:614787"
                     /translation="MADTDLFMECEEEELEPWQKISDVIEDSVVEDYNSVDKTTTVSV
                     SQQPVSAPVPIAAHASVAGHLSTSTTVSSSGAQNSDSTKKTLVTLIANNNAGNPLVQQ
                     GGQPLILTQNPAPGLGTMVTQPVLRPVQVMQNANHVTSSPVASQPIFITTQGFPVRNV
                     RPVQNAMNQVGIVLNVQQGQTVRPITLVPAPGTQFVKPTVGVPQVFSQMTPVRPGSTM
                     PVRPTTNTFTTVIPATLTIRSTVPQSQSQQTKSTPSTSTTPTATQPTSLGQLAVQSPG
                     QSNQTTNPKLAPSFPSPPAVSIASFVTVKRPGVTGENSNEVAKLVNTLNTIPSLGQSP
                     GPVVVSNNSSAHGSQRTSGPESSMKVTSSIPVFDLQDGGRKICPRCNAQFRVTEALRG
                     HMCYCCPEMVEYQKKGKSLDSEPSVPSAAKPPSPEKTAPVASTPSSTPIPALSPPTKV
                     PEPNENVGDAVQTKLIMLVDDFYYGRDGGKVAQLTNFPKVATSFRCPHCTKRLKNNIR
                     FMNHMKHHVELDQQNGEVDGHTICQHCYRQFSTPFQLQCHLENVHSPYESTTKCKICE
                     WAFESEPLFLQHMKDTHKPGEMPYVCQVCQYRSSLYSEVDVHFRMIHEDTRHLLCPYC
                     LKVFKNGNAFQQHYMRHQKRNVYHCNKCRLQFLFAKDKIEHKLQHHKTFRKPKQLEGL
                     KPGTKVTIRASRGQPRTVPVSSNDTPPSALQEAAPLTSSMDPLPVFLYPPVQRSIQKR
                     AVRKMSVMGRQTCLECSFEIPDFPNHFPTYVHCSLCRYSTCCSRAYANHMINNHVPRK
                     SPKYLALFKNSVSGIKLACTSCTFVTSVGDAMAKHLVFNPSHRSSSILPRGLTWIAHS
                     RHGQTRDRVHDRNVKNMYPPPSFPTNKAATVKSAGATPAEPEELLTPLAPALPSPAST
                     ATPPPTPTHPQALALPPLATEGAECLNVDDQDEGSPVTQEPELASGGGGSGGVGKKEQ
                     LSVKKLRVVLFALCCNTEQAAEHFRNPQRRIRRWLRRFQASQGENLEGKYLSFEAEEK
                     LAEWVLTQREQQLPVNEETLFQKATKIGRSLEGGFKISYEWAVRFMLRHHLTPHARRA
                     VAHTLPKDVAENAGLFIDFVQRQIHNQDLPLSMIVAIDEISLFLDTEVLSSDDRKENA
                     LQTVGTGEPWCDVVLAILADGTVLPTLVFYRGQMDQPANMPDSILLEAKESGYSDDEI
                     MELWSTRVWQKHTACQRSKGMLVMDCHRTHLSEEVLAMLSASSTLPAVVPAGCSSKIQ
                     PLDVCIKRTVKNFLHKKWKEQAREMADTACDSDVLLQLVLVWLGEVLGVIGDCPELVQ
                     RSFLVASVLPGPDGNINSPTRNADMQEELIASLEEQLKLSGEHSESSTPRPRSSPEET
                     IEPESLHQLFEGESETESFYGFEEADLDLMEI"
     exon            469..627
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            628..803
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            804..912
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1203
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1422
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1529
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1867
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2022
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2123
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2270
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2405
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2578
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2719
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2776
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2889
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..2914
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..6655
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6631..6636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /note="hexamer: AATAAA"
     polyA_site      6655
                     /gene="POGZ"
                     /gene_synonym="MRD37; WHSUS; ZNF280E; ZNF635; ZNF635m"
                     /note="major polyA site"
ORIGIN      
        1 gtatccctcc gcggggcgag agggtcggtg gggggagtcg gcgtctctct cccccgcgcc
       61 agctcccgta cacggagccg cattccttgg cccccccacc cccctccctc ggggcccccc
      121 cgcccccctc gggaaaaaaa tccaccccga atcactcgaa cccgagggag gcttcctttc
      181 acccttgggg agacgagctt tcaacggtta cctcttcttc gtctcccccc aagcccccgt
      241 cccctccccc tgctcccacc cccttctggc gccgggtgta aggtcccttt aaggcgacgg
      301 cgccttcctc gggtcagact accggcggcg acgaccacag gagcatggcg gacaccgacc
      361 tgttcatgga atgtgaggag gaggagttgg agccatggca gaaaatcagt gatgtcattg
      421 aggactctgt agttgaagat tataattcag tggataaaac taccacagtt tctgtgagcc
      481 agcagccagt ctcggctcca gtgcccatcg ctgcccatgc ttctgttgct gggcacctct
      541 ctacatccac caccgttagt agcagcgggg cacagaacag cgacagtaca aagaagactc
      601 ttgtcacact aattgccaac aacaatgctg gcaatccttt ggtccagcaa ggtggacagc
      661 cactcatcct gacccagaat ccagccccag gtctgggcac aatggttact caaccagtat
      721 tgaggcctgt tcaggtcatg cagaatgcca atcatgtgac tagttcccct gtggcctcac
      781 aaccaatatt tatcactacg cagggatttc ctgtaaggaa tgtccggcct gtacaaaatg
      841 caatgaatca ggttgggatt gtgctgaacg tacagcaagg ccaaacggtt agaccaatta
      901 cactagttcc agccccaggt acccagtttg ttaagccgac agttggagtt ccacaagtgt
      961 tctcccagat gacccctgtg aggccaggct ccacaatgcc tgtgaggccc accaccaaca
     1021 ccttcaccac cgtcatcccg gccactctta ccattcgaag caccgtccca cagtcccagt
     1081 cccagcagac caagtccact cccagcactt ctaccactcc cactgccaca cagccaacct
     1141 cactggggca actagctgtt cagtctccag gccagtcaaa ccagaccacg aatcccaagc
     1201 tagctccctc cttcccctct ccacctgcag tgagcattgc cagctttgtc actgtgaagc
     1261 gacctggtgt tacaggcgaa aatagcaatg aagtggccaa attggtgaat acccttaaca
     1321 ccatcccttc cctgggccag agtcctgggc cagtggtggt gtccaacaac agctctgctc
     1381 atggctctca aagaaccagc ggacctgagt cttcaatgaa agtgacctct tccatcccag
     1441 tatttgacct ccaggatggt ggacggaaaa tatgtccacg atgtaatgct caatttcgtg
     1501 ttactgaagc tttgagaggt cacatgtgtt actgttgccc agaaatggtt gaataccaga
     1561 agaaaggaaa gtccctggat tcagaaccca gtgtcccatc agcagcaaag cccccatccc
     1621 ctgagaaaac agctcctgtt gcttccacac cctcttctac acctattcct gctctgtcac
     1681 cgcctaccaa agtaccagaa ccaaatgaga acgtgggcga tgccgtccag accaaactca
     1741 ttatgcttgt agatgacttc tactatggac gggatggtgg caaagtagcc cagctcacaa
     1801 atttccctaa ggtcgccaca tctttccgat gcccacattg taccaaaagg ctaaaaaaca
     1861 atattcgatt catgaaccat atgaaacacc acgtagaact cgatcagcag aacggtgagg
     1921 tagatggtca cactatctgc cagcactgtt accgccagtt ttccactccc ttccagcttc
     1981 agtgccactt ggaaaatgtt catagtccct atgaatctac taccaagtgc aagatctgtg
     2041 aatgggcgtt tgaaagtgag ccactatttc tccagcatat gaaggatact cataagcctg
     2101 gagagatgcc ttatgtttgc caggtgtgtc aatatcgctc ctcactctac tctgaggtag
     2161 atgtccattt tcggatgatc catgaggata cccggcatct gctctgccct tattgcctga
     2221 aggtcttcaa aaatggcaat gcattccaac agcattacat gaggcaccag aagagaaatg
     2281 tttatcactg caacaaatgc cggctgcagt ttctctttgc caaggacaaa attgaacaca
     2341 agcttcaaca ccataaaacc ttccgtaaac ccaagcagct ggagggcttg aaaccaggca
     2401 ccaaggtgac aatccgggct tcccgagggc agccacgaac tgttcctgta tcctctaatg
     2461 atacacctcc cagcgccttg caggaggcag caccgctgac ctcctcaatg gaccctctgc
     2521 ctgtcttcct ttatccccct gtccagcgca gcatccagaa gagagctgtt aggaaaatga
     2581 gtgtcatggg ccggcagaca tgcctggagt gcagcttcga gatcccagac ttccctaatc
     2641 atttccctac ttacgtacac tgctctctgt gtcgctatag cacctgctgt tctcgagctt
     2701 atgccaacca catgatcaac aatcatgttc cacggaagag ccccaagtat ttggctttgt
     2761 ttaaaaattc tgtgagtgga atcaagctgg cctgcacttc atgtaccttt gttacctctg
     2821 tgggcgatgc tatggccaag catttggtat tcaacccctc tcacagatcc agcagcatcc
     2881 tgccacgggg actcacttgg atagctcact caaggcatgg ccagactcgt gaccgagtgc
     2941 atgaccggaa cgtgaagaat atgtaccctc ctccttcctt ccccactaac aaagctgcca
     3001 ctgtgaaatc tgcgggggcc accccagctg agcctgaaga gctactaact cccttagccc
     3061 cagcactccc atcaccagcc tcaactgcaa ccccaccacc aacccccact cacccgcagg
     3121 ctttagccct tccaccgctg gctacagagg gagccgaatg tctgaatgtt gatgatcagg
     3181 atgaagggag cccagtcacc caagaacctg agctagcatc aggtggtggt ggtagtggtg
     3241 gagttggcaa aaaggagcag ctgtctgtga agaagcttcg agtagtactg tttgctctat
     3301 gctgcaatac agaacaggca gctgaacact tccgaaatcc ccagcgacgt attcgccgtt
     3361 ggcttcgacg tttccaggcc tcccaggggg agaatctaga gggcaaatat ctgagctttg
     3421 aggcagaaga gaaactggct gagtgggtgc taacccagcg cgaacaacag ctacctgtaa
     3481 atgaggagac cttgttccag aaggccacca aaataggacg ttctttggaa ggggggttta
     3541 agatctccta tgagtgggct gtgcgtttca tgctgcggca ccacctgact ccccatgccc
     3601 ggcgagctgt ggcccacacc ctacctaagg atgtagcaga gaatgcagga ctcttcattg
     3661 attttgtaca acggcagatt cacaaccagg acttaccctt gtctatgatt gtggctattg
     3721 atgagatctc tttgttcctg gatacagagg tgctgagcag tgatgatcga aaggagaatg
     3781 ccctgcagac agtgggcaca ggggaacctt ggtgtgatgt agtcctagcc attctggcag
     3841 atggcactgt ccttcccacc ctggttttct acagagggca gatggatcag cctgctaaca
     3901 tgccagactc catattgcta gaggcaaagg agagtggcta cagtgatgac gagatcatgg
     3961 agctgtggtc aactcgagtg tggcagaagc acacagcttg ccagcgcagc aaaggcatgc
     4021 ttgtgatgga ctgtcatcgc actcacttgt cagaagaggt actggctatg cttagtgcct
     4081 ctagcacttt gcctgcagtg gtcccagcag gctgtagctc caaaattcag ccattagatg
     4141 tatgcatcaa aagaactgtc aagaacttcc tgcataaaaa atggaaggaa caggctcggg
     4201 aaatggcaga tactgcatgt gattctgatg tcctgcttca gctggtgctt gtctggctgg
     4261 gtgaagtgct aggtgtcatt ggggactgtc cagagctagt tcagcgctcc ttcctggtgg
     4321 ctagtgttct gcctggcccc gatggcaaca ttaactcacc tacaagaaat gctgacatgc
     4381 aggaggagct aattgcctcc ctagaggagc aactgaagct gagtggggaa cattctgagt
     4441 cttccactcc acgacccaga tcatctcctg aagagacaat tgagcctgaa agtcttcacc
     4501 agctctttga gggtgaaagt gagaccgagt ctttctatgg ctttgaagaa gctgacctag
     4561 atctgatgga gatttgagtg ttggggtcat gagggggtgt ggagtgaggg tgggaacatg
     4621 tgagggaggg taaaggggct tagggaaaag ggggcatacc aggtggggta tttggtttct
     4681 attttttaat tttataccac cactcccccc tgaagttgac ttacacttcc ctgtggattt
     4741 gtggattaat taggaaaacc aatagtaatc acgtctgagc caaggagctg gcccattggt
     4801 cattcacttc tgctaaaaac aggtttttgt gacttttttt ttttttaaat ttaaatcact
     4861 gtgtttggta tttttctgac aaaattaaga aaaagaaaaa aaattatttg tgggcaaatg
     4921 ttaaattttt ttgtttcccc ttttacctca attgtatcat agtactgggt ttttttgttt
     4981 gttttattgt gtggccaatg tctttgggca tgatgctatc taatcattgt taatgtgaga
     5041 acatttctga agatgggaaa gacaaattat gtagctcaca aactggttta ttatatatat
     5101 ggataaaaaa cttttttcat tgtggtctta acacttttat ataaaaatga aaatggaaaa
     5161 aaagtcccac tgaactctct cttccttctc cttttctttc cttccctctc cagagatgtt
     5221 ggtttctaca gcaaccctag atataaaatt gtggctttaa aaatgcatga aaccaccttt
     5281 aattatccag aatgaataga tttgtctttt cctcaccacc ttccctccaa aacatgacat
     5341 aaacaatatt ttttgcactt gtgatccttg gcccctttcc ccattctcaa caccatccat
     5401 ccctctggac aaaggatcat acaggtgtta ttagcaagca agagatactg aagcgatcaa
     5461 acagttttag ggtggaagcc attcccagtt tgagtcttca tcctgtaagc ccccaggggc
     5521 agtccctgct ttactgaact tcatcctgtt agatggagag catgcctgtt taagggatta
     5581 ctggtcctac agccaggagc taattgttca agaagtgttg aactttaaaa agacaagacc
     5641 acttgttgaa atccagcgtg ctctgtggct ttcccctatt tctcttaata cttagggaag
     5701 aatctgacag gaagaagcgc acaggggtgt gcacaaagaa aatgacatga atctttattt
     5761 ttcactgcca gcttcaagga aagaaaattt tttctacaat ttgcatgagg gattttttta
     5821 attgtatgta ctcatggttg taaaccaaaa cgtactgtac cgtacagaga aaaggagcaa
     5881 aaaaccaagt cttctgttta tcctgaggct ttccacaatg ttcccctcct gtgagccaag
     5941 gaggcaaact gcacaagctt gtaaatggtt cgtctttaaa atgtacataa gtggaacatt
     6001 taataaaatg aggggaaatg gatttataaa cttgtttttt ttctaggtga ccctgtttaa
     6061 taggctttca cagactgggg aatgctcaag atgtgatggg cctggtggta caggtgtgac
     6121 atttgttacc acccatttct cccaccccac cctgcttttt tgtttgtttg ttttttcatc
     6181 ccccagcaca ctataatata gtgaactgga aaagtccctt ccagaaacag cttggccagc
     6241 tttgtgaacc tttgacatct gaaaacaacc aaggatccat ctgggcttct cttccccagc
     6301 tttttgcctg atgccatttt attgacagac aatggacttt gaagtcagcc tttgcctttg
     6361 agaaagttca agaactatgg ttggtcacgt ctatctacaa cctaatccta ctctttggta
     6421 gtctctgcag cagccacagc cttagcagag ctggggttcc tgtcttctgc acacgattga
     6481 ctttcttgat gggtaatttt ttttaagatt ataccaacag tggatcagct gggttttggc
     6541 caggaagttg tctttgtgga ctctgcctgc atggcttagt agtagaagga aatttttttt
     6601 tggttttgtt ttttataatt cagtttaatc aataaacatg tatttattga ctgtt
//
