LOCUS       NM_153705               4253 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens protein O-glucosyltransferase 3 (POGLUT3), transcript
            variant 1, mRNA.
ACCESSION   NM_153705
VERSION     NM_153705.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4253)
  AUTHORS   Williamson,D.B., Sohn,C.J., Ito,A. and Haltiwanger,R.S.
  TITLE     POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in
            fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1
  JOURNAL   J Biol Chem 297 (3), 101055 (2021)
   PUBMED   34411563
  REMARK    GeneRIF: POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in
            fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.
REFERENCE   2  (bases 1 to 4253)
  AUTHORS   Takeuchi,H., Schneider,M., Williamson,D.B., Ito,A., Takeuchi,M.,
            Handford,P.A. and Haltiwanger,R.S.
  TITLE     Two novel protein O-glucosyltransferases that modify sites distinct
            from POGLUT1 and affect Notch trafficking and signaling
  JOURNAL   Proc Natl Acad Sci U S A 115 (36), E8395-E8402 (2018)
   PUBMED   30127001
REFERENCE   3  (bases 1 to 4253)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC036526.2, AF533708.1 and AI628702.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153705.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF533708.1, SRR1660803.186993.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267768 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323468.10/ ENSP00000315386.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-973               BC036526.2         3-975
            974-4005            AF533708.1         981-4012
            4006-4253           AI628702.1         11-258              c
FEATURES             Location/Qualifiers
     source          1..4253
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..4253
                     /gene="POGLUT3"
                     /gene_synonym="KDELC2"
                     /note="protein O-glucosyltransferase 3"
                     /db_xref="GeneID:143888"
                     /db_xref="HGNC:HGNC:28496"
                     /db_xref="MIM:618503"
     exon            1..220
                     /gene="POGLUT3"
                     /gene_synonym="KDELC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1542
                     /gene="POGLUT3"
                     /gene_synonym="KDELC2"
                     /EC_number="2.4.2.26"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; KDEL motif-containing protein 2; KDEL
                     (Lys-Asp-Glu-Leu) containing 2; protein
                     O-xylosyltransferase POGLUT3; KDEL motif containing 2"
                     /codon_start=1
                     /product="protein O-glucosyltransferase 3 isoform 1
                     precursor"
                     /protein_id="NP_714916.3"
                     /db_xref="CCDS:CCDS41711.1"
                     /db_xref="GeneID:143888"
                     /db_xref="HGNC:HGNC:28496"
                     /db_xref="MIM:618503"
                     /translation="MRRLPRALLLQLRLALLVAAGAPEVLVSAPRSLVWGPGLQAAVV
                     LPVRYFYLQAVNSEGQNLTRSPAGETPFKVVVKSLSPKELVRIHVPKPLDRNDGTFLM
                     RYRMYETVDEGLKIEVLYGDEHVAQSPYILKGPVYHEYCECPEDPQAWQKTLSCPTKE
                     PQIAKDFASFPSINLQQMLKEVPKRFGDERGAIVHYTILNNHVYRRSLGKYTDFKMFS
                     DEILLSLTRKVLLPDLEFYVNLGDWPLEHRKVNGTPSPIPIISWCGSLDSRDVVLPTY
                     DITHSMLEAMRGVTNDLLSIQGNTGPSWINKTERAFFRGRDSREERLQLVQLSKENPQ
                     LLDAGITGYFFFQEKEKELGKAKLMGFFDFFKYKYQVNVDGTVAAYRYPYLMLGDSLV
                     LKQDSPYYEHFYMALEPWKHYVPIKRNLSDLLEKVKWAKENDEEAKKIAKEGQLMARD
                     LLQPHRLYCYYYQVLQKYAERQSSKPEVRDGMELVPQPEDSTAICQCHRKKPSREEL"
     exon            221..418
                     /gene="POGLUT3"
                     /gene_synonym="KDELC2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..702
                     /gene="POGLUT3"
                     /gene_synonym="KDELC2"
                     /inference="alignment:Splign:2.1.0"
     exon            703..919
                     /gene="POGLUT3"
                     /gene_synonym="KDELC2"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1116
                     /gene="POGLUT3"
                     /gene_synonym="KDELC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1311
                     /gene="POGLUT3"
                     /gene_synonym="KDELC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1416
                     /gene="POGLUT3"
                     /gene_synonym="KDELC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..4253
                     /gene="POGLUT3"
                     /gene_synonym="KDELC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4233..4238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POGLUT3"
                     /gene_synonym="KDELC2"
                     /note="hexamer: AATAAA"
     polyA_site      4253
                     /gene="POGLUT3"
                     /gene_synonym="KDELC2"
                     /note="major polyA site"
ORIGIN      
        1 agttgtgccc cgccgaccat gcgccgcctc ccgcgggccc tgctgctgca gctgcgcctc
       61 gccctgctgg tggccgcggg ggccccggag gtgctggtca gcgcgccgcg gagcctggtg
      121 tgggggcccg ggctgcaggc ggccgtcgtc ctgccggtcc gctatttcta cctgcaggcg
      181 gtcaactcgg agggccagaa cctcactcgc tctcccgcag gtgaaacacc attcaaagtc
      241 gtagtcaaat ctctttcacc taaagagttg gtccggatac atgtccctaa acctttggac
      301 aggaatgatg gaacattttt gatgagatat aggatgtatg aaactgtcga tgaaggcctg
      361 aagatagagg tcctttatgg tgatgaacat gtggctcagt ctccctatat tttgaaagga
      421 ccagtgtacc atgagtactg tgagtgtccg gaagatcctc aggcctggca gaagactctt
      481 tcttgtccaa ccaaggaacc acagattgca aaagattttg cttcctttcc cagcatcaat
      541 ctccagcaaa tgctaaaaga agtccccaaa aggtttgggg atgagagagg tgccattgtt
      601 cattacacga ttctcaataa ccatgtttac cggagatctt tagggaaata cacagacttc
      661 aagatgttct ctgatgagat tttgttatca ttgacaagaa aggtccttct cccagattta
      721 gaattttatg ttaatcttgg agattggccc ttggagcatc gaaaagtcaa tggaacccct
      781 agccccatac ctatcatttc atggtgtggc tctctggatt caagagatgt tgtccttcca
      841 acgtatgaca tcacccactc catgcttgaa gccatgcggg gtgttacaaa tgatctcctc
      901 tctattcagg gaaatacagg gccttcctgg atcaataaaa cagagagagc tttcttcaga
      961 ggtagagaca gccgagagga gaggctccag ttggtacagc tgtccaaaga aaatcctcag
     1021 ctactagatg caggaattac aggatatttc tttttccaag agaaagaaaa ggagcttgga
     1081 aaagccaagt tgatgggttt ctttgatttc tttaagtaca agtatcaagt aaatgtggat
     1141 gggaccgtgg ctgcttacag atatccatat ctcatgctgg gcgacagtct ggttttaaag
     1201 caggactcgc catattatga acatttctac atggcactag aaccttggaa gcattatgtt
     1261 ccaattaaaa gaaatctgag tgatttatta gagaaagtta aatgggctaa ggaaaatgat
     1321 gaagaagcca agaagattgc aaaagaagga cagttgatgg ctagggacct actacagcca
     1381 cacaggcttt actgctacta ttaccaagta ctgcagaaat atgccgagcg ccagtccagc
     1441 aaacccgaag tacgtgatgg aatggaactt gttcctcagc cagaagatag cacagccatc
     1501 tgccagtgcc acaggaaaaa gccttcaaga gaagaacttt gagtcagccc agaatcacac
     1561 tcctgtgtat cccggctaca ctttaaggaa agattgaatc taagctgtga aggacagtat
     1621 agaagactgc accaagtgga ctagttctcc cggtggcttt atatatgtag atggatatag
     1681 cagtactggt tgagtatccc tcatctgaaa tgcttaggac caggagtgtt tcaggcttca
     1741 gattttttaa gatttgggaa tatttgcatg tacataatga ggtatcttgg ggatgagatc
     1801 caagtctaaa cacaaaattc atttatattt tatatatacc ttgttcacat accctgaagg
     1861 taattttata taatattttt aataatttgt gcatgaaaca aagtttgtat acattgaact
     1921 gtcagaaagc aaaggtgtca ctatcttagc gacccaagtg gtggtgtcag cactcaaaaa
     1981 gttttggatt ttggggtatt tcagatttta gatttttgta tgaggaatgt tcaacctgta
     2041 tttgaacaag cattaccaaa tatcattgaa tattaatatc ttttgcgtaa aaactgctat
     2101 tatcagcatc atagtttctc taaaaagaaa acttggggat catagccgat agagagactt
     2161 gctaaaatat aaatcagcct ctgcaaaact gtttacatat ttattggttt acatatttta
     2221 ttggtttatt tctatcccct gttcactttt tctcttccac ttccaattat gaagagaaaa
     2281 tatttgttca gggttgtccc cccgcccccc gtcactgcat aatttctcct cttacaagct
     2341 gcttttggct ttcattaata acagcttcct tttagaaggt ctgataagga tatttaagga
     2401 agaagagaat gactctgtta ttaaaggtgg catggagact gtggagggaa tattttttaa
     2461 agcactactc atatccttta aactaaattt tgccaaagcc cgagacaaca ttaaggagaa
     2521 attgtacctt aagttagtaa ttccaaatct atctgagttg tatacccatc aaagacaata
     2581 cagttattaa catagatgaa ggtatgctat aggcatcatt cattatctct atattgaata
     2641 ggtgaaagat aactgtagtc aggtgaaagg cattcattat ttttaagctg aaaaggggat
     2701 ccttgaaaac actgaaaacc tctacaacaa tcttcaggaa gcctgctatc ttgggattca
     2761 ctaataatag gccaagaaca aaggcaagca tccattcctc actccaccac ttttctattt
     2821 cagtgggtgt cgttgctacg atgaagactt tggaaatttc ctttctcttt taggacaggg
     2881 tcaggattta ggactcatag cctgaaagct cattacatac tccttgtaac catcagtcca
     2941 aggttcagtt cactaaagtg catgttctaa aacaagagct atcctcattc caaattttaa
     3001 aatatgtact ctggccggtt gcagtggctc acgcctgtaa tcccagcact ttggcaggcc
     3061 gagatgggcg gatcttttga ggtcaggagt ttgagaccag cctggccaac atggtgaaac
     3121 cccgtctcta ctaaaaatac aaaaattagc caggcatggt ggcatttgcc tgtaatccca
     3181 gctactcggg aggctgaggc aggagaatca cttgaacctg ggaggcagag gttgcagtga
     3241 gctgagatta caccactgca ctccagcctg ggtgacagag tgagactcca tctcaaaaac
     3301 tgaaaataaa aataaaaata tgtattctcc taactgaaat atttacttaa tctggaaaac
     3361 aatgtaacta tttttaaagt ggttacatct attcttgctg aagaacaata aacagaattt
     3421 tttgactaag cataaccaaa tttcagaaca gtctaatcaa tgccaagtat ccaaggcaaa
     3481 ctctaatacc catccattgt gcaaaaccac aagcacgcaa gtattaaata agagcaagct
     3541 gtcctgagcc catacctaat gaatttgtgt cttaaatatt gtacattgtg tttgaggctt
     3601 gtcaaaactg ggattatggc aagaaaggtt gcctaactca tacctttctg cctcaaattc
     3661 caggtgctaa aggctaatgg cattttaaac atcttacatt tttaaaaatt tatattgcct
     3721 ctgccaaaca ggcctaatag ttaaaagcaa gttgagacaa accaggcaga ttcagtgtgt
     3781 ggaacaggaa ggatgtgctt taaaaaaagg tggaatccct caaaaaattc tatagggaga
     3841 cagcagcctt aatctacata attcttcatc tcgccaattc agccgcagcc tttaaagagt
     3901 tagtgttaat ggctttctgg tttgaaaaca aaaatgcatc tatgtggttg aaagtttggg
     3961 aggagattca ccaatatctg aggagaagat ggagtgaagg gaattcttac tttttgcttt
     4021 atacctttct ataatattta gatttttttt tactgtaagt atggatcaaa ttgcaaaata
     4081 aagaaaaatg ccaaccttag aaaagacaat aaatgcacaa aagatataaa caggaacagc
     4141 aaatatttat attttttcca ttttgctctt tttaaatcta tgtttagaac tttatatctt
     4201 gggacttatg tatatatata ccttttaaat aaaataaatt ttctaaataa aaa
//
