LOCUS       NP_714916                507 aa            linear   PRI 28-APR-2025
DEFINITION  protein O-glucosyltransferase 3 isoform 1 precursor [Homo sapiens].
ACCESSION   NP_714916
VERSION     NP_714916.3
DBSOURCE    REFSEQ: accession NM_153705.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 507)
  AUTHORS   Williamson,D.B., Sohn,C.J., Ito,A. and Haltiwanger,R.S.
  TITLE     POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in
            fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1
  JOURNAL   J Biol Chem 297 (3), 101055 (2021)
   PUBMED   34411563
  REMARK    GeneRIF: POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in
            fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.
REFERENCE   2  (residues 1 to 507)
  AUTHORS   Takeuchi,H., Schneider,M., Williamson,D.B., Ito,A., Takeuchi,M.,
            Handford,P.A. and Haltiwanger,R.S.
  TITLE     Two novel protein O-glucosyltransferases that modify sites distinct
            from POGLUT1 and affect Notch trafficking and signaling
  JOURNAL   Proc Natl Acad Sci U S A 115 (36), E8395-E8402 (2018)
   PUBMED   30127001
REFERENCE   3  (residues 1 to 507)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC036526.2, AF533708.1 and AI628702.1.
            
            On Jul 24, 2007 this sequence version replaced NP_714916.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF533708.1, SRR1660803.186993.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267768 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323468.10/ ENSP00000315386.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     Protein         1..507
                     /product="protein O-glucosyltransferase 3 isoform 1
                     precursor"
                     /EC_number="2.4.2.26"
                     /note="KDEL motif-containing protein 2; KDEL
                     (Lys-Asp-Glu-Leu) containing 2; protein
                     O-xylosyltransferase POGLUT3; KDEL motif containing 2"
                     /calculated_mol_wt=56303
     sig_peptide     1..20
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7Z4H8.2)"
                     /calculated_mol_wt=2288
     mat_peptide     21..507
                     /product="Protein O-glucosyltransferase 3.
                     /id=PRO_0000247196"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z4H8.2)"
                     /calculated_mol_wt=56303
     Region          24..134
                     /region_name="Filamin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z4H8.2)"
     Region          27..131
                     /region_name="Filamin"
                     /note="Filamin/ABP280 repeat; pfam00630"
                     /db_xref="CDD:395505"
     Site            61
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218; propagated from
                     UniProtKB/Swiss-Prot (Q7Z4H8.2)"
     Region          151..485
                     /region_name="Glyco_transf_90"
                     /note="Glycosyl transferase family 90; cl23835"
                     /db_xref="CDD:329112"
     Site            306
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218; propagated from
                     UniProtKB/Swiss-Prot (Q7Z4H8.2)"
     Region          504..507
                     /region_name="Prevents secretion from ER.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU10138"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z4H8.2)"
     CDS             1..507
                     /gene="POGLUT3"
                     /gene_synonym="KDELC2"
                     /coded_by="NM_153705.5:19..1542"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS41711.1"
                     /db_xref="GeneID:143888"
                     /db_xref="HGNC:HGNC:28496"
                     /db_xref="MIM:618503"
ORIGIN      
        1 mrrlpralll qlrlallvaa gapevlvsap rslvwgpglq aavvlpvryf ylqavnsegq
       61 nltrspaget pfkvvvksls pkelvrihvp kpldrndgtf lmryrmyetv deglkievly
      121 gdehvaqspy ilkgpvyhey cecpedpqaw qktlscptke pqiakdfasf psinlqqmlk
      181 evpkrfgder gaivhytiln nhvyrrslgk ytdfkmfsde illsltrkvl lpdlefyvnl
      241 gdwplehrkv ngtpspipii swcgsldsrd vvlptydith smleamrgvt ndllsiqgnt
      301 gpswinkter affrgrdsre erlqlvqlsk enpqlldagi tgyfffqeke kelgkaklmg
      361 ffdffkykyq vnvdgtvaay rypylmlgds lvlkqdspyy ehfymalepw khyvpikrnl
      421 sdllekvkwa kendeeakki akegqlmard llqphrlycy yyqvlqkyae rqsskpevrd
      481 gmelvpqped staicqchrk kpsreel
//
