LOCUS       NM_152305               3508 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens protein O-glucosyltransferase 1 (POGLUT1), transcript
            variant 1, mRNA.
ACCESSION   NM_152305 NM_020231
VERSION     NM_152305.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3508)
  AUTHORS   Servian-Morilla,E., Cabrera-Serrano,M., Johnson,K., Pandey,A.,
            Ito,A., Rivas,E., Chamova,T., Muelas,N., Mongini,T., Nafissi,S.,
            Claeys,K.G., Grewal,R.P., Takeuchi,M., Hao,H., Bonnemann,C., Lopes
            Abath Neto,O., Medne,L., Brandsema,J., Topf,A., Taneva,A.,
            Vilchez,J.J., Tournev,I., Haltiwanger,R.S., Takeuchi,H.,
            Jafar-Nejad,H., Straub,V. and Paradas,C.
  TITLE     POGLUT1 biallelic mutations cause myopathy with reduced satellite
            cells, alpha-dystroglycan hypoglycosylation and a distinctive
            radiological pattern
  JOURNAL   Acta Neuropathol 139 (3), 565-582 (2020)
   PUBMED   31897643
  REMARK    GeneRIF: POGLUT1 biallelic mutations cause myopathy with reduced
            satellite cells, alpha-dystroglycan hypoglycosylation and a
            distinctive radiological pattern.
REFERENCE   2  (bases 1 to 3508)
  AUTHORS   Kono,M., Sawada,M., Nakazawa,Y., Ogi,T., Muro,Y. and Akiyama,M.
  TITLE     A Japanese Case of Galli-Galli Disease due to a Previously
            Unreported POGLUT1 Mutation
  JOURNAL   Acta Derm Venereol 99 (4), 458-459 (2019)
   PUBMED   30653241
  REMARK    GeneRIF: Case Report: Japanese female with Galli-Galli Disease due
            to novel POGLUT1 mutation.
REFERENCE   3  (bases 1 to 3508)
  AUTHORS   Hitomi,Y., Ueno,K., Kawai,Y., Nishida,N., Kojima,K., Kawashima,M.,
            Aiba,Y., Nakamura,H., Kouno,H., Kouno,H., Ohta,H., Sugi,K.,
            Nikami,T., Yamashita,T., Katsushima,S., Komeda,T., Ario,K.,
            Naganuma,A., Shimada,M., Hirashima,N., Yoshizawa,K., Makita,F.,
            Furuta,K., Kikuchi,M., Naeshiro,N., Takahashi,H., Mano,Y.,
            Yamashita,H., Matsushita,K., Tsunematsu,S., Yabuuchi,I.,
            Nishimura,H., Shimada,Y., Yamauchi,K., Komatsu,T., Sugimoto,R.,
            Sakai,H., Mita,E., Koda,M., Nakamura,Y., Kamitsukasa,H., Sato,T.,
            Nakamuta,M., Masaki,N., Takikawa,H., Tanaka,A., Ohira,H.,
            Zeniya,M., Abe,M., Kaneko,S., Honda,M., Arai,K., Arinaga-Hino,T.,
            Hashimoto,E., Taniai,M., Umemura,T., Joshita,S., Nakao,K.,
            Ichikawa,T., Shibata,H., Takaki,A., Yamagiwa,S., Seike,M.,
            Sakisaka,S., Takeyama,Y., Harada,M., Senju,M., Yokosuka,O.,
            Kanda,T., Ueno,Y., Ebinuma,H., Himoto,T., Murata,K., Shimoda,S.,
            Nagaoka,S., Abiru,S., Komori,A., Migita,K., Ito,M., Yatsuhashi,H.,
            Maehara,Y., Uemoto,S., Kokudo,N., Nagasaki,M., Tokunaga,K. and
            Nakamura,M.
  TITLE     POGLUT1, the putative effector gene driven by rs2293370 in primary
            biliary cholangitis susceptibility locus chromosome 3q13.33
  JOURNAL   Sci Rep 9 (1), 102 (2019)
   PUBMED   30643196
  REMARK    GeneRIF: This is the first study to demonstrate that POGLUT1 and
            not CD80 is the effector gene regulated by the primary functional
            SNP rs2293370, and that increased expression of POGLUT1 might be
            involved in the pathogenesis of Primary biliary cholangitis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3508)
  AUTHORS   Chammaa,M., Malysa,A., Redondo,C., Jang,H., Chen,W., Bepler,G. and
            Fernandez-Valdivia,R.
  TITLE     RUMI is a novel negative prognostic marker and therapeutic target
            in non-small-cell lung cancer
  JOURNAL   J Cell Physiol 233 (12), 9548-9562 (2018)
   PUBMED   29953591
  REMARK    GeneRIF: RUMI is a novel negative prognostic factor with
            significant therapeutic potential in non-small-cell lung cancer.
REFERENCE   5  (bases 1 to 3508)
  AUTHORS   Takeuchi,H., Schneider,M., Williamson,D.B., Ito,A., Takeuchi,M.,
            Handford,P.A. and Haltiwanger,R.S.
  TITLE     Two novel protein O-glucosyltransferases that modify sites distinct
            from POGLUT1 and affect Notch trafficking and signaling
  JOURNAL   Proc Natl Acad Sci U S A 115 (36), E8395-E8402 (2018)
   PUBMED   30127001
REFERENCE   6  (bases 1 to 3508)
  AUTHORS   Dubois,P.C., Trynka,G., Franke,L., Hunt,K.A., Romanos,J.,
            Curtotti,A., Zhernakova,A., Heap,G.A., Adany,R., Aromaa,A.,
            Bardella,M.T., van den Berg,L.H., Bockett,N.A., de la Concha,E.G.,
            Dema,B., Fehrmann,R.S., Fernandez-Arquero,M., Fiatal,S.,
            Grandone,E., Green,P.M., Groen,H.J., Gwilliam,R., Houwen,R.H.,
            Hunt,S.E., Kaukinen,K., Kelleher,D., Korponay-Szabo,I., Kurppa,K.,
            MacMathuna,P., Maki,M., Mazzilli,M.C., McCann,O.T., Mearin,M.L.,
            Mein,C.A., Mirza,M.M., Mistry,V., Mora,B., Morley,K.I.,
            Mulder,C.J., Murray,J.A., Nunez,C., Oosterom,E., Ophoff,R.A.,
            Polanco,I., Peltonen,L., Platteel,M., Rybak,A., Salomaa,V.,
            Schweizer,J.J., Sperandeo,M.P., Tack,G.J., Turner,G., Veldink,J.H.,
            Verbeek,W.H., Weersma,R.K., Wolters,V.M., Urcelay,E., Cukrowska,B.,
            Greco,L., Neuhausen,S.L., McManus,R., Barisani,D., Deloukas,P.,
            Barrett,J.C., Saavalainen,P., Wijmenga,C. and van Heel,D.A.
  TITLE     Multiple common variants for celiac disease influencing immune gene
            expression
  JOURNAL   Nat Genet 42 (4), 295-302 (2010)
   PUBMED   20190752
  REMARK    Erratum:[Nat Genet.2010 May;42(5):465]
REFERENCE   7  (bases 1 to 3508)
  AUTHORS   Wang,Y., Chang,N., Zhang,T., Liu,H., Ma,W., Chu,Q., Lai,Q., Liu,L.
            and Wang,W.
  TITLE     Overexpression of human CAP10-like protein 46 KD in T-acute
            lymphoblastic leukemia and acute myelogenous leukemia
  JOURNAL   Genet Test Mol Biomarkers 14 (1), 127-133 (2010)
   PUBMED   20143914
  REMARK    GeneRIF: CLP46 was overexpressed in AML, T-ALL, and leukemic cell
            lines. Considering that CLP46 has the capability of modifying the
            Notch pathway, our finding adds weight to the possible importance
            of Notch signaling in the pathogenesis of AML and T-ALL.
REFERENCE   8  (bases 1 to 3508)
  AUTHORS   Karadonta,A.V., Alexandrakis,M.G., Kourelis,T.V., Manola,A.,
            Garlemou,K., Stathakis,N.E. and Kyriakou,D.
  TITLE     Abnormal expression of C3ORF9 gene in patients with myelodysplastic
            syndromes
  JOURNAL   Int J Immunopathol Pharmacol 22 (3), 787-793 (2009)
   PUBMED   19822096
  REMARK    GeneRIF: Altered C3ORF9 expression in myelodysplastic syndrome was
            possibly due to different gene regulation in these patients and/or
            to the increased CD34+ cells.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3508)
  AUTHORS   Teng,Y., Liu,Q., Ma,J., Liu,F., Han,Z., Wang,Y. and Wang,W.
  TITLE     Cloning, expression and characterization of a novel human
            CAP10-like gene hCLP46 from CD34(+) stem/progenitor cells
  JOURNAL   Gene 371 (1), 7-15 (2006)
   PUBMED   16524674
REFERENCE   10 (bases 1 to 3508)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY298903.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_152305.2.
            
            Summary: This gene encodes a protein with both
            O-glucosyltransferase and O-xylosyltransferase activity which
            localizes to the lumen of the endoplasmic reticulum. This protein
            has a carboxy-terminal KTEL motif which is predicted to function as
            an endoplasmic reticulum retention signal. This gene is an
            essential regulator of Notch signalling and likely plays a role in
            cell fate and tissue formation during development. It may also play
            a role in the pathogenesis of leukemia. Mutations in this gene have
            been associated with the autosomal dominant genodermatosis
            Dowling-Degos disease 4. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and is protein coding.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY298903.1, SRR1803616.252076.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295588.9/ ENSP00000295588.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3508              AY298903.1         12-3519
FEATURES             Location/Qualifiers
     source          1..3508
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..3508
                     /gene="POGLUT1"
                     /gene_synonym="C3orf9; CLP46; hCLP46; KDELCL1; KTELC1;
                     LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi"
                     /note="protein O-glucosyltransferase 1"
                     /db_xref="GeneID:56983"
                     /db_xref="HGNC:HGNC:22954"
                     /db_xref="MIM:615618"
     exon            1..144
                     /gene="POGLUT1"
                     /gene_synonym="C3orf9; CLP46; hCLP46; KDELCL1; KTELC1;
                     LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1238
                     /gene="POGLUT1"
                     /gene_synonym="C3orf9; CLP46; hCLP46; KDELCL1; KTELC1;
                     LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi"
                     /EC_number="2.4.2.63"
                     /EC_number="2.4.1.376"
                     /note="KTEL (Lys-Tyr-Glu-Leu) containing 1; KDELC family
                     like 1; KTEL motif-containing protein 1; x 010 protein;
                     9630046K23Rik; hRumi; O-glucosyltransferase Rumi homolog;
                     CAP10-like 46 kDa protein; myelodysplastic syndromes
                     relative protein; protein O-xylosyltransferase POGLUT1"
                     /codon_start=1
                     /product="protein O-glucosyltransferase 1 precursor"
                     /protein_id="NP_689518.1"
                     /db_xref="CCDS:CCDS2988.1"
                     /db_xref="GeneID:56983"
                     /db_xref="HGNC:HGNC:22954"
                     /db_xref="MIM:615618"
                     /translation="MEWWASSPLRLWLLLFLLPSAQGRQKESGSKWKVFIDQINRSLE
                     NYEPCSSQNCSCYHGVIEEDLTPFRGGISRKMMAEVVRRKLGTHYQITKNRLYRENDC
                     MFPSRCSGVEHFILEVIGRLPDMEMVINVRDYPQVPKWMEPAIPVFSFSKTSEYHDIM
                     YPAWTFWEGGPAVWPIYPTGLGRWDLFREDLVRSAAQWPWKKKNSTAYFRGSRTSPER
                     DPLILLSRKNPKLVDAEYTKNQAWKSMKDTLGKPAAKDVHLVDHCKYKYLFNFRGVAA
                     SFRFKHLFLCGSLVFHVGDEWLEFFYPQLKPWVHYIPVKTDLSNVQELLQFVKANDDV
                     AQEIAERGSQFIRNHLQMDDITCYWENLLSEYSKFLSYNVTRRKGYDQIIPKMLKTEL
                     "
     exon            145..235
                     /gene="POGLUT1"
                     /gene_synonym="C3orf9; CLP46; hCLP46; KDELCL1; KTELC1;
                     LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi"
                     /inference="alignment:Splign:2.1.0"
     exon            236..379
                     /gene="POGLUT1"
                     /gene_synonym="C3orf9; CLP46; hCLP46; KDELCL1; KTELC1;
                     LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi"
                     /inference="alignment:Splign:2.1.0"
     exon            380..515
                     /gene="POGLUT1"
                     /gene_synonym="C3orf9; CLP46; hCLP46; KDELCL1; KTELC1;
                     LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi"
                     /inference="alignment:Splign:2.1.0"
     exon            516..637
                     /gene="POGLUT1"
                     /gene_synonym="C3orf9; CLP46; hCLP46; KDELCL1; KTELC1;
                     LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi"
                     /inference="alignment:Splign:2.1.0"
     exon            638..697
                     /gene="POGLUT1"
                     /gene_synonym="C3orf9; CLP46; hCLP46; KDELCL1; KTELC1;
                     LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi"
                     /inference="alignment:Splign:2.1.0"
     exon            698..797
                     /gene="POGLUT1"
                     /gene_synonym="C3orf9; CLP46; hCLP46; KDELCL1; KTELC1;
                     LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi"
                     /inference="alignment:Splign:2.1.0"
     exon            798..856
                     /gene="POGLUT1"
                     /gene_synonym="C3orf9; CLP46; hCLP46; KDELCL1; KTELC1;
                     LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1024
                     /gene="POGLUT1"
                     /gene_synonym="C3orf9; CLP46; hCLP46; KDELCL1; KTELC1;
                     LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1081
                     /gene="POGLUT1"
                     /gene_synonym="C3orf9; CLP46; hCLP46; KDELCL1; KTELC1;
                     LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..3508
                     /gene="POGLUT1"
                     /gene_synonym="C3orf9; CLP46; hCLP46; KDELCL1; KTELC1;
                     LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3480..3485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POGLUT1"
                     /gene_synonym="C3orf9; CLP46; hCLP46; KDELCL1; KTELC1;
                     LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi"
                     /note="hexamer: AATGAA"
     polyA_site      3508
                     /gene="POGLUT1"
                     /gene_synonym="C3orf9; CLP46; hCLP46; KDELCL1; KTELC1;
                     LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi"
                     /note="major polyA site"
ORIGIN      
        1 gtgcggggcc gcgcttccgc cagcgccgca gcggggaatc tgcagtaggt ctgccggcga
       61 tggagtggtg ggctagctcg ccgcttcggc tctggctgct gttgttcctc ctgccctcag
      121 cgcagggccg ccagaaggag tcaggttcaa aatggaaagt atttattgac caaattaaca
      181 ggtctttgga gaattacgaa ccatgttcaa gtcaaaactg cagctgctac catggtgtca
      241 tagaagagga tctaactcct ttccgaggag gcatctccag gaagatgatg gcagaggtag
      301 tcagacggaa gctagggacc cactatcaga tcactaagaa cagactgtac cgggaaaatg
      361 actgcatgtt cccctcaagg tgtagtggtg ttgagcactt tattttggaa gtgatcgggc
      421 gtctccctga catggagatg gtgatcaatg tacgagatta tcctcaggtt cctaaatgga
      481 tggagcctgc catcccagtc ttctccttca gtaagacatc agagtaccat gatatcatgt
      541 atcctgcttg gacattttgg gaagggggac ctgctgtttg gccaatttat cctacaggtc
      601 ttggacggtg ggacctcttc agagaagatc tggtaaggtc agcagcacag tggccatgga
      661 aaaagaaaaa ctctacagca tatttccgag gatcaaggac aagtccagaa cgagatcctc
      721 tcattcttct gtctcggaaa aacccaaaac ttgttgatgc agaatacacc aaaaaccagg
      781 cctggaaatc tatgaaagat accttaggaa agccagctgc taaggatgtc catcttgtgg
      841 atcactgcaa atacaagtat ctgtttaatt ttcgaggcgt agctgcaagt ttccggttta
      901 aacacctctt cctgtgtggc tcacttgttt tccatgttgg tgatgagtgg ctagaattct
      961 tctatccaca gctgaagcca tgggttcact atatcccagt caaaacagat ctctccaatg
     1021 tccaagagct gttacaattt gtaaaagcaa atgatgatgt agctcaagag attgctgaaa
     1081 ggggaagcca gtttattagg aaccatttgc agatggatga catcacctgt tactgggaga
     1141 acctcttgag tgaatactct aaattcctgt cttataatgt aacgagaagg aaaggttatg
     1201 atcaaattat tcccaaaatg ttgaaaactg aactatagta gtcatcatag gaccatagtc
     1261 ctctttgtgg caacagatct cagatatcct acggtgagaa gcttaccata agcttggcac
     1321 ctataccttg aatatctgct atcaagccaa atacctggtt ttccttatca tgctgcaccc
     1381 agagcaactc ttgagaaaga tttaaaatgt gtctaataca ctgatatgaa gcagttcaac
     1441 tttttggatg aataaggacc agaaatcgtg agatgtggat tttgaaccca actctacctt
     1501 tcattttctt aagaccaatc acagcttgtg cctcagatca tccacctgtg tgagtccatc
     1561 actgtgaaat tgactgtgtc catgtgatga tgccctttgt cccattattt ggagcagaaa
     1621 attcgtcatt tggaagtagt acaactcatt gctggaattg tgaaattatt caaggcgtga
     1681 tctctgtcac tttattttaa tgtaggaaac cctatggggt ttatgaaaaa tacttgggga
     1741 tcattctctg aatggtctaa ggaagcggta gccatgccat gcaatgatgt aggagttctc
     1801 ttttgtaaaa ccataaactg tgttactcag gaggtttcta taatgccaca tagaaagagg
     1861 ccaattgcat gagtaattat tgcaattgga tttcaggttc cctttttgtg ccttcatgcc
     1921 ctacttctta atgcctctct aaagccaaaa aaaaaaaaaa agacaaagcc tcttaataaa
     1981 tttaatggaa ctatacatag aacagcagct cttcctcacc ctttgcatac ctttaatatt
     2041 tttccttctt aaattggcca cagcaggggt cattcacact ctcactgtct tgcaggaatc
     2101 acaagaagtc ttcatatgtg aacgtgccat tcagttggta gttaagagca ttcaacttca
     2161 aatatataga agatatttgt tttagtgcaa atccatgatg gagtgcctcc cttttccttt
     2221 tttcactttt tgaaaaagat gttttgggta gtagtttaat atctcagggt gctctttcta
     2281 acatagtaaa aaatgaagaa aaatgtttag attaaaactc tgtagtctga tgacttagaa
     2341 ccatccttga cccttaggcc caacctttcc acagagaaat cacctctctt cctttgtctt
     2401 ttaagaacta tttggtatta actagtttca gaattagtaa atgtgagatt cagtcacata
     2461 attatcagac attccatttg tcagaaatgt atttggcttt ttaaactcct ttccacaaaa
     2521 gtttaagtct aatgaccttc ttagagaagt tgagcatgcc tggcaagatc atttcatgga
     2581 ataagcagat gtttaaagtt ggattttttt tttttttttt ttttgagtac tagcaatgca
     2641 cagggaccgt gttcttaggt tcttagtctg tgaatctagc aataggcagt ccagatttct
     2701 gagtcgtact atggttttgc cttgtcactg tgaggcccta ctaggtgtaa gcattctctc
     2761 tgaattttaa tttcctctca ttaaaatagg aacaaaattt gctatccttt agattaggag
     2821 ctgaagattc atttccctgg gaatgtttcc catttagctt caagtttcag ctcaaacatc
     2881 accttctttc tgactccttt cattcattcc tccaggcagt aaggggctac catagtactt
     2941 tgtttatgcc tgtattatat gacatcactg tagttgcttg actgtttctc ctactgttct
     3001 gtaaacttat taatgggtga gaatctaatt ttactcatct tgatggcttc atgatccagc
     3061 acagtgcctc acacaaagaa ctattgggtg ggtggatgga tggatggagg aatggagaca
     3121 gttggcttaa ccagatccta tatacagatt attactggct ccaaaggatg agtagataag
     3181 accataagaa ttggatcaat gtaaatcctc acctgccctt tgaagagcca ataagggcat
     3241 ctttgtcttt aaatacagca aatgttattc agattttgta cttgtctatc tgtttacctc
     3301 agtgtagatg atatgaggat ggtataacta tgtaaattgt ttttgaaaat aatttgtttc
     3361 cccacaactt ttgaaggttt tatttgttgt tgttattact agttcagtcc caaacttacc
     3421 ctttcctttt cagagagcta atggccatgc ttttcttcaa ggaaagaata atttatttga
     3481 atgaagtggg atacttgcat aacacaaa
//
