LOCUS       NM_015720               2175 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens podocalyxin like 2 (PODXL2), mRNA.
ACCESSION   NM_015720 XM_005275950 XM_006710151
VERSION     NM_015720.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2175)
  AUTHORS   Hsia,H.E., Tushaus,J., Feng,X., Hofmann,L.I., Wefers,B.,
            Marciano,D.K., Wurst,W. and Lichtenthaler,S.F.
  TITLE     Endoglycan (PODXL2) is proteolytically processed by ADAM10 (a
            disintegrin and metalloprotease 10) and controls neurite branching
            in primary neurons
  JOURNAL   FASEB J 35 (9), e21813 (2021)
   PUBMED   34390512
  REMARK    GeneRIF: Endoglycan (PODXL2) is proteolytically processed by ADAM10
            (a disintegrin and metalloprotease 10) and controls neurite
            branching in primary neurons.
REFERENCE   2  (bases 1 to 2175)
  AUTHORS   Soejima,Y., Takeuchi,M., Miyamoto,N., Sawabe,M. and Fukusato,T.
  TITLE     ITGB6-Knockout Suppresses Cholangiocarcinoma Cell Migration and
            Invasion with Declining PODXL2 Expression
  JOURNAL   Int J Mol Sci 22 (12), 6303 (2021)
   PUBMED   34208313
  REMARK    GeneRIF: ITGB6-Knockout Suppresses Cholangiocarcinoma Cell
            Migration and Invasion with Declining PODXL2 Expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2175)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2175)
  AUTHORS   Lin,Y.Y., Wang,C.Y., Phan,N.N., Chiao,C.C., Li,C.Y., Sun,Z.,
            Hung,J.H., Chen,Y.L., Yen,M.C., Weng,T.Y., Hsu,H.P. and Lai,M.D.
  TITLE     PODXL2 maintains cellular stemness and promotes breast cancer
            development through the Rac1/Akt pathway
  JOURNAL   Int J Med Sci 17 (11), 1639-1651 (2020)
   PUBMED   32669966
  REMARK    GeneRIF: PODXL2 maintains cellular stemness and promotes breast
            cancer development through the Rac1/Akt pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2175)
  AUTHORS   Nielsen,J.S. and McNagny,K.M.
  TITLE     Novel functions of the CD34 family
  JOURNAL   J Cell Sci 121 (Pt 22), 3683-3692 (2008)
   PUBMED   18987355
  REMARK    Erratum:[J Cell Sci. 2008 Dec 15;121(Pt 24):4145]
REFERENCE   6  (bases 1 to 2175)
  AUTHORS   Tan,P.C., Furness,S.G., Merkens,H., Lin,S., McCoy,M.L.,
            Roskelley,C.D., Kast,J. and McNagny,K.M.
  TITLE     Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for
            a subset of the CD34 family of stem cell surface proteins
  JOURNAL   Stem Cells 24 (5), 1150-1161 (2006)
   PUBMED   16410385
REFERENCE   7  (bases 1 to 2175)
  AUTHORS   Furness,S.G. and McNagny,K.
  TITLE     Beyond mere markers: functions for CD34 family of sialomucins in
            hematopoiesis
  JOURNAL   Immunol Res 34 (1), 13-32 (2006)
   PUBMED   16720896
  REMARK    Review article
REFERENCE   8  (bases 1 to 2175)
  AUTHORS   Sarangapani,K.K., Yago,T., Klopocki,A.G., Lawrence,M.B.,
            Fieger,C.B., Rosen,S.D., McEver,R.P. and Zhu,C.
  TITLE     Low force decelerates L-selectin dissociation from P-selectin
            glycoprotein ligand-1 and endoglycan
  JOURNAL   J Biol Chem 279 (3), 2291-2298 (2004)
   PUBMED   14573602
REFERENCE   9  (bases 1 to 2175)
  AUTHORS   Fieger,C.B., Sassetti,C.M. and Rosen,S.D.
  TITLE     Endoglycan, a member of the CD34 family, functions as an L-selectin
            ligand through modification with tyrosine sulfation and sialyl
            Lewis x
  JOURNAL   J Biol Chem 278 (30), 27390-27398 (2003)
   PUBMED   12889478
  REMARK    GeneRIF: endoglycan functions as an L-selectin ligand through
            modification with tyrosine sulfation and sialyl Lewis x
REFERENCE   10 (bases 1 to 2175)
  AUTHORS   Sassetti,C., Van Zante,A. and Rosen,S.D.
  TITLE     Identification of endoglycan, a member of the CD34/podocalyxin
            family of sialomucins
  JOURNAL   J Biol Chem 275 (12), 9001-9010 (2000)
   PUBMED   10722749
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL524055.3, BC052585.1 and
            BC019330.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015720.3.
            
            Summary: This gene is a member of the CD34 family of cell surface
            transmembrane proteins, which are characterized by an N-terminal
            extracellular mucin domain, globular and stalk domains, a single
            pass transmembrane region, and a charged cytoplasmic tail. The
            encoded protein is a ligand for vascular selectins. [provided by
            RefSeq, Oct 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.197064.1,
                                           SRR3476690.298298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342480.7/ ENSP00000345359.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AL524055.3         27-45
            20-433              BC052585.1         1-414
            434-434             BC019330.1         435-435
            435-2175            BC052585.1         416-2156
FEATURES             Location/Qualifiers
     source          1..2175
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..2175
                     /gene="PODXL2"
                     /gene_synonym="EG; PODLX2"
                     /note="podocalyxin like 2"
                     /db_xref="GeneID:50512"
                     /db_xref="HGNC:HGNC:17936"
                     /db_xref="MIM:616627"
     exon            1..105
                     /gene="PODXL2"
                     /gene_synonym="EG; PODLX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1853
                     /gene="PODXL2"
                     /gene_synonym="EG; PODLX2"
                     /note="endoglycan; podocalyxin-like protein 2"
                     /codon_start=1
                     /product="podocalyxin-like protein 2 precursor"
                     /protein_id="NP_056535.1"
                     /db_xref="CCDS:CCDS3044.1"
                     /db_xref="GeneID:50512"
                     /db_xref="HGNC:HGNC:17936"
                     /db_xref="MIM:616627"
                     /translation="MGRLLRAARLPPLLSPLLLLLVGGAFLGACVAGSDEPGPEGLTS
                     TSLLDLLLPTGLEPLDSEEPSETMGLGAGLGAPGSGFPSEENEESRILQPPQYFWEEE
                     EELNDSSLDLGPTADYVFPDLTEKAGSIEDTSQAQELPNLPSPLPKMNLVEPPWHMPP
                     REEEEEEEEEEEREKEEVEKQEEEEEEELLPVNGSQEEAKPQVRDFSLTSSSQTPGAT
                     KSRHEDSGDQASSGVEVESSMGPSLLLPSVTPTTVTPGDQDSTSQEAEATVLPAAGLG
                     VEFEAPQEASEEATAGAAGLSGQHEEVPALPSFPQTTAPSGAEHPDEDPLGSRTSASS
                     PLAPGDMELTPSSATLGQEDLNQQLLEGQAAEAQSRIPWDSTQVICKDWSNLAGKNYI
                     ILNMTENIDCEVFRQHRGPQLLALVEEVLPRHGSGHHGAWHISLSKPSEKEQHLLMTL
                     VGEQGVVPTQDVLSMLGDIRRSLEEIGIQNYSTTSSCQARASQVRSDYGTLFVVLVVI
                     GAICIIIIALGLLYNCWQRRLPKLKHVSHGEELRFVENGCHDNPTLDVASDSQSEMQE
                     KHPSLNGGGALNGPGSWGALMGGKRDPEDSDVFEEDTHL"
     exon            106..384
                     /gene="PODXL2"
                     /gene_synonym="EG; PODLX2"
                     /inference="alignment:Splign:2.1.0"
     exon            385..1166
                     /gene="PODXL2"
                     /gene_synonym="EG; PODLX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1241
                     /gene="PODXL2"
                     /gene_synonym="EG; PODLX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1398
                     /gene="PODXL2"
                     /gene_synonym="EG; PODLX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1460
                     /gene="PODXL2"
                     /gene_synonym="EG; PODLX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1640
                     /gene="PODXL2"
                     /gene_synonym="EG; PODLX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..2175
                     /gene="PODXL2"
                     /gene_synonym="EG; PODLX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2141..2146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PODXL2"
                     /gene_synonym="EG; PODLX2"
                     /note="hexamer: ATTAAA"
     polyA_site      2175
                     /gene="PODXL2"
                     /gene_synonym="EG; PODLX2"
                     /note="major polyA site"
ORIGIN      
        1 gcgccgctgc ggctgcaggc ggcgacggct acaccatggg ccggctgctg cgggccgccc
       61 ggctgccgcc gctgctttcg ccgctgctgc ttctgctggt tgggggagcg ttcctgggtg
      121 cctgtgtggc tgggtctgat gagcctggcc cagagggcct cacctccacc tccctgctag
      181 acctcctgct gcccactggc ttggagccac tggactcaga ggagcctagt gagaccatgg
      241 gcctgggagc tgggctggga gcccctggct caggcttccc cagcgaagag aatgaagagt
      301 ctcggattct gcagccacca cagtacttct gggaagagga ggaagagctg aatgactcaa
      361 gtctggacct gggacccact gcagattatg tttttcctga cttaactgag aaggcaggtt
      421 ccattgaaga caccagccag gctcaagagc tgccaaacct cccctctccc ttgcccaaga
      481 tgaatctggt tgagcctccc tggcatatgc ctcccagaga ggaggaagaa gaggaagagg
      541 aagaggagga gagggagaag gaagaggtag agaaacaaga ggaggaggaa gaggaggagc
      601 tgctccctgt gaatggatcc caagaagaag ccaagcctca ggtccgtgac ttttctctca
      661 ccagcagcag ccagacccca ggggccacca aaagcaggca tgaagactcc ggggaccagg
      721 cctcatcagg tgtggaggtg gagagcagca tggggcccag cttgctgctg ccttcagtca
      781 ccccaactac agtgactccg ggggaccagg actccaccag ccaagaggca gaggccacag
      841 tgctgccagc tgcagggctt ggggtagagt tcgaggctcc tcaggaagca agcgaggaag
      901 ccactgcagg agcagctggt ttgtctggcc agcacgagga ggtgccggcc ttgccttcat
      961 tccctcaaac cacagctccc agtggggccg agcacccaga tgaagatccc cttggctcta
     1021 gaacctcagc ctcttcccca ctggcccctg gagacatgga actgacacct tcctctgcta
     1081 ccttgggaca agaagatctc aaccagcagc tcctagaagg gcaggcagct gaagctcaat
     1141 ccaggatacc ctgggattct acgcaggtga tctgcaagga ctggagcaat ctggctggga
     1201 aaaactacat cattctgaac atgacagaga acatagactg tgaggtgttc cggcagcacc
     1261 gggggccaca gctcctggcc ctggtggaag aggtgctgcc ccgccatggc agtggccacc
     1321 atggggcctg gcacatctct ctgagcaagc ccagcgagaa ggagcagcac cttctcatga
     1381 cactggtggg cgagcagggg gtggtgccca ctcaagatgt cctttccatg ctgggtgaca
     1441 tccgcaggag cctggaggag attggcatcc agaactattc cacaaccagc agctgccagg
     1501 cgcgggccag ccaggtgcgc agcgactacg gcacgctctt cgtggtgctg gtggtcattg
     1561 gggccatctg catcatcatc attgcgcttg gcctgctcta caactgctgg cagcgccggc
     1621 tgcccaagct caagcacgtg tcgcacggcg aggagctgcg cttcgtggag aacggctgcc
     1681 acgacaaccc cacgctggac gtggccagcg acagccagtc ggagatgcag gagaagcacc
     1741 ccagcctgaa cggcggcggg gccctcaacg gcccggggag ctggggggcg ctcatggggg
     1801 gcaagcggga ccccgaggac tcggacgtgt tcgaggagga cacgcacctg tgagcgcagc
     1861 cgaggcgcag gccgagtggg ccgccaggac caagcgaggt ggaccccgaa acggacggcc
     1921 cggagcccgc accagccccg cgcctacccg ggccgccccc gcggcctggc cctcggcgcg
     1981 ggctccttcc cgcttccccc gacttcacac ggcggcttcg gaccaactcc ctcactcccg
     2041 cccgaggggc aggcctcaaa gcccgccttg gccccgcttt cccgcccctg aaccccggcc
     2101 ccgcgggcgg cgggcggcgc ttcctgcgcc ccgggactca attaaacccg cccggagacc
     2161 acgccgggcc cagcg
//
