LOCUS       NM_001018111            5986 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens podocalyxin like (PODXL), transcript variant 1, mRNA.
ACCESSION   NM_001018111
VERSION     NM_001018111.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5986)
  AUTHORS   Le Tran,N., Wang,Y., Bilandzic,M., Stephens,A. and Nie,G.
  TITLE     Podocalyxin promotes the formation of compact and chemoresistant
            cancer spheroids in high grade serous carcinoma
  JOURNAL   Sci Rep 14 (1), 7539 (2024)
   PUBMED   38553472
  REMARK    GeneRIF: Podocalyxin promotes the formation of compact and
            chemoresistant cancer spheroids in high grade serous carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5986)
  AUTHORS   Thach,B., Samarajeewa,N., Li,Y., Heng,S., Tsai,T., Pangestu,M.,
            Catt,S. and Nie,G.
  TITLE     Podocalyxin molecular characteristics and endometrial expression:
            high conservation between humans and macaques but divergence in
            micedagger
  JOURNAL   Biol Reprod 106 (6), 1143-1158 (2022)
   PUBMED   35284933
  REMARK    GeneRIF: Podocalyxin molecular characteristics and endometrial
            expression: high conservation between humans and macaques but
            divergence in micedagger.
REFERENCE   3  (bases 1 to 5986)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 5986)
  AUTHORS   Heng,S., Samarajeewa,N., Wang,Y., Paule,S.G., Breen,J. and Nie,G.
  TITLE     Podocalyxin promotes an impermeable epithelium and inhibits
            pro-implantation factors to negatively regulate endometrial
            receptivity
  JOURNAL   Sci Rep 11 (1), 24016 (2021)
   PUBMED   34907278
  REMARK    GeneRIF: Podocalyxin promotes an impermeable epithelium and
            inhibits pro-implantation factors to negatively regulate
            endometrial receptivity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5986)
  AUTHORS   Lee,H., Kong,J.S., Lee,S.S. and Kim,A.
  TITLE     Radiation-Induced Overexpression of TGFbeta and PODXL Contributes
            to Colorectal Cancer Cell Radioresistance through Enhanced Motility
  JOURNAL   Cells 10 (8), 2087 (2021)
   PUBMED   34440856
  REMARK    GeneRIF: Radiation-Induced Overexpression of TGFbeta and PODXL
            Contributes to Colorectal Cancer Cell Radioresistance through
            Enhanced Motility.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5986)
  AUTHORS   Takeda,T., McQuistan,T., Orlando,R.A. and Farquhar,M.G.
  TITLE     Loss of glomerular foot processes is associated with uncoupling of
            podocalyxin from the actin cytoskeleton
  JOURNAL   J Clin Invest 108 (2), 289-301 (2001)
   PUBMED   11457882
REFERENCE   7  (bases 1 to 5986)
  AUTHORS   Sassetti,C., Tangemann,K., Singer,M.S., Kershaw,D.B. and Rosen,S.D.
  TITLE     Identification of podocalyxin-like protein as a high endothelial
            venule ligand for L-selectin: parallels to CD34
  JOURNAL   J Exp Med 187 (12), 1965-1975 (1998)
   PUBMED   9625756
REFERENCE   8  (bases 1 to 5986)
  AUTHORS   Kershaw,D.B., Wiggins,J.E., Wharram,B.L. and Wiggins,R.C.
  TITLE     Assignment of the human podocalyxin-like protein (PODXL) gene to
            7q32-q33
  JOURNAL   Genomics 45 (1), 239-240 (1997)
   PUBMED   9339384
REFERENCE   9  (bases 1 to 5986)
  AUTHORS   Kershaw,D.B., Beck,S.G., Wharram,B.L., Wiggins,J.E., Goyal,M.,
            Thomas,P.E. and Wiggins,R.C.
  TITLE     Molecular cloning and characterization of human podocalyxin-like
            protein. Orthologous relationship to rabbit PCLP1 and rat
            podocalyxin
  JOURNAL   J Biol Chem 272 (25), 15708-15714 (1997)
   PUBMED   9188463
REFERENCE   10 (bases 1 to 5986)
  AUTHORS   Cook Shukla,L., Schulze,J., Farlow,J., Pankratz,N.D., Wojcieszek,J.
            and Foroud,T.
  TITLE     Parkinson Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301402
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008264.10, AK055816.1,
            AK223573.1, CN290641.1, BC042466.1 and BP355358.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001018111.2.
            
            Summary: This gene encodes a member of the sialomucin protein
            family. The encoded protein was originally identified as an
            important component of glomerular podocytes. Podocytes are highly
            differentiated epithelial cells with interdigitating foot processes
            covering the outer aspect of the glomerular basement membrane.
            Other biological activities of the encoded protein include: binding
            in a membrane protein complex with Na+/H+ exchanger regulatory
            factor to intracellular cytoskeletal elements, playing a role in
            hematopoetic cell differentiation, and being expressed in vascular
            endothelium cells and binding to L-selectin. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.140839.1,
                                           SRR1803615.185742.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378555.8/ ENSP00000367817.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC008264.10        66079-66089         c
            12-19               AK055816.1         1-8
            20-975              AK223573.1         1-956
            976-1544            CN290641.1         57-625
            1545-4591           BC042466.1         1726-4772
            4592-5038           BP355358.1         135-581
            5039-5986           BC042466.1         5220-6167
FEATURES             Location/Qualifiers
     source          1..5986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.3"
     gene            1..5986
                     /gene="PODXL"
                     /gene_synonym="gp135; Gp200; PC; PCLP; PCLP-1; PDX;
                     PODXL1"
                     /note="podocalyxin like"
                     /db_xref="GeneID:5420"
                     /db_xref="HGNC:HGNC:9171"
                     /db_xref="MIM:602632"
     exon            1..369
                     /gene="PODXL"
                     /gene_synonym="gp135; Gp200; PC; PCLP; PCLP-1; PDX;
                     PODXL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1946
                     /gene="PODXL"
                     /gene_synonym="gp135; Gp200; PC; PCLP; PCLP-1; PDX;
                     PODXL1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; podocalyxin-like protein 1; GCTM-2 antigen"
                     /codon_start=1
                     /product="podocalyxin isoform 1 precursor"
                     /protein_id="NP_001018121.1"
                     /db_xref="CCDS:CCDS34755.1"
                     /db_xref="GeneID:5420"
                     /db_xref="HGNC:HGNC:9171"
                     /db_xref="MIM:602632"
                     /translation="MRCALALSALLLLLSTPPLLPSSPSPSPSPSQNATQTTTDSSNK
                     TAPTPASSVTIMATDTAQQSTVPTSKANEILASVKATTLGVSSDSPGTTTLAQQVSGP
                     VNTTVARGGGSGNPTTTIESPKSTKSADTTTVATSTATAKPNTTSSQNGAEDTTNSGG
                     KSSHSVTTDLTSTKAEHLTTPHPTSPLSPRQPTSTHPVATPTSSGHDHLMKISSSSST
                     VAIPGYTFTSPGMTTTLLETVFHHVSQAGLELLTSGDLPTLASQSAGITASSVISQRT
                     QQTSSQMPASSTAPSSQETVQPTSPATALRTPTLPETMSSSPTAASTTHRYPKTPSPT
                     VAHESNWAKCEDLETQTQSEKQLVLNLTGNTLCAGGASDEKLISLICRAVKATFNPAQ
                     DKCGIRLASVPGSQTVVVKEITIHTKLPAKDVYERLKDKWDELKEAGVSDMKLGDQGP
                     PEEAEDRFSMPLIITIVCMASFLLLVAALYGCCHQRLSQRKDQQRLTEELQTVENGYH
                     DNPTLEVMETSSEMQEKKVVSLNGELGDSWIVPLDNLTKDDLDEEEDTHL"
     exon            370..975
                     /gene="PODXL"
                     /gene_synonym="gp135; Gp200; PC; PCLP; PCLP-1; PDX;
                     PODXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1071
                     /gene="PODXL"
                     /gene_synonym="gp135; Gp200; PC; PCLP; PCLP-1; PDX;
                     PODXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1292
                     /gene="PODXL"
                     /gene_synonym="gp135; Gp200; PC; PCLP; PCLP-1; PDX;
                     PODXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1370
                     /gene="PODXL"
                     /gene_synonym="gp135; Gp200; PC; PCLP; PCLP-1; PDX;
                     PODXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1518
                     /gene="PODXL"
                     /gene_synonym="gp135; Gp200; PC; PCLP; PCLP-1; PDX;
                     PODXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1580
                     /gene="PODXL"
                     /gene_synonym="gp135; Gp200; PC; PCLP; PCLP-1; PDX;
                     PODXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1748
                     /gene="PODXL"
                     /gene_synonym="gp135; Gp200; PC; PCLP; PCLP-1; PDX;
                     PODXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..5986
                     /gene="PODXL"
                     /gene_synonym="gp135; Gp200; PC; PCLP; PCLP-1; PDX;
                     PODXL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5966..5971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PODXL"
                     /gene_synonym="gp135; Gp200; PC; PCLP; PCLP-1; PDX;
                     PODXL1"
                     /note="hexamer: ATTAAA"
     polyA_site      5986
                     /gene="PODXL"
                     /gene_synonym="gp135; Gp200; PC; PCLP; PCLP-1; PDX;
                     PODXL1"
                     /note="major polyA site"
ORIGIN      
        1 agtggggccg cagccgcgca gacgccgccc aggacgcagc cgccgccgcc gccgctcctc
       61 tgccactggc tctgcgcccc agcccggctc tgctgcagcg gcagggagga agagccgccg
      121 cagcgcgact cgggagcccc gggccacagc ctggcctccg gagccaccca caggcctccc
      181 cgggcggcgc ccacgctcct accgcccgga cgcgcggatc ctccgccggc accgcagcca
      241 cctgctcccg gcccagaggc gacgacacga tgcgctgcgc gctggcgctc tcggcgctgc
      301 tgctactgtt gtcaacgccg ccgctgctgc cgtcgtcgcc gtcgccgtcg ccgtcgccct
      361 cccagaatgc aacccagact actacggact catctaacaa aacagcaccg actccagcat
      421 ccagtgtcac catcatggct acagatacag cccagcagag cacagtcccc acttccaagg
      481 ccaacgaaat cttggcctcg gtcaaggcga ccacccttgg tgtatccagt gactcaccgg
      541 ggactacaac cctggctcag caagtctcag gcccagtcaa cactaccgtg gctagaggag
      601 gcggctcagg caaccctact accaccatcg agagccccaa gagcacaaaa agtgcagaca
      661 ccactacagt tgcaacctcc acagccacag ctaaacctaa caccacaagc agccagaatg
      721 gagcagaaga tacaacaaac tctgggggga aaagcagcca cagtgtgacc acagacctca
      781 catccactaa ggcagaacat ctgacgaccc ctcaccctac aagtccactt agcccccgac
      841 aacccacttc gacgcatcct gtggccaccc caacaagctc gggacatgac catcttatga
      901 aaatttcaag cagttcaagc actgtggcta tccctggcta caccttcaca agcccgggga
      961 tgaccaccac cctactagag acagtgtttc accatgtcag ccaggctggt cttgaactcc
     1021 tgacctcggg tgatctgccc accttggcct cccaaagtgc tgggattaca gcgtcatcgg
     1081 ttatctcgca aagaactcaa cagacctcca gtcagatgcc agccagctct acggcccctt
     1141 cctcccagga gacagtgcag cccacgagcc cggcaacggc attgagaaca cctaccctgc
     1201 cagagaccat gagctccagc cccacagcag catcaactac ccaccgatac cccaaaacac
     1261 cttctcccac tgtggctcat gagagtaact gggcaaagtg tgaggatctt gagacacaga
     1321 cacagagtga gaagcagctc gtcctgaacc tcacaggaaa caccctctgt gcagggggcg
     1381 cttcggatga gaaattgatc tcactgatat gccgagcagt caaagccacc ttcaacccgg
     1441 cccaagataa gtgcggcata cggctggcat ctgttccagg aagtcagacc gtggtcgtca
     1501 aagaaatcac tattcacact aagctccctg ccaaggatgt gtacgagcgg ctgaaggaca
     1561 aatgggatga actaaaggag gcaggggtca gtgacatgaa gctaggggac caggggccac
     1621 cggaggaggc cgaggaccgc ttcagcatgc ccctcatcat caccatcgtc tgcatggcat
     1681 cattcctgct cctcgtggcg gccctctatg gctgctgcca ccagcgcctc tcccagagga
     1741 aggaccagca gcggctaaca gaggagctgc agacagtgga gaatggttac catgacaacc
     1801 caacactgga agtgatggag acctcttctg agatgcagga gaagaaggtg gtcagcctca
     1861 acggggagct gggggacagc tggatcgtcc ctctggacaa cctgaccaag gacgacctgg
     1921 atgaggagga agacacacac ctctagtccg gtctgccggt ggcctccagc agcaccacag
     1981 agctccagac caaccacccc aagtgccgtt tggatgggga agggaaagac tggggaggga
     2041 gagtgaactc cgaggggtgt cccctcccaa tccccccagg gccttaattt ttcccttttc
     2101 aacctgaaca aatcacattc tgtccagatt cctcttgtaa aataacccac tagtgcctga
     2161 gctcagtgct gctggatgat gagggagatc aagaaaaagc cacgtaaggg actttataga
     2221 tgaactagtg gaatcccttc attctgcagt gagattgccg agacctgaag agggtaagtg
     2281 acttgcccaa ggtcagagcc acttggtgac agagccagga tgagaacaaa gattccattt
     2341 gcaccatgcc acactgctgt gttcacatgt gccttccgtc cagagcagtc ccgggcaggg
     2401 gtgaaactcc agcaggtggc tgggctggaa aggagggcag ggctacatcc tggctcggtg
     2461 ggatctgacg acctgaaagt ccagctccca agttttcctt ctcctacccc agcctcgtgt
     2521 acccatcttc ccaccctcta tgttcttacc cctccctaca ctcagtgttt gttcccactt
     2581 actctgtcct ggggcctctg ggattagcac aggttattca taaccttgaa ccccttgttc
     2641 tggattcgga ttttctcaca tttgcttcgt gagatggggg cttaacccac acaggtctcc
     2701 gtgcgtgaac caggtctgct taggggacct gcgtgcaggt gaggagagaa ggggacactc
     2761 gagtccaggc tggtatctca gggcagctga tgaggggtca gcaggaacac tggcccattg
     2821 cccctggcac tccttgcaga ggccacccac gatcttcttt gggcttccat ttccaccagg
     2881 gactaaaatc tgctgtagct agtgagagca gcgtgttcct tttgttgttc actgctcagc
     2941 tgatgggagt gattccctga gacccagtat gaaagagcag tggctgcagg agaggccttc
     3001 ccggggcccc ccatcagcga tgtgtcttca gagacaatcc attaaagcag ccaggaagga
     3061 caggctttcc cctgtatatc ataggaaact cagggacatt tcaagttgct gagagttttg
     3121 ttatagttgt tttctaaccc agccctccac tgccaaaggc caaaagctca gacagttggc
     3181 agacgtccag ttagctcatc tcactcactc tgattctcct gtgccacagg aaaagagggc
     3241 ctggaaagcg cagtgcatgc tgggtgcatg aagggcagcc tgggggacag actgttgtgg
     3301 gaacgtccca ctgtcctggc ctggagctag gccttgctgt tcctcttctc tgtgagccta
     3361 gtggggctgc tgcggttctc ttgcagtttc tggtggcatc tcaggggaac acaaagctat
     3421 gtctattccc caatatagga cttttatggg ctcggcagtt agctgccatg tagaaggctc
     3481 ctaagcagtg ggcatggtga ggtttcatct gattgagaag ggggaatcct gtgtggaatg
     3541 ttgaactttc gccatggtct ccatcgttct gggcgtaaat tccctgggat caagtaggaa
     3601 aatgggcaga actgcttagg ggaatgaaat tgccattttt cgggtgaaac gccacacctc
     3661 cagggtctta agagtcaggc tccggctgta gtagctctga tgaaataggc tatccactcg
     3721 ggatggctta ctttttaaaa gggtaggggg aggggctggg gaagatctgt cctgcaccat
     3781 ctgcctaatt ccttcctcac agtctgtagc catctgatat cctaggggaa aaggaaggcc
     3841 aggggttcac atagggcccc agcgagtttc ccaggagtta gagggatgcg aggctaacaa
     3901 gttccaaaaa catctgcccc gatgctctag tgtttggagg tgggcaggat ggagaacagt
     3961 gcctgtttgg gggaaaacag gaaatcttgt taggcttgag tgaggtgttt gcttccttct
     4021 tgcccagcgc tgggttctct ccacccagta ggttttctgt tgtggtcccg tgggagaggc
     4081 cagactggat tattcctcct ttgctgatcc tgggtcacac ttcaccagcc agggcttttg
     4141 acggagacag caaataggcc tctgcaaatc aatcaaaggc tgcaacccta tggcctcttg
     4201 gagacagatg atgactggca aggactagag agcaggagtg cctggccagg tcggtcctga
     4261 ctctcctgac tctccatcgc tctgtccaag gagaacccgg agaggctctg ggctgattca
     4321 gaggttactg ctttatattc gtccaaactg tgttagtcta ggcttaggac agcttcagaa
     4381 tctgacacct tgccttgctc ttgccaccag gacacctatg tcaacaggcc aaacagccat
     4441 gcatctataa aggtcatcat cttctgccac ctttactggg ttctaaatgc tctctgataa
     4501 ttcagagagc attgggtctg ggaagaggta agaggaacac tagaagctca gcatgactta
     4561 aacaggttgt agcaaagaca gtttatcatc agctctttca gtggtaaact gtggtttccc
     4621 caagctgcac aggaggccag aaaccacaag tatgatgact aggaagccta ctgtcatgag
     4681 agtggggaga caggcagcaa agcttatgaa ggaggtacag aatattcttt gcgttgtaag
     4741 acagaatacg ggtttaatct agtctaggca ccagattttt ttcccgcttg ataaggaaag
     4801 ctagcagaaa gtttatttaa accacttctt gagctttatc ttttttgaca atatactgga
     4861 gaaactttga agaacaagtt caaactgata catatacaca tatttttttg ataatgtaaa
     4921 tacagtgacc atgttaacct accctgcact gctttaagtg aacatacttt gaaaaagcat
     4981 tatgttagct gagtgatggc caagtttttt ctctggacag gaatgtaaat gtcttactgg
     5041 aaatgacaag tttttgcttg attttttttt ttaaacaaaa aatgaaatat aacaagacaa
     5101 acttatgata aagtatttgt cttgtagatc aggtgttttg ttttgttttt ttaattttaa
     5161 aatgcaaccc tgccccctcc ccagcaaagt cacagctcca tttcagtaaa ggttggagtc
     5221 aatatgctct ggttggcagg caaccctgta gtcatggaga aaggtatttc aagatctagt
     5281 ccaatctttt tctagagaaa aagataatct gaagctcaca aagatgaagt gacttcctca
     5341 aaatcacatg gttcaggaca gaaacaagat taaaacctgg atccacagac tgtgcgcctc
     5401 agaaggaata atcggtaaat taagaattgc tactcgaagg tgccagaatg acacaaagga
     5461 cagaattcct ttcccagttg ttaccctagc aaggctaggg agggcatgaa cacaaacata
     5521 agaactggtc ttctacactt tctctgaatc atttaggttt aagatgtaag tgaacaattc
     5581 tttctttctg ccaagaaaca aagttttgga tgagctttta tatatggaac ttactccaac
     5641 aggactgagg gaccaaggaa acatgatggg ggaggcagag agggcaagag taaaactgta
     5701 gcatagcttt tgtcacggtc actagctgat ccctcaggtc tgctgcaaac acagcatgga
     5761 ggacacagat gactctttgg tgttggtctt tttgtctgca gtgaatgttc aacagtttgc
     5821 ccaggaactg ggggatcata tatgtcttag tggacagggg tctgaagtac actggaattt
     5881 actgagaaac ttgtttgtaa aaactatagt taataattat tgcattttct tacaaaaata
     5941 tattttggaa aattgtatac tgtcaattaa agtgtttttg tgtaaa
//
