LOCUS       NM_001370095            2511 bp    mRNA    linear   PRI 17-DEC-2024
DEFINITION  Homo sapiens podocan like 1 (PODNL1), transcript variant 4, mRNA.
ACCESSION   NM_001370095 XM_006722901
VERSION     NM_001370095.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2511)
  AUTHORS   Noor,H., Zaman,A., Teo,C. and Sughrue,M.E.
  TITLE     PODNL1 Methylation Serves as a Prognostic Biomarker and Associates
            with Immune Cell Infiltration and Immune Checkpoint Blockade
            Response in Lower-Grade Glioma
  JOURNAL   Int J Mol Sci 22 (22), 12572 (2021)
   PUBMED   34830454
  REMARK    GeneRIF: PODNL1 Methylation Serves as a Prognostic Biomarker and
            Associates with Immune Cell Infiltration and Immune Checkpoint
            Blockade Response in Lower-Grade Glioma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2511)
  AUTHORS   Ouni,E., Ruys,S.P.D., Dolmans,M.M., Herinckx,G., Vertommen,D. and
            Amorim,C.A.
  TITLE     Divide-and-Conquer Matrisome Protein (DC-MaP) Strategy: An
            MS-Friendly Approach to Proteomic Matrisome Characterization
  JOURNAL   Int J Mol Sci 21 (23), 9141 (2020)
   PUBMED   33266304
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2511)
  AUTHORS   Geng,Y., Zuo,P., Li,X.O. and Zhang,L.
  TITLE     PODNL1 promotes cell proliferation and migration in glioma via
            regulating Akt/mTOR pathway
  JOURNAL   J Cancer 11 (21), 6234-6242 (2020)
   PUBMED   33033506
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2511)
  AUTHORS   Lansky,Z., Mutsafi,Y., Houben,L., Ilani,T., Armony,G., Wolf,S.G.
            and Fass,D.
  TITLE     3D mapping of native extracellular matrix reveals cellular
            responses to the microenvironment
  JOURNAL   J Struct Biol X 1, 100002 (2019)
   PUBMED   32055794
REFERENCE   5  (bases 1 to 2511)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   6  (bases 1 to 2511)
  AUTHORS   Baiocchini,A., Montaldo,C., Conigliaro,A., Grimaldi,A.,
            Correani,V., Mura,F., Ciccosanti,F., Rotiroti,N., Brenna,A.,
            Montalbano,M., D'Offizi,G., Capobianchi,M.R., Alessandro,R.,
            Piacentini,M., Schinina,M.E., Maras,B., Del Nonno,F., Tripodi,M.
            and Mancone,C.
  TITLE     Extracellular Matrix Molecular Remodeling in Human Liver Fibrosis
            Evolution
  JOURNAL   PLoS One 11 (3), e0151736 (2016)
   PUBMED   26998606
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020916.8.
            
            On Nov 3, 2020 this sequence version replaced NM_001370095.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.111296.1,
                                           SRR14038193.2418602.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000588872.3/
                                                ENSP00000467395.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC020916.8         151319-151557       c
            240-461             AC020916.8         150925-151146       c
            462-555             AC020916.8         149507-149600       c
            556-620             AC020916.8         149120-149184       c
            621-730             AC020916.8         148861-148970       c
            731-887             AC020916.8         147394-147550       c
            888-1003            AC020916.8         147018-147133       c
            1004-1661           AC020916.8         145938-146595       c
            1662-1810           AC020916.8         145104-145252       c
            1811-2511           AC020916.8         144327-145027       c
FEATURES             Location/Qualifiers
     source          1..2511
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..2511
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /note="podocan like 1"
                     /db_xref="GeneID:79883"
                     /db_xref="HGNC:HGNC:26275"
                     /db_xref="MIM:621043"
     exon            1..239
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1961
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; podocan-like protein 1"
                     /codon_start=1
                     /product="podocan-like protein 1 isoform 4 precursor"
                     /protein_id="NP_001357024.2"
                     /db_xref="CCDS:CCDS92539.1"
                     /db_xref="GeneID:79883"
                     /db_xref="HGNC:HGNC:26275"
                     /db_xref="MIM:621043"
                     /translation="MWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCS
                     CPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNL
                     ISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGE
                     KPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQN
                     NLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPA
                     GLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHT
                     LHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARV
                     HHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRE
                     LSLAHNRLRVGDIGPGTWHELQALQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHV
                     GPEAFLSTPRLRALFLRANRLHMTSIAAEAFLGLPNLRVVDTAGNPEQVLIRLPPTTP
                     RGPRAGGP"
     exon            240..461
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /inference="alignment:Splign:2.1.0"
     exon            462..555
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /inference="alignment:Splign:2.1.0"
     exon            556..620
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /inference="alignment:Splign:2.1.0"
     exon            621..730
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /inference="alignment:Splign:2.1.0"
     exon            731..887
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1003
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1661
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1810
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..2511
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2204..2209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /note="hexamer: AATAAA"
     polyA_site      2230
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /note="major polyA site"
     regulatory      2493..2498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /note="hexamer: AATGAA"
     polyA_site      2511
                     /gene="PODNL1"
                     /gene_synonym="SLRR5B"
                     /note="major polyA site"
ORIGIN      
        1 gggctggcct gtcctcacca ccccatccgg ccgcctgccc gtcctcccca gggcggggaa
       61 gggggtgggc cagctccccc aaagccccgg gagaacaggc tgttgtgggg ggtggcatgg
      121 gtctggagat ggggggcggt ggtggccaca gcagaggctc caggaggtga ccgcctggtt
      181 tccattagga agtcctggtc agcagcttgg gcgagatggc agagtcaggg ctggccatgt
      241 ggccgagcct gctgctgctc ctgctgttgc cggggccccc gcccgtcgcc ggcttggaag
      301 acgctgcctt cccccacctg ggggagagct tgcagcccct gccccgggcc tgtcccctgc
      361 gctgctcctg cccccgagtc gacactgtgg actgtgatgg cttggacctt cgagtgttcc
      421 cggacaacat caccagagcc gctcagcacc tctccctgca gaacaaccag ctccaggaac
      481 tcccctacaa tgagctgtcc cgcctcagtg gcctgcgaac cctcaacctc cacaacaacc
      541 tcatctcctc cgaaggcctg cctgacgagg ccttcgagtc cctcacccag ctgcagcacc
      601 tctgcgtggc tcacaacaag ctctcagtgg cccctcagtt tctgccccgg tccctccgtg
      661 tcgcggatct ggctgccaac caagtgatgg agatcttccc cctcaccttt ggggagaagc
      721 cggcactcag gtccgtgtac ctccacaaca accagctgag caacgctggc ctgccccccg
      781 acgccttccg cggctccgag gccatcgcca ccctcagcct ctccaacaac cagctcagct
      841 acctgccgcc cagcctgccg ccctcactcg agcggctcca cctgcagaac aatctcatct
      901 ccaaggtgcc ccgaggagcc ctgagccgcc agactcaact ccgtgagctc tacctccagc
      961 acaaccagct gacagacagt ggcctggatg ccaccacctt cagcaagctg catagccttg
     1021 aatacctgga tctctcccac aaccagctga ccacagtgcc cgccggcctg ccccggaccc
     1081 tggctatcct gcacctgggc cgcaaccgca tccggcaggt ggaggcggct cggctgcacg
     1141 gggcgcgtgg tctgcgctat ttgttgctgc agcacaacca gctggggagc tcagggctgc
     1201 ccgccggggc tctgcggccg ctgcggggcc tgcacacgct gcacctctat ggcaatgggc
     1261 tggaccgcgt gcctccagcc ctgccccgcc gcctgcgtgc cctggtgctg ccccacaacc
     1321 acgtggccgc gctgggtgcc cgtgacctgg tcgccacacc gggcctgacg gagcttaacc
     1381 tggcctataa ccgcctggcc agcgcccgtg tgcaccaccg ggccttccgc cggttgcgtg
     1441 ccctgcgcag cctcgacctg gcagggaatc agctaacccg gctgcccatg ggcctgccca
     1501 ctggcctgcg caccctgcag ctgcaacgca accagctgcg gatgctcgag cccgagcctc
     1561 tggccggcct ggaccaactg cgggagctca gcctggcgca caaccggctc cgggtcggcg
     1621 acatcgggcc aggcacctgg catgagctcc aagccctcca gatgctggac ctcagccaca
     1681 atgagctgtc ctttgtgccc ccggacctgc ctgaggccct agaggagctg cacctcgagg
     1741 gcaaccgcat cggccacgtg ggccccgagg ccttcctcag cacaccccgc ctgcgtgccc
     1801 tcttcctcag ggccaacagg cttcacatga cgagcatcgc ggctgaggcc ttcctggggc
     1861 tcccaaacct gcgtgtggtg gacacggcag ggaatccgga gcaggtcctg atccggctgc
     1921 ctcccaccac cccacgtggg ccacgggcag ggggcccctg atcctagaga ggcccagcag
     1981 agcagctcag actcctggga ctccgctggg ccgtggactg aggagacaac gcccaccagg
     2041 ggcccttggt ctggctctcc tgggcctcca gggctgggcc tgctctgcct gccactggcc
     2101 gagacacaga ggcacacagc tggcatactc caggctcaca gaccacgccg gcctggcggg
     2161 acacacccta ccccaaactc ccaacacaga tggaggcagc aacaataaag ccaaaccctt
     2221 ccagcactca gcacggacca ggcacccttt gggggctctg tccacggact cctccccaca
     2281 accagtccag ctggggaaac tgaggctctg ggatgctaag tgggtcagga ctgaattttg
     2341 aggtcttgag gcacacactg gggtcaccaa acagcaccct gtgcgaccta gccacgtgtg
     2401 attgcaggga cgcccaaggc cacccactga aaaaacactg ggtgacagat atagggaccc
     2461 tcacatgtat ccccccccac agcaagcatg ggaatgaaat gcatccttca a
//
