LOCUS       NM_001199781            5281 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens POC1B-GALNT4 readthrough (POC1B-GALNT4), transcript
            variant 1, mRNA.
ACCESSION   NM_001199781
VERSION     NM_001199781.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5281)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025034.22, BX647258.1, KF455691.2 and AC010201.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001199781.1.
            
            Summary: This locus represents naturally occurring transcripts that
            splice the 5' exons of the POC1B (POC1 centriolar protein homolog
            B) gene on chromosome 12 to the GALNT4
            (UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase 4) gene, which is located within
            a POC1B intron. Alternative splicing results in two transcript
            variants, one of which encodes a fusion isoform that shares
            sequence identity with the products of each individual gene.
            [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1), which shares
            sequence identity with the products of both the POC1B and GALNT4
            genes.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647258.1, SRR1660807.46374.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 8693, 282809
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC025034.22        65022-65070
            50-951              BX647258.1         1-902
            952-4718            AC025034.22        67328-71094
            4719-4889           KF455691.2         1-171
            4890-5146           BX647258.1         4842-5098
            5147-5147           AC010201.18        39-39
            5148-5281           BX647258.1         5100-5233
FEATURES             Location/Qualifiers
     source          1..5281
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.33"
     gene            1..5281
                     /gene="POC1B-GALNT4"
                     /gene_synonym="GalNAc-T4; GALNT4"
                     /note="POC1B-GALNT4 readthrough"
                     /db_xref="GeneID:100528030"
                     /db_xref="HGNC:HGNC:42957"
     exon            1..167
                     /gene="POC1B-GALNT4"
                     /gene_synonym="GalNAc-T4; GALNT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1880
                     /gene="POC1B-GALNT4"
                     /gene_synonym="GalNAc-T4; GALNT4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     POC1B-GALNT4 fusion; Polypeptide
                     N-acetylgalactosaminyltransferase 4; Polypeptide GalNAc
                     transferase 4; Protein-UDP acetylgalactosaminyltransferase
                     4; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 4; pp-GaNTase 4"
                     /codon_start=1
                     /product="POC1B-GALNT4 protein isoform 1"
                     /protein_id="NP_001186710.1"
                     /db_xref="GeneID:100528030"
                     /db_xref="HGNC:HGNC:42957"
                     /translation="MASATEDPVLERYFKGHKAAITSLDLSPNGKQLGAGRARELGSR
                     RLSDLQKNTEDLSRPLYKKPPADSRALGEWGKASKLQLNEDELKQQEELIERYAINIY
                     LSDRISLHRHIEDKRMYECKSQKFNYRTLPTTSVIIAFYNEAWSTLLRTIHSVLETSP
                     AVLLKEIILVDDLSDRVYLKTQLETYISNLDRVRLIRTNKREGLVRARLIGATFATGD
                     VLTFLDCHCECNSGWLEPLLERIGRDETAVVCPVIDTIDWNTFEFYMQIGEPMIGGFD
                     WRLTFQWHSVPKQERDRRISRIDPIRSPTMAGGLFAVSKKYFQYLGTYDTGMEVWGGE
                     NLELSFRVWQCGGKLEIHPCSHVGHVFPKRAPYARPNFLQNTARAAEVWMDEYKEHFY
                     NRNPPARKEAYGDISERKLLRERLRCKSFDWYLKNVFPNLHVPEDRPGWHGAIRSRGI
                     SSECLDYNSPDNNPTGANLSLFGCHGQGGNQFFEYTSNKEIRFNSVTELCAEVPEQKN
                     YVGMQNCPKDGFPVPANIIWHFKEDGTIFHPHSGLCLSAYRTPEGRPDVQMRTCDALD
                     KNQIWSFEK"
     exon            168..252
                     /gene="POC1B-GALNT4"
                     /gene_synonym="GalNAc-T4; GALNT4"
                     /inference="alignment:Splign:2.1.0"
     exon            253..5281
                     /gene="POC1B-GALNT4"
                     /gene_synonym="GalNAc-T4; GALNT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5251..5256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POC1B-GALNT4"
                     /gene_synonym="GalNAc-T4; GALNT4"
                     /note="hexamer: AATAAA"
     polyA_site      5281
                     /gene="POC1B-GALNT4"
                     /gene_synonym="GalNAc-T4; GALNT4"
                     /note="major polyA site"
ORIGIN      
        1 gactgggccg ccgttgttgt agtgaccggg aggcgctgcc gctctgggca gacggttccg
       61 ggagccgcac ggtcccctct ccttccccat cctctcccct cccctctccg ggttccccca
      121 cccacaggag ccttgggccg accactcccc cgatggcctc agccacggag gaccccgttc
      181 tggagcgtta tttcaaaggc cacaaagctg cgatcacctc cttggacctc agccccaacg
      241 gcaagcaact tggagccggc cgtgccaggg agctggggtc aagaaggctc tcagacctcc
      301 agaaaaatac ggaggatttg tctcgaccgc tttataagaa gccccctgca gattcccgtg
      361 cacttgggga gtgggggaaa gccagcaaac tccagctcaa cgaggatgaa ctgaagcagc
      421 aagaagaact cattgagaga tacgccatca atatttacct cagtgacagg atttccctgc
      481 atcgacacat agaggataaa agaatgtatg agtgtaagtc ccagaagttc aactatagga
      541 cacttcctac cacctctgtt atcattgctt tctataacga agcctggtcg actttgctcc
      601 gtaccattca cagtgtttta gaaacttctc ctgcagttct tttgaaagag atcatcttgg
      661 tggatgactt gagtgacaga gtttatttga agacacaact tgaaacttac atcagcaatc
      721 ttgatagagt acgcttgatt aggaccaata agcgagaggg gctggttagg gcccgtctga
      781 ttggggccac tttcgccact ggggacgtcc tcactttcct ggattgtcac tgtgagtgta
      841 attccggttg gctggaaccg cttttggaaa ggattgggag agatgaaaca gcagttgtgt
      901 gtcctgttat agacacaatt gattggaata cttttgaatt ctatatgcag ataggggagc
      961 ccatgattgg tgggtttgac tggcgtttaa catttcagtg gcattctgtc cccaaacagg
     1021 aaagggacag gcggatatca agaattgacc ccatcagatc acctaccatg gctggaggac
     1081 tgtttgctgt cagcaagaaa tattttcagt accttggaac gtatgacaca ggaatggaag
     1141 tgtggggagg tgaaaacctt gagctgtctt ttagggtgtg gcagtgtggt ggcaaattgg
     1201 agatccaccc gtgttcccac gtgggccatg tgttccccaa gcgggcacca tatgctcgcc
     1261 ccaatttcct acagaatact gctcgggcag cagaagtttg gatggatgaa tacaaagagc
     1321 acttctacaa tagaaaccct ccagcaagaa aagaagctta tggtgatatt tctgaaagaa
     1381 aattactacg agagcggttg agatgcaaga gctttgactg gtatttgaaa aacgtttttc
     1441 ctaatttaca tgttccagag gatagaccag gctggcatgg ggctattcgc agtagaggga
     1501 tctcgtctga atgtttagat tataattctc ctgacaacaa ccccacaggt gctaaccttt
     1561 cactgtttgg atgccatggt caaggaggca atcaattctt tgaatatact tcaaacaaag
     1621 aaataaggtt taattctgtg acagagttat gtgcagaggt acctgagcaa aaaaattatg
     1681 tgggaatgca aaattgtccc aaagatgggt tccctgtacc agcaaacatt atttggcatt
     1741 ttaaagaaga tggaactatt tttcacccac actcaggact gtgtcttagt gcttatcgga
     1801 caccggaggg ccgacctgat gtacaaatga gaacttgtga tgctctagat aaaaatcaaa
     1861 tttggagttt tgagaaatag agcacaacag cactttcgtc atgagctgac agtagtgtca
     1921 agaaagtcaa agagccttaa gagcctcagt gaagattgta ttttatttta tcaaaagcca
     1981 cctagcagtc atctgtggag cactggaaag ctggggttca ttttggtata tcacactgaa
     2041 actgggtacc cagagtgctg ctgtttaata tttcacaatg ccttacttat tggttgtttt
     2101 atataagagt tttgtcaata tggtctcttc ttaaaagaag ttgactatga attgaaacac
     2161 acaaaacatt taagtgccag acttaatatt aaagaatgta aaggtccaag taaaatgagg
     2221 tatgatttat gttgatgtgt aagttcaccg cacatcccac tttttaacaa aactcatgaa
     2281 tgtgcagttt gagccattgc tattttgatt acatagaatt tgtatttctt ttttagccag
     2341 cacattaaat tttagatttt attttttaat ctaatttttt tctaatcaaa aagaaaattg
     2401 agcttaaggc aaaaggcctg gttttagaga tatgtgtaat tggaagaggg catttgtttg
     2461 agtgtgagtt tggaggcctt tttaacatgc agacataccc atatttaaat gaaatgggga
     2521 gatatttaca ttccgtactt tgtaaacttg agctattgga cttcactgat gtatatatta
     2581 atacctcaga ttcctctgat tttgtaagct gtcttctctg tgaacgtgtt tgtgtgtgta
     2641 gggcattttc tgattgcact tccttaagtt atgaatgtac tagaaaggga ctcatccaga
     2701 atactatgcc tccctttgtt aatgcttaat catttaaagt aaacacaatt gaagcctctc
     2761 tgaagttaaa cccaactatg tttattaaaa tgtgtgaaac tgaaagtggg ctaggttcta
     2821 ccaaggctgt ggaactctcc tacgagttct gctgatcagg aaatttaaga atttatctta
     2881 aaaatgcaag gaaaaaagac tgccttggca attgtgaatg gtgctttcaa tctcctagca
     2941 ccgagcctgg cacttaggca gctttcagta agtgggtgaa tgaatgactg aatgaatgaa
     3001 tgaatggctc agctgaggaa tgtaactttg gtcaagttat tatgatgtgt ttgggcttag
     3061 ttttctcatt ggtaaaatgt gggtgctgga ttggatctta aagatccctt ccagctctga
     3121 aatgctgatt gtacagtata ttcttcccag attgactcac tgtgcaatct ttacaatact
     3181 ttttatcttt tcacttttga cataggtaat gttgttgagc agttgagcaa tgttcagtcc
     3241 agttgtgaag ctggagaaga gaaatgggtt ttaaaaatta agtgagggga ggccgggtgc
     3301 ggtggctcac gcatgtaatc ccagcacttt gggaggccaa ggcaggtgga tcacgaggtc
     3361 aggagatcca gaccatcctg gctaacatgg tgaaacctcg tctctactaa aaatacaaaa
     3421 aattagccag ctgtggtggc gggcgcctgt agtcccagct actcaggagg ctgaggcagg
     3481 agaatggcgt gaacctgtga ggcagagctt acagtgagcc gagatcgtgc cactgcactc
     3541 cagcctgggc gacagagcaa gactctgtct caaaaaaaaa aaataataat aaaataagtg
     3601 agctgaactc acctgaagtg gtttacttct gtgggttaag aagttctagt cagtgttcat
     3661 agtcgtttcg ttttgataat tgttgaacca attttgtttt taaaaccttt agactctgaa
     3721 agtaatattt tgactaagaa tgtaaatatt tccaaactaa attactcggg aagtaaacgc
     3781 tttttttaaa agtattttta ctggttttat accaatatta tatgcagaaa tcacaggatg
     3841 aatttagaat taaatctcaa ttagttcact ttggcctaga tttatgaaaa atgcatgcct
     3901 cgtaaagagt ccactgtatt cacgagtaaa gttgctttta gtgttcactt gatgacttgg
     3961 agagtaggaa ttttgcaaaa tctgaattta aggaaattct ttaggataac catttcaaaa
     4021 aataaaattg ctatgcaatc ttgaatattt tctcttttgc ctcgtaaaat gaaaatgcat
     4081 tcacagtttc tgtaaattat ttagcagcct taaagtttat caaaaaattg tccagattcc
     4141 acgtgcagca tgcttggccc tgcatttaat ttaagaagga ttaataataa tgctctgaat
     4201 ttttcgaaag ggattctcct aaacccaccc acttctcttg cccaggctgc tttttaaaaa
     4261 tattttttta ttttttactt atttttaaat tttctctttt tatttatttt tggttttctt
     4321 gttagccacc tgttatatgg gagaacgaaa attgttatat tttgaaagta cttattacat
     4381 tatttttatt ttagtatctt gatgctcctg tcaaaaggga aatgaggctt ttaaaaataa
     4441 agtaccttaa ttctttattg actttttgcc ctaaattgct aggtgtgacc cagcaatctt
     4501 ttaggaagag attttacagt ggtgctttat ttatatcaat aatccagtat agttaggctg
     4561 ttcattcctc ataatagagt acataacaga aaagtgggac tttcacattt tcatatttag
     4621 gcacgttcca atttaattcc aaaaatactc tgtaattcta catctaaaaa aaccgattcc
     4681 ctaattcgaa tttattggta ccaaagctct ctttggctat agacaattaa gagttgacct
     4741 tttaagttaa tgtatatgct taaaaacagt tttaggaaaa tatttggtag acaaagagtt
     4801 tcaactttaa atgttcacta tgtcatttag tgtccaactt tacggatagg ttgactatct
     4861 aaataggcat ttttagtcat taaaaaaaat ctagtcacca ggaggatccc tataactcaa
     4921 aataacttgt ttgtaaaaga aaatttgttt acttacccat tagtaagttc ctgcatattc
     4981 attataagat ggcaaatcaa acttttctag gatgaagaca gcttattttt aagttgtata
     5041 gtcttagttg gtttagggtc tcaattttaa ttaataaaat acttggtttt tatttgcttg
     5101 tccttttgaa ttcctgtttt aataatttta aaatgagcac aaagaacgtt gaagttcaga
     5161 ttaatctctt ctgaatgatg tttttttcct ctgtgatgag ttgtttctga cttttttcct
     5221 tttgtatttg taatgttgat taagatgtaa aataaaaagt gtgcctgatt atttttgcaa
     5281 a
//
