LOCUS       NM_017761               2400 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens proline rich nuclear receptor coactivator 2 (PNRC2),
            mRNA.
ACCESSION   NM_017761 XM_001713881
VERSION     NM_017761.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2400)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2400)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2400)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2400)
  AUTHORS   Nicholson,P., Gkratsou,A., Josi,C., Colombo,M. and Muhlemann,O.
  TITLE     Dissecting the functions of SMG5, SMG7, and PNRC2 in
            nonsense-mediated mRNA decay of human cells
  JOURNAL   RNA 24 (4), 557-573 (2018)
   PUBMED   29348139
  REMARK    GeneRIF: UPF1 interacts with PNRC2 and that it triggers 5'-3'
            exonucleolytic decay of reporter transcripts in tethering assays.
            PNRC2 is probably an important mRNA decapping factor but that it
            does not appear to be required for nonsense-mediated mRNA decay.
REFERENCE   5  (bases 1 to 2400)
  AUTHORS   Cho,H., Park,O.H., Park,J., Ryu,I., Kim,J., Ko,J. and Kim,Y.K.
  TITLE     Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent
            manner to recruit UPF1 for rapid mRNA degradation
  JOURNAL   Proc Natl Acad Sci U S A 112 (13), E1540-E1549 (2015)
   PUBMED   25775514
  REMARK    GeneRIF: GR and PNRC2 interact in a ligand-dependent manner to
            recruit UPF1 for rapid mRNA degradation
REFERENCE   6  (bases 1 to 2400)
  AUTHORS   Lai,T., Cho,H., Liu,Z., Bowler,M.W., Piao,S., Parker,R., Kim,Y.K.
            and Song,H.
  TITLE     Structural basis of the PNRC2-mediated link between mrna
            surveillance and decapping
  JOURNAL   Structure 20 (12), 2025-2037 (2012)
   PUBMED   23085078
  REMARK    GeneRIF: PNRC2 acts in synergy with Dcp1a to stimulate the
            decapping activity of Dcp2 by bridging the interaction between
            Dcp1a and Dcp2.
REFERENCE   7  (bases 1 to 2400)
  AUTHORS   Cho,H., Kim,K.M. and Kim,Y.K.
  TITLE     Human proline-rich nuclear receptor coregulatory protein 2 mediates
            an interaction between mRNA surveillance machinery and decapping
            complex
  JOURNAL   Mol Cell 33 (1), 75-86 (2009)
   PUBMED   19150429
  REMARK    GeneRIF: PNRC2 plays an essential role in mammalian
            Nonsense-mediated mRNA decay (NMD), mediating the interaction
            between the NMD machinery and the decapping complex.
REFERENCE   8  (bases 1 to 2400)
  AUTHORS   Hentschke,M. and Borgmeyer,U.
  TITLE     Identification of PNRC2 and TLE1 as activation function-1 cofactors
            of the orphan nuclear receptor ERRgamma
  JOURNAL   Biochem Biophys Res Commun 312 (4), 975-982 (2003)
   PUBMED   14651967
  REMARK    GeneRIF: Not only PNRC2 but also the corepressor TLE1 functioned as
            ERRgamma coactivator in a reporter gene analysis.
REFERENCE   9  (bases 1 to 2400)
  AUTHORS   Zhou,D. and Chen,S.
  TITLE     PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors
            through an SH3-binding motif
  JOURNAL   Nucleic Acids Res 29 (19), 3939-3948 (2001)
   PUBMED   11574675
REFERENCE   10 (bases 1 to 2400)
  AUTHORS   Zhou,D., Quach,K.M., Yang,C., Lee,S.Y., Pohajdak,B. and Chen,S.
  TITLE     PNRC: a proline-rich nuclear receptor coregulatory protein that
            modulates transcriptional activation of multiple nuclear receptors
            including orphan receptors SF1 (steroidogenic factor 1) and
            ERRalpha1 (estrogen related receptor alpha-1)
  JOURNAL   Mol Endocrinol 14 (7), 986-998 (2000)
   PUBMED   10894149
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA043474.1, BC078177.1, BC001959.1 and AK311305.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017761.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.32589.1,
                                           SRR1660803.47214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334351.8/ ENSP00000334840.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DA043474.1         28-58
            32-631              BC078177.1         1-600
            632-923             BC001959.1         620-911
            924-976             BC078177.1         893-945
            977-981             AK311305.1         779-783
            982-2400            BC078177.1         946-2364
FEATURES             Location/Qualifiers
     source          1..2400
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..2400
                     /gene="PNRC2"
                     /note="proline rich nuclear receptor coactivator 2"
                     /db_xref="GeneID:55629"
                     /db_xref="HGNC:HGNC:23158"
                     /db_xref="MIM:611882"
     exon            1..171
                     /gene="PNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            172..377
                     /gene="PNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..2400
                     /gene="PNRC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..815
                     /gene="PNRC2"
                     /codon_start=1
                     /product="proline-rich nuclear receptor coactivator 2"
                     /protein_id="NP_060231.1"
                     /db_xref="CCDS:CCDS246.1"
                     /db_xref="GeneID:55629"
                     /db_xref="HGNC:HGNC:23158"
                     /db_xref="MIM:611882"
                     /translation="MGGGERYNIPAPQSRNVSKNQQQLNRQKTKEQNSQMKIVHKKKE
                     RGHGYNSSAAAWQAMQNGGKNKNFPNNQSWNSSLSGPRLLFKSQANQNYAGAKFSEPP
                     SPSVLPKPPSHWVPVSFNPSDKEIMTFQLKTLLKVQV"
     regulatory      2361..2366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNRC2"
                     /note="hexamer: AATAAA"
     polyA_site      2377
                     /gene="PNRC2"
                     /note="major polyA site"
ORIGIN      
        1 gtcggtagag gcagaaggag aaggtcgggt tgtagaagct ggggtggccg gcagctcgct
       61 catcggtgtt cgtgggcttt gtcggtccgt gcctcgtctc tccctggaaa gggagggagg
      121 cttcgacgtc gagagggagc cgctgccgcg ttagttccga gcttgaagtc actaggactt
      181 ctctcaaact tgtgtgctga ggagactcag atgttggcct cagctcctag gctgaactca
      241 gcagatcggc ccatgaaaac ttctgtattg agacaaagga agggatctgt cagaaagcaa
      301 cacttgttat cttgggcttg gcagcaagga agaggacagg tagtggagat cctgcaatct
      361 gaaaagcaga ctgaaaggtg acaaagaagc tgaagatggg tggtggagag aggtataaca
      421 ttccagcccc tcaatctaga aatgttagta agaaccaaca acagcttaac agacagaaga
      481 ccaaggaaca gaattcccag atgaagattg ttcataagaa aaaagaaaga ggacatggtt
      541 ataactcatc agcagctgcc tggcaggcca tgcaaaatgg ggggaagaac aaaaattttc
      601 caaataatca aagttggaat tctagcttat caggtcccag gttacttttt aaatctcaag
      661 ctaatcagaa ctatgctggt gccaaattta gtgagccgcc atcaccaagt gttcttccca
      721 aaccaccaag ccactgggtc cctgtttcct ttaatccttc agataaggaa ataatgacat
      781 ttcaacttaa aaccttactt aaagtacagg tataaaataa gacaaatgtt taaatttagt
      841 tatgttcacg gatagttgtc aattggtctg aaacaaattc gctagggaat ctatttgtgt
      901 agaactaatt aatgtaaaaa aaatagacca tctcgtgttg tgtgcactgt gatataatgg
      961 tagtatcagt gcaacttaaa ctaatgattg tacttgatat taagtgttct caactgagta
     1021 acttttaagt ggaaaccaag tttagatttg gggagtggta aaggaatcag ctttttctat
     1081 tgttagggga agacagtaat ttatcattca tggaccagta gattgttgaa agttggtgaa
     1141 tcggattata agcttctagc taacacaagg attcagaatt aggtaaacat ctgaaggttt
     1201 agtatattag aaacacccaa accagtaata tgctaacctg atgcactgct gaaagaaaat
     1261 gtgaattttt cgtaataatt gcattttagt gaattgtaca gtgggtggaa agggcatttg
     1321 gagctcatta gaatgagaca tagtacaccc caatggccct gtttattaaa tgtagtggat
     1381 taagtgtctg tcaacaaata caccaaaacc attttttata gaaacagtat ttaatggtca
     1441 ctcaatagct ttcaaaatac atttttgtat tacagcactg cacaagctat tctaatagtg
     1501 ctctggcctc atcattcctg caaagcttgc tttggggagt tggataatgt gaaaatttta
     1561 agtacctagg ggagaaagag ccatgtaaat atctgtaata aacttgtagc atatgtaaag
     1621 ttttcttggc ctttatctta caaaaatgga gtattttagt atgaatttgc tgaatgtaag
     1681 accgtggact gttttttata atatggccta attttaaagg tccaaaataa cttgttttta
     1741 aagtttgccc ttgtgctaaa gtgccagtgt atgtatgtta tacttgattt ggttgtaaac
     1801 tatatttcaa agtaaaccct agtgtaataa gttttataac taaaaaggtt taagctgcta
     1861 aaactatttt taagagatgt gaaatgcagt atgggactat ctttttttcc tcctctaagc
     1921 ccaaagatta actagagtcc ctccaacctt atagattgtt ggctttcaca atcttataac
     1981 ctaggataca ggtagtttcg agtatggtgc cagtgatgtt ttgtttttgt ttggtcaagg
     2041 ggtaggtgca acccaatgga ccacttatgc aaaagatgta aactcttgca taatacattg
     2101 ataacatgtt ttgccaactt taaatgctta aacataagcg aaaccagtag caagtatgtg
     2161 ggtcagctta aaaattttga ttgttaatgc cctattttct aatttggcac ctcttgatgc
     2221 ctaagcaggt aagcagatgc ctaagctgta tttctccaaa taaatcaaga tgaagtactg
     2281 cccaagttaa atattgatag cctaaagaca agtttatgta gtacttaatg tacatgatat
     2341 gaatgtgaag cataaaatta aataaaattt ttccccattg gcttggtttt attttaaaaa
//
