LOCUS       NM_006813               2092 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens proline rich nuclear receptor coactivator 1 (PNRC1),
            mRNA.
ACCESSION   NM_006813
VERSION     NM_006813.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2092)
  AUTHORS   Yao,L., Zhang,W., Zheng,J., Lu,X. and Zhang,F.
  TITLE     miR-199a Targeting PNRC1 to Promote Keratinocyte Proliferation and
            Invasion in Cholesteatoma
  JOURNAL   Biomed Res Int 2021, 1442093 (2021)
   PUBMED   34825000
  REMARK    GeneRIF: miR-199a Targeting PNRC1 to Promote Keratinocyte
            Proliferation and Invasion in Cholesteatoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2092)
  AUTHORS   Gaviraghi,M., Vivori,C., Pareja Sanchez,Y., Invernizzi,F.,
            Cattaneo,A., Santoliquido,B.M., Frenquelli,M., Segalla,S.,
            Bachi,A., Doglioni,C., Pelechano,V., Cittaro,D. and Tonon,G.
  TITLE     Tumor suppressor PNRC1 blocks rRNA maturation by recruiting the
            decapping complex to the nucleolus
  JOURNAL   EMBO J 37 (23) (2018)
   PUBMED   30373810
  REMARK    GeneRIF: PNRC1 ablates the enhanced proliferation triggered by
            established oncogenes such as RAS and MYC These observations
            uncover a previously undescribed mechanism of tumor suppression,
            whereby the cytoplasmic decapping machinery is hauled within
            nucleoli, tightly regulating ribosomal RNA maturation.
REFERENCE   3  (bases 1 to 2092)
  AUTHORS   Zhang,Y., Chen,B., Li,Y.P., Lou,G.Y., Chen,M. and Zhou,D.J.
  TITLE     [Transcriptional regulation of the human gene coding for
            proline-rich nuclear receptor coactivator (pnrc) by regulatory
            factor x (rfx1)]
  JOURNAL   Mol Biol (Mosk) 43 (1), 77-84 (2009)
   PUBMED   19334528
  REMARK    GeneRIF: RFX1 specifically bind to promoter region and negatively
            regulate the transcription of the human PNRC gene.
REFERENCE   4  (bases 1 to 2092)
  AUTHORS   Wang,Y., Li,Y., Chen,B., Zhang,Y., Lou,G., Chen,S. and Zhou,D.
  TITLE     Identification and characterization of PNRC splicing variants
  JOURNAL   Gene 423 (2), 116-124 (2008)
   PUBMED   18703122
  REMARK    GeneRIF: Three human PNRC splicing variants designated PNRC1c,
            PNRC1d and PNRC1f, are identified.
REFERENCE   5  (bases 1 to 2092)
  AUTHORS   Zhang,Y., Chen,B., Li,Y., Chen,J., Lou,G., Chen,M. and Zhou,D.
  TITLE     Transcriptional regulation of the human PNRC promoter by NFY in
            HepG2 cells
  JOURNAL   J Biochem 143 (5), 675-683 (2008)
   PUBMED   18281297
  REMARK    GeneRIF: Functional analysis of the 5' flanking region of the human
            PNRC gene by deletion mutagenesis, transient transfection and
            luciferase assays revealed that the -123/+27 region is the minimal
            promoter of the human PNRC gene.
REFERENCE   6  (bases 1 to 2092)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 2092)
  AUTHORS   Zhou,D. and Chen,S.
  TITLE     PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors
            through an SH3-binding motif
  JOURNAL   Nucleic Acids Res 29 (19), 3939-3948 (2001)
   PUBMED   11574675
REFERENCE   8  (bases 1 to 2092)
  AUTHORS   Zhou,D., Quach,K.M., Yang,C., Lee,S.Y., Pohajdak,B. and Chen,S.
  TITLE     PNRC: a proline-rich nuclear receptor coregulatory protein that
            modulates transcriptional activation of multiple nuclear receptors
            including orphan receptors SF1 (steroidogenic factor 1) and
            ERRalpha1 (estrogen related receptor alpha-1)
  JOURNAL   Mol Endocrinol 14 (7), 986-998 (2000)
   PUBMED   10894149
REFERENCE   9  (bases 1 to 2092)
  AUTHORS   Hsiao,P.W. and Chang,C.
  TITLE     Isolation and characterization of ARA160 as the first androgen
            receptor N-terminal-associated coactivator in human prostate cells
  JOURNAL   J Biol Chem 274 (32), 22373-22379 (1999)
   PUBMED   10428808
REFERENCE   10 (bases 1 to 2092)
  AUTHORS   Chen,J., Liu,L. and Pohajdak,B.
  TITLE     Cloning a cDNA from human NK/T cells which codes for a protein with
            high proline content
  JOURNAL   Biochim Biophys Acta 1264 (1), 19-22 (1995)
   PUBMED   7578250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK312665.1, AK130046.1 and U03105.1.
            
            On May 17, 2019 this sequence version replaced NM_006813.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U03105.1, SRR7346977.679146.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336032.4/ ENSP00000336931.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AK312665.1         5-98
            95-1765             AK130046.1         94-1764
            1766-2092           U03105.1           1735-2061
FEATURES             Location/Qualifiers
     source          1..2092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..2092
                     /gene="PNRC1"
                     /gene_synonym="B4-2; PNAS-145; PROL2; PRR2"
                     /note="proline rich nuclear receptor coactivator 1"
                     /db_xref="GeneID:10957"
                     /db_xref="HGNC:HGNC:17278"
                     /db_xref="MIM:606714"
     exon            1..684
                     /gene="PNRC1"
                     /gene_synonym="B4-2; PNAS-145; PROL2; PRR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1128
                     /gene="PNRC1"
                     /gene_synonym="B4-2; PNAS-145; PROL2; PRR2"
                     /note="proline-rich protein with nuclear targeting signal;
                     proline-rich polypeptide 2; proline rich 2 protein;
                     protein B4-2; proline-rich protein 2"
                     /codon_start=1
                     /product="proline-rich nuclear receptor coactivator 1"
                     /protein_id="NP_006804.1"
                     /db_xref="CCDS:CCDS5018.1"
                     /db_xref="GeneID:10957"
                     /db_xref="HGNC:HGNC:17278"
                     /db_xref="MIM:606714"
                     /translation="MTVVSVPQREPLVLGGRLAPLGFSSRGYFGALPMVTTAPPPLPR
                     IPDPRALPPTLFLPHFLGGDGPCLTPQPRAPAALPNRSLAVAGGTPRAAPKKRRKKKV
                     RASPAGQLPSRFHQYQQHRPSLEGGRSPATGPSGAQEVPGPAAALAPSPAAAAGTEGA
                     SPDLAPLRPAAPGQTPLRKEVLKSKMGKSEKIALPHGQLVHGIHLYEQPKINRQKSKY
                     NLPLTKITSAKRNENNFWQDSVSSDRIQKQEKKPFKNTENIKNSHLKKSAFLTEVSQK
                     ENYAGAKFSDPPSPSVLPKPPSHWMGSTVENSNQNRELMAVHLKTLLKVQT"
     exon            685..2092
                     /gene="PNRC1"
                     /gene_synonym="B4-2; PNAS-145; PROL2; PRR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1712..1717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNRC1"
                     /gene_synonym="B4-2; PNAS-145; PROL2; PRR2"
                     /note="hexamer: AACAAA"
     regulatory      1746..1751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNRC1"
                     /gene_synonym="B4-2; PNAS-145; PROL2; PRR2"
                     /note="hexamer: AATAAT"
     polyA_site      1765
                     /gene="PNRC1"
                     /gene_synonym="B4-2; PNAS-145; PROL2; PRR2"
     polyA_site      1770
                     /gene="PNRC1"
                     /gene_synonym="B4-2; PNAS-145; PROL2; PRR2"
                     /note="major polyA site"
ORIGIN      
        1 gttgctgcgc cgccaccgcc cgagtcatgt tccgcgatct tctcaggctc tcctagcagc
       61 atccatcgcc gccaccctat cttcactggc ttcattcacc ttctccttct ctcttcgttg
      121 ctgagcgaca agcttcctag cgctatgact gtcgtctccg tcccgcagcg ggagccgctc
      181 gtcctgggtg gccgccttgc gccgcttggc ttttcctccc gaggttactt tggggccctc
      241 ccgatggtga ccacggctcc gcctccttta ccccggatcc cggacccccg ggcactgccc
      301 ccgaccctct tcctccctca tttcctaggg ggagatggcc cgtgtctgac cccccagcct
      361 cgcgctccag cagctctgcc caaccgcagc ctcgccgtgg cgggaggcac tcctcgggca
      421 gcgccgaaga agcggcgaaa gaagaaggtg cgggccagcc ccgcagggca gctgcccagc
      481 cgcttccacc agtaccagca gcaccggccg agtctggagg gcggccggag ccccgcgacc
      541 ggcccgagcg gagcgcagga ggtcccgggc ccggccgccg ccttggcccc gagtcctgca
      601 gccgcagccg gcacggaggg agccagcccc gaccttgccc cgctgcggcc cgcggctccc
      661 ggccaaaccc ccctcaggaa agaggtttta aaatcaaaga tgggaaaatc ggagaaaatt
      721 gcccttcccc atggccagct tgttcatggt atacacttgt atgagcaacc aaagataaac
      781 agacagaaaa gcaaatataa cttgccacta accaagatca cctctgcaaa aagaaatgaa
      841 aacaactttt ggcaggattc tgtttcatct gacagaattc agaagcagga aaaaaagcct
      901 tttaaaaata ccgagaacat taaaaattcg catttgaaga aatcagcatt tctaactgaa
      961 gtgagccaaa aggaaaatta tgctggggca aagtttagtg atccaccttc tcctagtgtt
     1021 cttccaaagc ctcctagtca ctggatggga agcactgttg aaaattccaa ccaaaacagg
     1081 gagctgatgg cagtacactt aaaaacgctc ctcaaagttc aaacttagat ttcagatttc
     1141 agtatgtgtg taaaacataa tttttcccat atccctggac tcttgagaaa attggtacag
     1201 aaatggaaat ttgccttgtt gcaacataca attgcaaaag atgagtttaa aaaattacat
     1261 acaaacagct tgtattatat tttatatttt gtaaatactg tataccatgt attatgtgta
     1321 tattgttcat acttgagagg tatattatag ttttgttatg aaagtatgta ttttgccctg
     1381 cccacattgc aggtgttttg tatatataca atggataaat tttaagtgtg tgctaaggca
     1441 catggaagac cgattttatt tgcacaaggt actgagattt ttttcaagaa acagctgtca
     1501 aatctcaagg tgaagatcta aatgtgaaca gtttactaat gcactactga agtttaaatc
     1561 tgtggcacaa tcaatgtaag catggggttt gtttctctaa attgatttgt aatctgaaat
     1621 tactgaacaa ctcctattcc catttttgct aaactcaatt tctggttttg gtatatatcc
     1681 attccagctt aatgcctcta attttaatgc caacaaaatt ggttgtaatc aaattttaaa
     1741 ataataataa tttggccccc ccttttaaaa tagtcttgac tctttgtgtg tgactgtttc
     1801 tcatgtttga atgtgtgact aggagatgat tttgtgtggt tggatttttt tgacttctac
     1861 tttactggct gagtgtgagc cgccatgcct ggccataatc tacattttct taccaggagc
     1921 agcattgagg tttttgagca tagtacttga ctactctaga ggctgagacg ggagcatctc
     1981 ttgagcctga gaagtggaga ttgcaattga gctaggatca ggccactgca ctccagcctg
     2041 ggtaacagac gctgtctcaa aaaaaaggcc aagagaaagt aagggagaca ga
//
