LOCUS       NM_001098537            4675 bp    mRNA    linear   PRI 19-FEB-2025
DEFINITION  Homo sapiens patatin like domain 7, lysophospholipase (PNPLA7),
            transcript variant 1, mRNA.
ACCESSION   NM_001098537
VERSION     NM_001098537.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4675)
  AUTHORS   Bai,Y., Luo,K. and Xie,W.
  TITLE     The phospholipase PNPLA7 functions as a positive indicator in human
            colorectal and gastric cancers
  JOURNAL   Medicine (Baltimore) 102 (42), e35279 (2023)
   PUBMED   37861523
  REMARK    GeneRIF: The phospholipase PNPLA7 functions as a positive indicator
            in human colorectal and gastric cancers.
REFERENCE   2  (bases 1 to 4675)
  AUTHORS   Harada,S., Taketomi,Y., Aiba,T., Kawaguchi,M., Hirabayashi,T.,
            Uranbileg,B., Kurano,M., Yatomi,Y. and Murakami,M.
  TITLE     The Lysophospholipase PNPLA7 Controls Hepatic Choline and
            Methionine Metabolism
  JOURNAL   Biomolecules 13 (3), 471 (2023)
   PUBMED   36979406
  REMARK    GeneRIF: The Lysophospholipase PNPLA7 Controls Hepatic Choline and
            Methionine Metabolism.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4675)
  AUTHORS   Zhao,Z., Heier,C., Pang,H., Wang,Y., Huang,F. and Chang,P.
  TITLE     The Patatin-Like Phospholipase Domain Containing Protein 7
            Regulates Macrophage Classical Activation through SIRT1/NF-kappaB
            and p38 MAPK Pathways
  JOURNAL   Int J Mol Sci 23 (23), 14983 (2022)
   PUBMED   36499308
  REMARK    GeneRIF: The Patatin-Like Phospholipase Domain Containing Protein 7
            Regulates Macrophage Classical Activation through SIRT1/NF-kappaB
            and p38 MAPK Pathways.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4675)
  AUTHORS   Wang,X., Guo,M., Wang,Q., Wang,Q., Zuo,S., Zhang,X., Tong,H.,
            Chen,J., Wang,H., Chen,X., Guo,J., Su,X., Liang,H., Zhou,H. and
            Li,J.Z.
  TITLE     The Patatin-Like Phospholipase Domain Containing Protein 7
            Facilitates VLDL Secretion by Modulating ApoE Stability
  JOURNAL   Hepatology 72 (5), 1569-1585 (2020)
   PUBMED   32103509
  REMARK    GeneRIF: The Patatin-Like Phospholipase Domain Containing Protein 7
            Facilitates VLDL Secretion by Modulating ApoE Stability.
REFERENCE   5  (bases 1 to 4675)
  AUTHORS   Heier,C., Kien,B., Huang,F., Eichmann,T.O., Xie,H., Zechner,R. and
            Chang,P.A.
  TITLE     The phospholipase PNPLA7 functions as a lysophosphatidylcholine
            hydrolase and interacts with lipid droplets through its catalytic
            domain
  JOURNAL   J Biol Chem 292 (46), 19087-19098 (2017)
   PUBMED   28887301
  REMARK    GeneRIF: PNPLA7 acts as an endoplasmic reticulum -anchored
            lysophosphatidylcholine hydrolase that is composed of specific
            functional domains mediating catalytic activity, subcellular
            positioning, and interactions with cellular organelles.
REFERENCE   6  (bases 1 to 4675)
  AUTHORS   Su,Y., Kong,G.L., Su,Y.L., Zhou,Y., Lv,L.F., Wang,Q., Huang,B.P.,
            Zheng,R.Z., Li,Q.Z., Yuan,H.J. and Zhao,Z.G.
  TITLE     Correlation analysis of the PNPLA7 gene polymorphism and
            susceptibility to menstrual disorder
  JOURNAL   Genet Mol Res 14 (1), 1733-1740 (2015)
   PUBMED   25867316
  REMARK    GeneRIF: We explored Single Nucleotide Polymorphism in the PNPLA7
            gene on chromosome 9 and investigated their correlation with the
            susceptibility to menstrual disorder.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4675)
  AUTHORS   Kienesberger,P.C., Oberer,M., Lass,A. and Zechner,R.
  TITLE     Mammalian patatin domain containing proteins: a family with diverse
            lipolytic activities involved in multiple biological functions
  JOURNAL   J Lipid Res 50 Suppl (Suppl), S63-S68 (2009)
   PUBMED   19029121
  REMARK    Review article
REFERENCE   8  (bases 1 to 4675)
  AUTHORS   Wilson,P.A., Gardner,S.D., Lambie,N.M., Commans,S.A. and
            Crowther,D.J.
  TITLE     Characterization of the human patatin-like phospholipase family
  JOURNAL   J Lipid Res 47 (9), 1940-1949 (2006)
   PUBMED   16799181
REFERENCE   9  (bases 1 to 4675)
  AUTHORS   Winrow,C.J., Hemming,M.L., Allen,D.M., Quistad,G.B., Casida,J.E.
            and Barlow,C.
  TITLE     Loss of neuropathy target esterase in mice links organophosphate
            exposure to hyperactivity
  JOURNAL   Nat Genet 33 (4), 477-485 (2003)
   PUBMED   12640454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA963194.1, AK126267.1, AK125060.1, AL365502.57 and AL832944.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001098537.2.
            
            Summary: Human patatin-like phospholipases, such as PNPLA7, have
            been implicated in regulation of adipocyte differentiation and have
            been induced by metabolic stimuli (Wilson et al., 2006 [PubMed
            16799181]).[supplied by OMIM, Jun 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.130318.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000406427.6/ ENSP00000384610.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DA963194.1         136-153
            19-796              AK126267.1         3-780
            797-1256            AK125060.1         704-1163
            1257-1257           AL365502.57        74650-74650         c
            1258-1504           AK125060.1         1165-1411
            1505-1505           AL365502.57        60710-60710         c
            1506-3427           AK125060.1         1413-3334
            3428-3428           AL365502.57        18830-18830         c
            3429-3442           AK125060.1         3336-3349
            3443-3443           AL365502.57        18221-18221         c
            3444-4572           AK125060.1         3351-4479
            4573-4675           AL832944.1         2135-2237
FEATURES             Location/Qualifiers
     source          1..4675
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..4675
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /note="patatin like domain 7, lysophospholipase"
                     /db_xref="GeneID:375775"
                     /db_xref="HGNC:HGNC:24768"
                     /db_xref="MIM:612122"
     exon            1..235
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..4234
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /EC_number="3.1.1.5"
                     /note="isoform a is encoded by transcript variant 1;
                     patatin-like phospholipase domain-containing protein 7;
                     patatin like phospholipase domain containing 7"
                     /codon_start=1
                     /product="patatin-like phospholipase domain-containing
                     protein 7 isoform a"
                     /protein_id="NP_001092007.2"
                     /db_xref="CCDS:CCDS48070.1"
                     /db_xref="GeneID:375775"
                     /db_xref="HGNC:HGNC:24768"
                     /db_xref="MIM:612122"
                     /translation="MEEEKDDSPQADFCLGTALHSWGLWFTEEGSPSTMLTGIAVGAL
                     LALALVGVLILFMFRRLRQFRQAQPTPQYRFRKRDKVMFYGRKIMRKVTTLPNTLVEN
                     TALPRQRARKRTKVLSLAKRILRFKKEYPALQPKEPPPSLLEADLTEFDVKNSHLPSE
                     VLYMLKNVRVLGHFEKPLFLELCKHIVFVQLQEGEHVFQPREPDPSICVVQDGRLEVC
                     IQDTDGTEVVVKEVLAGDSVHSLLSILDIITGHAAPYKTVSVRAAIPSTILRLPAAAF
                     HGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNAESQAIPLVSVASVAA
                     GKAKKQVFYGEEERLKKPPRLQESCDSDHGGGRPAAAGPLLKRSHSVPAPSIRKQILE
                     ELEKPGAGDPDPSAPQGGPGSATSDLGMACDRARVFLHSDEHPGSSVASKSRKSVMVA
                     EIPSTVSQHSESHTDETLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHVPAG
                     TVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIF
                     TVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVKRMSSFVRQIDFALDWVEVEA
                     GRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARAT
                     TVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGPVTGHQLGLPT
                     EGSKWDLGNPAVNLSTVAVMPVSEEVPLTAFALELEHALSAIGPTLLLTSDNIKRRLG
                     SAALDSVHEYRLSSWLGQQEDTHRIVLYQADGTLTPWTQRCVRQADCILIVGLGDQEP
                     TVGELERMLESTAVRAQKQLILLHREEGPAPARTVEWLNMRSWCSGHLHLCCPRRVFS
                     RRSLPKLVEMYKHVFQRPPDRHSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKAL
                     AECGIPVDMVGGTSIGAFVGALYSEERNYSQMRIRAKQWAEGMTSLMKAALDLTYPIT
                     SMFSGAGFNSSIFSVFKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSL
                     SGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDAL
                     SGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEVVKSSDYCEYLRPPIDSYS
                     TLDFGKFNEICEVGYQHGRTVFDIWGRSGVLEKMLRDQQGPSKKPASAVLTCPNASFT
                     DLAEIVSRIEPAKPAMVDDESDYQTEYEEELLDVPRDAYADFQSTSAQQGSDLEDESS
                     LRHRHPSLAFPKLSEGSSDQDG"
     exon            236..310
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..398
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..478
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..570
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..711
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..871
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..952
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1081
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1162
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1289
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1430
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1531
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1678
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1756
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1962
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2094
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2218
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2332
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2402
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2552
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2616
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2785
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2968
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3087
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3244
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3361
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3431
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3432..3548
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..3697
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..3850
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3851..3961
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3962..4046
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            4047..4150
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            4151..4675
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4653..4658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /note="hexamer: AATAAA"
     polyA_site      4675
                     /gene="PNPLA7"
                     /gene_synonym="C9orf111; NTE-R1; NTEL1"
                     /note="major polyA site"
ORIGIN      
        1 agatgacaga cacttctcaa aagacagctt ttcttcctgg agaacagact ttttcagcag
       61 gattttcctt tcagtgaaac ataatttgac ttgaaaggaa cccagggaaa agtgtccagg
      121 tgtgagcatg agcgggtaga ggtgtgccct tgtttgcttc aggctgtctg cttttcgccc
      181 ctgactgttt tttctgtttc tggccatgga ggaagagaaa gatgacagcc cacaggctga
      241 cttctgcctg ggcaccgccc tgcactcttg gggactgtgg ttcacggagg aaggttcacc
      301 gtccaccatg ctgacgggga ttgcagttgg agccctcctg gccctggcct tggttggtgt
      361 cctcatcctt ttcatgttca gaaggcttag acaatttcga caagcacagc ccactcctca
      421 gtaccggttc cggaagagag acaaagtgat gttttacggc cggaagatca tgaggaaggt
      481 gaccacactc cccaacaccc ttgtggagaa cactgccctg ccccggcagc gggccaggaa
      541 gaggaccaag gtgctgtctt tggccaagag gattctgcgt ttcaagaagg aatacccggc
      601 cctgcagccc aaggagcccc cgccctccct gctggaggcc gacctcacgg agtttgacgt
      661 gaagaattct cacctgccat cggaagttct gtacatgctg aaaaacgttc gggtcctggg
      721 ccactttgag aagccgctgt tcctggagct ttgcaaacac atcgtctttg tgcagctgca
      781 ggaaggggag cacgtcttcc agcccaggga gccggacccc agcatctgtg tggtgcagga
      841 cgggcggctg gaggtctgca tccaggacac tgacggcacc gaggtggtgg tgaaagaggt
      901 tctggcggga gacagcgtcc acagcctgct cagcatcctg gacatcatca ccggccatgc
      961 tgcaccttac aaaacggtct ccgtccgcgc ggccatcccg tccaccatcc tccggcttcc
     1021 agctgcggct tttcatggag tttttgagaa atatccggaa actctggtga gggtggtgca
     1081 gatcatcatg gtgcggctgc agagggtgac ctttctggct ctgcacaact acctcggcct
     1141 gaccacagag ctcttcaacg ctgagagcca ggccatccct ctcgtgtctg tagccagtgt
     1201 ggctgccggg aaggccaaga agcaggtgtt ctatggcgaa gaagagcggc ttaaaaagcc
     1261 accgcggctc caggagtcct gtgactcaga tcacgggggc ggccgcccgg cagctgctgg
     1321 gcccctgctg aagaggagcc actccgtccc cgcgccttcc attcgcaaac agatcttgga
     1381 ggagctggag aagcccgggg caggtgaccc tgacccttcg gccccacaag ggggcccagg
     1441 cagtgccact tctgatctgg ggatggcatg tgaccgtgcc agggtcttcc tgcactcgga
     1501 cgagcacccc gggagctccg tggccagcaa gtccaggaaa agcgtgatgg ttgcagagat
     1561 accctccacg gtctcccagc actcagagag tcacacggat gagaccctgg ccagcaggaa
     1621 gtcggatgcc atcttcagag ctgccaagaa ggacctgctc accctgatga agctggaaga
     1681 ctcatctctg ttggatggcc gggtggcgct tctgcacgtt cctgcaggca cggtggtgtc
     1741 aaggcaggga gaccaggacg ccagcatcct gttcgtggtc tcggggctgc tgcacgtgta
     1801 ccagcggaag atcggcagcc aggaggacac ctgcttgttc ctcacgcgcc ccggggagat
     1861 ggtgggccag ctggccgtgc tcaccgggga gcctctcatc ttcaccgtca aggccaacag
     1921 ggactgcagc ttcctgtcca tctccaaggc ccacttctat gaaatcatgc ggaagcagcc
     1981 gaccgtcgtc ctgggtgtgg cgcacactgt ggtgaagagg atgtcgtcct tcgtgcggca
     2041 aatcgacttt gccctggact gggtggaggt ggaggccggg cgagcaatat acaggcaggg
     2101 ggacaagtcc gactgcacgt acatcatgct cagcggccgg ctgcgctctg tgatccggaa
     2161 ggatgatggg aagaagcgcc tggccgggga gtacggccga ggagacctcg tcggcgtggt
     2221 ggagacactg acccaccagg cccgggcgac cacggtgcat gccgttcggg actcagaatt
     2281 ggccaagctg ccggcaggag ccctcacgtc catcaagcgc aggtacccac aggtggtgac
     2341 tcggctgatt catctcttgg gtgagaagat cctgggcagc ctccagcagg gacctgtgac
     2401 aggccaccag cttgggctcc ccacggaggg cagcaagtgg gacttgggga acccggctgt
     2461 caacctgtcc acggtggcag tgatgcccgt gtcagaggaa gtgcccctca ccgccttcgc
     2521 cctggagctg gagcatgccc tcagcgccat cggcccgacc ctgctgctga ctagtgacaa
     2581 cataaaacgg cgccttggct ccgctgccct ggacagtgtt cacgagtacc ggctgtccag
     2641 ctggctgggg cagcaggagg acacccacag gatcgtgctc taccaggcag atggcacgct
     2701 cacaccctgg acccagcgct gcgtgcgcca ggccgactgc atcctcatcg tgggcctggg
     2761 tgaccaggag cccacagtgg gcgagctgga gcggatgctg gagagcacag ctgtgcgtgc
     2821 ccagaagcag ctgatcctgc tgcacaggga ggagggcccg gcgccagcgc gcaccgtgga
     2881 gtggctcaac atgcggagct ggtgctccgg ccacctgcac ctctgctgcc cgcgccgcgt
     2941 cttctccagg aggagcctgc ccaagctggt ggagatgtac aagcatgtct tccagcggcc
     3001 cccggaccga cactcagact tctcccgcct ggcgagggtg ctgacgggca acgccattgc
     3061 cctggtgctt gggggagggg gagcaagagg ctgtgcccag gtgggcgttc tcaaggcctt
     3121 ggcggagtgc ggcatccctg tggacatggt gggaggcacg tccatcgggg ccttcgtggg
     3181 tgccctgtac tctgaggagc ggaactacag ccagatgcgg atccgggcca agcagtgggc
     3241 cgagggcatg acgtccttga tgaaggccgc gctggacctc acctacccca tcacgtccat
     3301 gttctccgga gccggcttca acagcagcat cttcagcgtc ttcaaggacc agcagatcga
     3361 ggacctgtgg attccttatt tcgccatcac caccgacatc acagcctcgg ccatgcgggt
     3421 ccacaccgac ggctccctgt ggtggtacgt gcgtgccagc atgtccctgt ccggttacat
     3481 gccccctctc tgtgacccga aggacggaca cctgctgatg gacgggggct acatcaacaa
     3541 cctcccagcg gatgtggccc ggtccatggg ggcaaaagtg gtgatcgcca ttgacgtggg
     3601 cagccgagat gagacggacc tcaccaacta tggggatgcg ctgtctgggt ggtggctgct
     3661 gtggaaacgc tggaacccct tggccacgaa agtcaaggtg ttgaacatgg cagagattca
     3721 gacgcgcctg gcctacgtgt gttgcgtgcg gcagctggag gtggtgaaga gcagtgacta
     3781 ctgcgagtac ctgcgccccc ccatcgacag ctacagcacc ctggacttcg gcaagttcaa
     3841 cgagatctgc gaagtgggct accagcacgg gcgcacggtg tttgacatct ggggccgcag
     3901 cggcgtgctg gagaagatgc tccgcgacca gcaggggccg agcaagaagc ccgcgagtgc
     3961 ggtcctcacc tgtcccaacg cctccttcac ggaccttgcc gaaattgtgt ctcgcattga
     4021 gcccgccaag cccgccatgg tggatgacga atctgactac cagacggagt acgaggagga
     4081 gctgctggac gtccccaggg atgcatacgc agacttccag agcacctcag cccagcaggg
     4141 ctcagacttg gaggacgagt cctcactgcg gcatcgacac cccagtctgg ctttcccaaa
     4201 actgtctgag ggctcctctg accaggacgg gtagaggcct ctgctaaaga gcccggatgc
     4261 agcgtcttcc gtgggactgt ccccaaggct gaggctcctg ccaagtccta ggggcctctg
     4321 tacctgccct gctggaagcc ctgacttccc cggggcccca ggctgtgtta gggttctctg
     4381 ggcctcttct ttgtaccagc agccctgcat acagggccct gtgagccccc ctgcagtcct
     4441 gtgaggcccc tgaagctctg tgaggcccct gaagctctgt gaaccccctg cagccctgtg
     4501 aggccccccg aagccctgtg aggccccccg aagccctgtg aaccacctgc tgccctgtga
     4561 ggcccccaaa gccctgtgaa ctgcctgctg tcctgtgaac tgcctgctgc cctgtgaggt
     4621 gtgggagccc tgatgctgcc gtgtgatgtt tcaataaagg tggatctcac tgttg
//
