LOCUS       NM_020143               2242 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens partner of NOB1 homolog (PNO1), transcript variant 1,
            mRNA.
ACCESSION   NM_020143
VERSION     NM_020143.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2242)
  AUTHORS   Fang,L., Wang,B., Yang,Z., Zhao,T. and Hao,W.
  TITLE     PNO1 promotes the progression of osteosarcoma via TGF-beta and
            YAP/TAZ pathway
  JOURNAL   Sci Rep 13 (1), 21827 (2023)
   PUBMED   38071381
  REMARK    GeneRIF: PNO1 promotes the progression of osteosarcoma via TGF-beta
            and YAP/TAZ pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2242)
  AUTHORS   Yang,Q., Yang,B. and Chen,M.
  TITLE     Partner of NOB1 homolog transcriptionally activated by E2F
            transcription factor 1 promotes the malignant progression and
            inhibits ferroptosis of pancreatic cancer
  JOURNAL   Chin J Physiol 66 (5), 388-399 (2023)
   PUBMED   37929351
  REMARK    GeneRIF: Partner of NOB1 homolog transcriptionally activated by E2F
            transcription factor 1 promotes the malignant progression and
            inhibits ferroptosis of pancreatic cancer.
REFERENCE   3  (bases 1 to 2242)
  AUTHORS   Roy,S.K., Srivastava,S., Hancock,A., Shrivastava,A., Morvant,J.,
            Shankar,S. and Srivastava,R.K.
  TITLE     Inhibition of ribosome assembly factor PNO1 by CRISPR/Cas9
            technique suppresses lung adenocarcinoma and Notch pathway:
            Clinical application
  JOURNAL   J Cell Mol Med 27 (3), 365-378 (2023)
   PUBMED   36625087
  REMARK    GeneRIF: Inhibition of ribosome assembly factor PNO1 by CRISPR/Cas9
            technique suppresses lung adenocarcinoma and Notch pathway:
            Clinical application.
REFERENCE   4  (bases 1 to 2242)
  AUTHORS   Hu,X., He,Y., Han,Z., Liu,W., Liu,D., Zhang,X., Chen,L., Qi,L.,
            Chen,L., Luo,Y., Li,Q., Chen,P., Wu,Q., Zhu,X. and Guo,H.
  TITLE     PNO1 inhibits autophagy-mediated ferroptosis by GSH metabolic
            reprogramming in hepatocellular carcinoma
  JOURNAL   Cell Death Dis 13 (11), 1010 (2022)
   PUBMED   36446769
  REMARK    GeneRIF: PNO1 inhibits autophagy-mediated ferroptosis by GSH
            metabolic reprogramming in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2242)
  AUTHORS   Li,J., Liu,L., Chen,Y., Wu,M., Lin,X., Shen,Z., Cheng,Y., Chen,X.,
            Weygant,N., Wu,X., Wei,L., Sferra,T.J., Han,Y., Chen,X., Shen,A.,
            Shen,A. and Peng,J.
  TITLE     Ribosome assembly factor PNO1 is associated with progression and
            promotes tumorigenesis in triple-negative breast cancer
  JOURNAL   Oncol Rep 47 (6) (2022)
   PUBMED   35445733
  REMARK    GeneRIF: Ribosome assembly factor PNO1 is associated with
            progression and promotes tumorigenesis in triplenegative breast
            cancer.
REFERENCE   6  (bases 1 to 2242)
  AUTHORS   Lin,C., Yuan,H., Wang,W., Zhu,Z., Lu,Y., Wang,J., Feng,F. and Wu,J.
  TITLE     Importance of PNO1 for growth and survival of urinary bladder
            carcinoma: Role in core-regulatory circuitry
  JOURNAL   J Cell Mol Med 24 (2), 1504-1515 (2020)
   PUBMED   31800162
  REMARK    GeneRIF: Importance of PNO1 for growth and survival of urinary
            bladder carcinoma: Role in core-regulatory circuitry.
REFERENCE   7  (bases 1 to 2242)
  AUTHORS   Shen,A., Chen,Y., Liu,L., Huang,Y., Chen,H., Qi,F., Lin,J.,
            Shen,Z., Wu,X., Wu,M., Li,Q., Qiu,L., Yu,N., Sferra,T.J. and
            Peng,J.
  TITLE     EBF1-Mediated Upregulation of Ribosome Assembly Factor PNO1
            Contributes to Cancer Progression by Negatively Regulating the p53
            Signaling Pathway
  JOURNAL   Cancer Res 79 (9), 2257-2270 (2019)
   PUBMED   30862720
  REMARK    GeneRIF: High PNO1 expression is associated with colorectal cancer.
REFERENCE   8  (bases 1 to 2242)
  AUTHORS   Raoelijaona,F., Thore,S. and Fribourg,S.
  TITLE     Domain definition and interaction mapping for the endonuclease
            complex hNob1/hPno1
  JOURNAL   RNA Biol 15 (9), 1174-1180 (2018)
   PUBMED   30176151
  REMARK    GeneRIF: A detailed characterization of PNO1 organization and its
            interaction with NOB1.
REFERENCE   9  (bases 1 to 2242)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   10 (bases 1 to 2242)
  AUTHORS   Zhou,G.J., Zhang,Y., Wang,J., Guo,J.H., Ni,J., Zhong,Z.M.,
            Wang,L.Q., Dang,Y.J., Dai,J.F. and Yu,L.
  TITLE     Cloning and characterization of a novel human RNA binding protein
            gene PNO1
  JOURNAL   DNA Seq 15 (3), 219-224 (2004)
   PUBMED   15497447
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC008304.1 and AC017083.7.
            
            On Nov 23, 2018 this sequence version replaced NM_020143.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.180277.1,
                                           SRR1803611.81905.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263657.7/ ENSP00000263657.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1963              BC008304.1         16-1978
            1964-2242           AC017083.7         95471-95749
FEATURES             Location/Qualifiers
     source          1..2242
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p14"
     gene            1..2242
                     /gene="PNO1"
                     /gene_synonym="KHRBP1; RRP20"
                     /note="partner of NOB1 homolog"
                     /db_xref="GeneID:56902"
                     /db_xref="HGNC:HGNC:32790"
                     /db_xref="MIM:618710"
     exon            1..254
                     /gene="PNO1"
                     /gene_synonym="KHRBP1; RRP20"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..806
                     /gene="PNO1"
                     /gene_synonym="KHRBP1; RRP20"
                     /note="isoform 1 is encoded by transcript variant 1;
                     KH-type RNA-binding protein 1; RNA binding protein;
                     RNA-binding protein PNO1"
                     /codon_start=1
                     /product="RNA-binding protein PNO1 isoform 1"
                     /protein_id="NP_064528.1"
                     /db_xref="CCDS:CCDS1885.1"
                     /db_xref="GeneID:56902"
                     /db_xref="HGNC:HGNC:32790"
                     /db_xref="MIM:618710"
                     /translation="MESEMETQSARAEEGFTQVTRKGGRRAKKRQAEQLSAAGEGGDA
                     GRMDTEEARPAKRPVFPPLCGDGLLSGKEETRKIPVPANRYTPLKENWMKIFTPIVEH
                     LGLQIRFNLKSRNVEIRTCKETKDVSALTKAADFVKAFILGFQVEDALALIRLDDLFL
                     ESFEITDVKPLKGDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVKVHILGSFQNI
                     KMARTAICNLILGNPPSKVYGNIRAVASRSADRF"
     exon            255..404
                     /gene="PNO1"
                     /gene_synonym="KHRBP1; RRP20"
                     /inference="alignment:Splign:2.1.0"
     exon            405..488
                     /gene="PNO1"
                     /gene_synonym="KHRBP1; RRP20"
                     /inference="alignment:Splign:2.1.0"
     exon            489..549
                     /gene="PNO1"
                     /gene_synonym="KHRBP1; RRP20"
                     /inference="alignment:Splign:2.1.0"
     exon            550..667
                     /gene="PNO1"
                     /gene_synonym="KHRBP1; RRP20"
                     /inference="alignment:Splign:2.1.0"
     exon            668..738
                     /gene="PNO1"
                     /gene_synonym="KHRBP1; RRP20"
                     /inference="alignment:Splign:2.1.0"
     exon            739..2242
                     /gene="PNO1"
                     /gene_synonym="KHRBP1; RRP20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1203..1208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNO1"
                     /gene_synonym="KHRBP1; RRP20"
                     /note="hexamer: AATAGA"
     polyA_site      1222
                     /gene="PNO1"
                     /gene_synonym="KHRBP1; RRP20"
                     /note="major polyA site"
     regulatory      1936..1941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNO1"
                     /gene_synonym="KHRBP1; RRP20"
                     /note="hexamer: AATAAA"
     polyA_site      1958
                     /gene="PNO1"
                     /gene_synonym="KHRBP1; RRP20"
                     /note="major polyA site"
     regulatory      2220..2225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNO1"
                     /gene_synonym="KHRBP1; RRP20"
                     /note="hexamer: ATTAAA"
     polyA_site      2242
                     /gene="PNO1"
                     /gene_synonym="KHRBP1; RRP20"
ORIGIN      
        1 gcagctgcgc acgtgtttca gccggcagcg ctttaagatt tccggggatg gaatccgaaa
       61 tggaaacgca gagcgccagg gcagaggagg gctttaccca ggtcacccgc aagggtggcc
      121 gacgggcgaa gaaacgacag gctgaacagc tgtccgcagc aggagagggc ggggatgcgg
      181 gccgcatgga cacagaggag gccaggccgg cgaagaggcc cgtcttccca cccctctgtg
      241 gggacgggct cctgagtggg aaagaagaaa caaggaaaat tccagtccca gctaacagat
      301 acacaccatt gaaagaaaac tggatgaaga tatttactcc tattgtggaa catttgggac
      361 ttcagatacg ctttaacttg aaatcaagga atgtagaaat caggacttgt aaagaaacca
      421 aggatgttag tgctctgaca aaagcagctg attttgtgaa agcttttatt ctcggctttc
      481 aggtggagga tgcacttgcc ctcatcaggt tggatgacct cttcctagag tcttttgaaa
      541 ttacagatgt taaaccccta aagggagacc atctatccag ggcaatagga agaatcgctg
      601 gcaaaggagg aaaaaccaaa ttcaccatag agaatgtgac acggacaagg atagttttgg
      661 ctgatgtgaa agttcacatc cttggctcct tccaaaatat caagatggca agaactgcca
      721 tttgcaacct aatcttggga aatcctcctt ccaaggttta tggcaatatt cgagctgtgg
      781 ctagcagatc agcagatcga ttctgatttc aagtcagaga ctttttatct tgcctttgga
      841 ctctggtgaa aaatacttta cagtggtcgg tcacaagaaa ccagctgaac aatttcagtc
      901 atttgaagcc tccgtccctt cttccattct cagccagaag cataaacaga aaagaaagat
      961 ttaagaggat tcacactcaa caggttttag gataatttaa atatcaaaaa ttgattgtta
     1021 tacttaacac attaggtata atttatcatt tatctgaaat cacatgtagc agattgcata
     1081 gtctgtaatc ctctcagagg gaaacttctt gtttaaacag ctctatatgg atttatactt
     1141 ttatatttat aaatttataa cttcatacaa atttataaac atttctttat aaattgtaat
     1201 ttaatagatt atctcagaaa aacctctctg aatgatgacc cttccttaat actgggtgat
     1261 gtgtgaatat ttgtttgttg gcagacaggg tctcactttg tcacccaggc tagagtgcag
     1321 tggtgcaatc tcagctcact gcagcctctg cctcctgagt tcaagtgatc ctcctgcttc
     1381 agcctcccta gtagctggga ctacaggtat gcaccaccat gcctggctaa ttttttgtat
     1441 tttttgtaga gatggggttt cgccatgttg accaggctgg tcttgaactc ctggcctcaa
     1501 gggatccgtc cgcctcagcc tcccaaagtg ctgggattac aggcataagc cactgcgcct
     1561 ggccttgatg tgtgaatatt tgagaggtca taagcagtgg ttttggccat accgtattat
     1621 accatataca tcagtaagag ctcatcttgg aacctgtttt gcagtttctt gcagtttcaa
     1681 aaattaaaga cctacatcac agggttaatg tgaagaaagc tttatttttc aaatgagtat
     1741 ttaatgaaag tatacataac caatgttggg tatacagatg cttctcaact tatgatgggt
     1801 ttaggtccag ataagcccac tgtgagttga aaataccaaa agtcaaacat catagcttag
     1861 cctaccttaa aagggctccg aacactacat tagcctacag ttgggcaaaa tcgtctaata
     1921 caaagcctat tttataataa agtatgttga atatctcatg taatttttga agattacatt
     1981 gaaagtgaaa aacagaatgg ttgggtactt gaaatacagc ttctactgaa tgaataattc
     2041 taaagttgaa aaataatagt aagaaccatc ataagtctgt ttcttctagt aaaggtgaaa
     2101 tgatgaaaga atgctttttt cccacccaaa aaactatgct ctataaatgc agattagcta
     2161 gtttctgcct gtttaaatgg tattatttta tacattacaa aatggaagga acttacttta
     2221 ttaaacttaa ctttgatact tc
//
