LOCUS       NM_002687               3537 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens pinin, desmosome associated protein (PNN), mRNA.
ACCESSION   NM_002687
VERSION     NM_002687.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3537)
  AUTHORS   Piccinno,E., Scalavino,V., Labarile,N., De Marinis,L.,
            Armentano,R., Giannelli,G. and Serino,G.
  TITLE     Identification of a Novel miR-195-5p/PNN Axis in Colorectal Cancer
  JOURNAL   Int J Mol Sci 25 (11), 5980 (2024)
   PUBMED   38892168
  REMARK    GeneRIF: Identification of a Novel miR-195-5p/PNN Axis in
            Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3537)
  AUTHORS   He,M., Jiang,D., Xun,A., Yang,J., Luo,Q. and Wu,H.
  TITLE     Methyltransferase like 3 enhances pinin mRNA stability through N6
            -methyladenosine modification to augment tumourigenesis of colon
            adenocarcinoma
  JOURNAL   Exp Physiol 107 (11), 1283-1297 (2022)
   PUBMED   35996844
  REMARK    GeneRIF: Methyltransferase like 3 enhances pinin mRNA stability
            through N(6) -methyladenosine modification to augment
            tumourigenesis of colon adenocarcinoma.
REFERENCE   3  (bases 1 to 3537)
  AUTHORS   Zhang,H., Jin,M., Ye,M., Bei,Y., Yang,S. and Liu,K.
  TITLE     The prognostic effect of PNN in digestive tract cancers and its
            correlation with the tumor immune landscape in colon adenocarcinoma
  JOURNAL   J Clin Lab Anal 36 (4), e24327 (2022)
   PUBMED   35257416
  REMARK    GeneRIF: The prognostic effect of PNN in digestive tract cancers
            and its correlation with the tumor immune landscape in colon
            adenocarcinoma.
REFERENCE   4  (bases 1 to 3537)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3537)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3537)
  AUTHORS   Shi,Y., Ouyang,P. and Sugrue,S.P.
  TITLE     Characterization of the gene encoding pinin/DRS/memA and evidence
            for its potential tumor suppressor function
  JOURNAL   Oncogene 19 (2), 289-297 (2000)
   PUBMED   10645008
REFERENCE   7  (bases 1 to 3537)
  AUTHORS   Ouyang,P.
  TITLE     Antibodies differentiate desmosome-form and nucleus-form pinin:
            evidence that pinin is a moonlighting protein with dual location at
            the desmosome and within the nucleus
  JOURNAL   Biochem Biophys Res Commun 263 (1), 192-200 (1999)
   PUBMED   10486276
REFERENCE   8  (bases 1 to 3537)
  AUTHORS   Degen,W.G., Agterbos,M.A., Muyrers,J.P., Bloemers,H.P. and
            Swart,G.W.
  TITLE     memA/DRS, a putative mediator of multiprotein complexes, is
            overexpressed in the metastasizing human melanoma cell lines BLM
            and MV3
  JOURNAL   Biochim Biophys Acta 1444 (3), 384-394 (1999)
   PUBMED   10095061
REFERENCE   9  (bases 1 to 3537)
  AUTHORS   Brandner,J.M., Reidenbach,S. and Franke,W.W.
  TITLE     Evidence that 'pinin', reportedly a differentiation-specific
            desmosomal protein, is actually a widespread nuclear protein
  JOURNAL   Differentiation 62 (3), 119-127 (1997)
   PUBMED   9447706
REFERENCE   10 (bases 1 to 3537)
  AUTHORS   Ouyang,P. and Sugrue,S.P.
  TITLE     Characterization of pinin, a novel protein associated with the
            desmosome-intermediate filament complex
  JOURNAL   J Cell Biol 135 (4), 1027-1042 (1996)
   PUBMED   8922384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL132639.4.
            
            On Nov 23, 2018 this sequence version replaced NM_002687.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.112731.1,
                                           SRR1660803.118083.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216832.9/ ENSP00000216832.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AL132639.4         18084-18222
            140-211             AL132639.4         18908-18979
            212-280             AL132639.4         19357-19425
            281-353             AL132639.4         20242-20314
            354-448             AL132639.4         20423-20517
            449-524             AL132639.4         20671-20746
            525-680             AL132639.4         21921-22076
            681-819             AL132639.4         22154-22292
            820-3537            AL132639.4         23333-26050
FEATURES             Location/Qualifiers
     source          1..3537
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.1"
     gene            1..3537
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /note="pinin, desmosome associated protein"
                     /db_xref="GeneID:5411"
                     /db_xref="HGNC:HGNC:9162"
                     /db_xref="MIM:603154"
     exon            1..139
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2180
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /note="neutrophil protein; SR-like protein; nuclear
                     protein SDK3; domain-rich serine protein;
                     desmosome-associated protein; melanoma metastasis clone A
                     protein; 140 kDa nuclear and cell adhesion-related
                     phosphoprotein"
                     /codon_start=1
                     /product="pinin"
                     /protein_id="NP_002678.3"
                     /db_xref="CCDS:CCDS9671.1"
                     /db_xref="GeneID:5411"
                     /db_xref="HGNC:HGNC:9162"
                     /db_xref="MIM:603154"
                     /translation="MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARL
                     LALSGPGGGRGRGSLLLRRGFSDSGGGPPAKQRDLEGAVSRLGGERRTRRESRQESDP
                     EDDDVKKPALQSSVVATSKERTRRDLIQDQNMDEKGKQRNRRIFGLLMGTLQKFKQES
                     TVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQL
                     QEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEGRRIEFAE
                     QINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVAQREEELEETGNQHNDVEIEEA
                     GEEEEKEIAIVHSDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQDSQPEEVMDVLEM
                     VENVKHVIADQEVMETNRVESVEPSENEASKELEPEMEFEIEPDKECKTLSPGKENVS
                     ALDMEKESEEKEEKESEPQPEPVAQPQPQSQPQLQLQSQSQPVLQSQPPSQPEDLSLA
                     VLQPTPQVTQEQGHLLPERKDFPVESVKLTEVPVEPVLTVHPESKSKTKTRSRSRGRA
                     RNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSS
                     TSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGSKDKN
                     SRSDRKRSISESSRSGKRSSRSERDRKSDRKDKRR"
     exon            140..211
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /inference="alignment:Splign:2.1.0"
     exon            212..280
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /inference="alignment:Splign:2.1.0"
     exon            281..353
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /inference="alignment:Splign:2.1.0"
     exon            354..448
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /inference="alignment:Splign:2.1.0"
     exon            449..524
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /inference="alignment:Splign:2.1.0"
     exon            525..680
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /inference="alignment:Splign:2.1.0"
     exon            681..819
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /inference="alignment:Splign:2.1.0"
     exon            820..3537
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2411..2416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /note="hexamer: AATAAA"
     polyA_site      2431
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /note="major polyA site"
     regulatory      2545..2550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /note="hexamer: AATAAA"
     polyA_site      2568
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /note="major polyA site"
     regulatory      3236..3241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /note="hexamer: AATAAA"
     polyA_site      3269
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /note="major polyA site"
     regulatory      3394..3399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /note="hexamer: AGTAAA"
     polyA_site      3420
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
     polyA_site      3500
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
     regulatory      3518..3523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
                     /note="hexamer: ATTAAA"
     polyA_site      3537
                     /gene="PNN"
                     /gene_synonym="DRS; DRSP; memA; SDK3"
ORIGIN      
        1 agtctcaagc ctgccgcagg gagaagatgg cggtcgccgt gagaactttg caggaacagc
       61 tggaaaaggc caaagagagt cttaagaacg tggatgagaa cattcgcaag ctcaccgggc
      121 gggatccgaa tgacgtgagg cccatccaag ccagattgct ggccctttct ggtcctggtg
      181 gaggtagagg acgtggtagt ttattactga ggcgtggatt ctcagatagt ggaggaggac
      241 ccccagccaa acagagagac cttgaagggg cagtcagtag gctgggcggg gagcgtcgga
      301 ccagaagaga atcacgccag gaaagcgacc cggaggatga tgatgttaaa aagccagcat
      361 tgcagtcttc agttgtagct acctccaaag agcgcacacg tagagacctt atccaggatc
      421 aaaatatgga tgaaaaggga aagcaaagga accggcgaat atttggcttg ttgatgggta
      481 cccttcaaaa atttaaacaa gaatccactg ttgctactga aaggcaaaag cggcgccagg
      541 aaattgaaca aaaacttgaa gttcaggcag aagaagagag aaagcaggtt gaaaatgaaa
      601 ggagagaact gtttgaagag aggcgtgcta aacagacaga actgcggctt ttggaacaga
      661 aagttgagct tgcgcagctg caagaagaat ggaatgaaca taatgccaaa ataattaaat
      721 atataagaac taagacaaag ccccatttgt tttatattcc tggaagaatg tgtccagcta
      781 cccaaaaact aatagaagag tcacagagaa aaatgaacgc tttatttgaa ggtagacgca
      841 tcgaatttgc agaacaaata aataaaatgg aggctaggcc tagaagacaa tcaatgaagg
      901 aaaaagagca tcaggtggtg cgtaatgaag aacagaaggc ggaacaagaa gagggtaagg
      961 tggctcagcg agaggaagag ttggaggaga caggtaatca gcacaatgat gtagaaatag
     1021 aggaagcagg agaggaagag gaaaaggaaa tagcgattgt tcatagtgat gcagagaaag
     1081 aacaggagga ggaagaacaa aaacaggaaa tggaggttaa gatggaggag gaaactgagg
     1141 taagggaaag tgagaagcag caggatagtc agcctgaaga agttatggat gtgctagaga
     1201 tggttgagaa tgtcaaacat gtaattgctg accaggaggt aatggaaact aatcgagttg
     1261 aaagtgtaga accttcagaa aatgaagcta gcaaagaatt ggaaccagaa atggaatttg
     1321 aaattgagcc agataaagaa tgtaaaaccc tttctcctgg gaaagagaat gtcagtgctt
     1381 tagacatgga aaaggagtct gaggaaaaag aagaaaaaga atctgagccc caacctgagc
     1441 ctgtggctca acctcagcct cagtctcagc cccagcttca gcttcaatcc cagtcccaac
     1501 cagtactcca gtcccagcct ccctctcagc ctgaggattt gtcattagct gttttacagc
     1561 caacacccca agttactcag gagcaagggc atttactacc tgagaggaag gattttcctg
     1621 tagagtctgt aaaactcact gaggtaccag tagagccagt cttgacagta catccagaga
     1681 gcaagagcaa aaccaaaact aggagcagaa gtagaggtcg agctagaaat aaaacaagca
     1741 agagtagaag tcgaagcagt agcagtagca gttctagtag cagttcaacc agtagcagca
     1801 gtggaagtag ttccagcagt ggaagtagta gcagtcgcag tagttccagt agcagctcca
     1861 gtacaagtgg cagcagcagc agagatagta gcagtagcac tagtagtagt agtgagagta
     1921 gaagtcggag taggggccgg ggacataata gagatagaaa gcacagaagg agcgtggatc
     1981 ggaagagaag ggatacttca ggactagaaa gaagtcacaa atcttcaaaa ggtggtagta
     2041 gtagagatac aaaaggatca aaggataaga attcccggtc cgacagaaag aggtctatat
     2101 cagagagtag tcgatcaggc aaaagatctt caagaagtga aagagaccga aaatcagaca
     2161 ggaaagacaa aaggcgttaa tggaagaagc caggctttct tagccattct ttgcagcaga
     2221 agatttcttg ataaaaaagg attacctttc cttgtaaaga ggatgctgcc ttaagaattg
     2281 catgttgtaa aaaatctttt tggaaaatac agactgtttg tttaccagac attcttgtac
     2341 tttttgcata attttgtaag agttatttat caaaattatg tgaggttcca aaatatgtaa
     2401 aaatgataat aataaaaaaa gattaacatc ccttgtcatc ttttttaaat atcctatact
     2461 cttcagtaag aatctgtata ttttaatagg caaatcttta agtctgttcc cttctaattc
     2521 tgtatcatac attgcttttg tagaaataaa tgtgtgttta tttcattatt tttgggatgt
     2581 cctcgttgac acttgtataa taaatatcct ctttatcatt ttcagctttt aacactagat
     2641 actgcacgtg attagaatgt ttttgaaggt ttcctcgttt ttatttgcct tggacagttt
     2701 ttagttgtca gagtcagagc tttgcagctt tgagggggaa cagttctctt taaaatcatt
     2761 tgctattttc tattctccct tgttatttta atctaagcat tttcccccgt ttctcatatt
     2821 ttaaccatat gttcggtaga taactaaaca gtatgatctg gttggcattt tcttcctgat
     2881 gatgggagcg tcattctttt gtcttcatgg ttacttgtgt gatataacat acatctgtta
     2941 aagaaaatca cttctttcta ggggagggag gtagaaaagt atctttcaaa cttggttttt
     3001 gagtttgtgt cttgtcttaa ctttgtgttg gctctaactt aaacatgctg atatgtgttt
     3061 tcaagaattt tgtttaagga agtattgtat ggaagtccac aaaatgaagg aagttcatct
     3121 aggttttaat atgtaagcaa gataacacac aagtgtacca agtgattatt aactttgttg
     3181 ttttacaaat ttgtatgaac ttggagtatc tgttggccat tactatacat gtgcaaataa
     3241 atgtggctta gacttgtgtg actgcttaag actagtactt gtattaactt tctgatgctt
     3301 tatacaagag agcacttaaa ttgcatcctt ctttgagttt aacactgtag ctttagcctt
     3361 gactttgaat attcattttg ccttcccttg acaagtaaat ggttacagtg aaaatgtgaa
     3421 gaagtatttc cagttagttt ttgtgtgtat ataactcact tgtgtaagtg gatgtgttaa
     3481 aagatctctt tttaaaaatc cttttattgg agtaattatt aaaacagtaa atgcata
//
