LOCUS       NM_018215               3684 bp    mRNA    linear   PRI 29-AUG-2024
DEFINITION  Homo sapiens PNMA family member 8A (PNMA8A), transcript variant 1,
            mRNA.
ACCESSION   NM_018215
VERSION     NM_018215.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3684)
  AUTHORS   Figueiredo,J.C., Hsu,L., Hutter,C.M., Lin,Y., Campbell,P.T.,
            Baron,J.A., Berndt,S.I., Jiao,S., Casey,G., Fortini,B., Chan,A.T.,
            Cotterchio,M., Lemire,M., Gallinger,S., Harrison,T.A., Le
            Marchand,L., Newcomb,P.A., Slattery,M.L., Caan,B.J., Carlson,C.S.,
            Zanke,B.W., Rosse,S.A., Brenner,H., Giovannucci,E.L., Wu,K.,
            Chang-Claude,J., Chanock,S.J., Curtis,K.R., Duggan,D., Gong,J.,
            Haile,R.W., Hayes,R.B., Hoffmeister,M., Hopper,J.L., Jenkins,M.A.,
            Kolonel,L.N., Qu,C., Rudolph,A., Schoen,R.E., Schumacher,F.R.,
            Seminara,D., Stelling,D.L., Thibodeau,S.N., Thornquist,M.,
            Warnick,G.S., Henderson,B.E., Ulrich,C.M., Gauderman,W.J.,
            Potter,J.D., White,E. and Peters,U.
  CONSRTM   CCFR; GECCO
  TITLE     Genome-wide diet-gene interaction analyses for risk of colorectal
            cancer
  JOURNAL   PLoS Genet 10 (4), e1004228 (2014)
   PUBMED   24743840
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3684)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA325514.1, DA219062.1, BC051688.1, BC032508.1, BU844519.1,
            BQ637225.1 and AL834344.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018215.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.75702.1,
                                           SRR1803615.13414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149178, SAMEA2158188
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313683.15/ ENSP00000318131.10
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                DA325514.1         1-26
            27-161              DA219062.1         1-135
            162-292             DA219062.1         137-267
            293-1670            BC051688.1         250-1627
            1671-2080           BC032508.1         1649-2058
            2081-2704           BU844519.1         71-694
            2705-3049           BQ637225.1         247-591
            3050-3684           AL834344.1         2689-3323
FEATURES             Location/Qualifiers
     source          1..3684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..3684
                     /gene="PNMA8A"
                     /gene_synonym="PNMAL1"
                     /note="PNMA family member 8A"
                     /db_xref="GeneID:55228"
                     /db_xref="HGNC:HGNC:25578"
                     /db_xref="MIM:620933"
     exon            1..227
                     /gene="PNMA8A"
                     /gene_synonym="PNMAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            228..1609
                     /gene="PNMA8A"
                     /gene_synonym="PNMAL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..1626
                     /gene="PNMA8A"
                     /gene_synonym="PNMAL1"
                     /note="isoform a is encoded by transcript variant 1;
                     PNMA-like protein 1; paraneoplastic Ma antigen family like
                     1; paraneoplastic antigen-like protein 8A; paraneoplastic
                     Ma antigen family member 8A"
                     /codon_start=1
                     /product="paraneoplastic antigen-like protein 8A isoform
                     a"
                     /protein_id="NP_060685.2"
                     /db_xref="CCDS:CCDS33059.1"
                     /db_xref="GeneID:55228"
                     /db_xref="HGNC:HGNC:25578"
                     /db_xref="MIM:620933"
                     /translation="MSKTMAMNLLEDWCRGMEVDIHRSLLVTGIPEDCGQAEIEETLN
                     GVLSPLGPYRVLNKIFVREENVKAALIEVGEGVNLSTIPREFPGRGGVWRVVCRDPTQ
                     DAEFLKNLNEFLDAEGRTWEDVVRLLQLNHPTLSQNQHQPPENWAEALGVLLGAVVQI
                     IFCMDAEIRSREEARAQEAAEFEEMAAWALAAGRKVKKEPGLAAEVGSALKAETPNNW
                     NATEDQHEPTKPLVRRAGAKSRSRRKKQKKNSRQEAVPWKKPKGINSNSTANLEDPEV
                     GDAESMAISEPIKGSRKPCVNKEELALKKPMAKCAWKGPREPPQDARAEAESPGGASE
                     SDQDGGHESPPKKKAVAWVSAKNPAPMRKKKKVSLGPVSYVLVDSEDGRKKPVMPKKG
                     PGSRREASDQKAPRGQQPAEATASTSRGPKAKPEGSPRRATNESRKV"
     exon            1610..3684
                     /gene="PNMA8A"
                     /gene_synonym="PNMAL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3665..3670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNMA8A"
                     /gene_synonym="PNMAL1"
                     /note="hexamer: AATAAA"
     polyA_site      3684
                     /gene="PNMA8A"
                     /gene_synonym="PNMAL1"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgcagg cgcgcgctgc gacgccaacc tcggcttctc gccgctaacg gcatcgagtc
       61 tggacgcccc gtgacccgcc tgggccggag cgggggcgga cggcgccttc ttggcccttt
      121 ctgcctctag cagcggcgcc ggggtagccg gagccagcga ctgggaaacg gctgcattcc
      181 actgcgtctc cttggcctgg ctgggcggtc ggaggctgat ctgccaagat tactgtttgg
      241 agaccgctgc agcccacgtc cacctgatag actatttact acacatagta ggttcagagc
      301 cgctaaatgt ccaagaccat ggcgatgaac cttctggagg attggtgcag gggaatggaa
      361 gtggacatcc acaggtcctt gttggtcaca ggcatcccag aggactgtgg gcaggcagaa
      421 attgaggaga ccttgaatgg ggtcctctcc ccactgggcc cgtaccgcgt gctcaacaag
      481 atttttgtga gggaagagaa tgttaaagct gccctcattg aggttggtga aggtgtgaat
      541 ctgagcacca tcccccgtga attcccagga aggggtggtg tctggagagt ggtctgtaga
      601 gaccctaccc aggatgccga gtttttaaaa aatctgaatg aattcctgga tgccgagggg
      661 cgcacctggg aggatgtggt ccgcctgctc cagctcaacc accccaccct gtcccagaac
      721 cagcatcagc ccccagagaa ctgggcagaa gctctggggg tgcttctggg agcagtggtg
      781 cagatcatct tctgcatgga tgccgagatc cgcagccggg aggaagccag ggcccaggag
      841 gccgctgaat tcgaggagat ggcagcctgg gctttagcag cagggaggaa ggtgaagaaa
      901 gaaccggggc ttgcagcaga ggtgggttct gccttaaagg cagagacccc caacaactgg
      961 aatgccacgg aagaccagca tgagcctacc aaacctttgg ttcgcagggc tggagctaag
     1021 tctcgctcca ggagaaagaa gcagaagaag aactccaggc aggaagcagt gccctggaaa
     1081 aaacccaaag gcatcaattc caacagcaca gctaacttgg aggatcctga ggtgggtgat
     1141 gctgaaagca tggcgatctc agagccgatc aagggcagca gaaagccctg tgtgaataag
     1201 gaggagttgg ctttgaagaa gcccatggcg aaatgtgcct ggaagggtcc cagagagcca
     1261 cctcaggatg cccgggcaga agccgagagc ccaggaggcg cctctgagtc agaccaagat
     1321 ggtggccatg aaagcccacc aaagaagaag gccgtggcct gggtgtctgc caagaacccc
     1381 gctcccatga ggaagaagaa gaaggtgagc ttgggccctg tctcctacgt cttggttgac
     1441 tcagaagatg gcaggaagaa gccggtgatg ccaaagaaag ggccaggctc aagaagggag
     1501 gcatcagatc agaaggcccc tcggggccag cagcctgccg aggcaacagc ctcaacctct
     1561 aggggtccga aggccaagcc agaaggctct cctcggcgtg ccaccaatga atccagaaag
     1621 gtttgatctg ggggaccacc catactgagg agttgaaaga acaaggaaga agtaccaagt
     1681 caaccaagtt ctctcttgtc actgaataag actttggact ctcttagggc ccctgttgat
     1741 agagatctgg ccctgaggta aacgataggt gaggtcttgg gtgggaggga gttggggaag
     1801 ggaggtggat ctctatgccc ttttctctac caggcctgcc gtttcaccgc cttctctact
     1861 caccttctct tcggaggcag gagagttggt aagaggattg ggaaaattct agaacattca
     1921 ttccccttta tgcatgagca gggtcactgt tacactcatc catgttcagc ttttctcccc
     1981 cacgccttgc tccctcctcg gaatggtcag cgacctctgc aggccctggc atttggaaga
     2041 gctgggtggc cctgccatat tcttcctccc gccttcctct cgtgtaacca gcggggtaag
     2101 ttaagccagg accttcgctg caaacctggt tttattgctc cttcagtctc cagcttccat
     2161 cctccagtta tctagccagg aggtcccaag agttagtttt agggaaaaag aatgtctgcc
     2221 tagacctcaa agtctttgag ttttagagtc tgttagtaaa aatggcactt tgattcccat
     2281 ttgggatgag ccctctcagg aatcctgtgg ggaagggggg tgattatagg gaaggacgca
     2341 ggcattccta ggtccccagc tctaattcca tccatctacc caactgtcac catctttgca
     2401 ccaaactgtc accatctttg cagcagaagg tcactactca cattatagta agaggggaaa
     2461 aaaatctttt aaaacttggc tgttggccgg gcacggtggc tcacgcctgt aatcccagca
     2521 ctttgggagg ctgaggcagg tcgatcacga ggtcaggcgt ttaagaccag cttgaccaac
     2581 atggtgaaac cccatctcta caaaaattag ctgggcgtgg tggcgcgcgc ctgtaatccc
     2641 agctactcag gaggctgagg cagatgaatt gcttgaatcc aggaggcaga ggttgcaatg
     2701 agccgagatt gtgccacggc actccagcct gggcagcaga gtgagactct ctctcaaaaa
     2761 aacaaaactt ggctgttaat gtctgccctc tgaattcaga cacactatat tagaccagac
     2821 caccatgtgt cattgtgtgt gtgtgtgtgt gtgtttgcgt gcgcatgtgt agaggagaga
     2881 gcagggtccc tgagataatg gtttccaaac tgtatcgtag ccgtccacaa agatgtaatc
     2941 caaatctatt tttctcacgt gtttaaaaaa ctgaaaagtg actactcaga tatgttggaa
     3001 gtcacatcga agactatcag aatattacct tgtgttcata ggttaacttg tttttgtaca
     3061 cgtcttagtt atttcaggca tctctttgct taaaattgag tttcttgtaa atgtgactga
     3121 tgagcgaggt tagaagtgga agaaattcct gtgcatgttc tataatctga caccctgaaa
     3181 gcaagtttcc tttcgtcatt cacatgctct tgttctgccg tgactgttca ggtgtatggt
     3241 agtaagtaaa tgtattaaca tggtgaacag tagtaatatt ctatcataga gtattagccc
     3301 ttgcaagttt tcagggcgtc ttttccgact tcagtttttg tgataaagaa tgtgaacagt
     3361 tgttagatgt tctcagtgat tcaactttaa aacaaatttc tcgtgatgat tcatttcaaa
     3421 atcctgagtg agtctgactg aaaaatacga gagaaaagag agtggtttcc gtttgcagct
     3481 acacagctgt gtgcatcgac gttctcctgg ggtgtgtgcc aagcgaaacc caggggtgaa
     3541 ttggattctt gaagagacca aagcctgtaa ctgtccagct tctaatttca aaacgggtcc
     3601 attagggctt cgttgtgtta acaagttgac accatgacta gtaaatgtaa acgtgtatgt
     3661 ataaaataaa gtttagcaaa ttaa
//
