LOCUS       NM_001367770            3389 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens PNMA family member 6E (PNMA6E), transcript variant 3,
            mRNA.
ACCESSION   NM_001367770
VERSION     NM_001367770.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Wright,J.C., Mudge,J., Weisser,H., Barzine,M.P., Gonzalez,J.M.,
            Brazma,A., Choudhary,J.S. and Harrow,J.
  TITLE     Improving GENCODE reference gene annotation using a high-stringency
            proteogenomics workflow
  JOURNAL   Nat Commun 7, 11778 (2016)
   PUBMED   27250503
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY051803.1, HY237141.1, U82695.3 and BX469942.8.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HY051803.1, HY050160.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000445091.3/ ENSP00000488500.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-373               HY051803.1         72-444
            374-664             HY237141.1         56-346              c
            665-1764            U82695.3           2001-3100           c
            1765-3389           BX469942.8         13060-14684         c
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..3389
                     /gene="PNMA6E"
                     /note="PNMA family member 6E"
                     /db_xref="GeneID:649238"
                     /db_xref="HGNC:HGNC:50767"
     exon            1..107
                     /gene="PNMA6E"
                     /inference="alignment:Splign:2.1.0"
     exon            108..3389
                     /gene="PNMA6E"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..2122
                     /gene="PNMA6E"
                     /note="isoform 2 is encoded by transcript variant 3;
                     putative paraneoplastic antigen-like protein 6B-like;
                     paraneoplastic antigen Ma6E; paraneoplastic Ma antigen
                     family member 6E"
                     /codon_start=1
                     /product="paraneoplastic antigen Ma6E isoform 2"
                     /protein_id="NP_001354699.1"
                     /db_xref="CCDS:CCDS94694.1"
                     /db_xref="GeneID:649238"
                     /db_xref="HGNC:HGNC:50767"
                     /translation="MALAMLRDWCRWMGANAERSLLILGIPDDCKEHEFQEAVRAALS
                     PLGRYRVLTKHFRKELGAKAALVEFAEYLNRSLIPHQIPGNGGPWKVIFLPQVPVIEF
                     QDMPSFPAQPQGQAVAKAAGEGGGAGEAGGVGEVGAAGEAGGTGEAGATGEAGAAGEA
                     GGAGEAGGVGEAGAAGEAGGAGEAGAAGEGGAAGEAGGAGEAGGVGEAGAAGEAGGAG
                     EAGGVGEAGAAGEAGGAGEAGAAGEAGGAGEGRAAGEAGAAGEAGAVGEAGAAGEAGA
                     VGEAGAAGEAGAVGEAGGTNVTKAWVQPWRCTLQPVLENRAYRELRPFSRREQPGCEE
                     ESFESWVEHAKDMLQLWCHASEREKKRWLLESLGGPALEVVSGLLEEDTNLSALDCLA
                     ALGQVFRNQDTRMTSRLKFLTCTQGPQEGLFAFVVRLEGLLQRAVEKGAVCPALANYL
                     RLQQVLSWARPSEALQDTLRGMQLEKRPPGFLGLLRLIREMEAWAAFPARSQQGVAWA
                     AAPVESEDPAAAQASPAQGNASEAGPGAEDAAEAASATKEAARGAPAAGEGESAPAGP
                     EGLGQARPIEVPWGSSPARMSSAVWVFPRGLSWGPEGLIQVRGQEARKPPLEGLQTIL
                     EEPENEDEDGAGDEGQPKSSQGK"
     regulatory      3367..3372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNMA6E"
                     /note="hexamer: AATAAA"
     polyA_site      3389
                     /gene="PNMA6E"
                     /note="major polyA site"
ORIGIN      
        1 acacgcttcc acgctgcgga gctgaggtga tctcttcaga cccttcggag agacccagat
       61 atctgacttc ccactgagag acccggaatt gcccagagtt tgagaaagct gtgtcggaga
      121 ctgcaacagt cagcacacat tcctgattga tcaggctccc tccctcaagt cctctgcgat
      181 ggctctggcg atgcttcggg actggtgcag gtggatgggt gcgaacgcag agcgctccct
      241 gctcatcctg ggtatccctg atgactgcaa ggaacatgag ttccaggagg ccgtgcgggc
      301 tgccctgtcg cccctgggca ggtaccgagt actcaccaag cacttcagaa aggagctcgg
      361 ggccaaggca gccttggtgg agttcgctga gtatttaaac cgaagcttga ttccccatca
      421 aataccaggc aatggggggc cctggaaagt gatcttcctg ccccaagtac ctgttattga
      481 gtttcaggat atgcccagtt ttcctgcaca gccccagggt caagcagtag caaaagctgc
      541 aggtgaggga ggaggcgcag gtgaggcagg aggtgtaggt gaggtaggag cagcaggtga
      601 ggcaggaggc acaggtgagg caggagcaac aggtgaggca ggagcagcag gtgaggcagg
      661 aggcgcaggt gaggcaggag gtgtaggtga ggcaggagca gcaggtgagg caggaggcgc
      721 aggtgaggca ggagcagcag gtgagggagg agcagcaggt gaggcaggag gcgcaggtga
      781 ggcaggaggt gtaggtgagg caggagcagc aggtgaggca ggaggcgcag gtgaggcagg
      841 aggtgtaggt gaggcaggag cagcaggtga ggcaggaggc gcaggtgagg caggagcagc
      901 aggtgaggca ggaggcgcag gtgagggaag agcagcaggt gaggcaggag cagcaggtga
      961 ggcaggagct gtgggtgagg caggagcagc aggtgaggca ggagctgtgg gtgaggcagg
     1021 agctgcaggt gaggcaggag ctgtgggtga agcaggaggg acaaatgtaa caaaagcctg
     1081 ggtccagcct tggcgctgca ccctacagcc tgtgctggaa aacagggcct accgggaatt
     1141 gagacccttt tccaggaggg agcagccagg ctgcgaggaa gagtcctttg agagctgggt
     1201 ggagcatgcc aaggatatgc tgcagctgtg gtgccatgcg tcggaaaggg agaagaagag
     1261 gtggctgctg gagagcttgg gcggcccggc cctggaagtc gtgagcggcc tcctggagga
     1321 agataccaac ttgtccgcgc tggactgcct ggcggcgctg gggcaggtat ttaggaacca
     1381 ggacactcga atgacttcga ggctgaagtt cctgacctgc acgcaggggc cccaggaggg
     1441 gctgtttgcc ttcgtggtgc gcctggaagg cctgctgcag agggctgtgg agaagggggc
     1501 cgtctgccca gccttggcca attacctgcg actacagcag gtgctgtctt gggcccgccc
     1561 cagcgaggca ctccaggata ccctgagagg gatgcagctg gagaagaggc cacctggctt
     1621 cctggggctg ctccggctca tccgggagat ggaggcatgg gcagccttcc cagcgaggag
     1681 ccagcagggt gtggcctggg cagcggcccc agtggagagt gaagacccag ctgctgccca
     1741 ggcctcccca gcccagggga atgccagcga ggctggtccc ggagcagaag atgctgccga
     1801 ggccgcttct gccaccaaag aggctgcaag gggagcccct gccgctgggg aaggtgaaag
     1861 tgcccctgca ggccccgaag gcctaggtca ggcaaggccc atagaggtcc cctggggctc
     1921 ctccccagcc cggatgagca gtgctgtctg ggtgttccca agaggtctta gctggggtcc
     1981 agagggcctc atccaggtga gaggccagga agccaggaaa cccccactgg aggggctcca
     2041 gaccatcttg gaggagccgg aaaacgagga tgaggatggg gccggggacg agggccagcc
     2101 caagtcctcc cagggcaaat aggctcctag ggccccgggg cctcctctcc tctcaggcag
     2161 cagcgccttg gaggcagaca gaggccaggc cagggccagt ccctcacccc acattcagga
     2221 gtaagggccc cccacctccc ccaaggggct ctggccacca cccccattcc ttccctgtga
     2281 cccggatgac cacgtttgat acaaaatggg gtggggagag gcgccccccc gctcccttgc
     2341 acccagcaca cccagcccca gccccaaacc ctgccgccac ggggggctgg cctggaggga
     2401 gccctgagtg ggcagctgtg gcctgggtgg gggcacctga agatgtctgc ccccaaccca
     2461 ggccgtgagt tgggagagac agggggaaag aggccctctc aaggttgcca gctgcctggg
     2521 tctctcaaga ggggtcagcc cacttgccat ctccggggca ggctgccctc tgttccggga
     2581 agctcaccct cacctgtgtg acccacgcgc ccagcagacg cccacccact gctagccatc
     2641 atttctgcga aaagtcatgt actgtgcgcc catgcaggcg gccacctctg ggcccggggc
     2701 acgtgctgtg agcttcctgc gagcccaggc tctgcttgct gctgtcctgc atcgtgagca
     2761 ccacctctgc tttcctggcg tagatctagg ccaggggctg cttgttctcg tggagctgcg
     2821 tgtgttcttc tctgagcagc ctctccccgg agacccccag cgcagtccca ggagatggcg
     2881 ggaaggaggc accagggcac ggcggacgct caccccgtga ccacgatggt gaccctgact
     2941 gcgggaagaa gaaccggacc cggggcacag cggggctgcg tgaggatcca caagaactat
     3001 gctttggcgt ttcacccctg ttgttacttg tgactcagtt tcttcagcct ggtggggtgt
     3061 tccctggtgt ttcccagtgt tctgtgactg tcctgtgaag gccataggga tgggctcagg
     3121 agggggctcc ctgaagccag tggacactgc cagagtccac tgtcctggca aaaggcagac
     3181 cctggggccc tcgggaagga gggaggtggc agcgggggca gcagcgggag ggggagcaga
     3241 tgacgtgcct tgccaggaac cccaggagga gggggcctgg gacctgtgtc ctgtggtggc
     3301 tgtttacagt ttctctctgt attgtggttt ccttctcttc aatagtttca gtatatgttt
     3361 ctcttcaata aatttcattc cgtgttcca
//
