LOCUS       NM_013364               3682 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens PNMA family member 3 (PNMA3), transcript variant 1,
            mRNA.
ACCESSION   NM_013364
VERSION     NM_013364.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3682)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3682)
  AUTHORS   Wills,N.M., Moore,B., Hammer,A., Gesteland,R.F. and Atkins,J.F.
  TITLE     A functional -1 ribosomal frameshift signal in the human
            paraneoplastic Ma3 gene
  JOURNAL   J Biol Chem 281 (11), 7082-7088 (2006)
   PUBMED   16407312
  REMARK    GeneRIF: analysis of a ribosomal frameshift signal in the human
            paraneoplastic Ma3 gene
REFERENCE   3  (bases 1 to 3682)
  AUTHORS   Schuller,M., Jenne,D. and Voltz,R.
  TITLE     The human PNMA family: novel neuronal proteins implicated in
            paraneoplastic neurological disease
  JOURNAL   J Neuroimmunol 169 (1-2), 172-176 (2005)
   PUBMED   16214224
REFERENCE   4  (bases 1 to 3682)
  AUTHORS   Rosenfeld,M.R., Eichen,J.G., Wade,D.F., Posner,J.B. and Dalmau,J.
  TITLE     Molecular and clinical diversity in paraneoplastic immunity to Ma
            proteins
  JOURNAL   Ann Neurol 50 (3), 339-348 (2001)
   PUBMED   11558790
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR001205.1, AF083116.1,
            AL136878.1, AC243428.4 and AI689415.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_013364.5.
            
            Summary: The protein encoded by this gene belongs to the
            paraneoplastic antigen MA (PNMA) family, which shares homology with
            retroviral Gag proteins. The PNMA antigens are highly expressed in
            the brain and also in a range of tumors associated with serious
            neurological phenotypes. PMID:16407312 reports the presence of a
            functional -1 ribosomal frameshift signal (consisting of a
            heptanucleotide shift motif followed 3' by a pseudoknot structure)
            in this gene, however, the frame-shifted product has not been
            characterized. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.134916.1,
                                           SRR1660805.47079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000593810.3/ ENSP00000469445.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-605               DR001205.1         62-666
            606-1701            AF083116.1         358-1453
            1702-2454           AL136878.1         1534-2286
            2455-2788           AL136878.1         2290-2623
            2789-3524           AC243428.4         29044-29779
            3525-3682           AI689415.1         26-183              c
FEATURES             Location/Qualifiers
     source          1..3682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..3682
                     /gene="PNMA3"
                     /gene_synonym="MA3; MA5"
                     /note="PNMA family member 3"
                     /db_xref="GeneID:29944"
                     /db_xref="HGNC:HGNC:18742"
                     /db_xref="MIM:300675"
     exon            1..169
                     /gene="PNMA3"
                     /gene_synonym="MA3; MA5"
                     /inference="alignment:Splign:2.1.0"
     exon            170..3682
                     /gene="PNMA3"
                     /gene_synonym="MA3; MA5"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1667
                     /gene="PNMA3"
                     /gene_synonym="MA3; MA5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     paraneoplastic cancer-testis-brain antigen; paraneoplastic
                     antigen MA3; paraneoplastic Ma antigen 3"
                     /codon_start=1
                     /product="paraneoplastic antigen Ma3 isoform 1"
                     /protein_id="NP_037496.4"
                     /db_xref="CCDS:CCDS35435.2"
                     /db_xref="GeneID:29944"
                     /db_xref="HGNC:HGNC:18742"
                     /db_xref="MIM:300675"
                     /translation="MPLTLLQDWCRGEHLNTRRCMLILGIPEDCGEDEFEETLQEACR
                     HLGRYRVIGRMFRREENAQAILLELAQDIDYALLPREIPGKGGPWEVIVKPRNSDGEF
                     LNRLNRFLEEERRTVSDMNRVLGSDTNCSAPRVTISPEFWTWAQTLGAAVQPLLEQML
                     YRELRVFSGNTISIPGALAFDAWLEHTTEMLQMWQVPEGEKRRRLMECLRGPALQVVS
                     GLRASNASITVEECLAALQQVFGPVESHKIAQVKLCKAYQEAGEKVSSFVLRLEPLLQ
                     RAVENNVVSRRNVNQTRLKRVLSGATLPDKLRDKLKLMKQRRKPPGFLALVKLLREEE
                     EWEATLGPDRESLEGLEVAPRPPARITGVGAVPLPASGNSFDARPSQGYRRRRGRGQH
                     RRGGVARAGSRGSRKRKRHTFCYSCGEDGHIRVQCINPSNLLLVKQKKQAAVESGNGN
                     WAWDKSHPKSKAK"
     regulatory      3660..3665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNMA3"
                     /gene_synonym="MA3; MA5"
                     /note="hexamer: AATAAA"
     polyA_site      3682
                     /gene="PNMA3"
                     /gene_synonym="MA3; MA5"
                     /note="major polyA site"
ORIGIN      
        1 gcactggccc acgtgctgcg cgagcgaggg agagccacag tctgagcgaa cgtccgcgct
       61 gggagccagg ggtgcccgac ccccgtccgc cgccgccgcc gccgccgcgc atagcccccg
      121 gagagccctc tggggacccc gaccagaagg gaccttgccc tgggagaagg ctgtggagac
      181 ctgggccttc tgcgatcacc ctaggagttg atccagatat gtgcctcacg ccctgatcac
      241 tccccccaaa ttagtatccg cagagattcg aggacatgcc gttgaccttg ttacaggact
      301 ggtgtcgggg ggaacacctg aacacccgga ggtgcatgct catcctgggg atccccgagg
      361 actgtggcga ggatgagttt gaggagacac tccaggaggc ttgcaggcac ctgggcagat
      421 acagggtgat tggcaggatg tttaggaggg aggagaacgc ccaggcgatt ctactggagc
      481 tggcacaaga tatcgactat gctttgctcc caagggaaat accaggaaag ggggggccct
      541 gggaagtgat tgtaaaaccc cgtaactcag atggggaatt tctcaacaga ctgaaccgct
      601 tcttagagga ggagaggcgg accgtgtcag atatgaaccg agtcctcggg tcggacacca
      661 attgttcggc tccaagagtg actatatcac cagagttctg gacctgggcc cagactctgg
      721 gggcagcagt gcagcctctg ctagaacaaa tgttgtaccg agaactaaga gtgttttctg
      781 ggaacaccat atccatccca ggtgcactgg cctttgatgc ctggcttgag cacaccactg
      841 agatgctaca gatgtggcag gtgcccgagg gggaaaagag gcggaggctg atggaatgct
      901 tacggggccc tgctctccag gtggtcagtg ggctccgggc cagcaatgct tccataactg
      961 tggaggagtg cctggctgcc ttgcagcagg tgttcggacc tgtggagagc cataaaattg
     1021 cccaggtgaa gttgtgtaaa gcctatcagg aggcaggaga gaaagtatct agctttgtgt
     1081 tacgtttgga acccctgctc caaagagctg tagaaaacaa tgtggtatca cgtagaaacg
     1141 tgaatcagac tcgcctgaaa cgagtcttaa gtggggccac ccttcctgac aaactccgag
     1201 ataagcttaa gctgatgaaa cagcgaagga agcctcctgg tttcctggcc ctggtgaagc
     1261 tcctgcgtga ggaggaggaa tgggaggcca ctttaggtcc agatagggag agtctggagg
     1321 ggctggaagt agccccaagg ccacctgcca ggatcactgg ggttggggca gtacctctcc
     1381 ctgcctctgg caacagtttt gatgcgaggc cttcccaggg ctaccggcgc cggaggggca
     1441 gaggccaaca ccgaaggggt ggtgtggcaa gggctggctc tcgaggctca agaaaacgga
     1501 aacgccacac attctgctat agctgtgggg aagacggcca catcagggta cagtgcatca
     1561 acccctccaa cctgctcttg gtaaagcaga agaaacaggc tgcagttgag tcgggaaacg
     1621 ggaactgggc ttgggacaag agccatccca agtccaaggc caagtaggct cgggagaaca
     1681 gggcaacatt tcctaccaca ggccaaggag acaaaagaga tattggaagg aggggaaaga
     1741 gaagcccaga caaacagcag atgagttgag tggggcagag ggacagggca gccagaccaa
     1801 ggccaagcct tctcaccctt ggccagctgg aagggacttc agcaaccaag accacctggc
     1861 aacaggctca gtgggggtca ggtccaggtc cccgaagagg tgctggagag gaaagcaggg
     1921 agccactgca tccagcacat ggggtgcctg ggcctcagat ggggacccca aagaagcaga
     1981 agctgaagaa ggtacggctg ggggttctgt cctgctcatc caaccacccc taaataccca
     2041 ccctgtggac tttgagctga acatgcccac tggcccccag gccacatggg acctggagga
     2101 gcctacctgg ggcctgcccc tgccagcagg tgccagggct ggtgaggaag agctgggggg
     2161 cagaggtaaa gccctgcagg ggaggccaca gggtccatcc cgtcttcagg atcatctaca
     2221 ctgcactagg ggagccccag gaaggcagca ccctggaggc cctgtgccag tgaggacagg
     2281 agaccctaag gccccgggag cccagtgcca gccagaggtt gtgcaggcaa ggagaccaaa
     2341 gattgatgag aagaccccca gcaggggtac tgggtacccg gcaggccagt gccctcacag
     2401 ttgacttgga ccagggtggc tgtgaaggga agtctttgtt gcaaaggagg aggaaaaggg
     2461 aggacttggt agggttttgt ttcttctgct tgtttctgta cagggccacc agactcctgg
     2521 agagatcaag caaggagaac ctggggctgc catggccaaa gcaactcaac agatgccaat
     2581 gccaattcca aggccagcca caaccctgcc accttgggga atccagcctg gaggcatccc
     2641 ctaagcagcc agccatggcc tgggtggagg cacctgaaga cgtctgtccc aaactccccc
     2701 agccctgagc tgggagatga cagggggaaa gaggccctct caagggtgcc agatgcctgg
     2761 gtctcccaag aggggtcccc caactcactg ttcccgggac aggctgcccc ctgttccagg
     2821 aagctcatcc tcacctgtgt aggcccctgt agtgacccac gcgtccagca gacgcccacc
     2881 caccgctagc cgttgttcct gtgcaaagta gtgtgctatg cacccaccca ggtggccgcc
     2941 tctgggccca aggcacatgc tgtgagcttc ctgtgagccc aggctctgct cactgctgtc
     3001 ccgcgtcatg agcaccacct ctgctttccc tgtgtagatc taggccagtg gctgcttgtt
     3061 cttgtggagc tgtgtgtgtt cttctctgag cagctcctcc ccggagtccc ccagcacagt
     3121 cccaggagat gacaggaagg aagcaccagg gcaaggcgga cgctcaccct gtgaccacga
     3181 tggtgaccgt gactgtggga ggaagaactg gacccaggac ggagcggggc tgccctgcct
     3241 gaggctcccg aggagctttg tgctttggtg ttccacccct gttgttactc atgactcagt
     3301 ttccttaacc tggtagggtg ttccctgctg tgttttccag tgtcctgtga ctgtcctgtg
     3361 cgggccatag ggcagggccc tgccccagca gatgggcttg ggaggggact ccctaaagcc
     3421 agtggacact gccagagtct accttcctgg caagaggcag accccggggc cctcaggaag
     3481 gagggagttg gcagcggggg ctgcagcagg agtaggagca gatgaggcgt cttgccagga
     3541 acctcaggag gagggggccc gggacctgtg tgggacctgt gtcctgtggt ggccgtttgc
     3601 agtttctctc tgtgttgtga ttcccttctc ttcaacgttt tcagtacgtg tttctcttca
     3661 ataaacttca ttcagtgttc ca
//
