LOCUS       NM_007257               4730 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens PNMA family member 2 (PNMA2), mRNA.
ACCESSION   NM_007257 XM_376764
VERSION     NM_007257.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4730)
  AUTHORS   Madigan,V., Zhang,Y., Raghavan,R., Wilkinson,M.E., Faure,G.,
            Puccio,E., Segel,M., Lash,B., Macrae,R.K. and Zhang,F.
  TITLE     Human paraneoplastic antigen Ma2 (PNMA2) forms icosahedral capsids
            that can be engineered for mRNA delivery
  JOURNAL   Proc Natl Acad Sci U S A 121 (11), e2307812120 (2024)
   PUBMED   38437549
  REMARK    GeneRIF: Human paraneoplastic antigen Ma2 (PNMA2) forms icosahedral
            capsids that can be engineered for mRNA delivery.
REFERENCE   2  (bases 1 to 4730)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4730)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4730)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4730)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 4730)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   7  (bases 1 to 4730)
  AUTHORS   Schuller,M., Jenne,D. and Voltz,R.
  TITLE     The human PNMA family: novel neuronal proteins implicated in
            paraneoplastic neurological disease
  JOURNAL   J Neuroimmunol 169 (1-2), 172-176 (2005)
   PUBMED   16214224
REFERENCE   8  (bases 1 to 4730)
  AUTHORS   Rosenfeld,M.R., Eichen,J.G., Wade,D.F., Posner,J.B. and Dalmau,J.
  TITLE     Molecular and clinical diversity in paraneoplastic immunity to Ma
            proteins
  JOURNAL   Ann Neurol 50 (3), 339-348 (2001)
   PUBMED   11558790
REFERENCE   9  (bases 1 to 4730)
  AUTHORS   Voltz,R., Gultekin,S.H., Rosenfeld,M.R., Gerstner,E., Eichen,J.,
            Posner,J.B. and Dalmau,J.
  TITLE     A serologic marker of paraneoplastic limbic and brain-stem
            encephalitis in patients with testicular cancer
  JOURNAL   N Engl J Med 340 (23), 1788-1795 (1999)
   PUBMED   10362822
REFERENCE   10 (bases 1 to 4730)
  AUTHORS   Dalmau,J., Gultekin,S.H., Voltz,R., Hoard,R., DesChamps,T.,
            Balmaceda,C., Batchelor,T., Gerstner,E., Eichen,J., Frennier,J.,
            Posner,J.B. and Rosenfeld,M.R.
  TITLE     Ma1, a novel neuron- and testis-specific protein, is recognized by
            the serum of patients with paraneoplastic neurological disorders
  JOURNAL   Brain 122 (Pt 1), 27-39 (1999)
   PUBMED   10050892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA779744.1, BC047515.1, AB020690.1 and BC036489.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007257.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.191837.1,
                                           SRR1660803.74733.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000522362.7/ ENSP00000429344.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-483               DA779744.1         96-578
            484-2294            BC047515.1         484-2294
            2295-3508           AB020690.1         1797-3010
            3509-3919           BC036489.1         3534-3944
            3920-4730           AB020690.1         3422-4232
FEATURES             Location/Qualifiers
     source          1..4730
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..4730
                     /gene="PNMA2"
                     /gene_synonym="MA2; MM2; RGAG2"
                     /note="PNMA family member 2"
                     /db_xref="GeneID:10687"
                     /db_xref="HGNC:HGNC:9159"
                     /db_xref="MIM:603970"
     exon            1..57
                     /gene="PNMA2"
                     /gene_synonym="MA2; MM2; RGAG2"
                     /inference="alignment:Splign:2.1.0"
     exon            58..187
                     /gene="PNMA2"
                     /gene_synonym="MA2; MM2; RGAG2"
                     /inference="alignment:Splign:2.1.0"
     exon            188..4730
                     /gene="PNMA2"
                     /gene_synonym="MA2; MM2; RGAG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             676..1770
                     /gene="PNMA2"
                     /gene_synonym="MA2; MM2; RGAG2"
                     /note="onconeuronal antigen MA2; retrotransposon gag
                     domain containing 2; 40 kDa neuronal protein;
                     paraneoplastic neuronal antigen MM2; paraneoplastic Ma
                     antigen 2"
                     /codon_start=1
                     /product="paraneoplastic antigen Ma2"
                     /protein_id="NP_009188.1"
                     /db_xref="CCDS:CCDS34868.1"
                     /db_xref="GeneID:10687"
                     /db_xref="HGNC:HGNC:9159"
                     /db_xref="MIM:603970"
                     /translation="MALALLEDWCRIMSVDEQKSLMVTGIPADFEEAEIQEVLQETLK
                     SLGRYRLLGKIFRKQENANAVLLELLEDTDVSAIPSEVQGKGGVWKVIFKTPNQDTEF
                     LERLNLFLEKEGQTVSGMFRALGQEGVSPATVPCISPELLAHLLGQAMAHAPQPLLPM
                     RYRKLRVFSGSAVPAPEEESFEVWLEQATEIVKEWPVTEAEKKRWLAESLRGPALDLM
                     HIVQADNPSISVEECLEAFKQVFGSLESRRTAQVRYLKTYQEEGEKVSAYVLRLETLL
                     RRAVEKRAIPRRIADQVRLEQVMAGATLNQMLWCRLRELKDQGPPPSFLELMKVIREE
                     EEEEASFENESIEEPEERDGYGRWNHEGDD"
     regulatory      4714..4719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNMA2"
                     /gene_synonym="MA2; MM2; RGAG2"
                     /note="hexamer: AATATA"
     polyA_site      4730
                     /gene="PNMA2"
                     /gene_synonym="MA2; MM2; RGAG2"
                     /note="major polyA site"
ORIGIN      
        1 agaccaccag ctaatggatg cggagcggag ggcccgctga ccgctctccg cgcctggagc
       61 agcttggctt ggctggagct aagagccaga cacaccactg tgtggaggtg ggtgatgtct
      121 tcctgtgcta aaaggtgaat aaataagctc ctcacctctc gcggaacact cgggaacaca
      181 tcaacagggg tccaagccgc cctgctggga ggcttctctt caagagttct gggtcccaga
      241 gtggaaggca ttttcccatc aactggagag agacgaaaca tcagagacca ggaggctgtg
      301 gagaaagcag ctgtcccagg tgcctcaact atcagagaag ggtcagcgtc acgtggctgc
      361 cagcatcttt gagaaaatca ctggcaatcg gacttcagag ctgcgggcac aggtgtggtt
      421 agaactgaga tacgacctgc ccacctgggt caggcctaaa gacaagaagt cctgagttct
      481 tgccactgag taggccaggg tcatttgtcc agaaaacttt gtgactgtct ttgagtgacc
      541 tagtctggga cccattcatt ggtgggttct aaggttagaa gctcatccag gatattttca
      601 atattaagtc agtgcatagc tgcaccacta acaaattggt gcctgtagag tcagagtggg
      661 tcaattctta ggacaatggc gctggcactg ttagaggact ggtgcaggat aatgagtgtg
      721 gatgagcaga agtcactgat ggttacgggg ataccggcgg actttgagga ggctgagatt
      781 caggaggtcc ttcaggagac tttaaagtct ctgggcaggt atagactgct tggcaagata
      841 ttccggaagc aggagaatgc caatgctgtc ttactagagc ttctggaaga tactgatgtc
      901 tcggccattc ccagtgaggt ccagggaaag gggggtgtct ggaaggtgat ctttaagacc
      961 cctaatcagg acactgagtt tcttgaaaga ttgaacctgt ttctagaaaa agaggggcag
     1021 acggtctcgg gtatgtttcg agccctgggg caggagggcg tgtctccagc cacagtgccc
     1081 tgcatctcac cagaattact ggcccatttg ttgggacagg caatggcaca tgcgcctcag
     1141 cccctgctac ccatgagata ccggaaactg cgagtattct cagggagtgc tgtcccagcc
     1201 ccagaggaag agtcctttga ggtctggttg gaacaggcca cggagatagt caaagagtgg
     1261 ccagtaacag aggcagaaaa gaaaaggtgg ctggcggaaa gcctgcgggg ccctgccctg
     1321 gacctcatgc acatagtgca ggcagacaac ccgtccatca gtgtagaaga gtgtttggag
     1381 gcctttaagc aagtgtttgg gagcctagag agccgcagga cagcccaggt gaggtatctg
     1441 aagacctatc aggaggaagg agagaaggtc tcagcctatg tgttacggct agaaaccctg
     1501 ctccggagag cggtggagaa acgcgccatc cctcggcgta ttgcggacca ggtccgcctg
     1561 gagcaggtca tggctggggc cactcttaac cagatgctgt ggtgccggct tagggagctg
     1621 aaggatcagg gcccgccccc cagcttcctt gagctaatga aggtaatacg ggaagaagag
     1681 gaggaagagg cctcctttga gaatgagagt atcgaagagc cagaggaacg agatggctat
     1741 ggccgctgga atcatgaggg agacgactga aaaccacctg ggggcaggac ccacagccag
     1801 tgggctaaga cctttaaaaa atttttttct ttaatgtatg ggactgaaat caaaccatga
     1861 aagccaatta ttgaccttcc ttccttcctt ccttccctcc cttcctcctt ctctccttct
     1921 ctcctcctct ctcctctcct ctcctctctt tccttccttc cttccttttt tctttttctc
     1981 tttcttcttt atttcttggg tctcactctc atcacccagg ctagagtgca gtggcacaaa
     2041 aatctcggct cactgcagcc ttgacttccc aggctcaggc tcaggtgatc ctcacacctt
     2101 agcctcccaa gtacctggga ctacaggcac gcaccaccat gcctagctat tcttttgtat
     2161 ttttggtaga gacagggttt tgctgtgttg ctcaggctgg tctggaaccc ctaggctcaa
     2221 atgatgtgcc caactcggcc tcccaaagtg ctgggattac aggcatgaac cgccatgcct
     2281 ggcccttgat ttttcttttt aagaaaaaaa tatctaggag tttcttagac cctatgtaga
     2341 ttattaatga acaaaagatt aaactccaaa tattaaatag taagcctgaa ggaatctgaa
     2401 acacttgtac ttccaatttt ctttaaataa tcccaaatag accagaattg gcccatacca
     2461 tagaagaaag aattggcagt caaaaaaaaa aatacctttt gtaatgtttg aaaaataaag
     2521 ctgtttgact tgtcaggtgt tttcctttct caaatcagca aattctctct gagtgcctgg
     2581 ctttgtgaga cactgtacaa ggagttacaa gactacagct ataacctgca gttgagcagt
     2641 tataaaccta caaaatgggc cctgccctca gagaggttcc agtctagatg aggagctgat
     2701 ctagacaggt aaaaggctaa ctaacccttt gtgtaaataa gttcatcacc ccagtaaaag
     2761 tgtcatcacc cagtgaatag gaccacctct gcctgcagat ttttgttgtt gttgttgtca
     2821 ttgttgttgt tgttttaacc tgggaagtgt tcttcctgcc tttctgctag gtgtcagata
     2881 gatggtccca gagctaggtg ctgtgtcagg ccctgaagac acagatgact caacctaagc
     2941 tttactttcc agaggtccac agcctgagag gtgtccccaa agaaaggggg acatgagggg
     3001 actgcatgct tgagagcagg gttgtttagg gcaggtttgg atttagtgag caggctggtt
     3061 tgcttagaga aggcttttag tggcaacaaa ggatgaagag gagagaaaag gaactcacat
     3121 ttattgaggg cctactgtgt gcaaagtgtt tcatgtatat ctcattgaat gtatacagcc
     3181 accctgttgt ggtataattt tgctctttat aaagagaaag accgaagctc agatgagtta
     3241 agtggtctcc tcaacaccaa aatgccaaga agtgatggag cctagacaga agcccagaac
     3301 tttctgactc acactagtcc atcctctacc atcacgatga ctttcaaatt gtgctctgca
     3361 gttctgcaga ttttctagca gtgccatctc caaaatgtgt tttaaactct ttattttttt
     3421 aattattatt agtattattt tgagactgag tcttgctcta tcacccaggc tggagtgcag
     3481 tggtgcaatc tcagctcact gcaacctccg cctcccaggt tcaagcgatt tcgtgcctca
     3541 gcctcccgag tagctgggat tacaggcacc caccaccacg cccagctaat ttttgtattt
     3601 ttagtagaaa tggggtttca ccatgttggc caggctggtc tcgaactcct gacctcaagt
     3661 gatccactca cctcggcctc ccaaagtgct gggattacag gtgtgagcca ccatgcctgg
     3721 gctaaactct ttaagtctct agtaaatgca gctagattca aatgggctga taaccaaatt
     3781 ttaacacatc agcattcacc accaggttta cttttatttt cagattggct cattttgtgc
     3841 agaccttaga gcaaagtttc ctttatggta tctgtgtacg tatccaaact tcttttaatt
     3901 gttcacagat tttaaaagcg gtagcaccac atggttgtgt agatcagacc tgtgtattta
     3961 gatcagacct gtgtatcacg taagtgtgtg agtgcagtgc agatgagcac catttagtta
     4021 tatgtgctag gcaaatctcc aacacagttg atgtgtagtc ttgtggtaga tttgtgcata
     4081 ctgtaagcaa attgcttagc ttctctagac atcagtttcc acatctgaaa aataagaaga
     4141 tgagagtaca cggttgttat gaacaaatga cttaatgctt tttaagcacg ttgcatgaca
     4201 tctggaacac agaaagccct caatacattg aagctcttag gattttcacg atgttcctgt
     4261 ctgctcaatg catgctttct ttattgttct gacagttgtg tggtaacaag ctaatatgct
     4321 tccagttgac ttccagtcta ccctggtgtt agaaaccgtt tcatctctta ttgtaaattt
     4381 gagtgcttgt tgttttttat atttgtgatg actcttccag cagttgttga caattgttag
     4441 aggtttgact tttaaataat tacttatttt ttctgattgt ggttcagttt aactgaagaa
     4501 tatcctgaga ttgtaagaaa agcatttttt aaaaggtatc acttgtgatc atttatcttt
     4561 ctaaattcta tttttaatac tgttccacca aagtgatgca gtggttacca tgacacccta
     4621 atttcatgtg tttttgtatt tatgaaaata gtttcattgt catttattgg cggtatacaa
     4681 agtaaaatgt tataaatgtg aagttataaa ataaatatat gctaataaaa
//
