LOCUS       NP_009188                364 aa            linear   PRI 28-APR-2025
DEFINITION  paraneoplastic antigen Ma2 [Homo sapiens].
ACCESSION   NP_009188 XP_376764
VERSION     NP_009188.1
DBSOURCE    REFSEQ: accession NM_007257.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 364)
  AUTHORS   Madigan,V., Zhang,Y., Raghavan,R., Wilkinson,M.E., Faure,G.,
            Puccio,E., Segel,M., Lash,B., Macrae,R.K. and Zhang,F.
  TITLE     Human paraneoplastic antigen Ma2 (PNMA2) forms icosahedral capsids
            that can be engineered for mRNA delivery
  JOURNAL   Proc Natl Acad Sci U S A 121 (11), e2307812120 (2024)
   PUBMED   38437549
  REMARK    GeneRIF: Human paraneoplastic antigen Ma2 (PNMA2) forms icosahedral
            capsids that can be engineered for mRNA delivery.
REFERENCE   2  (residues 1 to 364)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 364)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 364)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 364)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (residues 1 to 364)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   7  (residues 1 to 364)
  AUTHORS   Schuller,M., Jenne,D. and Voltz,R.
  TITLE     The human PNMA family: novel neuronal proteins implicated in
            paraneoplastic neurological disease
  JOURNAL   J Neuroimmunol 169 (1-2), 172-176 (2005)
   PUBMED   16214224
REFERENCE   8  (residues 1 to 364)
  AUTHORS   Rosenfeld,M.R., Eichen,J.G., Wade,D.F., Posner,J.B. and Dalmau,J.
  TITLE     Molecular and clinical diversity in paraneoplastic immunity to Ma
            proteins
  JOURNAL   Ann Neurol 50 (3), 339-348 (2001)
   PUBMED   11558790
REFERENCE   9  (residues 1 to 364)
  AUTHORS   Voltz,R., Gultekin,S.H., Rosenfeld,M.R., Gerstner,E., Eichen,J.,
            Posner,J.B. and Dalmau,J.
  TITLE     A serologic marker of paraneoplastic limbic and brain-stem
            encephalitis in patients with testicular cancer
  JOURNAL   N Engl J Med 340 (23), 1788-1795 (1999)
   PUBMED   10362822
REFERENCE   10 (residues 1 to 364)
  AUTHORS   Dalmau,J., Gultekin,S.H., Voltz,R., Hoard,R., DesChamps,T.,
            Balmaceda,C., Batchelor,T., Gerstner,E., Eichen,J., Frennier,J.,
            Posner,J.B. and Rosenfeld,M.R.
  TITLE     Ma1, a novel neuron- and testis-specific protein, is recognized by
            the serum of patients with paraneoplastic neurological disorders
  JOURNAL   Brain 122 (Pt 1), 27-39 (1999)
   PUBMED   10050892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA779744.1, BC047515.1, AB020690.1 and BC036489.1.
            
            On Mar 24, 2005 this sequence version replaced XP_376764.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.191837.1,
                                           SRR1660803.74733.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000522362.7/ ENSP00000429344.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     Protein         1..364
                     /product="paraneoplastic antigen Ma2"
                     /note="onconeuronal antigen MA2; retrotransposon gag
                     domain containing 2; 40 kDa neuronal protein;
                     paraneoplastic neuronal antigen MM2; paraneoplastic Ma
                     antigen 2"
                     /calculated_mol_wt=41378
     Region          1..328
                     /region_name="PNMA"
                     /note="pfam14893"
                     /db_xref="CDD:464357"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine. /evidence=ECO:0000269|Ref.7;
                     propagated from UniProtKB/Swiss-Prot (Q9UL42.2)"
     Region          335..364
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UL42.2)"
     CDS             1..364
                     /gene="PNMA2"
                     /gene_synonym="MA2; MM2; RGAG2"
                     /coded_by="NM_007257.6:676..1770"
                     /db_xref="CCDS:CCDS34868.1"
                     /db_xref="GeneID:10687"
                     /db_xref="HGNC:HGNC:9159"
                     /db_xref="MIM:603970"
ORIGIN      
        1 malalledwc rimsvdeqks lmvtgipadf eeaeiqevlq etlkslgryr llgkifrkqe
       61 nanavllell edtdvsaips evqgkggvwk vifktpnqdt eflerlnlfl ekegqtvsgm
      121 fralgqegvs patvpcispe llahllgqam ahapqpllpm ryrklrvfsg savpapeees
      181 fevwleqate ivkewpvtea ekkrwlaesl rgpaldlmhi vqadnpsisv eecleafkqv
      241 fgslesrrta qvrylktyqe egekvsayvl rletllrrav ekraiprria dqvrleqvma
      301 gatlnqmlwc rlrelkdqgp ppsflelmkv ireeeeeeas fenesieepe erdgygrwnh
      361 egdd
//
