LOCUS       NM_001011709            2374 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens pancreatic lipase related protein 3 (PNLIPRP3), mRNA.
ACCESSION   NM_001011709 XM_058404
VERSION     NM_001011709.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2374)
  AUTHORS   Saelee,P., Wongkham,S., Puapairoj,A., Khuntikeo,N., Petmitr,S.,
            Chariyalertsak,S., Sumethchotimaytha,W. and Karalak,A.
  TITLE     Novel PNLIPRP3 and DOCK8 gene expression and prognostic
            implications of DNA loss on chromosome 10q25.3 in hepatocellular
            carcinoma
  JOURNAL   Asian Pac J Cancer Prev 10 (3), 501-506 (2009)
   PUBMED   19640199
  REMARK    GeneRIF: Over expression of pancreatic lipase-related protein 3 is
            associated with hepatocellular carcinoma.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011328.11 and BC117224.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001011709.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833418.1, BC117224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369230.4/ ENSP00000358232.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC011328.11        118079-118143
            66-1306             BC117224.1         1-1241
            1307-1310           AC011328.11        162080-162083
            1311-2234           BC117224.1         1246-2169
            2235-2374           AC011328.11        168050-168189
FEATURES             Location/Qualifiers
     source          1..2374
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..2374
                     /gene="PNLIPRP3"
                     /note="pancreatic lipase related protein 3"
                     /db_xref="GeneID:119548"
                     /db_xref="HGNC:HGNC:23492"
     exon            1..215
                     /gene="PNLIPRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1570
                     /gene="PNLIPRP3"
                     /EC_number="3.1.1.3"
                     /note="PL-RP3"
                     /codon_start=1
                     /product="pancreatic lipase-related protein 3 precursor"
                     /protein_id="NP_001011709.2"
                     /db_xref="CCDS:CCDS31292.1"
                     /db_xref="GeneID:119548"
                     /db_xref="HGNC:HGNC:23492"
                     /translation="MLGIWIVAFLFFGTSRGKEVCYERLGCFKDGLPWTRTFSTELVG
                     LPWSPEKINTRFLLYTIHNPNAYQEISAVNSSTIQASYFGTDKITRINIAGWKTDGKW
                     QRDMCNVLLQLEDINCINLDWINGSREYIHAVNNLRVVGAEVAYFIDVLMKKFEYSPS
                     KVHLIGHSLGAHLAGEAGSRIPGLGRITGLDPAGPFFHNTPKEVRLDPSDANFVDVIH
                     TNAARILFELGVGTIDACGHLDFYPNGGKHMPGCEDLITPLLKFNFNAYKKEMASFFD
                     CNHARSYQFYAESILNPDAFIAYPCRSYTSFKAGNCFFCSKEGCPTMGHFADRFHFKN
                     MKTNGSHYFLNTGSLSPFARWRHKLSVKLSGSEVTQGTVFLRVGGAVRKTGEFAIVSG
                     KLEPGMTYTKLIDADVNVGNITSVQFIWKKHLFEDSQNKLGAEMVINTSGKYGYKSTF
                     CSQDIMGPNILQNLKPC"
     exon            216..370
                     /gene="PNLIPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            371..490
                     /gene="PNLIPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            491..622
                     /gene="PNLIPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            623..731
                     /gene="PNLIPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            732..851
                     /gene="PNLIPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            852..974
                     /gene="PNLIPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1093
                     /gene="PNLIPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1226
                     /gene="PNLIPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1338
                     /gene="PNLIPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1506
                     /gene="PNLIPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..2374
                     /gene="PNLIPRP3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2374
                     /gene="PNLIPRP3"
                     /note="major polyA site"
ORIGIN      
        1 atttactttg cagagcataa ggtggaataa catgttcttt taaacgtaga gtttaaacat
       61 tgagttgcat cattgtgagg aaaaccactt agtattttat agtgaggtga ctttacaagt
      121 aaagatcttc aagaagattt ttatgtgatt taaaaaatca gcttagatgc ttggaatttg
      181 gattgttgca ttcttgttct ttggcacatc aagaggaaaa gaagtttgct atgaaaggtt
      241 agggtgtttc aaagatggtt taccatggac caggactttc tcaacagagt tggtaggttt
      301 accctggtct ccagagaaga taaacactcg tttcctgctc tacactatac acaatcccaa
      361 tgcctatcag gagatcagtg cggttaattc ttcaactatc caagcctcat attttggaac
      421 agacaagatc acccgtatca acatagctgg atggaaaaca gatggcaaat ggcagagaga
      481 catgtgcaat gtgttgctac agctggaaga tataaattgc attaatttag attggatcaa
      541 cggttcacgg gaatacatcc atgctgtaaa caatctccgt gttgttggtg ctgaggtggc
      601 ttattttatt gatgttctca tgaaaaaatt tgaatattcc ccttctaaag tgcacttgat
      661 tggccacagc ttgggagcac acctggctgg ggaagctggg tcaaggatac caggccttgg
      721 aagaataact gggttggacc cagctgggcc atttttccac aacactccaa aggaagtcag
      781 gctagacccc tcggatgcca actttgttga cgttattcat acaaatgcag ctcgcatcct
      841 ctttgagctt ggtgttggaa ccattgatgc ttgtggtcat cttgactttt acccaaatgg
      901 agggaagcac atgccaggat gtgaagactt aattacacct ttactgaaat ttaacttcaa
      961 tgcttacaaa aaagaaatgg cttccttctt tgactgtaac catgcccgaa gttatcaatt
     1021 ttatgctgaa agcattctta atcctgatgc atttattgct tatccttgta gatcctacac
     1081 atcttttaaa gcaggaaatt gcttcttttg ttccaaagaa ggttgcccaa caatgggtca
     1141 ttttgctgat agatttcact tcaaaaatat gaagactaat ggatcacatt attttttaaa
     1201 cacagggtcc ctttccccat ttgcccgttg gaggcacaaa ttgtctgtta aactcagtgg
     1261 aagcgaagtc actcaaggaa ctgtctttct tcgtgtaggc ggggcagtta ggaaaactgg
     1321 ggagtttgcc attgtcagtg gaaaacttga gccaggcatg acttacacaa aattaatcga
     1381 tgcagatgtt aacgttggaa acattacaag tgttcagttc atctggaaaa aacatttgtt
     1441 tgaagattct cagaataagt tgggagcaga aatggtgata aatacatctg ggaaatatgg
     1501 atataaatct accttctgta gccaagacat tatgggacct aatattctcc agaacctgaa
     1561 accatgctaa tctcagatac agtcttgatg gatttcttta gtaggagcaa tgaagaaaag
     1621 tgtctccttc cacctggcat ccagaccaaa tttgaccctt gtaaatgact tagtcattta
     1681 caagggtctt actcagagtc aagtacgggt ttgctttttt tctgtgtaga atgttcatct
     1741 aactgcacct taaaaacaca ctgaaccctg ggacaaaaga taattactat gatctgtagg
     1801 aatctggata tcattgacaa aatagagctg ttttggaatt ttcctgaata agaggaggtg
     1861 atgcaaatgt atgttgagtg tataaactca ctggacaaaa gtaagcctct ggcttgctga
     1921 gtttttgaag tatattttca ggtataataa tcattgttct aaaattatat aaaactattt
     1981 gttatgttgt taaatcttgc tgagacaaat tatgactata gtgcatgata tatagtagat
     2041 tataaccttg tgggttgatg tgtctatcta gtaataataa aaactaatga gatggcacta
     2101 gtatttccaa ggtgttcctt ggtgttcagg gtgtgcacaa gagagatttt ggagcttatc
     2161 tgttatgtgt tcatcagtta gcaatgggac ctgaagttca acaacccagg gtatagcccc
     2221 cttcctccaa agtccctgcc acaggagaat tactcctctc cctgggtctt gaatgctcta
     2281 tggtgaattt gtatttagcc tcaaggcagc atttcatttg taaagcactt gggtaaccct
     2341 ttgttcttgc aataacaata ttataatatt taaa
//
