LOCUS       NM_006229               1500 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens pancreatic lipase related protein 1 (PNLIPRP1),
            transcript variant 1, mRNA.
ACCESSION   NM_006229
VERSION     NM_006229.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1500)
  AUTHORS   Maurin,L., Marselli,L., Boissel,M., Ning,L., Boutry,R.,
            Fernandes,J., Suleiman,M., De Luca,C., Leloire,A., Pascat,V.,
            Toussaint,B., Amanzougarene,S., Derhourhi,M., Jorns,A., Lenzen,S.,
            Pattou,F., Kerr-Conte,J., Canouil,M., Marchetti,P., Bonnefond,A.,
            Froguel,P. and Khamis,A.
  TITLE     PNLIPRP1 Hypermethylation in Exocrine Pancreas Links Type 2
            Diabetes and Cholesterol Metabolism
  JOURNAL   Diabetes 73 (11), 1908-1918 (2024)
   PUBMED   39137110
  REMARK    GeneRIF: PNLIPRP1 Hypermethylation in Exocrine Pancreas Links Type
            2 Diabetes and Cholesterol Metabolism.
REFERENCE   2  (bases 1 to 1500)
  AUTHORS   Yadav,N. and Paul,A.T.
  TITLE     Pancreatic lipase and its related proteins: where are we now?
  JOURNAL   Drug Discov Today 29 (1), 103855 (2024)
   PUBMED   38081381
  REMARK    GeneRIF: Pancreatic lipase and its related proteins: where are we
            now?
            Review article
REFERENCE   3  (bases 1 to 1500)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1500)
  AUTHORS   Zhang,G., He,P., Tan,H., Budhu,A., Gaedcke,J., Ghadimi,B.M.,
            Ried,T., Yfantis,H.G., Lee,D.H., Maitra,A., Hanna,N.,
            Alexander,H.R. and Hussain,S.P.
  TITLE     Integration of metabolomics and transcriptomics revealed a fatty
            acid network exerting growth inhibitory effects in human pancreatic
            cancer
  JOURNAL   Clin Cancer Res 19 (18), 4983-4993 (2013)
   PUBMED   23918603
  REMARK    GeneRIF: Low PNLIPRP1 expression is associated with pancreatic
            cancer.
REFERENCE   5  (bases 1 to 1500)
  AUTHORS   Berton,A., Sebban-Kreuzer,C., Rouvellac,S., Lopez,C. and Crenon,I.
  TITLE     Individual and combined action of pancreatic lipase and pancreatic
            lipase-related proteins 1 and 2 on native versus homogenized milk
            fat globules
  JOURNAL   Mol Nutr Food Res 53 (12), 1592-1602 (2009)
   PUBMED   19824014
REFERENCE   6  (bases 1 to 1500)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   7  (bases 1 to 1500)
  AUTHORS   Giller,T., Buchwald,P., Blum-Kaelin,D. and Hunziker,W.
  TITLE     Two novel human pancreatic lipase related proteins, hPLRP1 and
            hPLRP2. Differences in colipase dependence and in lipase activity
  JOURNAL   J Biol Chem 267 (23), 16509-16516 (1992)
   PUBMED   1379598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC005233.1, M93283.1, CD622211.1 and BC025784.2.
            
            On Nov 23, 2018 this sequence version replaced NM_006229.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M93283.1, DRR138526.306964.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2151405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358834.9/ ENSP00000351695.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BC005233.1         1-19
            20-1200             M93283.1           2-1182
            1201-1201           CD622211.1         238-238             c
            1202-1499           M93283.1           1184-1481
            1500-1500           BC025784.2         1463-1463
FEATURES             Location/Qualifiers
     source          1..1500
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..1500
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /note="pancreatic lipase related protein 1"
                     /db_xref="GeneID:5407"
                     /db_xref="HGNC:HGNC:9156"
                     /db_xref="MIM:604422"
     exon            1..37
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1441
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /EC_number="3.1.1.3"
                     /note="inactive pancreatic lipase-related protein 1"
                     /codon_start=1
                     /product="inactive pancreatic lipase-related protein 1
                     precursor"
                     /protein_id="NP_006220.1"
                     /db_xref="CCDS:CCDS7595.1"
                     /db_xref="GeneID:5407"
                     /db_xref="HGNC:HGNC:9156"
                     /db_xref="MIM:604422"
                     /translation="MLIFWTITLFLLGAAKGKEVCYEDLGCFSDTEPWGGTAIRPLKI
                     LPWSPEKIGTRFLLYTNENPNNFQILLLSDPSTIEASNFQMDRKTRFIIHGFIDKGDE
                     SWVTDMCKKLFEVEEVNCICVDWKKGSQATYTQAANNVRVVGAQVAQMLDILLTEYSY
                     PPSKVHLIGHSLGAHVAGEAGSKTPGLSRITGLDPVEASFESTPEEVRLDPSDADFVD
                     VIHTDAAPLIPFLGFGTNQQMGHLDFFPNGGESMPGCKKNALSQIVDLDGIWAGTRDF
                     VACNHLRSYKYYLESILNPDGFAAYPCTSYKSFESDKCFPCPDQGCPQMGHYADKFAG
                     RTSEEQQKFFLNTGEASNFARWRYGVSITLSGRTATGQIKVALFGNKGNTHQYSIFRG
                     ILKPGSTHSYEFDAKLDVGTIEKVKFLWNNNVINPTLPKVGATKITVQKGEEKTVYNF
                     CSEDTVREDTLLTLTPC"
     exon            38..86
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            87..241
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            242..367
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..502
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..611
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..731
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..851
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..970
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1100
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1209
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1377
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1500
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1476..1481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /note="hexamer: AATAAA"
     polyA_site      1500
                     /gene="PNLIPRP1"
                     /gene_synonym="PLRP1"
                     /note="major polyA site"
ORIGIN      
        1 gatccggtgg gagggaacat ctggaacatt agacaggatg ctgatcttct ggacaatcac
       61 acttttcctg ctgggagcag ccaaaggaaa agaagtttgc tatgaggacc tcgggtgctt
      121 ttctgacact gagccctggg gcgggacagc aatcaggccc ctgaaaattc tcccctggag
      181 ccctgagaag atcggcaccc gcttcctgct gtacaccaat gaaaacccaa acaactttca
      241 aattctcctc ctctctgatc catcaacaat tgaggcatca aattttcaaa tggacagaaa
      301 gacccggttc atcatccatg gcttcataga caaaggagat gagagctggg tgacagacat
      361 gtgcaagaaa ctgttcgagg tggaggaggt gaactgcatc tgcgtggact ggaagaaggg
      421 ctcccaagcc acctacacac aggctgccaa caacgtgcga gtggtgggcg cccaggtggc
      481 ccagatgctc gacatcctct tgacagagta tagctacccc ccttccaaag ttcacctcat
      541 tggccacagc ctgggagccc acgtggctgg agaggcagga agcaagactc caggcctgag
      601 caggattaca gggttggatc ctgtagaagc aagtttcgag agtactcctg aagaggtgcg
      661 acttgatccc tctgatgctg actttgttga tgtgattcac acggatgcag ctcccctgat
      721 cccattcttg ggttttggaa cgaaccaaca gatgggtcat cttgacttct tccccaatgg
      781 aggagagagc atgccgggat gcaagaagaa tgccctgtct cagatcgtgg atctagatgg
      841 catctgggcg ggaacccggg actttgtggc ttgcaatcac ctaagaagct acaagtatta
      901 cttggaaagc atcctcaatc ccgatgggtt tgctgcatat ccctgcactt cctacaagtc
      961 ctttgagtct gacaagtgct tcccgtgtcc agatcaagga tgcccacaga tgggtcacta
     1021 tgctgataaa tttgctggca ggacaagtga agagcagcag aaattcttct tgaacacagg
     1081 agaggctagc aatttcgctc gctggagata tggggtttcc atcacactgt ctggaagaac
     1141 agccactggt cagatcaaag ttgctttgtt tggaaataag ggaaacactc accagtacag
     1201 tatcttcagg gggattctca aaccaggctc aacccattcc tatgagtttg atgcaaagct
     1261 ggatgttgga acaattgaga aagtcaagtt tctttggaat aacaatgtga taaatccaac
     1321 cctccccaaa gtgggtgcca ccaagatcac tgtgcaaaag ggagaagaga agacagtgta
     1381 caacttctgt agcgaagaca cagtgcggga agacacgctg ctcaccctca cgccctgcta
     1441 agctcccggg gcgacgaggc tgctgcgttc acactaataa aatccactgg tgcatctgta
//
