LOCUS       NM_000936               1483 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens pancreatic lipase (PNLIP), mRNA.
ACCESSION   NM_000936
VERSION     NM_000936.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1483)
  AUTHORS   Cassidy,B.M., Jiang,F., Lin,J., Chen,J.M., Curry,G.E., Ma,G.X.,
            Wilhelm,S.J., Deng,S.J., Zhu,G., Liao,Z., Lowe,M.E., Xiao,X.K. and
            Zou,W.B.
  TITLE     Exploring the enigmatic association between PNLIP variants and risk
            of chronic pancreatitis in a large Chinese cohort
  JOURNAL   Pancreatology 24 (4), 511-521 (2024)
   PUBMED   38485544
  REMARK    GeneRIF: Exploring the enigmatic association between PNLIP variants
            and risk of chronic pancreatitis in a large Chinese cohort.
REFERENCE   2  (bases 1 to 1483)
  AUTHORS   Yadav,N. and Paul,A.T.
  TITLE     Pancreatic lipase and its related proteins: where are we now?
  JOURNAL   Drug Discov Today 29 (1), 103855 (2024)
   PUBMED   38081381
  REMARK    GeneRIF: Pancreatic lipase and its related proteins: where are we
            now?
            Review article
REFERENCE   3  (bases 1 to 1483)
  AUTHORS   Masson,E., Berthet,S., Le Gac,G., Le Rhun,M., Ka,C., Autret,S.,
            Gourlaouen,I., Cooper,D.N., Ferec,C., Rebours,V. and Chen,J.M.
  CONSRTM   French GREPAN Study Group
  TITLE     Identification of protease-sensitive but not misfolding PNLIP
            variants in familial and hereditary pancreatitis
  JOURNAL   Pancreatology 23 (5), 507-511 (2023)
   PUBMED   37270400
  REMARK    GeneRIF: Identification of protease-sensitive but not misfolding
            PNLIP variants in familial and hereditary pancreatitis.
REFERENCE   4  (bases 1 to 1483)
  AUTHORS   Blasi,F., Ianni,F., Mangiapelo,L., Pinna,N. and Cossignani,L.
  TITLE     In vitro anti-obesity activity by pancreatic lipase inhibition -
            Simple HPLC approach using EVOO as natural substrate
  JOURNAL   J Sci Food Agric 103 (6), 2786-2793 (2023)
   PUBMED   36583522
  REMARK    GeneRIF: In vitro anti-obesity activity by pancreatic lipase
            inhibition - Simple HPLC approach using EVOO as natural substrate.
REFERENCE   5  (bases 1 to 1483)
  AUTHORS   Toldi,V., Kassay,N. and Szabo,A.
  TITLE     Missense PNLIP mutations impeding pancreatic lipase secretion cause
            protein misfolding and endoplasmic reticulum stress
  JOURNAL   Pancreatology 21 (7), 1317-1325 (2021)
   PUBMED   34373204
  REMARK    GeneRIF: Missense PNLIP mutations impeding pancreatic lipase
            secretion cause protein misfolding and endoplasmic reticulum
            stress.
REFERENCE   6  (bases 1 to 1483)
  AUTHORS   Sims,H.F., Jennens,M.L. and Lowe,M.E.
  TITLE     The human pancreatic lipase-encoding gene: structure and
            conservation of an Alu sequence in the lipase gene family
  JOURNAL   Gene 131 (2), 281-285 (1993)
   PUBMED   8406023
REFERENCE   7  (bases 1 to 1483)
  AUTHORS   van Tilbeurgh,H., Sarda,L., Verger,R. and Cambillau,C.
  TITLE     Structure of the pancreatic lipase-procolipase complex
  JOURNAL   Nature 359 (6391), 159-162 (1992)
   PUBMED   1522902
REFERENCE   8  (bases 1 to 1483)
  AUTHORS   Giller,T., Buchwald,P., Blum-Kaelin,D. and Hunziker,W.
  TITLE     Two novel human pancreatic lipase related proteins, hPLRP1 and
            hPLRP2. Differences in colipase dependence and in lipase activity
  JOURNAL   J Biol Chem 267 (23), 16509-16516 (1992)
   PUBMED   1379598
REFERENCE   9  (bases 1 to 1483)
  AUTHORS   Davis,R.C., Diep,A., Hunziker,W., Klisak,I., Mohandas,T.,
            Schotz,M.C., Sparkes,R.S. and Lusis,A.J.
  TITLE     Assignment of human pancreatic lipase gene (PNLIP) to chromosome
            10q24-q26
  JOURNAL   Genomics 11 (4), 1164-1166 (1991)
   PUBMED   1783385
REFERENCE   10 (bases 1 to 1483)
  AUTHORS   Winkler,F.K., D'Arcy,A. and Hunziker,W.
  TITLE     Structure of human pancreatic lipase
  JOURNAL   Nature 343 (6260), 771-774 (1990)
   PUBMED   2106079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL731653.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000936.3.
            
            Summary: This gene encodes a member of the lipase family of
            proteins. The encoded enzyme is secreted by the pancreas and
            hydrolyzes triglycerides in the small intestine, and is essential
            for the efficient digestion of dietary fats. Inhibition of the
            encoded enzyme may prevent high-fat diet-induced obesity in mice
            and result in weight loss in human patients with obesity. Mutations
            in this gene cause congenital pancreatic lipase deficiency, a rare
            disorder characterized by steatorrhea. [provided by RefSeq, Jul
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.242809.1,
                                           SRR5189667.132593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369221.2/ ENSP00000358223.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AL731653.1         22132-22159
            29-74               AL731653.1         22294-22339
            75-229              AL731653.1         23495-23649
            230-352             AL731653.1         24561-24683
            353-487             AL731653.1         27299-27433
            488-599             AL731653.1         29928-30039
            600-719             AL731653.1         31379-31498
            720-839             AL731653.1         31589-31708
            840-958             AL731653.1         32201-32319
            959-1088            AL731653.1         35355-35484
            1089-1197           AL731653.1         36617-36725
            1198-1362           AL731653.1         37673-37837
            1363-1483           AL731653.1         43936-44056
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..1483
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /note="pancreatic lipase"
                     /db_xref="GeneID:5406"
                     /db_xref="HGNC:HGNC:9155"
                     /db_xref="MIM:246600"
     exon            1..28
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1426
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /EC_number="3.1.1.3"
                     /note="pancreatic triacylglycerol lipase; triacylglycerol
                     acylhydrolase"
                     /codon_start=1
                     /product="pancreatic triacylglycerol lipase precursor"
                     /protein_id="NP_000927.1"
                     /db_xref="CCDS:CCDS7594.1"
                     /db_xref="GeneID:5406"
                     /db_xref="HGNC:HGNC:9155"
                     /db_xref="MIM:246600"
                     /translation="MLPLWTLSLLLGAVAGKEVCYERLGCFSDDSPWSGITERPLHIL
                     PWSPKDVNTRFLLYTNENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENW
                     LANVCKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSP
                     SNVHVIGHSLGAHAAGEAGRRTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDV
                     IHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFA
                     ACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPCPSGGCPQMGHYADRYPGK
                     TNDVGQKFYLDTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNKGNSKQYEIFKGT
                     LKPDSTHSNEFDSDVDVGDLQMVKFIWYNNVINPTLPRVGASKIIVETNVGKQFNFCS
                     PETVREEVLLTLTPC"
     exon            29..74
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            75..229
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            230..352
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            353..487
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            488..599
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            600..719
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            720..839
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            840..958
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1088
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1197
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1362
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1483
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1462..1467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /note="hexamer: AATAAA"
     polyA_site      1483
                     /gene="PNLIP"
                     /gene_synonym="PL; PNLIPD; PTL"
                     /note="major polyA site"
ORIGIN      
        1 gcgtgtggaa cctgacggaa ctgccacgat gctgccactt tggactcttt cactgctgct
       61 gggagcagta gcaggaaaag aagtttgcta cgaaagactc ggctgcttca gtgatgactc
      121 cccatggtca ggaattacgg aaagacccct ccatatattg ccttggtctc caaaagatgt
      181 caacacccgc ttcctcctat atactaatga gaacccaaac aactttcaag aagttgccgc
      241 agattcatca agcatcagtg gctccaattt caaaacaaat agaaaaactc gctttattat
      301 tcatggattc atagacaagg gagaagaaaa ctggctggcc aatgtgtgca agaatctgtt
      361 caaggtggaa agtgtgaact gtatctgtgt ggactggaaa ggtggctccc gaactggata
      421 cacacaagcc tcgcagaaca tcaggatcgt gggagcagaa gtggcatatt ttgttgaatt
      481 tcttcagtcg gcgttcggtt actcaccttc caatgtgcat gtcattggcc acagcctggg
      541 tgcccacgct gctggggagg ctggaaggag aaccaatggg accattggac gcatcacagg
      601 gttggaccca gcagaacctt gctttcaggg cacacctgaa ttagtccgat tggaccccag
      661 cgatgccaaa tttgtggatg taattcacac ggatggtgcc cccatagtcc ccaatttggg
      721 gtttggaatg agccaagtcg tgggccacct agatttcttt ccaaatggag gagtggaaat
      781 gcctggatgt aaaaagaaca ttctctctca gattgtggac atagacggaa tctgggaagg
      841 gactcgagac tttgcggcct gtaatcactt aagaagctac aaatattaca ctgatagcat
      901 cgtcaaccct gatggctttg ctggattccc ctgtgcctct tacaacgtct tcactgcaaa
      961 caagtgtttc ccttgtccaa gtggaggctg cccacagatg ggtcactatg ctgatagata
     1021 tcctgggaaa acaaatgatg tgggccagaa attttatcta gacactggtg atgccagtaa
     1081 ttttgcacgt tggaggtata aggtatctgt cacactgtct ggaaaaaagg ttacaggaca
     1141 catactagtt tctttgttcg gaaataaagg aaactctaag cagtatgaaa ttttcaaggg
     1201 cactctcaaa ccagatagta ctcattccaa tgaatttgac tcagatgtgg atgttgggga
     1261 cttgcagatg gttaaattta tttggtataa caatgtgatc aacccaactt tacctagagt
     1321 gggagcatcc aagattatag tggagacaaa tgttggaaaa cagttcaact tctgtagtcc
     1381 agaaaccgtc agggaggaag ttctgctcac cctcacaccg tgttaggaga ctactgttat
     1441 ttgaccaatg aattgacttc taataaaatc tagtggtgat gca
//
