LOCUS       NM_032870               5113 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens PNN interacting serine and arginine rich protein
            (PNISR), transcript variant 1, mRNA.
ACCESSION   NM_032870
VERSION     NM_032870.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5113)
  AUTHORS   Szlavicz,E., Olah,P., Szabo,K., Pagani,F., Bata-Csorgo,Z.,
            Kemeny,L. and Szell,M.
  TITLE     Analysis of psoriasis-relevant gene expression and exon usage
            alterations after silencing of SR-rich splicing regulators
  JOURNAL   Exp Dermatol 27 (6), 656-662 (2018)
   PUBMED   29512856
  REMARK    GeneRIF: In our present RNA-Seq experiment, we demonstrated that
            the LUC7L3 and SFRS18 splicing factors contribute to the regulation
            of several well-known psoriasis-associated pathways, including the
            IFN signalling pathway, antiviral immunity and ubiquitination.
REFERENCE   2  (bases 1 to 5113)
  AUTHORS   Szlavicz,E., Szabo,K., Groma,G., Bata-Csorgo,Z., Pagani,F.,
            Kemeny,L. and Szell,M.
  TITLE     Splicing factors differentially expressed in psoriasis alter mRNA
            maturation of disease-associated EDA+ fibronectin
  JOURNAL   Mol Cell Biochem 436 (1-2), 189-199 (2017)
   PUBMED   28589370
  REMARK    GeneRIF: results indicate that LUC7L3, PPIG, and SFRS18 are not
            only implicated in EDA+ fibronectin formation, but also that they
            could possess multiple roles in psoriasis-associated molecular
            abnormalities.
            Erratum:[Mol Cell Biochem. 2017 Dec;436(1-2):201. doi:
            10.1007/s11010-017-3105-y.. PMID: 28770468]
REFERENCE   3  (bases 1 to 5113)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 5113)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   5  (bases 1 to 5113)
  AUTHORS   Zimowska,G., Shi,J., Munguba,G., Jackson,M.R., Alpatov,R.,
            Simmons,M.N., Shi,Y. and Sugrue,S.P.
  TITLE     Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal
            epithelial cells
  JOURNAL   Invest Ophthalmol Vis Sci 44 (11), 4715-4723 (2003)
   PUBMED   14578391
REFERENCE   6  (bases 1 to 5113)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA326969.1, BC012780.2, AL513550.9 and BM893682.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032870.3.
            
            Transcript Variant: This variant (1) encodes isoform a. Variants 1,
            2, 3, 4 and 5 all encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.103918.1,
                                           SRR1803614.151744.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369239.10/ ENSP00000358242.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA326969.1         38-58
            22-1696             BC012780.2         1-1675
            1697-5086           AL513550.9         43399-46788         c
            5087-5112           BM893682.1         16-41               c
            5113-5113           AL513550.9         43372-43372         c
FEATURES             Location/Qualifiers
     source          1..5113
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.2"
     gene            1..5113
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="PNN interacting serine and arginine rich protein"
                     /db_xref="GeneID:25957"
                     /db_xref="HGNC:HGNC:21222"
                     /db_xref="MIM:616653"
     exon            1..94
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            95..174
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            175..293
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2623
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="isoform a is encoded by transcript variant 1;
                     splicing factor, arginine/serine-rich 18; splicing factor,
                     arginine/serine-rich 130; PNN-interacting
                     serine/arginine-rich protein;
                     serine-arginine-rich-splicing regulatory protein 130;
                     SR-rich protein; SR-related protein; arginine/serine-rich
                     protein PNISR"
                     /codon_start=1
                     /product="arginine/serine-rich protein PNISR isoform a"
                     /protein_id="NP_116259.2"
                     /db_xref="CCDS:CCDS5043.1"
                     /db_xref="GeneID:25957"
                     /db_xref="HGNC:HGNC:21222"
                     /db_xref="MIM:616653"
                     /translation="MWDQGGQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQ
                     REASGQQSMVEQPPGMMPNGQDMSTMESGPNNHGNFQGDSNFNRMWQPEWGMHQQPPH
                     PPPDQPWMPPTPGPMDIVPPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGP
                     VNQFDYQHGAAFGPPQGGFHPPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVK
                     QEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEG
                     GDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQM
                     MLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYG
                     SGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTER
                     VTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRS
                     RSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTI
                     KARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSR
                     DRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDK
                     EREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDS
                     KKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKH
                     KSKSRSR"
     exon            294..482
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            483..706
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            707..878
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1069
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1207
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1307
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1361
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1532
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..5113
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3170..3175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      3199
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="major polyA site"
     regulatory      4201..4206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      4222
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
     regulatory      4486..4491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      4505
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
     regulatory      5091..5096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      5113
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
ORIGIN      
        1 atcttgtctt gttcccgaag aagtagaagc atcgaaagcg ttggagaggt gttaccggaa
       61 cggcggcgac aagggtgttc ccgaactaga gtggggcata cataatcttg ctgctatgct
      121 tcgaagctgt agtctgaatc aacctaagtt ttaaacagaa ggtgaacctc tgagatagaa
      181 aatcaagtat attttaaaag aagggatgtg ggatcaagga ggacagcctt ggcagcagtg
      241 gcccttgaac cagcaacaat ggatgcagtc attccagcac caacaggatc caagccagat
      301 tgattgggct gcattggccc aagcttggat tgcccaaaga gaagcttcag gacagcaaag
      361 catggtagaa caaccaccag gaatgatgcc aaatggacaa gatatgtcta caatggaatc
      421 tggtccaaac aatcatggga atttccaagg ggattcaaac ttcaacagaa tgtggcaacc
      481 agaatgggga atgcatcagc aacccccaca cccccctcca gatcagccat ggatgccacc
      541 aacaccaggc ccaatggaca ttgttcctcc ttctgaagac agcaacagtc aggacagtgg
      601 ggaatttgcc cctgacaaca ggcatatatt taaccagaac aatcacaact ttggtggacc
      661 acccgataat tttgcagtgg ggccagtgaa ccagtttgac tatcagcatg gggctgcttt
      721 tggtccaccg caaggtggat ttcatcctcc ttattggcaa ccaggacctc caggacctcc
      781 agcacctccc cagaatcgaa gagaaaggcc atcatcattc agggatcgtc agcgttcacc
      841 tattgcactt cctgtgaagc aggagcctcc acaaattgac gcagtaaaac gcaggactct
      901 tcccgcttgg attcgcgaag gtcttgaaaa aatggaacgt gaaaagcaga agaaattgga
      961 gaaagaaaga atggaacaac aacgttcaca attgtccaaa aaagaaaaaa aggccacaga
     1021 agatgctgaa ggaggggatg gccctcgttt acctcagaga agtaaatttg atagtgatga
     1081 ggaagaagaa gacactgaaa atgttgaggc tgcaagtagt gggaaagtca ccagaagtcc
     1141 atccccagtt cctcaagaag agcacagtga ccctgagatg actgaagagg agaaagagta
     1201 tcaaatgatg ttgctgacaa aaatgcttct aacagaaatt ctgctggatg tcacagatga
     1261 agaaatttat tacgtagcca aagatgcaca ccgcaaagca acgaaagctc ctgcaaaaca
     1321 gctggcacag tccagtgcac tggcttccct cactggactc ggtggactgg gtggttatgg
     1381 atcaggagac agtgaagatg agaggagtga cagaggatct gagtcatctg acactgatga
     1441 tgaagaatta cggcatcgaa tccggcaaaa acaggaagct ttttggagaa aagaaaaaga
     1501 acagcagcta ttacatgata aacagatgga agaagaaaag cagcaaacag aaagggttac
     1561 aaaagagatg aatgaattta tccataaaga gcaaaatagt ttatcactac tagaagcaag
     1621 agaagcagac ggtgatgtgg ttaatgaaaa gaagagaact ccaaatgaaa ccacatcagt
     1681 tttagaacca aaaaaagagc ataaagaaaa agaaaaacaa ggaaggagta ggtcgggaag
     1741 ttctagtagt ggtagttcca gtagcaatag cagaactagt agtactagta gtactgtctc
     1801 tagctcttca tacagttcta gctcaggtag tagtcgtact tcttctcggt cttcttctcc
     1861 taaaaggaaa aagagacaca gtaggagtag atctccaaca atcaaagcta gacgtagcag
     1921 gagtagaagc tattctcgca gaattaaaat agagagcaat agggctaggg taaagattag
     1981 agatagaagg agatctaata gaaatagcat tgaaagagaa agacgacgaa atcggagtcc
     2041 ttcccgagag agacgtagaa gtagaagtcg ctcaagggat agacgaacca atcgtgccag
     2101 tcgcagtagg agtcgagata ggcgtaaaat tgatgatcaa cgtggaaatc ttagtgggaa
     2161 cagtcataag cataaaggtg aggctaaaga acaagagagg aaaaaggaga ggagtcgaag
     2221 tatagataaa gataggaaaa agaaagacaa agaaagggaa cgtgaacagg ataaaagaaa
     2281 agagaaacaa aaaagggaag aaaaagattt taagttcagt agtcaggatg atagattaaa
     2341 aaggaaacga gaaagtgaaa gaacattttc taggagtggt tctatatctg ttaaaatcat
     2401 aagacatgat tctagacagg atagtaagaa aagtactacc aaagatagta aaaaacattc
     2461 aggctctgat tctagtggaa ggagcagttc tgagtctcca ggaagtagca aagaaaagaa
     2521 ggctaagaag cctaaacata gtcgatcgcg atccgtggag aaatctcaaa ggtctggtaa
     2581 gaaggcaagc cgcaaacaca agtctaagtc ccgatcaagg tagtatactt tttaaagtat
     2641 tttgtctgat ttttaaaaaa aattgactga atttattcaa agttgaaagt gtcctttctc
     2701 tctctcttta ataaactcag tttggtactt gataaataat catagtctta aatgttagaa
     2761 atcctatata atattattta tttaaaattg cagattttta atttaaaata catttttatt
     2821 tttaaatttt gtcttttccc ttttttttca gatcaacaac ccctccccgt cgtaaacgct
     2881 gaggaatgat gtggcaagaa tgccatgatg ttctttaaaa aaattccatg agttttaagg
     2941 gcttgtctca ttatagaggc acattgtggc tgtgtaggtg aaaccagaat cttttttttt
     3001 tttaatctgt aaataggtgt actttttcca atgctgctcc aagttactta ataggatttc
     3061 tttgtattac gtttttttca aaaaatatag tgcataataa gactataaac atgccattct
     3121 ctttcagctg taatgttctt aaaattattc ttgaatgtac tgtgatgtca ataaagctct
     3181 ttagttcatt tttgttaaac tcttgcacct taattttatg gttttaatct aaggaacgta
     3241 cttttataaa aaggcagctg gaattttgta taacaggttt taaaggtacc ttctctcacc
     3301 tcccccaaag aaaatggttt ttacttaata gtttgtcaaa gtttgtaaat tgtacccatg
     3361 gacttttgcc agattccaac tttaagggta tgaaagaggg ctagaaatag acctttactt
     3421 ttcatttgga agtatttgac aactttctaa acttttcttc ctattttggg gattttcaag
     3481 taatatattc tctgtgtgta taacgtgtgg ttcactcctg taaaatgaaa ttgctggaat
     3541 caatcaagcc agtgcaccag tagagttatt tgtaaggaac gattgtgttt gacagtaata
     3601 gtcaagtctg gaactatatt ctacagtcac ccacttctgt tttagaagca ttttgaaaca
     3661 ctttttgggg ttatagaaat aagactcatg attcaatata tttatttata tttttaaagt
     3721 ataatatgac ctcaaatcaa tggaggaatg ctgtattatg caggtttgtg tcaatttcct
     3781 gacattaaaa ttgtctgatt ttgtccgttt cttaaaatta tgattagtga gtggtctaac
     3841 agtttaaggc attgataact tacaagtaga atggggctct caaagcattt taactcagtt
     3901 gctttagggt ccattttttt atgtaatcac ttactcagtg ataaatgaat ctctgaaaac
     3961 aaatgctttt acattttaat ttaaaaagaa aacaggtgca ggccacagaa aagttttaaa
     4021 gtatgccttc ttaccagcaa tagttcattt taaaaatcat gccagatttt tgccaagatc
     4081 agtgtttcct caacatgaag atagaaatag atttgtatag tgtgctcttg tacctctaca
     4141 tagattatta tataattttg agcagttaca catttatcta aaggaaataa atcaactgtg
     4201 aataaatgca tgtttaccaa aatggctgtt tacagtgcat ttagttctga tatttataaa
     4261 gatgacattt cacagaataa ctttaaaata gtttgaaatt ctatatagtt tagacatcga
     4321 tcacatctgg agacaaaata aaatgtgcaa tattttttat gtaggcgagc taacacagtg
     4381 tacctaattg cagaattatc tgattaattt gtaatagata agttgtataa cattttcata
     4441 tcttaaaatg ttttttagat caatcttgaa gtgaaatatt ttcaaaataa aattctacag
     4501 aaaaattctg ttggctatga tatgcacatt tttgggcaag ttatgaacta gagccaaaag
     4561 tagtatttga cagttttatt tactctgccg taatttgcaa gcttatcagt taagtctgta
     4621 gtttttttaa aagccgtcat gatatttgtg attattagta cataaaccag tgttataatt
     4681 tgatatttgg gtttttcaga cttttagtgg cagatttaga gaattcttta ttttcttgac
     4741 atgtgatata gtatttattt accttgagtg gtaaggtttt ataaggtagg gtttccatga
     4801 tttaggatgt gaatgcaaaa acttacacat aagttaatta gatgtataat ttggttatga
     4861 aatcttttct aaaataatac caccagaaaa ttaacagatc aaatttttga gacaatcctt
     4921 ggtctggatt ggttaatgaa aatgtcttgt ttaagaggtt ctattaaaaa atatttctag
     4981 tgtattagtc ataattgttt ttgtggagtg ggggtaaacc acaccattaa gggaataaaa
     5041 tgtaatttga aagaggtgat tataagattt gtttcaggcc ccaaaatata aataaaaatt
     5101 ggtgtggaat ctc
//
