LOCUS       NM_015491               5033 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens PNN interacting serine and arginine rich protein
            (PNISR), transcript variant 2, mRNA.
ACCESSION   NM_015491
VERSION     NM_015491.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5033)
  AUTHORS   Szlavicz,E., Olah,P., Szabo,K., Pagani,F., Bata-Csorgo,Z.,
            Kemeny,L. and Szell,M.
  TITLE     Analysis of psoriasis-relevant gene expression and exon usage
            alterations after silencing of SR-rich splicing regulators
  JOURNAL   Exp Dermatol 27 (6), 656-662 (2018)
   PUBMED   29512856
  REMARK    GeneRIF: In our present RNA-Seq experiment, we demonstrated that
            the LUC7L3 and SFRS18 splicing factors contribute to the regulation
            of several well-known psoriasis-associated pathways, including the
            IFN signalling pathway, antiviral immunity and ubiquitination.
REFERENCE   2  (bases 1 to 5033)
  AUTHORS   Szlavicz,E., Szabo,K., Groma,G., Bata-Csorgo,Z., Pagani,F.,
            Kemeny,L. and Szell,M.
  TITLE     Splicing factors differentially expressed in psoriasis alter mRNA
            maturation of disease-associated EDA+ fibronectin
  JOURNAL   Mol Cell Biochem 436 (1-2), 189-199 (2017)
   PUBMED   28589370
  REMARK    GeneRIF: results indicate that LUC7L3, PPIG, and SFRS18 are not
            only implicated in EDA+ fibronectin formation, but also that they
            could possess multiple roles in psoriasis-associated molecular
            abnormalities.
            Erratum:[Mol Cell Biochem. 2017 Dec;436(1-2):201. doi:
            10.1007/s11010-017-3105-y.. PMID: 28770468]
REFERENCE   3  (bases 1 to 5033)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 5033)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   5  (bases 1 to 5033)
  AUTHORS   Zimowska,G., Shi,J., Munguba,G., Jackson,M.R., Alpatov,R.,
            Simmons,M.N., Shi,Y. and Sugrue,S.P.
  TITLE     Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal
            epithelial cells
  JOURNAL   Invest Ophthalmol Vis Sci 44 (11), 4715-4723 (2003)
   PUBMED   14578391
REFERENCE   6  (bases 1 to 5033)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK074628.1, AL513550.9 and BM893682.1.
            
            On Aug 13, 2020 this sequence version replaced NM_015491.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4 and 5 all encode isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.7529.1,
                                           SRR1660805.113804.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1680              AK074628.1         1-1680
            1681-5006           AL513550.9         43399-46724         c
            5007-5032           BM893682.1         16-41               c
            5033-5033           AL513550.9         43372-43372         c
FEATURES             Location/Qualifiers
     source          1..5033
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.2"
     gene            1..5033
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="PNN interacting serine and arginine rich protein"
                     /db_xref="GeneID:25957"
                     /db_xref="HGNC:HGNC:21222"
                     /db_xref="MIM:616653"
     exon            1..94
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            95..213
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..2543
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="isoform a is encoded by transcript variant 2;
                     splicing factor, arginine/serine-rich 18; splicing factor,
                     arginine/serine-rich 130; PNN-interacting
                     serine/arginine-rich protein;
                     serine-arginine-rich-splicing regulatory protein 130;
                     SR-rich protein; SR-related protein; arginine/serine-rich
                     protein PNISR"
                     /codon_start=1
                     /product="arginine/serine-rich protein PNISR isoform a"
                     /protein_id="NP_056306.1"
                     /db_xref="CCDS:CCDS5043.1"
                     /db_xref="GeneID:25957"
                     /db_xref="HGNC:HGNC:21222"
                     /db_xref="MIM:616653"
                     /translation="MWDQGGQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQ
                     REASGQQSMVEQPPGMMPNGQDMSTMESGPNNHGNFQGDSNFNRMWQPEWGMHQQPPH
                     PPPDQPWMPPTPGPMDIVPPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGP
                     VNQFDYQHGAAFGPPQGGFHPPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVK
                     QEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEG
                     GDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQM
                     MLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYG
                     SGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTER
                     VTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRS
                     RSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTI
                     KARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSR
                     DRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDK
                     EREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDS
                     KKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKH
                     KSKSRSR"
     exon            214..402
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            403..626
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            627..798
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            799..989
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1127
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1227
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1281
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1452
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..5033
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3090..3095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      3119
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="major polyA site"
     regulatory      4121..4126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      4142
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
     regulatory      4406..4411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      4425
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
     regulatory      5011..5016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      5033
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
ORIGIN      
        1 atcttgtctt gttcccgaag aagtagaagc atcgaaagcg ttggagaggt gttaccggaa
       61 cggcggcgac aagggtgttc ccgaactaga gtggatagaa aatcaagtat attttaaaag
      121 aagggatgtg ggatcaagga ggacagcctt ggcagcagtg gcccttgaac cagcaacaat
      181 ggatgcagtc attccagcac caacaggatc caagccagat tgattgggct gcattggccc
      241 aagcttggat tgcccaaaga gaagcttcag gacagcaaag catggtagaa caaccaccag
      301 gaatgatgcc aaatggacaa gatatgtcta caatggaatc tggtccaaac aatcatggga
      361 atttccaagg ggattcaaac ttcaacagaa tgtggcaacc agaatgggga atgcatcagc
      421 aacccccaca cccccctcca gatcagccat ggatgccacc aacaccaggc ccaatggaca
      481 ttgttcctcc ttctgaagac agcaacagtc aggacagtgg ggaatttgcc cctgacaaca
      541 ggcatatatt taaccagaac aatcacaact ttggtggacc acccgataat tttgcagtgg
      601 ggccagtgaa ccagtttgac tatcagcatg gggctgcttt tggtccaccg caaggtggat
      661 ttcatcctcc ttattggcaa ccaggacctc caggacctcc agcacctccc cagaatcgaa
      721 gagaaaggcc atcatcattc agggatcgtc agcgttcacc tattgcactt cctgtgaagc
      781 aggagcctcc acaaattgac gcagtaaaac gcaggactct tcccgcttgg attcgcgaag
      841 gtcttgaaaa aatggaacgt gaaaagcaga agaaattgga gaaagaaaga atggaacaac
      901 aacgttcaca attgtccaaa aaagaaaaaa aggccacaga agatgctgaa ggaggggatg
      961 gccctcgttt acctcagaga agtaaatttg atagtgatga ggaagaagaa gacactgaaa
     1021 atgttgaggc tgcaagtagt gggaaagtca ccagaagtcc atccccagtt cctcaagaag
     1081 agcacagtga ccctgagatg actgaagagg agaaagagta tcaaatgatg ttgctgacaa
     1141 aaatgcttct aacagaaatt ctgctggatg tcacagatga agaaatttat tacgtagcca
     1201 aagatgcaca ccgcaaagca acgaaagctc ctgcaaaaca gctggcacag tccagtgcac
     1261 tggcttccct cactggactc ggtggactgg gtggttatgg atcaggagac agtgaagatg
     1321 agaggagtga cagaggatct gagtcatctg acactgatga tgaagaatta cggcatcgaa
     1381 tccggcaaaa acaggaagct ttttggagaa aagaaaaaga acagcagcta ttacatgata
     1441 aacagatgga agaagaaaag cagcaaacag aaagggttac aaaagagatg aatgaattta
     1501 tccataaaga gcaaaatagt ttatcactac tagaagcaag agaagcagac ggtgatgtgg
     1561 ttaatgaaaa gaagagaact ccaaatgaaa ccacatcagt tttagaacca aaaaaagagc
     1621 ataaagaaaa agaaaaacaa ggaaggagta ggtcgggaag ttctagtagt ggtagttcca
     1681 gtagcaatag cagaactagt agtactagta gtactgtctc tagctcttca tacagttcta
     1741 gctcaggtag tagtcgtact tcttctcggt cttcttctcc taaaaggaaa aagagacaca
     1801 gtaggagtag atctccaaca atcaaagcta gacgtagcag gagtagaagc tattctcgca
     1861 gaattaaaat agagagcaat agggctaggg taaagattag agatagaagg agatctaata
     1921 gaaatagcat tgaaagagaa agacgacgaa atcggagtcc ttcccgagag agacgtagaa
     1981 gtagaagtcg ctcaagggat agacgaacca atcgtgccag tcgcagtagg agtcgagata
     2041 ggcgtaaaat tgatgatcaa cgtggaaatc ttagtgggaa cagtcataag cataaaggtg
     2101 aggctaaaga acaagagagg aaaaaggaga ggagtcgaag tatagataaa gataggaaaa
     2161 agaaagacaa agaaagggaa cgtgaacagg ataaaagaaa agagaaacaa aaaagggaag
     2221 aaaaagattt taagttcagt agtcaggatg atagattaaa aaggaaacga gaaagtgaaa
     2281 gaacattttc taggagtggt tctatatctg ttaaaatcat aagacatgat tctagacagg
     2341 atagtaagaa aagtactacc aaagatagta aaaaacattc aggctctgat tctagtggaa
     2401 ggagcagttc tgagtctcca ggaagtagca aagaaaagaa ggctaagaag cctaaacata
     2461 gtcgatcgcg atccgtggag aaatctcaaa ggtctggtaa gaaggcaagc cgcaaacaca
     2521 agtctaagtc ccgatcaagg tagtatactt tttaaagtat tttgtctgat ttttaaaaaa
     2581 aattgactga atttattcaa agttgaaagt gtcctttctc tctctcttta ataaactcag
     2641 tttggtactt gataaataat catagtctta aatgttagaa atcctatata atattattta
     2701 tttaaaattg cagattttta atttaaaata catttttatt tttaaatttt gtcttttccc
     2761 ttttttttca gatcaacaac ccctccccgt cgtaaacgct gaggaatgat gtggcaagaa
     2821 tgccatgatg ttctttaaaa aaattccatg agttttaagg gcttgtctca ttatagaggc
     2881 acattgtggc tgtgtaggtg aaaccagaat cttttttttt tttaatctgt aaataggtgt
     2941 actttttcca atgctgctcc aagttactta ataggatttc tttgtattac gtttttttca
     3001 aaaaatatag tgcataataa gactataaac atgccattct ctttcagctg taatgttctt
     3061 aaaattattc ttgaatgtac tgtgatgtca ataaagctct ttagttcatt tttgttaaac
     3121 tcttgcacct taattttatg gttttaatct aaggaacgta cttttataaa aaggcagctg
     3181 gaattttgta taacaggttt taaaggtacc ttctctcacc tcccccaaag aaaatggttt
     3241 ttacttaata gtttgtcaaa gtttgtaaat tgtacccatg gacttttgcc agattccaac
     3301 tttaagggta tgaaagaggg ctagaaatag acctttactt ttcatttgga agtatttgac
     3361 aactttctaa acttttcttc ctattttggg gattttcaag taatatattc tctgtgtgta
     3421 taacgtgtgg ttcactcctg taaaatgaaa ttgctggaat caatcaagcc agtgcaccag
     3481 tagagttatt tgtaaggaac gattgtgttt gacagtaata gtcaagtctg gaactatatt
     3541 ctacagtcac ccacttctgt tttagaagca ttttgaaaca ctttttgggg ttatagaaat
     3601 aagactcatg attcaatata tttatttata tttttaaagt ataatatgac ctcaaatcaa
     3661 tggaggaatg ctgtattatg caggtttgtg tcaatttcct gacattaaaa ttgtctgatt
     3721 ttgtccgttt cttaaaatta tgattagtga gtggtctaac agtttaaggc attgataact
     3781 tacaagtaga atggggctct caaagcattt taactcagtt gctttagggt ccattttttt
     3841 atgtaatcac ttactcagtg ataaatgaat ctctgaaaac aaatgctttt acattttaat
     3901 ttaaaaagaa aacaggtgca ggccacagaa aagttttaaa gtatgccttc ttaccagcaa
     3961 tagttcattt taaaaatcat gccagatttt tgccaagatc agtgtttcct caacatgaag
     4021 atagaaatag atttgtatag tgtgctcttg tacctctaca tagattatta tataattttg
     4081 agcagttaca catttatcta aaggaaataa atcaactgtg aataaatgca tgtttaccaa
     4141 aatggctgtt tacagtgcat ttagttctga tatttataaa gatgacattt cacagaataa
     4201 ctttaaaata gtttgaaatt ctatatagtt tagacatcga tcacatctgg agacaaaata
     4261 aaatgtgcaa tattttttat gtaggcgagc taacacagtg tacctaattg cagaattatc
     4321 tgattaattt gtaatagata agttgtataa cattttcata tcttaaaatg ttttttagat
     4381 caatcttgaa gtgaaatatt ttcaaaataa aattctacag aaaaattctg ttggctatga
     4441 tatgcacatt tttgggcaag ttatgaacta gagccaaaag tagtatttga cagttttatt
     4501 tactctgccg taatttgcaa gcttatcagt taagtctgta gtttttttaa aagccgtcat
     4561 gatatttgtg attattagta cataaaccag tgttataatt tgatatttgg gtttttcaga
     4621 cttttagtgg cagatttaga gaattcttta ttttcttgac atgtgatata gtatttattt
     4681 accttgagtg gtaaggtttt ataaggtagg gtttccatga tttaggatgt gaatgcaaaa
     4741 acttacacat aagttaatta gatgtataat ttggttatga aatcttttct aaaataatac
     4801 caccagaaaa ttaacagatc aaatttttga gacaatcctt ggtctggatt ggttaatgaa
     4861 aatgtcttgt ttaagaggtt ctattaaaaa atatttctag tgtattagtc ataattgttt
     4921 ttgtggagtg ggggtaaacc acaccattaa gggaataaaa tgtaatttga aagaggtgat
     4981 tataagattt gtttcaggcc ccaaaatata aataaaaatt ggtgtggaat ctc
//
