LOCUS       NM_001322418            3371 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens PNN interacting serine and arginine rich protein
            (PNISR), transcript variant 13, mRNA.
ACCESSION   NM_001322418
VERSION     NM_001322418.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3371)
  AUTHORS   Szlavicz,E., Olah,P., Szabo,K., Pagani,F., Bata-Csorgo,Z.,
            Kemeny,L. and Szell,M.
  TITLE     Analysis of psoriasis-relevant gene expression and exon usage
            alterations after silencing of SR-rich splicing regulators
  JOURNAL   Exp Dermatol 27 (6), 656-662 (2018)
   PUBMED   29512856
  REMARK    GeneRIF: In our present RNA-Seq experiment, we demonstrated that
            the LUC7L3 and SFRS18 splicing factors contribute to the regulation
            of several well-known psoriasis-associated pathways, including the
            IFN signalling pathway, antiviral immunity and ubiquitination.
REFERENCE   2  (bases 1 to 3371)
  AUTHORS   Szlavicz,E., Szabo,K., Groma,G., Bata-Csorgo,Z., Pagani,F.,
            Kemeny,L. and Szell,M.
  TITLE     Splicing factors differentially expressed in psoriasis alter mRNA
            maturation of disease-associated EDA+ fibronectin
  JOURNAL   Mol Cell Biochem 436 (1-2), 189-199 (2017)
   PUBMED   28589370
  REMARK    GeneRIF: results indicate that LUC7L3, PPIG, and SFRS18 are not
            only implicated in EDA+ fibronectin formation, but also that they
            could possess multiple roles in psoriasis-associated molecular
            abnormalities.
            Erratum:[Mol Cell Biochem. 2017 Dec;436(1-2):201. doi:
            10.1007/s11010-017-3105-y.. PMID: 28770468]
REFERENCE   3  (bases 1 to 3371)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 3371)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   5  (bases 1 to 3371)
  AUTHORS   Zimowska,G., Shi,J., Munguba,G., Jackson,M.R., Alpatov,R.,
            Simmons,M.N., Shi,Y. and Sugrue,S.P.
  TITLE     Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal
            epithelial cells
  JOURNAL   Invest Ophthalmol Vis Sci 44 (11), 4715-4723 (2003)
   PUBMED   14578391
REFERENCE   6  (bases 1 to 3371)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA326969.1, BX648520.1, BU675213.1, DA948286.1, DB108627.1 and
            BM674898.1.
            
            On May 31, 2019 this sequence version replaced NM_001322418.1.
            
            Transcript Variant: This variant (13) differs in the 5' UTR and
            lacks several 3' exons but contains an alternate 3' terminal exon,
            and it thus differs in the 3' coding region and 3' UTR, compared to
            variant 1. The encoded isoform (f) has a distinct C-terminus and is
            significantly shorter than isoform a. Both variants 13 and 14
            encode isoform f.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.153096.1, BX648520.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DA326969.1         38-70
            34-926              BX648520.1         2-894
            927-1100            BX648520.1         897-1070
            1101-2142           BX648520.1         1075-2116
            2143-2370           BU675213.1         17-244              c
            2371-2886           DA948286.1         60-575
            2887-3218           DB108627.1         253-584
            3219-3371           BM674898.1         18-170              c
FEATURES             Location/Qualifiers
     source          1..3371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.2"
     gene            1..3371
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="PNN interacting serine and arginine rich protein"
                     /db_xref="GeneID:25957"
                     /db_xref="HGNC:HGNC:21222"
                     /db_xref="MIM:616653"
     exon            1..94
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            95..209
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..403
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="isoform f is encoded by transcript variant 13;
                     splicing factor, arginine/serine-rich 18; splicing factor,
                     arginine/serine-rich 130; PNN-interacting
                     serine/arginine-rich protein;
                     serine-arginine-rich-splicing regulatory protein 130;
                     SR-rich protein; SR-related protein; arginine/serine-rich
                     protein PNISR"
                     /codon_start=1
                     /product="arginine/serine-rich protein PNISR isoform f"
                     /protein_id="NP_001309347.1"
                     /db_xref="GeneID:25957"
                     /db_xref="HGNC:HGNC:21222"
                     /db_xref="MIM:616653"
                     /translation="MWDQGGQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQ
                     REASGQQSMVEQPPGMMPNGQDMSTMESGPNNHGNFQGDSNFNRMWQPG"
     exon            210..398
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            399..3371
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1463..1468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: TATAAA"
     polyA_site      1481
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="major polyA site"
     regulatory      2124..2129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: ATTAAA"
     polyA_site      2143
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="major polyA site"
     regulatory      2338..2343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     regulatory      2345..2350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATATA"
     polyA_site      2357
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
     polyA_site      2370
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
     regulatory      2616..2621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: TATAAA"
     polyA_site      2640
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
     regulatory      3350..3355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      3371
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
ORIGIN      
        1 atcttgtctt gttcccgaag aagtagaagc atcgaaagcg ttggagaggt gttaccggaa
       61 cggcggcgac aagggtgttc ccgaactaga gtggaaaatc aagtatattt taaaagaagg
      121 gatgtgggat caaggaggac agccttggca gcagtggccc ttgaaccagc aacaatggat
      181 gcagtcattc cagcaccaac aggatccaag ccagattgat tgggctgcat tggcccaagc
      241 ttggattgcc caaagagaag cttcaggaca gcaaagcatg gtagaacaac caccaggaat
      301 gatgccaaat ggacaagata tgtctacaat ggaatctggt ccaaacaatc atgggaattt
      361 ccaaggggat tcaaacttca acagaatgtg gcaaccaggc tgacaggggc tgggaacact
      421 ctggaaacct cacttggcat ctagggaaga gagcattctt tgtctctcta ttgcaacctc
      481 tggccttttc agaagcagca ctggcagagt aaaacatgtc tagcctctaa ttaaagaaaa
      541 attgtgtcac tgtgtgacaa attagtctgt caaatatact ctgcccctac catccgccta
      601 cctttttctt cccttttttt ttttcagata gtgaagatct ttcataagtt tttgtgtgtt
      661 ttactttttt gtttgtttta tttcacagta tgatgtagat ttcttgatgc taattcagtc
      721 ttccatggct tgtgttattc ctttttaata gtcacttgaa actatggagg aatcagcctc
      781 tcatttgggt atgctgatgg tgaagtcata acctcctttc cctattaata ctttttgttt
      841 ctccttataa gaatggagac ctcagtcgag accagcctgg gcaacatagc aaggccctgt
      901 ctctacaaaa aaaaaaaaaa aaaaaacctt aaaacttagt caggcataga ggcgcatgcc
      961 tgtagtccca gctacttggg aggctgaggt gggaggattg cttgagccta ggggattgag
     1021 actgcaatga gctgtgatca cgccactgca ctccagcctg ggtgacagaa tgagtccctc
     1081 atttaaaaca aacaaacaaa aaaaacgaga attcagatta cttttaaaaa cataaatatt
     1141 ctagtctttg atactgtgag gtggttcatt tctagctttc ttgaaagtga aatttcccca
     1201 catttgaaaa tgttttagtt cctaagttta agttcttaaa tgactcccgc gggcatccct
     1261 accccttagt tttactctac tttgtgaccc tgggcaagtg atttacctct gtgtgcctcg
     1321 attttccctc ccgaaattgg caaaaataat acctaatttc tccctacctc acagggatgt
     1381 tgtgaggata aatgtgttcg tgtaagaaag aaattatata aaacctcaag gtattatttt
     1441 tgtggtgttg ttactaaaca aatataaaaa ttcaacaaaa atagtgcttt ggattttgtt
     1501 acatttgtta aaaataactt tgggcatttg gttaggatat gaattagagt ggagttagct
     1561 cattttgaat tatatatgac agtttagttc attgcttatt tttaagataa acaaaaggaa
     1621 tttgaccaag aagtcataag ttgtttttta aatctgtatg tttactgaaa aatctttctt
     1681 gagatcttaa aattctgtgt tgattttgtt ataaccgcct gttgaatgtt tttatgccta
     1741 aatcttaaat agaatgggga atgcatcagc aacccccaca cccccctcca gatcagccat
     1801 ggatgccacc aacaccaggc ccaatggaca ttgttcctcc ttctgaagac agcaacagtc
     1861 aggacagtgg ggaatttgcc cctgacaaca ggcatatatt taaccagaac aatcacaact
     1921 ttggtggacc acccgataat tttgcagtgg ggccagtgaa ccagtttgac tatcaggtga
     1981 aagatatttt gttgctttaa tattgtagat gtgcacgtaa tccattcttt ggaagtgtct
     2041 catcaagaat acctaagata cgtgtttcac ttttcagact tgtataaata agcacattct
     2101 gtctcagtta tcaatttttg agtattaaaa taattagaat ttgttttctg atttttttat
     2161 ttcattagga aaatggtata aaagatcatt acggaaaact tttgaaaaaa ttaaaaatgt
     2221 ataagtgcaa tagctatatg atgttttatt ttctaattta tatttcaaaa tggtatattt
     2281 aaatgttaaa gactagagaa tgcacagtaa ttgaatatag ctcatggtta agacatgaat
     2341 aaaaaatata gatcattttc ctaagtgtaa ttccttgtgc tatgtagaat tatgactgtt
     2401 tttctagtgt catttttttt ccattctgac atgacatgtt aatggaattg tatataattt
     2461 cctctgtagc atccaattca ttcctaggga catagaactc tgtggggaat agtgttgtat
     2521 gttgggcttt atttacttca ttccctctgc cagggtctac ccttaaatta tagtgctagg
     2581 tgtcattttg aaataactga ttgcaattat taacttataa actgctatca taatttaaaa
     2641 ttttgaaaga attatttcat gaattctagg gtagatttga taatggacat ctagtattca
     2701 ccttgagatg gtaatcctct cattaataaa tattcagata cttgtatact tggtatacag
     2761 atacaacagt ttttatgttg tttgaagaaa tataatggca gggagcatct gcttacccta
     2821 cttttgcatg gtagatccca tgtaaacaag acaaagagct gtattggcag ctggcctaga
     2881 aaagcctctg aaaatagcaa aattgcagaa aatatttaat gattcattaa cttctatctt
     2941 tgcttataaa tgaatatatc tgcaagatta tagaaacagc ttaagttgtt tagttcactt
     3001 tttgttcact gtaagtagga tgttgaaatt gacaaaaatg tctagttaaa gagaaattag
     3061 tatctatttg atgtcttagt gttggtagga ttagcttgta aatggattca gaatgaaaaa
     3121 tttcatatac ttcttgaaag tagcttatca gctggctttt agaagcctct ttgcatttac
     3181 atagccggaa aatcttaaga caagtaagcc taggttcttg ggaccataga agtatcggtg
     3241 gatattagag ccatggaatt cttggatgtg ctgcacacat ggatttctac tgtcccagtt
     3301 cataacacac gtgtgtccca gagagtatat tgtattaatt tgaagaaaaa ataaactgca
     3361 atactctttc a
//
