LOCUS       NM_001322413            4801 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens PNN interacting serine and arginine rich protein
            (PNISR), transcript variant 8, mRNA.
ACCESSION   NM_001322413 XM_005266917
VERSION     NM_001322413.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4801)
  AUTHORS   Szlavicz,E., Olah,P., Szabo,K., Pagani,F., Bata-Csorgo,Z.,
            Kemeny,L. and Szell,M.
  TITLE     Analysis of psoriasis-relevant gene expression and exon usage
            alterations after silencing of SR-rich splicing regulators
  JOURNAL   Exp Dermatol 27 (6), 656-662 (2018)
   PUBMED   29512856
  REMARK    GeneRIF: In our present RNA-Seq experiment, we demonstrated that
            the LUC7L3 and SFRS18 splicing factors contribute to the regulation
            of several well-known psoriasis-associated pathways, including the
            IFN signalling pathway, antiviral immunity and ubiquitination.
REFERENCE   2  (bases 1 to 4801)
  AUTHORS   Szlavicz,E., Szabo,K., Groma,G., Bata-Csorgo,Z., Pagani,F.,
            Kemeny,L. and Szell,M.
  TITLE     Splicing factors differentially expressed in psoriasis alter mRNA
            maturation of disease-associated EDA+ fibronectin
  JOURNAL   Mol Cell Biochem 436 (1-2), 189-199 (2017)
   PUBMED   28589370
  REMARK    GeneRIF: results indicate that LUC7L3, PPIG, and SFRS18 are not
            only implicated in EDA+ fibronectin formation, but also that they
            could possess multiple roles in psoriasis-associated molecular
            abnormalities.
            Erratum:[Mol Cell Biochem. 2017 Dec;436(1-2):201. doi:
            10.1007/s11010-017-3105-y.. PMID: 28770468]
REFERENCE   3  (bases 1 to 4801)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 4801)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   5  (bases 1 to 4801)
  AUTHORS   Zimowska,G., Shi,J., Munguba,G., Jackson,M.R., Alpatov,R.,
            Simmons,M.N., Shi,Y. and Sugrue,S.P.
  TITLE     Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal
            epithelial cells
  JOURNAL   Invest Ophthalmol Vis Sci 44 (11), 4715-4723 (2003)
   PUBMED   14578391
REFERENCE   6  (bases 1 to 4801)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK074628.1, AF314184.1, BQ000404.1, AL513550.9 and BM893682.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001322413.1.
            
            Transcript Variant: This variant (8) differs in the 5' UTR and
            splices out a portion of the 3' terminal exon, resulting in an
            alternate 3' coding region, compared to variant 1. The encoded
            isoform (b) has a distinct and longer C-terminus, compared to
            isoform a. Variants 6, 7 and 8 all encode isoform b.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2271576.1,
                                           SRR14038195.1839059.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1680              AK074628.1         1-1680
            1681-2214           AF314184.1         1588-2121
            2215-2887           BQ000404.1         16-688              c
            2888-4774           AL513550.9         43399-45285         c
            4775-4800           BM893682.1         16-41               c
            4801-4801           AL513550.9         43372-43372         c
FEATURES             Location/Qualifiers
     source          1..4801
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.2"
     gene            1..4801
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="PNN interacting serine and arginine rich protein"
                     /db_xref="GeneID:25957"
                     /db_xref="HGNC:HGNC:21222"
                     /db_xref="MIM:616653"
     exon            1..94
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            95..213
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..2570
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="isoform b is encoded by transcript variant 8;
                     splicing factor, arginine/serine-rich 18; splicing factor,
                     arginine/serine-rich 130; PNN-interacting
                     serine/arginine-rich protein;
                     serine-arginine-rich-splicing regulatory protein 130;
                     SR-rich protein; SR-related protein; arginine/serine-rich
                     protein PNISR"
                     /codon_start=1
                     /product="arginine/serine-rich protein PNISR isoform b"
                     /protein_id="NP_001309342.1"
                     /db_xref="CCDS:CCDS93978.1"
                     /db_xref="GeneID:25957"
                     /db_xref="HGNC:HGNC:21222"
                     /db_xref="MIM:616653"
                     /translation="MWDQGGQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQ
                     REASGQQSMVEQPPGMMPNGQDMSTMESGPNNHGNFQGDSNFNRMWQPEWGMHQQPPH
                     PPPDQPWMPPTPGPMDIVPPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGP
                     VNQFDYQHGAAFGPPQGGFHPPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVK
                     QEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEG
                     GDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQM
                     MLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYG
                     SGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTER
                     VTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRS
                     RSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTI
                     KARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSR
                     DRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDK
                     EREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDS
                     KKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKH
                     KSKSRSRSTTPPRRKR"
     exon            214..402
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            403..626
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            627..798
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            799..989
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1127
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1227
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1281
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1452
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..2539
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..4801
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2858..2863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      2887
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="major polyA site"
     regulatory      3889..3894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      3910
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
     regulatory      4174..4179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      4193
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
     regulatory      4779..4784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      4801
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
ORIGIN      
        1 atcttgtctt gttcccgaag aagtagaagc atcgaaagcg ttggagaggt gttaccggaa
       61 cggcggcgac aagggtgttc ccgaactaga gtggatagaa aatcaagtat attttaaaag
      121 aagggatgtg ggatcaagga ggacagcctt ggcagcagtg gcccttgaac cagcaacaat
      181 ggatgcagtc attccagcac caacaggatc caagccagat tgattgggct gcattggccc
      241 aagcttggat tgcccaaaga gaagcttcag gacagcaaag catggtagaa caaccaccag
      301 gaatgatgcc aaatggacaa gatatgtcta caatggaatc tggtccaaac aatcatggga
      361 atttccaagg ggattcaaac ttcaacagaa tgtggcaacc agaatgggga atgcatcagc
      421 aacccccaca cccccctcca gatcagccat ggatgccacc aacaccaggc ccaatggaca
      481 ttgttcctcc ttctgaagac agcaacagtc aggacagtgg ggaatttgcc cctgacaaca
      541 ggcatatatt taaccagaac aatcacaact ttggtggacc acccgataat tttgcagtgg
      601 ggccagtgaa ccagtttgac tatcagcatg gggctgcttt tggtccaccg caaggtggat
      661 ttcatcctcc ttattggcaa ccaggacctc caggacctcc agcacctccc cagaatcgaa
      721 gagaaaggcc atcatcattc agggatcgtc agcgttcacc tattgcactt cctgtgaagc
      781 aggagcctcc acaaattgac gcagtaaaac gcaggactct tcccgcttgg attcgcgaag
      841 gtcttgaaaa aatggaacgt gaaaagcaga agaaattgga gaaagaaaga atggaacaac
      901 aacgttcaca attgtccaaa aaagaaaaaa aggccacaga agatgctgaa ggaggggatg
      961 gccctcgttt acctcagaga agtaaatttg atagtgatga ggaagaagaa gacactgaaa
     1021 atgttgaggc tgcaagtagt gggaaagtca ccagaagtcc atccccagtt cctcaagaag
     1081 agcacagtga ccctgagatg actgaagagg agaaagagta tcaaatgatg ttgctgacaa
     1141 aaatgcttct aacagaaatt ctgctggatg tcacagatga agaaatttat tacgtagcca
     1201 aagatgcaca ccgcaaagca acgaaagctc ctgcaaaaca gctggcacag tccagtgcac
     1261 tggcttccct cactggactc ggtggactgg gtggttatgg atcaggagac agtgaagatg
     1321 agaggagtga cagaggatct gagtcatctg acactgatga tgaagaatta cggcatcgaa
     1381 tccggcaaaa acaggaagct ttttggagaa aagaaaaaga acagcagcta ttacatgata
     1441 aacagatgga agaagaaaag cagcaaacag aaagggttac aaaagagatg aatgaattta
     1501 tccataaaga gcaaaatagt ttatcactac tagaagcaag agaagcagac ggtgatgtgg
     1561 ttaatgaaaa gaagagaact ccaaatgaaa ccacatcagt tttagaacca aaaaaagagc
     1621 ataaagaaaa agaaaaacaa ggaaggagta ggtcgggaag ttctagtagt ggtagttcca
     1681 gtagcaatag cagaactagt agtactagta gtactgtctc tagctcttca tacagttcta
     1741 gctcaggtag tagtcgtact tcttctcggt cttcttctcc taaaaggaaa aagagacaca
     1801 gtaggagtag atctccaaca atcaaagcta gacgtagcag gagtagaagc tattctcgca
     1861 gaattaaaat agagagcaat agggctaggg taaagattag agatagaagg agatctaata
     1921 gaaatagcat tgaaagagaa agacgacgaa atcggagtcc ttcccgagag agacgtagaa
     1981 gtagaagtcg ctcaagggat agacgaacca atcgtgccag tcgcagtagg agtcgagata
     2041 ggcgtaaaat tgatgatcaa cgtggaaatc ttagtgggaa cagtcataag cataaaggtg
     2101 aggctaaaga acaagagagg aaaaaggaga ggagtcgaag tatagataaa gataggaaaa
     2161 agaaagacaa agaaagggaa cgtgaacagg ataaaagaaa agagaaacaa aaaagggaag
     2221 aaaaagattt taagttcagt agtcaggatg atagattaaa aaggaaacga gaaagtgaaa
     2281 gaacattttc taggagtggt tctatatctg ttaaaatcat aagacatgat tctagacagg
     2341 atagtaagaa aagtactacc aaagatagta aaaaacattc aggctctgat tctagtggaa
     2401 ggagcagttc tgagtctcca ggaagtagca aagaaaagaa ggctaagaag cctaaacata
     2461 gtcgatcgcg atccgtggag aaatctcaaa ggtctggtaa gaaggcaagc cgcaaacaca
     2521 agtctaagtc ccgatcaaga tcaacaaccc ctccccgtcg taaacgctga ggaatgatgt
     2581 ggcaagaatg ccatgatgtt ctttaaaaaa attccatgag ttttaagggc ttgtctcatt
     2641 atagaggcac attgtggctg tgtaggtgaa accagaatct tttttttttt taatctgtaa
     2701 ataggtgtac tttttccaat gctgctccaa gttacttaat aggatttctt tgtattacgt
     2761 ttttttcaaa aaatatagtg cataataaga ctataaacat gccattctct ttcagctgta
     2821 atgttcttaa aattattctt gaatgtactg tgatgtcaat aaagctcttt agttcatttt
     2881 tgttaaactc ttgcacctta attttatggt tttaatctaa ggaacgtact tttataaaaa
     2941 ggcagctgga attttgtata acaggtttta aaggtacctt ctctcacctc ccccaaagaa
     3001 aatggttttt acttaatagt ttgtcaaagt ttgtaaattg tacccatgga cttttgccag
     3061 attccaactt taagggtatg aaagagggct agaaatagac ctttactttt catttggaag
     3121 tatttgacaa ctttctaaac ttttcttcct attttgggga ttttcaagta atatattctc
     3181 tgtgtgtata acgtgtggtt cactcctgta aaatgaaatt gctggaatca atcaagccag
     3241 tgcaccagta gagttatttg taaggaacga ttgtgtttga cagtaatagt caagtctgga
     3301 actatattct acagtcaccc acttctgttt tagaagcatt ttgaaacact ttttggggtt
     3361 atagaaataa gactcatgat tcaatatatt tatttatatt tttaaagtat aatatgacct
     3421 caaatcaatg gaggaatgct gtattatgca ggtttgtgtc aatttcctga cattaaaatt
     3481 gtctgatttt gtccgtttct taaaattatg attagtgagt ggtctaacag tttaaggcat
     3541 tgataactta caagtagaat ggggctctca aagcatttta actcagttgc tttagggtcc
     3601 atttttttat gtaatcactt actcagtgat aaatgaatct ctgaaaacaa atgcttttac
     3661 attttaattt aaaaagaaaa caggtgcagg ccacagaaaa gttttaaagt atgccttctt
     3721 accagcaata gttcatttta aaaatcatgc cagatttttg ccaagatcag tgtttcctca
     3781 acatgaagat agaaatagat ttgtatagtg tgctcttgta cctctacata gattattata
     3841 taattttgag cagttacaca tttatctaaa ggaaataaat caactgtgaa taaatgcatg
     3901 tttaccaaaa tggctgttta cagtgcattt agttctgata tttataaaga tgacatttca
     3961 cagaataact ttaaaatagt ttgaaattct atatagttta gacatcgatc acatctggag
     4021 acaaaataaa atgtgcaata ttttttatgt aggcgagcta acacagtgta cctaattgca
     4081 gaattatctg attaatttgt aatagataag ttgtataaca ttttcatatc ttaaaatgtt
     4141 ttttagatca atcttgaagt gaaatatttt caaaataaaa ttctacagaa aaattctgtt
     4201 ggctatgata tgcacatttt tgggcaagtt atgaactaga gccaaaagta gtatttgaca
     4261 gttttattta ctctgccgta atttgcaagc ttatcagtta agtctgtagt ttttttaaaa
     4321 gccgtcatga tatttgtgat tattagtaca taaaccagtg ttataatttg atatttgggt
     4381 ttttcagact tttagtggca gatttagaga attctttatt ttcttgacat gtgatatagt
     4441 atttatttac cttgagtggt aaggttttat aaggtagggt ttccatgatt taggatgtga
     4501 atgcaaaaac ttacacataa gttaattaga tgtataattt ggttatgaaa tcttttctaa
     4561 aataatacca ccagaaaatt aacagatcaa atttttgaga caatccttgg tctggattgg
     4621 ttaatgaaaa tgtcttgttt aagaggttct attaaaaaat atttctagtg tattagtcat
     4681 aattgttttt gtggagtggg ggtaaaccac accattaagg gaataaaatg taatttgaaa
     4741 gaggtgatta taagatttgt ttcaggcccc aaaatataaa taaaaattgg tgtggaatct
     4801 c
//
