LOCUS       NM_001322410            4881 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens PNN interacting serine and arginine rich protein
            (PNISR), transcript variant 6, mRNA.
ACCESSION   NM_001322410 XM_005266915
VERSION     NM_001322410.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4881)
  AUTHORS   Szlavicz,E., Olah,P., Szabo,K., Pagani,F., Bata-Csorgo,Z.,
            Kemeny,L. and Szell,M.
  TITLE     Analysis of psoriasis-relevant gene expression and exon usage
            alterations after silencing of SR-rich splicing regulators
  JOURNAL   Exp Dermatol 27 (6), 656-662 (2018)
   PUBMED   29512856
  REMARK    GeneRIF: In our present RNA-Seq experiment, we demonstrated that
            the LUC7L3 and SFRS18 splicing factors contribute to the regulation
            of several well-known psoriasis-associated pathways, including the
            IFN signalling pathway, antiviral immunity and ubiquitination.
REFERENCE   2  (bases 1 to 4881)
  AUTHORS   Szlavicz,E., Szabo,K., Groma,G., Bata-Csorgo,Z., Pagani,F.,
            Kemeny,L. and Szell,M.
  TITLE     Splicing factors differentially expressed in psoriasis alter mRNA
            maturation of disease-associated EDA+ fibronectin
  JOURNAL   Mol Cell Biochem 436 (1-2), 189-199 (2017)
   PUBMED   28589370
  REMARK    GeneRIF: results indicate that LUC7L3, PPIG, and SFRS18 are not
            only implicated in EDA+ fibronectin formation, but also that they
            could possess multiple roles in psoriasis-associated molecular
            abnormalities.
            Erratum:[Mol Cell Biochem. 2017 Dec;436(1-2):201. doi:
            10.1007/s11010-017-3105-y.. PMID: 28770468]
REFERENCE   3  (bases 1 to 4881)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 4881)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   5  (bases 1 to 4881)
  AUTHORS   Zimowska,G., Shi,J., Munguba,G., Jackson,M.R., Alpatov,R.,
            Simmons,M.N., Shi,Y. and Sugrue,S.P.
  TITLE     Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal
            epithelial cells
  JOURNAL   Invest Ophthalmol Vis Sci 44 (11), 4715-4723 (2003)
   PUBMED   14578391
REFERENCE   6  (bases 1 to 4881)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA326969.1, BC012780.2, AJ420559.1, BQ000404.1, AL513550.9 and
            BM893682.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001322410.1.
            
            Transcript Variant: This variant (6) splices out a portion of the
            3' terminal exon, resulting in an alternate 3' coding region,
            compared to variant 1. The encoded isoform (b) has a distinct and
            longer C-terminus, compared to isoform a. Variants 6, 7 and 8 all
            encode isoform b.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1103051.1,
                                           SRR14038192.3734302.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA326969.1         38-58
            22-1696             BC012780.2         1-1675
            1697-2294           AJ420559.1         973-1570
            2295-2967           BQ000404.1         16-688              c
            2968-4854           AL513550.9         43399-45285         c
            4855-4880           BM893682.1         16-41               c
            4881-4881           AL513550.9         43372-43372         c
FEATURES             Location/Qualifiers
     source          1..4881
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.2"
     gene            1..4881
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="PNN interacting serine and arginine rich protein"
                     /db_xref="GeneID:25957"
                     /db_xref="HGNC:HGNC:21222"
                     /db_xref="MIM:616653"
     exon            1..94
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            95..174
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            175..293
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2650
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="isoform b is encoded by transcript variant 6;
                     splicing factor, arginine/serine-rich 18; splicing factor,
                     arginine/serine-rich 130; PNN-interacting
                     serine/arginine-rich protein;
                     serine-arginine-rich-splicing regulatory protein 130;
                     SR-rich protein; SR-related protein; arginine/serine-rich
                     protein PNISR"
                     /codon_start=1
                     /product="arginine/serine-rich protein PNISR isoform b"
                     /protein_id="NP_001309339.1"
                     /db_xref="CCDS:CCDS93978.1"
                     /db_xref="GeneID:25957"
                     /db_xref="HGNC:HGNC:21222"
                     /db_xref="MIM:616653"
                     /translation="MWDQGGQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQ
                     REASGQQSMVEQPPGMMPNGQDMSTMESGPNNHGNFQGDSNFNRMWQPEWGMHQQPPH
                     PPPDQPWMPPTPGPMDIVPPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGP
                     VNQFDYQHGAAFGPPQGGFHPPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVK
                     QEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEG
                     GDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQM
                     MLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYG
                     SGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTER
                     VTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRS
                     RSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTI
                     KARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSR
                     DRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDK
                     EREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDS
                     KKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKH
                     KSKSRSRSTTPPRRKR"
     exon            294..482
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            483..706
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            707..878
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1069
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1207
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1307
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1361
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1532
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..2619
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..4881
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2938..2943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      2967
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="major polyA site"
     regulatory      3969..3974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      3990
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
     regulatory      4254..4259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      4273
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
     regulatory      4859..4864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      4881
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
ORIGIN      
        1 atcttgtctt gttcccgaag aagtagaagc atcgaaagcg ttggagaggt gttaccggaa
       61 cggcggcgac aagggtgttc ccgaactaga gtggggcata cataatcttg ctgctatgct
      121 tcgaagctgt agtctgaatc aacctaagtt ttaaacagaa ggtgaacctc tgagatagaa
      181 aatcaagtat attttaaaag aagggatgtg ggatcaagga ggacagcctt ggcagcagtg
      241 gcccttgaac cagcaacaat ggatgcagtc attccagcac caacaggatc caagccagat
      301 tgattgggct gcattggccc aagcttggat tgcccaaaga gaagcttcag gacagcaaag
      361 catggtagaa caaccaccag gaatgatgcc aaatggacaa gatatgtcta caatggaatc
      421 tggtccaaac aatcatggga atttccaagg ggattcaaac ttcaacagaa tgtggcaacc
      481 agaatgggga atgcatcagc aacccccaca cccccctcca gatcagccat ggatgccacc
      541 aacaccaggc ccaatggaca ttgttcctcc ttctgaagac agcaacagtc aggacagtgg
      601 ggaatttgcc cctgacaaca ggcatatatt taaccagaac aatcacaact ttggtggacc
      661 acccgataat tttgcagtgg ggccagtgaa ccagtttgac tatcagcatg gggctgcttt
      721 tggtccaccg caaggtggat ttcatcctcc ttattggcaa ccaggacctc caggacctcc
      781 agcacctccc cagaatcgaa gagaaaggcc atcatcattc agggatcgtc agcgttcacc
      841 tattgcactt cctgtgaagc aggagcctcc acaaattgac gcagtaaaac gcaggactct
      901 tcccgcttgg attcgcgaag gtcttgaaaa aatggaacgt gaaaagcaga agaaattgga
      961 gaaagaaaga atggaacaac aacgttcaca attgtccaaa aaagaaaaaa aggccacaga
     1021 agatgctgaa ggaggggatg gccctcgttt acctcagaga agtaaatttg atagtgatga
     1081 ggaagaagaa gacactgaaa atgttgaggc tgcaagtagt gggaaagtca ccagaagtcc
     1141 atccccagtt cctcaagaag agcacagtga ccctgagatg actgaagagg agaaagagta
     1201 tcaaatgatg ttgctgacaa aaatgcttct aacagaaatt ctgctggatg tcacagatga
     1261 agaaatttat tacgtagcca aagatgcaca ccgcaaagca acgaaagctc ctgcaaaaca
     1321 gctggcacag tccagtgcac tggcttccct cactggactc ggtggactgg gtggttatgg
     1381 atcaggagac agtgaagatg agaggagtga cagaggatct gagtcatctg acactgatga
     1441 tgaagaatta cggcatcgaa tccggcaaaa acaggaagct ttttggagaa aagaaaaaga
     1501 acagcagcta ttacatgata aacagatgga agaagaaaag cagcaaacag aaagggttac
     1561 aaaagagatg aatgaattta tccataaaga gcaaaatagt ttatcactac tagaagcaag
     1621 agaagcagac ggtgatgtgg ttaatgaaaa gaagagaact ccaaatgaaa ccacatcagt
     1681 tttagaacca aaaaaagagc ataaagaaaa agaaaaacaa ggaaggagta ggtcgggaag
     1741 ttctagtagt ggtagttcca gtagcaatag cagaactagt agtactagta gtactgtctc
     1801 tagctcttca tacagttcta gctcaggtag tagtcgtact tcttctcggt cttcttctcc
     1861 taaaaggaaa aagagacaca gtaggagtag atctccaaca atcaaagcta gacgtagcag
     1921 gagtagaagc tattctcgca gaattaaaat agagagcaat agggctaggg taaagattag
     1981 agatagaagg agatctaata gaaatagcat tgaaagagaa agacgacgaa atcggagtcc
     2041 ttcccgagag agacgtagaa gtagaagtcg ctcaagggat agacgaacca atcgtgccag
     2101 tcgcagtagg agtcgagata ggcgtaaaat tgatgatcaa cgtggaaatc ttagtgggaa
     2161 cagtcataag cataaaggtg aggctaaaga acaagagagg aaaaaggaga ggagtcgaag
     2221 tatagataaa gataggaaaa agaaagacaa agaaagggaa cgtgaacagg ataaaagaaa
     2281 agagaaacaa aaaagggaag aaaaagattt taagttcagt agtcaggatg atagattaaa
     2341 aaggaaacga gaaagtgaaa gaacattttc taggagtggt tctatatctg ttaaaatcat
     2401 aagacatgat tctagacagg atagtaagaa aagtactacc aaagatagta aaaaacattc
     2461 aggctctgat tctagtggaa ggagcagttc tgagtctcca ggaagtagca aagaaaagaa
     2521 ggctaagaag cctaaacata gtcgatcgcg atccgtggag aaatctcaaa ggtctggtaa
     2581 gaaggcaagc cgcaaacaca agtctaagtc ccgatcaaga tcaacaaccc ctccccgtcg
     2641 taaacgctga ggaatgatgt ggcaagaatg ccatgatgtt ctttaaaaaa attccatgag
     2701 ttttaagggc ttgtctcatt atagaggcac attgtggctg tgtaggtgaa accagaatct
     2761 tttttttttt taatctgtaa ataggtgtac tttttccaat gctgctccaa gttacttaat
     2821 aggatttctt tgtattacgt ttttttcaaa aaatatagtg cataataaga ctataaacat
     2881 gccattctct ttcagctgta atgttcttaa aattattctt gaatgtactg tgatgtcaat
     2941 aaagctcttt agttcatttt tgttaaactc ttgcacctta attttatggt tttaatctaa
     3001 ggaacgtact tttataaaaa ggcagctgga attttgtata acaggtttta aaggtacctt
     3061 ctctcacctc ccccaaagaa aatggttttt acttaatagt ttgtcaaagt ttgtaaattg
     3121 tacccatgga cttttgccag attccaactt taagggtatg aaagagggct agaaatagac
     3181 ctttactttt catttggaag tatttgacaa ctttctaaac ttttcttcct attttgggga
     3241 ttttcaagta atatattctc tgtgtgtata acgtgtggtt cactcctgta aaatgaaatt
     3301 gctggaatca atcaagccag tgcaccagta gagttatttg taaggaacga ttgtgtttga
     3361 cagtaatagt caagtctgga actatattct acagtcaccc acttctgttt tagaagcatt
     3421 ttgaaacact ttttggggtt atagaaataa gactcatgat tcaatatatt tatttatatt
     3481 tttaaagtat aatatgacct caaatcaatg gaggaatgct gtattatgca ggtttgtgtc
     3541 aatttcctga cattaaaatt gtctgatttt gtccgtttct taaaattatg attagtgagt
     3601 ggtctaacag tttaaggcat tgataactta caagtagaat ggggctctca aagcatttta
     3661 actcagttgc tttagggtcc atttttttat gtaatcactt actcagtgat aaatgaatct
     3721 ctgaaaacaa atgcttttac attttaattt aaaaagaaaa caggtgcagg ccacagaaaa
     3781 gttttaaagt atgccttctt accagcaata gttcatttta aaaatcatgc cagatttttg
     3841 ccaagatcag tgtttcctca acatgaagat agaaatagat ttgtatagtg tgctcttgta
     3901 cctctacata gattattata taattttgag cagttacaca tttatctaaa ggaaataaat
     3961 caactgtgaa taaatgcatg tttaccaaaa tggctgttta cagtgcattt agttctgata
     4021 tttataaaga tgacatttca cagaataact ttaaaatagt ttgaaattct atatagttta
     4081 gacatcgatc acatctggag acaaaataaa atgtgcaata ttttttatgt aggcgagcta
     4141 acacagtgta cctaattgca gaattatctg attaatttgt aatagataag ttgtataaca
     4201 ttttcatatc ttaaaatgtt ttttagatca atcttgaagt gaaatatttt caaaataaaa
     4261 ttctacagaa aaattctgtt ggctatgata tgcacatttt tgggcaagtt atgaactaga
     4321 gccaaaagta gtatttgaca gttttattta ctctgccgta atttgcaagc ttatcagtta
     4381 agtctgtagt ttttttaaaa gccgtcatga tatttgtgat tattagtaca taaaccagtg
     4441 ttataatttg atatttgggt ttttcagact tttagtggca gatttagaga attctttatt
     4501 ttcttgacat gtgatatagt atttatttac cttgagtggt aaggttttat aaggtagggt
     4561 ttccatgatt taggatgtga atgcaaaaac ttacacataa gttaattaga tgtataattt
     4621 ggttatgaaa tcttttctaa aataatacca ccagaaaatt aacagatcaa atttttgaga
     4681 caatccttgg tctggattgg ttaatgaaaa tgtcttgttt aagaggttct attaaaaaat
     4741 atttctagtg tattagtcat aattgttttt gtggagtggg ggtaaaccac accattaagg
     4801 gaataaaatg taatttgaaa gaggtgatta taagatttgt ttcaggcccc aaaatataaa
     4861 taaaaattgg tgtggaatct c
//
