LOCUS       NM_001322405            5109 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens PNN interacting serine and arginine rich protein
            (PNISR), transcript variant 3, mRNA.
ACCESSION   NM_001322405
VERSION     NM_001322405.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5109)
  AUTHORS   Szlavicz,E., Olah,P., Szabo,K., Pagani,F., Bata-Csorgo,Z.,
            Kemeny,L. and Szell,M.
  TITLE     Analysis of psoriasis-relevant gene expression and exon usage
            alterations after silencing of SR-rich splicing regulators
  JOURNAL   Exp Dermatol 27 (6), 656-662 (2018)
   PUBMED   29512856
  REMARK    GeneRIF: In our present RNA-Seq experiment, we demonstrated that
            the LUC7L3 and SFRS18 splicing factors contribute to the regulation
            of several well-known psoriasis-associated pathways, including the
            IFN signalling pathway, antiviral immunity and ubiquitination.
REFERENCE   2  (bases 1 to 5109)
  AUTHORS   Szlavicz,E., Szabo,K., Groma,G., Bata-Csorgo,Z., Pagani,F.,
            Kemeny,L. and Szell,M.
  TITLE     Splicing factors differentially expressed in psoriasis alter mRNA
            maturation of disease-associated EDA+ fibronectin
  JOURNAL   Mol Cell Biochem 436 (1-2), 189-199 (2017)
   PUBMED   28589370
  REMARK    GeneRIF: results indicate that LUC7L3, PPIG, and SFRS18 are not
            only implicated in EDA+ fibronectin formation, but also that they
            could possess multiple roles in psoriasis-associated molecular
            abnormalities.
            Erratum:[Mol Cell Biochem. 2017 Dec;436(1-2):201. doi:
            10.1007/s11010-017-3105-y.. PMID: 28770468]
REFERENCE   3  (bases 1 to 5109)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 5109)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   5  (bases 1 to 5109)
  AUTHORS   Zimowska,G., Shi,J., Munguba,G., Jackson,M.R., Alpatov,R.,
            Simmons,M.N., Shi,Y. and Sugrue,S.P.
  TITLE     Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal
            epithelial cells
  JOURNAL   Invest Ophthalmol Vis Sci 44 (11), 4715-4723 (2003)
   PUBMED   14578391
REFERENCE   6  (bases 1 to 5109)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA326969.1, BC064413.1, AL513550.9 and BM893682.1.
            
            On May 31, 2019 this sequence version replaced NM_001322405.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4 and 5 all encode isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.127045.1,
                                           SRR1803615.178299.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DA326969.1         38-62
            26-999              BC064413.1         1-974
            1000-1692           BC064413.1         976-1668
            1693-5082           AL513550.9         43399-46788         c
            5083-5108           BM893682.1         16-41               c
            5109-5109           AL513550.9         43372-43372         c
FEATURES             Location/Qualifiers
     source          1..5109
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.2"
     gene            1..5109
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="PNN interacting serine and arginine rich protein"
                     /db_xref="GeneID:25957"
                     /db_xref="HGNC:HGNC:21222"
                     /db_xref="MIM:616653"
     exon            1..94
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            95..174
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            175..289
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..2619
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="isoform a is encoded by transcript variant 3;
                     splicing factor, arginine/serine-rich 18; splicing factor,
                     arginine/serine-rich 130; PNN-interacting
                     serine/arginine-rich protein;
                     serine-arginine-rich-splicing regulatory protein 130;
                     SR-rich protein; SR-related protein; arginine/serine-rich
                     protein PNISR"
                     /codon_start=1
                     /product="arginine/serine-rich protein PNISR isoform a"
                     /protein_id="NP_001309334.1"
                     /db_xref="CCDS:CCDS5043.1"
                     /db_xref="GeneID:25957"
                     /db_xref="HGNC:HGNC:21222"
                     /db_xref="MIM:616653"
                     /translation="MWDQGGQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQ
                     REASGQQSMVEQPPGMMPNGQDMSTMESGPNNHGNFQGDSNFNRMWQPEWGMHQQPPH
                     PPPDQPWMPPTPGPMDIVPPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGP
                     VNQFDYQHGAAFGPPQGGFHPPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVK
                     QEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEG
                     GDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQM
                     MLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYG
                     SGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTER
                     VTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRS
                     RSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTI
                     KARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSR
                     DRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDK
                     EREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDS
                     KKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKH
                     KSKSRSR"
     exon            290..478
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            479..702
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            703..874
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1065
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1203
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1303
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1357
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1528
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..5109
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3166..3171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      3195
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="major polyA site"
     regulatory      4197..4202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      4218
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
     regulatory      4482..4487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      4501
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
     regulatory      5087..5092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
                     /note="hexamer: AATAAA"
     polyA_site      5109
                     /gene="PNISR"
                     /gene_synonym="bA98I9.2; C6orf111; HSPC306; SFRS18;
                     SRrp130"
ORIGIN      
        1 atcttgtctt gttcccgaag aagtagaagc atcgaaagcg ttggagaggt gttaccggaa
       61 cggcggcgac aagggtgttc ccgaactaga gtggggcata cataatcttg ctgctatgct
      121 tcgaagctgt agtctgaatc aacctaagtt ttaaacagaa ggtgaacctc tgagaaaatc
      181 aagtatattt taaaagaagg gatgtgggat caaggaggac agccttggca gcagtggccc
      241 ttgaaccagc aacaatggat gcagtcattc cagcaccaac aggatccaag ccagattgat
      301 tgggctgcat tggcccaagc ttggattgcc caaagagaag cttcaggaca gcaaagcatg
      361 gtagaacaac caccaggaat gatgccaaat ggacaagata tgtctacaat ggaatctggt
      421 ccaaacaatc atgggaattt ccaaggggat tcaaacttca acagaatgtg gcaaccagaa
      481 tggggaatgc atcagcaacc cccacacccc cctccagatc agccatggat gccaccaaca
      541 ccaggcccaa tggacattgt tcctccttct gaagacagca acagtcagga cagtggggaa
      601 tttgcccctg acaacaggca tatatttaac cagaacaatc acaactttgg tggaccaccc
      661 gataattttg cagtggggcc agtgaaccag tttgactatc agcatggggc tgcttttggt
      721 ccaccgcaag gtggatttca tcctccttat tggcaaccag gacctccagg acctccagca
      781 cctccccaga atcgaagaga aaggccatca tcattcaggg atcgtcagcg ttcacctatt
      841 gcacttcctg tgaagcagga gcctccacaa attgacgcag taaaacgcag gactcttccc
      901 gcttggattc gcgaaggtct tgaaaaaatg gaacgtgaaa agcagaagaa attggagaaa
      961 gaaagaatgg aacaacaacg ttcacaattg tccaaaaaag aaaaaaaggc cacagaagat
     1021 gctgaaggag gggatggccc tcgtttacct cagagaagta aatttgatag tgatgaggaa
     1081 gaagaagaca ctgaaaatgt tgaggctgca agtagtggga aagtcaccag aagtccatcc
     1141 ccagttcctc aagaagagca cagtgaccct gagatgactg aagaggagaa agagtatcaa
     1201 atgatgttgc tgacaaaaat gcttctaaca gaaattctgc tggatgtcac agatgaagaa
     1261 atttattacg tagccaaaga tgcacaccgc aaagcaacga aagctcctgc aaaacagctg
     1321 gcacagtcca gtgcactggc ttccctcact ggactcggtg gactgggtgg ttatggatca
     1381 ggagacagtg aagatgagag gagtgacaga ggatctgagt catctgacac tgatgatgaa
     1441 gaattacggc atcgaatccg gcaaaaacag gaagcttttt ggagaaaaga aaaagaacag
     1501 cagctattac atgataaaca gatggaagaa gaaaagcagc aaacagaaag ggttacaaaa
     1561 gagatgaatg aatttatcca taaagagcaa aatagtttat cactactaga agcaagagaa
     1621 gcagacggtg atgtggttaa tgaaaagaag agaactccaa atgaaaccac atcagtttta
     1681 gaaccaaaaa aagagcataa agaaaaagaa aaacaaggaa ggagtaggtc gggaagttct
     1741 agtagtggta gttccagtag caatagcaga actagtagta ctagtagtac tgtctctagc
     1801 tcttcataca gttctagctc aggtagtagt cgtacttctt ctcggtcttc ttctcctaaa
     1861 aggaaaaaga gacacagtag gagtagatct ccaacaatca aagctagacg tagcaggagt
     1921 agaagctatt ctcgcagaat taaaatagag agcaataggg ctagggtaaa gattagagat
     1981 agaaggagat ctaatagaaa tagcattgaa agagaaagac gacgaaatcg gagtccttcc
     2041 cgagagagac gtagaagtag aagtcgctca agggatagac gaaccaatcg tgccagtcgc
     2101 agtaggagtc gagataggcg taaaattgat gatcaacgtg gaaatcttag tgggaacagt
     2161 cataagcata aaggtgaggc taaagaacaa gagaggaaaa aggagaggag tcgaagtata
     2221 gataaagata ggaaaaagaa agacaaagaa agggaacgtg aacaggataa aagaaaagag
     2281 aaacaaaaaa gggaagaaaa agattttaag ttcagtagtc aggatgatag attaaaaagg
     2341 aaacgagaaa gtgaaagaac attttctagg agtggttcta tatctgttaa aatcataaga
     2401 catgattcta gacaggatag taagaaaagt actaccaaag atagtaaaaa acattcaggc
     2461 tctgattcta gtggaaggag cagttctgag tctccaggaa gtagcaaaga aaagaaggct
     2521 aagaagccta aacatagtcg atcgcgatcc gtggagaaat ctcaaaggtc tggtaagaag
     2581 gcaagccgca aacacaagtc taagtcccga tcaaggtagt atacttttta aagtattttg
     2641 tctgattttt aaaaaaaatt gactgaattt attcaaagtt gaaagtgtcc tttctctctc
     2701 tctttaataa actcagtttg gtacttgata aataatcata gtcttaaatg ttagaaatcc
     2761 tatataatat tatttattta aaattgcaga tttttaattt aaaatacatt tttattttta
     2821 aattttgtct tttccctttt ttttcagatc aacaacccct ccccgtcgta aacgctgagg
     2881 aatgatgtgg caagaatgcc atgatgttct ttaaaaaaat tccatgagtt ttaagggctt
     2941 gtctcattat agaggcacat tgtggctgtg taggtgaaac cagaatcttt ttttttttta
     3001 atctgtaaat aggtgtactt tttccaatgc tgctccaagt tacttaatag gatttctttg
     3061 tattacgttt ttttcaaaaa atatagtgca taataagact ataaacatgc cattctcttt
     3121 cagctgtaat gttcttaaaa ttattcttga atgtactgtg atgtcaataa agctctttag
     3181 ttcatttttg ttaaactctt gcaccttaat tttatggttt taatctaagg aacgtacttt
     3241 tataaaaagg cagctggaat tttgtataac aggttttaaa ggtaccttct ctcacctccc
     3301 ccaaagaaaa tggtttttac ttaatagttt gtcaaagttt gtaaattgta cccatggact
     3361 tttgccagat tccaacttta agggtatgaa agagggctag aaatagacct ttacttttca
     3421 tttggaagta tttgacaact ttctaaactt ttcttcctat tttggggatt ttcaagtaat
     3481 atattctctg tgtgtataac gtgtggttca ctcctgtaaa atgaaattgc tggaatcaat
     3541 caagccagtg caccagtaga gttatttgta aggaacgatt gtgtttgaca gtaatagtca
     3601 agtctggaac tatattctac agtcacccac ttctgtttta gaagcatttt gaaacacttt
     3661 ttggggttat agaaataaga ctcatgattc aatatattta tttatatttt taaagtataa
     3721 tatgacctca aatcaatgga ggaatgctgt attatgcagg tttgtgtcaa tttcctgaca
     3781 ttaaaattgt ctgattttgt ccgtttctta aaattatgat tagtgagtgg tctaacagtt
     3841 taaggcattg ataacttaca agtagaatgg ggctctcaaa gcattttaac tcagttgctt
     3901 tagggtccat ttttttatgt aatcacttac tcagtgataa atgaatctct gaaaacaaat
     3961 gcttttacat tttaatttaa aaagaaaaca ggtgcaggcc acagaaaagt tttaaagtat
     4021 gccttcttac cagcaatagt tcattttaaa aatcatgcca gatttttgcc aagatcagtg
     4081 tttcctcaac atgaagatag aaatagattt gtatagtgtg ctcttgtacc tctacataga
     4141 ttattatata attttgagca gttacacatt tatctaaagg aaataaatca actgtgaata
     4201 aatgcatgtt taccaaaatg gctgtttaca gtgcatttag ttctgatatt tataaagatg
     4261 acatttcaca gaataacttt aaaatagttt gaaattctat atagtttaga catcgatcac
     4321 atctggagac aaaataaaat gtgcaatatt ttttatgtag gcgagctaac acagtgtacc
     4381 taattgcaga attatctgat taatttgtaa tagataagtt gtataacatt ttcatatctt
     4441 aaaatgtttt ttagatcaat cttgaagtga aatattttca aaataaaatt ctacagaaaa
     4501 attctgttgg ctatgatatg cacatttttg ggcaagttat gaactagagc caaaagtagt
     4561 atttgacagt tttatttact ctgccgtaat ttgcaagctt atcagttaag tctgtagttt
     4621 ttttaaaagc cgtcatgata tttgtgatta ttagtacata aaccagtgtt ataatttgat
     4681 atttgggttt ttcagacttt tagtggcaga tttagagaat tctttatttt cttgacatgt
     4741 gatatagtat ttatttacct tgagtggtaa ggttttataa ggtagggttt ccatgattta
     4801 ggatgtgaat gcaaaaactt acacataagt taattagatg tataatttgg ttatgaaatc
     4861 ttttctaaaa taataccacc agaaaattaa cagatcaaat ttttgagaca atccttggtc
     4921 tggattggtt aatgaaaatg tcttgtttaa gaggttctat taaaaaatat ttctagtgta
     4981 ttagtcataa ttgtttttgt ggagtggggg taaaccacac cattaaggga ataaaatgta
     5041 atttgaaaga ggtgattata agatttgttt caggccccaa aatataaata aaaattggtg
     5101 tggaatctc
//
