LOCUS       NM_001366977            1473 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens pregnancy up-regulated nonubiquitous CaM kinase
            (PNCK), transcript variant 5, mRNA.
ACCESSION   NM_001366977 XM_005274651
VERSION     NM_001366977.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1473)
  AUTHORS   Cho,Y.A., Choi,S., Park,S., Park,C.K. and Ha,S.Y.
  TITLE     Expression of Pregnancy Up-regulated Non-ubiquitous Calmodulin
            Kinase (PNCK) in Hepatocellular Carcinoma
  JOURNAL   Cancer Genomics Proteomics 17 (6), 747-755 (2020)
   PUBMED   33099476
  REMARK    GeneRIF: Expression of Pregnancy Up-regulated Non-ubiquitous
            Calmodulin Kinase (PNCK) in Hepatocellular Carcinoma.
REFERENCE   2  (bases 1 to 1473)
  AUTHORS   Deb,T.B., Zuo,A.H., Barndt,R.J., Sengupta,S., Jankovic,R. and
            Johnson,M.D.
  TITLE     Pnck overexpression in HER-2 gene-amplified breast cancer causes
            Trastuzumab resistance through a paradoxical PTEN-mediated process
  JOURNAL   Breast Cancer Res Treat 150 (2), 347-361 (2015)
   PUBMED   25773930
  REMARK    GeneRIF: Pnck may be a marker of Trastuzumab resistance and
            possibly a therapeutic target in breast cancer.
REFERENCE   3  (bases 1 to 1473)
  AUTHORS   Wu,S., Lv,Z., Wang,Y., Sun,L., Jiang,Z., Xu,C., Zhao,J., Sun,X.,
            Li,X., Hu,L., Tang,A., Gui,Y., Zhou,F., Cai,Z. and Wang,R.
  TITLE     Increased expression of pregnancy up-regulated non-ubiquitous
            calmodulin kinase is associated with poor prognosis in clear cell
            renal cell carcinoma
  JOURNAL   PLoS One 8 (4), e59936 (2013)
   PUBMED   23634203
  REMARK    GeneRIF: the relationship between PNCK and prognosis in clear cell
            renal cell carcinoma
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1473)
  AUTHORS   Deb,T.B., Zuo,A.H., Wang,Y., Barndt,R.J., Cheema,A.K., Sengupta,S.,
            Coticchia,C.M. and Johnson,M.D.
  TITLE     Pnck induces ligand-independent EGFR degradation by probable
            perturbation of the Hsp90 chaperone complex
  JOURNAL   Am J Physiol Cell Physiol 300 (5), C1139-C1154 (2011)
   PUBMED   21325639
  REMARK    GeneRIF: Pnck induces epidermal growth factor receptor degradation,
            most likely through perturbation of Hsp90 chaperone activity due to
            Hsp90 phosphorylation.  Epidermal growth factor receptor
            degradation is coupled to proteasomal degradation of Pnck.
REFERENCE   5  (bases 1 to 1473)
  AUTHORS   Deb,T.B., Coticchia,C.M., Barndt,R., Zuo,H., Dickson,R.B. and
            Johnson,M.D.
  TITLE     Pregnancy-upregulated nonubiquitous calmodulin kinase induces
            ligand-independent EGFR degradation
  JOURNAL   Am J Physiol Cell Physiol 295 (2), C365-C377 (2008)
   PUBMED   18562482
  REMARK    GeneRIF: Pnck induces ligand-independent EGFR degradation, and it
            may represent an attractive therapeutic target in EGFR-regulated
            oncogenesis.
REFERENCE   6  (bases 1 to 1473)
  AUTHORS   Gardner,H.P., Ha,S.I., Reynolds,C. and Chodosh,L.A.
  TITLE     The caM kinase, Pnck, is spatially and temporally regulated during
            murine mammary gland development and may identify an epithelial
            cell subtype involved in breast cancer
  JOURNAL   Cancer Res 60 (19), 5571-5577 (2000)
   PUBMED   11034105
REFERENCE   7  (bases 1 to 1473)
  AUTHORS   Gardner,H.P., Rajan,J.V., Ha,S.I., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Marquis,S.T. and Chodosh,L.A.
  TITLE     Cloning, characterization, and chromosomal localization of Pnck, a
            Ca(2+)/calmodulin-dependent protein kinase
  JOURNAL   Genomics 63 (2), 279-288 (2000)
   PUBMED   10673339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U52111.3.
            
            On Oct 30, 2018 this sequence version replaced XM_005274651.2.
            
            Summary: PNCK is a member of the calcium/calmodulin-dependent
            protein kinase family of protein serine/threonine kinases (see
            CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed
            10673339]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (5), as well as variants 3, 6, 7,
            and 8, encodes isoform c.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1082285.1,
                                           SRR3476690.994398.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340888.8/ ENSP00000340586.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                U52111.3           56989-57022         c
            35-104              U52111.3           56218-56287         c
            105-236             U52111.3           55775-55906         c
            237-311             U52111.3           55335-55409         c
            312-450             U52111.3           55089-55227         c
            451-574             U52111.3           54758-54881         c
            575-650             U52111.3           54494-54569         c
            651-763             U52111.3           54287-54399         c
            764-842             U52111.3           54127-54205         c
            843-930             U52111.3           53953-54040         c
            931-1075            U52111.3           53659-53803         c
            1076-1473           U52111.3           52942-53339         c
FEATURES             Location/Qualifiers
     source          1..1473
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1473
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /note="pregnancy up-regulated nonubiquitous CaM kinase"
                     /db_xref="GeneID:139728"
                     /db_xref="HGNC:HGNC:13415"
                     /db_xref="MIM:300680"
     exon            1..34
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            35..104
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1068
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /EC_number="2.7.11.17"
                     /note="isoform c is encoded by transcript variant 5;
                     pregnancy upregulated non-ubiquitously expressed CaM
                     kinase; calcium/calmodulin-dependent protein kinase type
                     1B; caMKI-beta; caM-KI beta; caM kinase IB; caM kinase I
                     beta; pregnancy up-regulated non-ubiquitously-expressed
                     CaM kinase"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     1B isoform c"
                     /protein_id="NP_001353906.1"
                     /db_xref="CCDS:CCDS94698.1"
                     /db_xref="GeneID:139728"
                     /db_xref="HGNC:HGNC:13415"
                     /db_xref="MIM:300680"
                     /translation="MLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALK
                     CIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRI
                     MERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGL
                     SKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDP
                     ELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAF
                     DRDILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSG
                     LRAGQPPKW"
     exon            105..236
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            237..311
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            312..450
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            451..574
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            575..650
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            651..763
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            764..842
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            843..930
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1075
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1473
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1454..1459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /note="hexamer: AATAAA"
     polyA_site      1473
                     /gene="PNCK"
                     /gene_synonym="BSTK3; CaMK1b"
                     /note="major polyA site"
ORIGIN      
        1 actgcgcggc acgacgctgc ggcacccgct ccagacatgc tgctgctgaa gaaacacacg
       61 gaggacatca gcagcgtcta cgagatccgc gagaggctcg gctcgggtgc cttctccgag
      121 gtggtgctgg cccaggagcg gggctccgca cacctcgtgg ccctcaagtg catccccaag
      181 aaggccctcc ggggcaagga ggccctggtg gagaacgaga tcgcagtgct ccgtaggatc
      241 agtcacccca acatcgtcgc tctggaggat gtccacgaga gcccttccca cctctacctg
      301 gccatggaac tggtgacggg tggcgagctg tttgaccgca tcatggagcg cggctcctac
      361 acagagaagg atgccagcca tctggtgggt caggtccttg gcgccgtctc ctacctgcac
      421 agcctgggga tcgtgcaccg ggacctcaag cccgaaaacc tcctgtatgc cacgcccttt
      481 gaggactcga agatcatggt ctctgacttt ggactctcca aaatccaggc tgggaacatg
      541 ctaggcaccg cctgtgggac ccctggatat gtggccccag agctcttgga gcagaaaccc
      601 tacgggaagg ccgtagatgt gtgggccctg ggcgtcatct cctacatcct gctgtgtggg
      661 taccccccct tctacgacga gagcgaccct gagctcttca gccagatcct gagggccagc
      721 tatgagtttg actctccttt ctgggatgac atctcagaat cagccaaaga cttcatccgg
      781 caccttctgg agcgagaccc ccagaagagg ttcacctgcc aacaggcctt gcggcacctt
      841 tggatctctg gggacacagc cttcgacagg gacatcttag gctctgtcag tgagcagatc
      901 cggaagaact ttgctcggac acactggaag cgagccttca atgccacctc gttcctgcgc
      961 cacatccgga agctggggca gatcccagag ggcgaggggg cctctgagca gggcatggcc
     1021 cgccacagcc actcaggcct ccgtgctggc cagcccccca agtggtgatg cccaggcaga
     1081 tgccgaggcc aagtggactg acccccagat ttccttccct tggatgcttt cggtcccctc
     1141 ccccaacccc tccccctggg gctggcctct gctggatttt gagatttgag ggtgtggcgc
     1201 atggcgctgg ggttggaatg gggcaccccc aagtctgtcc ccaggctctg ccctgcctgg
     1261 gggcagtggc tcccctcccc tgttgcctct cccgcccctg ccccccccgc cccgccaaaa
     1321 gccgaggggg tgctggcagg cgggcctcag gggctgtctt tcctgcacgg ctgttgtgtg
     1381 cttcgctgag tgtgggtggt cctgcttgtg tcatggtcat ggccttccag ccccctccag
     1441 ttttccccaa accaataaag aaagatacag caa
//
