LOCUS       XM_047444778            2458 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens PMS1 homolog 1, mismatch repair system
            component (PMS1), transcript variant X11, mRNA.
ACCESSION   XM_047444778
VERSION     XM_047444778.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2458
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..2458
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /note="PMS1 homolog 1, mismatch repair system component;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 27 ESTs, 225 long SRA reads, 2 Proteins,
                     and 100% coverage of the annotated genomic feature by
                     RNAseq alignments, including 10 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
     CDS             136..2265
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /codon_start=1
                     /product="PMS1 protein homolog 1 isoform X6"
                     /protein_id="XP_047300734.1"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
                     /translation="MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKL
                     VLITTRTAADNFSTQYVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAK
                     KCKDEIKKIQDLLMSFGILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNN
                     MESFQYHSEESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHH
                     YNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCY
                     GPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMH
                     NDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSWENSQTEY
                     SKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKNSVGEN
                     IEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLLSNR
                     VIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSEEEKLNLFNGSHYL
                     DVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGV
                     ADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMK
                     HQFGNEIKECVHGRPFFHHLTYLPETT"
ORIGIN      
        1 agtgccgcgc tctctgcacc cgctctgccg cgcgcgtgcg tgctgggtgc gggtgcgggt
       61 gcggggttgg gcctgcgcat cgggtgagac gctggctgct tgcggctagt ggatgctgct
      121 ctgttaaaag cgaaaatgaa acaattgcct gcggcaacag ttcgactcct ttcaagttct
      181 cagatcatca cttcggtggt cagtgttgta aaagagctta ttgaaaactc cttggatgct
      241 ggtgccacaa gcgtagatgt taaactggtt ttaattacaa caagaacggc tgctgataat
      301 tttagcaccc agtatgtttt agatggcagt ggccacatac tttctcagaa accttcacat
      361 cttggtcaag gtacaactgt aactgcttta agattattta agaatctacc tgtaagaaag
      421 cagttttact caactgcaaa aaaatgtaaa gatgaaataa aaaagatcca agatctcctc
      481 atgagctttg gtatccttaa acctgactta aggattgtct ttgtacataa caaggcagtt
      541 atttggcaga aaagcagagt atcagatcac aagatggctc tcatgtcagt tctggggact
      601 gctgttatga acaatatgga atcctttcag taccactctg aagaatctca gatttatctc
      661 agtggatttc ttccaaagtg tgatgcagac cactctttca ctagtctttc aacaccagaa
      721 agaagtttca tcttcataaa cagtcgacca gtacatcaaa aagatatctt aaagttaatc
      781 cgacatcatt acaatctgaa atgcctaaag gaatctactc gtttgtatcc tgttttcttt
      841 ctgaaaatcg atgttcctac agctgatgtt gatgtaaatt taacaccaga taaaagccaa
      901 gtattattac aaaataagga atctgtttta attgctcttg aaaatctgat gacgacttgt
      961 tatggaccat tacctagtac aaattcttat gaaaataata aaacagatgt ttccgcagct
     1021 gacatcgttc ttagtaaaac agcagaaaca gatgtgcttt ttaataaagt ggaatcatct
     1081 ggaaagaatt attcaaatgt tgatacttca gtcattccat tccaaaatga tatgcataat
     1141 gatgaatctg gaaaaaacac tgatgattgt ttaaatcacc agataagtat tggtgacttt
     1201 ggttatggtc attgtagtag tgaaatttct aacattgata aaaacactaa gaatgcattt
     1261 caggacattt caatgagtaa tgtatcatgg gagaactctc agacggaata tagtaaaact
     1321 tgttttataa gttccgttaa gcacacccag tcagaaaatg gcaataaaga ccatatagat
     1381 gagagtgggg aaaatgagga agaagcaggt cttgaaaact cttcggaaat ttctgcagat
     1441 gagtggagca ggggaaatat acttaaaaat tcagtgggag agaatattga acctgtgaaa
     1501 attttagtgc ctgaaaaaag tttaccatgt aaagtaagta ataataatta tccaatccct
     1561 gaacaaatga atcttaatga agattcatgt aacaaaaaat caaatgtaat agataataaa
     1621 tctggaaaag ttacagctta tgatttactt agcaatcgag taatcaagaa acccatgtca
     1681 gcaagtgctc tttttgttca agatcatcgt cctcagtttc tcatagaaaa tcctaagact
     1741 agtttagagg atgcaacact acaaattgaa gaactgtgga agacattgag tgaagaggaa
     1801 aaactgaatc tttttaatgg atctcattat ttagacgttt tatataaaat gacagcagat
     1861 gaccaaagat acagtggatc aacttacctg tctgatcctc gtcttacagc gaatggtttc
     1921 aagataaaat tgataccagg agtttcaatt actgaaaatt acttggaaat agaaggaatg
     1981 gctaattgtc tcccattcta tggagtagca gatttaaaag aaattcttaa tgctatatta
     2041 aacagaaatg caaaggaagt ttatgaatgt agacctcgca aagtgataag ttatttagag
     2101 ggagaagcag tgcgtctatc cagacaatta cccatgtact tatcaaaaga ggacatccaa
     2161 gacattatct acagaatgaa gcaccagttt ggaaatgaaa ttaaagagtg tgttcatggt
     2221 cgcccatttt ttcatcattt aacctatctt ccagaaacta catgattaaa tatgtttaag
     2281 aagattagtt accattgaaa ttggttctgt cataaaacag catgagtctg gttttaaatt
     2341 atctttgtat tatgtgtcac atggttattt tttaaatgag gattcactga cttgttttta
     2401 tattgaaaaa agttccacgt attgtagaaa acgtaaataa actaatatag actattca
//
