LOCUS       XM_047444776            2732 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens PMS1 homolog 1, mismatch repair system
            component (PMS1), transcript variant X6, mRNA.
ACCESSION   XM_047444776
VERSION     XM_047444776.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2732
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..2732
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /note="PMS1 homolog 1, mismatch repair system component;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 3 mRNAs, 17 ESTs, 173 long SRA reads, 6
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 14 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
     CDS             291..2645
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /codon_start=1
                     /product="PMS1 protein homolog 1 isoform X3"
                     /protein_id="XP_047300732.1"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
                     /translation="MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKL
                     ENYGFDKIEVRDNGEGIKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICC
                     IAEVLITTRTAADNFSTQYVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYS
                     TAKKCKDEIKKIQDLLMSFGILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAV
                     MNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLI
                     RHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMT
                     TCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTSVIPFQN
                     DMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSWENSQ
                     TEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKNSV
                     GENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLL
                     SNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSEEEKLKYEEKA
                     TKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELL
                     QSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTS
                     KTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTERRFI"
ORIGIN      
        1 agtgccgcgc tctctgcacc cgctctgccg cgcgcgtgcg tgctgggtgc gggtgcgggt
       61 gcggggttgg gcctgcgcat cgggtgagac gctggctgct tgcggctagt ggatggtaat
      121 tgcctgcctc gcgctagcag gaaggcacac ctgttgtcct taactgactt tccgggtcat
      181 cagcacttct tcagaagtgt tccttttccc tcccagcaaa tatggaagac tgactatcct
      241 gatattccca gacattcttt gctgtgattt ctgctctgtt aaaagcgaaa atgaaacaat
      301 tgcctgcggc aacagttcga ctcctttcaa gttctcagat catcacttcg gtggtcagtg
      361 ttgtaaaaga gcttattgaa aactccttgg atgctggtgc cacaagcgta gatgttaaac
      421 tggagaacta tggatttgat aaaattgagg tgcgagataa cggggagggt atcaaggctg
      481 ttgatgcacc tgtaatggca atgaagtact acacctcaaa aataaatagt catgaagatc
      541 ttgaaaattt gacaacttac ggttttcgtg gagaagcctt ggggtcaatt tgttgtatag
      601 ctgaggtttt aattacaaca agaacggctg ctgataattt tagcacccag tatgttttag
      661 atggcagtgg ccacatactt tctcagaaac cttcacatct tggtcaaggt acaactgtaa
      721 ctgctttaag attatttaag aatctacctg taagaaagca gttttactca actgcaaaaa
      781 aatgtaaaga tgaaataaaa aagatccaag atctcctcat gagctttggt atccttaaac
      841 ctgacttaag gattgtcttt gtacataaca aggcagttat ttggcagaaa agcagagtat
      901 cagatcacaa gatggctctc atgtcagttc tggggactgc tgttatgaac aatatggaat
      961 cctttcagta ccactctgaa gaatctcaga tttatctcag tggatttctt ccaaagtgtg
     1021 atgcagacca ctctttcact agtctttcaa caccagaaag aagtttcatc ttcataaaca
     1081 gtcgaccagt acatcaaaaa gatatcttaa agttaatccg acatcattac aatctgaaat
     1141 gcctaaagga atctactcgt ttgtatcctg ttttctttct gaaaatcgat gttcctacag
     1201 ctgatgttga tgtaaattta acaccagata aaagccaagt attattacaa aataaggaat
     1261 ctgttttaat tgctcttgaa aatctgatga cgacttgtta tggaccatta cctagtacaa
     1321 attcttatga aaataataaa acagatgttt ccgcagctga catcgttctt agtaaaacag
     1381 cagaaacaga tgtgcttttt aataaagtgg aatcatctgg aaagaattat tcaaatgttg
     1441 atacttcagt cattccattc caaaatgata tgcataatga tgaatctgga aaaaacactg
     1501 atgattgttt aaatcaccag ataagtattg gtgactttgg ttatggtcat tgtagtagtg
     1561 aaatttctaa cattgataaa aacactaaga atgcatttca ggacatttca atgagtaatg
     1621 tatcatggga gaactctcag acggaatata gtaaaacttg ttttataagt tccgttaagc
     1681 acacccagtc agaaaatggc aataaagacc atatagatga gagtggggaa aatgaggaag
     1741 aagcaggtct tgaaaactct tcggaaattt ctgcagatga gtggagcagg ggaaatatac
     1801 ttaaaaattc agtgggagag aatattgaac ctgtgaaaat tttagtgcct gaaaaaagtt
     1861 taccatgtaa agtaagtaat aataattatc caatccctga acaaatgaat cttaatgaag
     1921 attcatgtaa caaaaaatca aatgtaatag ataataaatc tggaaaagtt acagcttatg
     1981 atttacttag caatcgagta atcaagaaac ccatgtcagc aagtgctctt tttgttcaag
     2041 atcatcgtcc tcagtttctc atagaaaatc ctaagactag tttagaggat gcaacactac
     2101 aaattgaaga actgtggaag acattgagtg aagaggaaaa actgaaatat gaagagaagg
     2161 ctactaaaga cttggaacga tacaatagtc aaatgaagag agccattgaa caggagtcac
     2221 aaatgtcact aaaagatggc agaaaaaaga taaaacccac cagcgcatgg aatttggccc
     2281 agaagcacaa gttaaaaacc tcattatcta atcaaccaaa acttgatgaa ctccttcagt
     2341 cccaaattga aaaaagaagg agtcaaaata ttaaaatggt acagatcccc ttttctatga
     2401 aaaacttaaa aataaatttt aagaaacaaa acaaagttga cttagaagag aaggatgaac
     2461 cttgcttgat ccacaatctc aggtttcctg atgcatggct aatgacatcc aaaacagagg
     2521 taatgttatt aaatccatat agagtagaag aagccctgct atttaaaaga cttcttgaga
     2581 atcataaact tcctgcagag ccactggaaa agccaattat gttaacagag agacgtttta
     2641 tataaaatga cagcagatga ccaaagatac agtggatcaa cttacctgtc tgatcctcgt
     2701 cttacagcga atggtttcaa gataaaattg at
//
