LOCUS       XM_024452967            3010 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens PMS1 homolog 1, mismatch repair system
            component (PMS1), transcript variant X4, mRNA.
ACCESSION   XM_024452967
VERSION     XM_024452967.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_024452967.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3010
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..3010
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /note="PMS1 homolog 1, mismatch repair system component;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 3 mRNAs, 30 ESTs, 468 long SRA reads, 6
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 37 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
     CDS             136..2817
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /codon_start=1
                     /product="PMS1 protein homolog 1 isoform X1"
                     /protein_id="XP_024308735.1"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
                     /translation="MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKL
                     ENYGFDKIEVRDNGEGIKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICC
                     IAEVLITTRTAADNFSTQYVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYS
                     TAKKCKDEIKKIQDLLMSFGILKPDLRIVFVHNKIYLSGFLPKCDADHSFTSLSTPER
                     SFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKS
                     QVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKV
                     ESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKN
                     TKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLEN
                     SSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCN
                     KKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQI
                     EELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLA
                     QKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEEK
                     DEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLT
                     ESLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEG
                     MANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKE
                     DIQDIIYRMKHQFGNEIKECVHGRPFFHHLTYLPETT"
ORIGIN      
        1 agtgccgcgc tctctgcacc cgctctgccg cgcgcgtgcg tgctgggtgc gggtgcgggt
       61 gcggggttgg gcctgcgcat cgggtgagac gctggctgct tgcggctagt ggatgctgct
      121 ctgttaaaag cgaaaatgaa acaattgcct gcggcaacag ttcgactcct ttcaagttct
      181 cagatcatca cttcggtggt cagtgttgta aaagagctta ttgaaaactc cttggatgct
      241 ggtgccacaa gcgtagatgt taaactggag aactatggat ttgataaaat tgaggtgcga
      301 gataacgggg agggtatcaa ggctgttgat gcacctgtaa tggcaatgaa gtactacacc
      361 tcaaaaataa atagtcatga agatcttgaa aatttgacaa cttacggttt tcgtggagaa
      421 gccttggggt caatttgttg tatagctgag gttttaatta caacaagaac ggctgctgat
      481 aattttagca cccagtatgt tttagatggc agtggccaca tactttctca gaaaccttca
      541 catcttggtc aaggtacaac tgtaactgct ttaagattat ttaagaatct acctgtaaga
      601 aagcagtttt actcaactgc aaaaaaatgt aaagatgaaa taaaaaagat ccaagatctc
      661 ctcatgagct ttggtatcct taaacctgac ttaaggattg tctttgtaca taacaagatt
      721 tatctcagtg gatttcttcc aaagtgtgat gcagaccact ctttcactag tctttcaaca
      781 ccagaaagaa gtttcatctt cataaacagt cgaccagtac atcaaaaaga tatcttaaag
      841 ttaatccgac atcattacaa tctgaaatgc ctaaaggaat ctactcgttt gtatcctgtt
      901 ttctttctga aaatcgatgt tcctacagct gatgttgatg taaatttaac accagataaa
      961 agccaagtat tattacaaaa taaggaatct gttttaattg ctcttgaaaa tctgatgacg
     1021 acttgttatg gaccattacc tagtacaaat tcttatgaaa ataataaaac agatgtttcc
     1081 gcagctgaca tcgttcttag taaaacagca gaaacagatg tgctttttaa taaagtggaa
     1141 tcatctggaa agaattattc aaatgttgat acttcagtca ttccattcca aaatgatatg
     1201 cataatgatg aatctggaaa aaacactgat gattgtttaa atcaccagat aagtattggt
     1261 gactttggtt atggtcattg tagtagtgaa atttctaaca ttgataaaaa cactaagaat
     1321 gcatttcagg acatttcaat gagtaatgta tcatgggaga actctcagac ggaatatagt
     1381 aaaacttgtt ttataagttc cgttaagcac acccagtcag aaaatggcaa taaagaccat
     1441 atagatgaga gtggggaaaa tgaggaagaa gcaggtcttg aaaactcttc ggaaatttct
     1501 gcagatgagt ggagcagggg aaatatactt aaaaattcag tgggagagaa tattgaacct
     1561 gtgaaaattt tagtgcctga aaaaagttta ccatgtaaag taagtaataa taattatcca
     1621 atccctgaac aaatgaatct taatgaagat tcatgtaaca aaaaatcaaa tgtaatagat
     1681 aataaatctg gaaaagttac agcttatgat ttacttagca atcgagtaat caagaaaccc
     1741 atgtcagcaa gtgctctttt tgttcaagat catcgtcctc agtttctcat agaaaatcct
     1801 aagactagtt tagaggatgc aacactacaa attgaagaac tgtggaagac attgagtgaa
     1861 gaggaaaaac tgaaatatga agagaaggct actaaagact tggaacgata caatagtcaa
     1921 atgaagagag ccattgaaca ggagtcacaa atgtcactaa aagatggcag aaaaaagata
     1981 aaacccacca gcgcatggaa tttggcccag aagcacaagt taaaaacctc attatctaat
     2041 caaccaaaac ttgatgaact ccttcagtcc caaattgaaa aaagaaggag tcaaaatatt
     2101 aaaatggtac agatcccctt ttctatgaaa aacttaaaaa taaattttaa gaaacaaaac
     2161 aaagttgact tagaagagaa ggatgaacct tgcttgatcc acaatctcag gtttcctgat
     2221 gcatggctaa tgacatccaa aacagaggta atgttattaa atccatatag agtagaagaa
     2281 gccctgctat ttaaaagact tcttgagaat cataaacttc ctgcagagcc actggaaaag
     2341 ccaattatgt taacagagag tctttttaat ggatctcatt atttagacgt tttatataaa
     2401 atgacagcag atgaccaaag atacagtgga tcaacttacc tgtctgatcc tcgtcttaca
     2461 gcgaatggtt tcaagataaa attgatacca ggagtttcaa ttactgaaaa ttacttggaa
     2521 atagaaggaa tggctaattg tctcccattc tatggagtag cagatttaaa agaaattctt
     2581 aatgctatat taaacagaaa tgcaaaggaa gtttatgaat gtagacctcg caaagtgata
     2641 agttatttag agggagaagc agtgcgtcta tccagacaat tacccatgta cttatcaaaa
     2701 gaggacatcc aagacattat ctacagaatg aagcaccagt ttggaaatga aattaaagag
     2761 tgtgttcatg gtcgcccatt ttttcatcat ttaacctatc ttccagaaac tacatgatta
     2821 aatatgttta agaagattag ttaccattga aattggttct gtcataaaac agcatgagtc
     2881 tggttttaaa ttatctttgt attatgtgtc acatggttat tttttaaatg aggattcact
     2941 gacttgtttt tatattgaaa aaagttccac gtattgtaga aaacgtaaat aaactaatat
     3001 agactattca
//
