LOCUS       XM_024452966            3060 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens PMS1 homolog 1, mismatch repair system
            component (PMS1), transcript variant X1, mRNA.
ACCESSION   XM_024452966
VERSION     XM_024452966.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_024452966.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3060
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..3060
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /note="PMS1 homolog 1, mismatch repair system component;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 3 mRNAs, 29 ESTs, 465 long SRA reads, 6
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 31 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
     CDS             186..2867
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /codon_start=1
                     /product="PMS1 protein homolog 1 isoform X1"
                     /protein_id="XP_024308734.1"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
                     /translation="MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKL
                     ENYGFDKIEVRDNGEGIKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICC
                     IAEVLITTRTAADNFSTQYVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYS
                     TAKKCKDEIKKIQDLLMSFGILKPDLRIVFVHNKIYLSGFLPKCDADHSFTSLSTPER
                     SFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKS
                     QVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKV
                     ESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKN
                     TKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLEN
                     SSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCN
                     KKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQI
                     EELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLA
                     QKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEEK
                     DEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLT
                     ESLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEG
                     MANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKE
                     DIQDIIYRMKHQFGNEIKECVHGRPFFHHLTYLPETT"
ORIGIN      
        1 agtgccgcgc tctctgcacc cgctctgccg cgcgcgtgcg tgctgggtgc gggtgcgggt
       61 gcggggttgg gcctgcgcat cgggtgagac gctggctgct tgcggctagt ggatggtaat
      121 tgcctgcctc gcgctagcag gaaggtagtg tggtgtgact aacggctgct ctgttaaaag
      181 cgaaaatgaa acaattgcct gcggcaacag ttcgactcct ttcaagttct cagatcatca
      241 cttcggtggt cagtgttgta aaagagctta ttgaaaactc cttggatgct ggtgccacaa
      301 gcgtagatgt taaactggag aactatggat ttgataaaat tgaggtgcga gataacgggg
      361 agggtatcaa ggctgttgat gcacctgtaa tggcaatgaa gtactacacc tcaaaaataa
      421 atagtcatga agatcttgaa aatttgacaa cttacggttt tcgtggagaa gccttggggt
      481 caatttgttg tatagctgag gttttaatta caacaagaac ggctgctgat aattttagca
      541 cccagtatgt tttagatggc agtggccaca tactttctca gaaaccttca catcttggtc
      601 aaggtacaac tgtaactgct ttaagattat ttaagaatct acctgtaaga aagcagtttt
      661 actcaactgc aaaaaaatgt aaagatgaaa taaaaaagat ccaagatctc ctcatgagct
      721 ttggtatcct taaacctgac ttaaggattg tctttgtaca taacaagatt tatctcagtg
      781 gatttcttcc aaagtgtgat gcagaccact ctttcactag tctttcaaca ccagaaagaa
      841 gtttcatctt cataaacagt cgaccagtac atcaaaaaga tatcttaaag ttaatccgac
      901 atcattacaa tctgaaatgc ctaaaggaat ctactcgttt gtatcctgtt ttctttctga
      961 aaatcgatgt tcctacagct gatgttgatg taaatttaac accagataaa agccaagtat
     1021 tattacaaaa taaggaatct gttttaattg ctcttgaaaa tctgatgacg acttgttatg
     1081 gaccattacc tagtacaaat tcttatgaaa ataataaaac agatgtttcc gcagctgaca
     1141 tcgttcttag taaaacagca gaaacagatg tgctttttaa taaagtggaa tcatctggaa
     1201 agaattattc aaatgttgat acttcagtca ttccattcca aaatgatatg cataatgatg
     1261 aatctggaaa aaacactgat gattgtttaa atcaccagat aagtattggt gactttggtt
     1321 atggtcattg tagtagtgaa atttctaaca ttgataaaaa cactaagaat gcatttcagg
     1381 acatttcaat gagtaatgta tcatgggaga actctcagac ggaatatagt aaaacttgtt
     1441 ttataagttc cgttaagcac acccagtcag aaaatggcaa taaagaccat atagatgaga
     1501 gtggggaaaa tgaggaagaa gcaggtcttg aaaactcttc ggaaatttct gcagatgagt
     1561 ggagcagggg aaatatactt aaaaattcag tgggagagaa tattgaacct gtgaaaattt
     1621 tagtgcctga aaaaagttta ccatgtaaag taagtaataa taattatcca atccctgaac
     1681 aaatgaatct taatgaagat tcatgtaaca aaaaatcaaa tgtaatagat aataaatctg
     1741 gaaaagttac agcttatgat ttacttagca atcgagtaat caagaaaccc atgtcagcaa
     1801 gtgctctttt tgttcaagat catcgtcctc agtttctcat agaaaatcct aagactagtt
     1861 tagaggatgc aacactacaa attgaagaac tgtggaagac attgagtgaa gaggaaaaac
     1921 tgaaatatga agagaaggct actaaagact tggaacgata caatagtcaa atgaagagag
     1981 ccattgaaca ggagtcacaa atgtcactaa aagatggcag aaaaaagata aaacccacca
     2041 gcgcatggaa tttggcccag aagcacaagt taaaaacctc attatctaat caaccaaaac
     2101 ttgatgaact ccttcagtcc caaattgaaa aaagaaggag tcaaaatatt aaaatggtac
     2161 agatcccctt ttctatgaaa aacttaaaaa taaattttaa gaaacaaaac aaagttgact
     2221 tagaagagaa ggatgaacct tgcttgatcc acaatctcag gtttcctgat gcatggctaa
     2281 tgacatccaa aacagaggta atgttattaa atccatatag agtagaagaa gccctgctat
     2341 ttaaaagact tcttgagaat cataaacttc ctgcagagcc actggaaaag ccaattatgt
     2401 taacagagag tctttttaat ggatctcatt atttagacgt tttatataaa atgacagcag
     2461 atgaccaaag atacagtgga tcaacttacc tgtctgatcc tcgtcttaca gcgaatggtt
     2521 tcaagataaa attgatacca ggagtttcaa ttactgaaaa ttacttggaa atagaaggaa
     2581 tggctaattg tctcccattc tatggagtag cagatttaaa agaaattctt aatgctatat
     2641 taaacagaaa tgcaaaggaa gtttatgaat gtagacctcg caaagtgata agttatttag
     2701 agggagaagc agtgcgtcta tccagacaat tacccatgta cttatcaaaa gaggacatcc
     2761 aagacattat ctacagaatg aagcaccagt ttggaaatga aattaaagag tgtgttcatg
     2821 gtcgcccatt ttttcatcat ttaacctatc ttccagaaac tacatgatta aatatgttta
     2881 agaagattag ttaccattga aattggttct gtcataaaac agcatgagtc tggttttaaa
     2941 ttatctttgt attatgtgtc acatggttat tttttaaatg aggattcact gacttgtttt
     3001 tatattgaaa aaagttccac gtattgtaga aaacgtaaat aaactaatat agactattca
//
