LOCUS       XM_017004348            2847 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens PMS1 homolog 1, mismatch repair system
            component (PMS1), transcript variant X8, mRNA.
ACCESSION   XM_017004348
VERSION     XM_017004348.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017004348.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2847
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..2847
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /note="PMS1 homolog 1, mismatch repair system component;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 4 mRNAs, 28 ESTs, 294 long SRA reads, 8
                     Proteins, and 99% coverage of the annotated genomic
                     feature by RNAseq alignments, including 7 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
     CDS             342..2654
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /codon_start=1
                     /product="PMS1 protein homolog 1 isoform X4"
                     /protein_id="XP_016859837.1"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
                     /translation="MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKL
                     ENYGFDKIEVRDNGEGIKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICC
                     IAEVLITTRTAADNFSTQYVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYS
                     TAKKCKDEIKKIQDLLMSFGILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAV
                     MNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLI
                     RHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMT
                     TCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTSVIPFQN
                     DMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSWENSQ
                     TEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKNSV
                     GENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLL
                     SNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSEEEKLNLFNGS
                     HYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPF
                     YGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIY
                     RMKHQFGNEIKECVHGRPFFHHLTYLPETT"
ORIGIN      
        1 agtgccgcgc tctctgcacc cgctctgccg cgcgcgtgcg tgctgggtgc gggtgcgggt
       61 gcggggttgg gcctgcgcat cgggtgagac gctggctgct tgcggctagt ggatggtaat
      121 tgcctgcctc gcgctagcag gaaggtagtg tggtgtgact aacgggtatt tattatatcc
      181 tcgatggctc gagggccccg tcccctctac tcgtcctggt ccgggcgcga acgctatagg
      241 gcagctaagg gcgctccccg cggggcggga agcgaagccg ggcttgcggg cgcgcacacg
      301 tggaacgcgt tttctgagca gctgctctgt taaaagcgaa aatgaaacaa ttgcctgcgg
      361 caacagttcg actcctttca agttctcaga tcatcacttc ggtggtcagt gttgtaaaag
      421 agcttattga aaactccttg gatgctggtg ccacaagcgt agatgttaaa ctggagaact
      481 atggatttga taaaattgag gtgcgagata acggggaggg tatcaaggct gttgatgcac
      541 ctgtaatggc aatgaagtac tacacctcaa aaataaatag tcatgaagat cttgaaaatt
      601 tgacaactta cggttttcgt ggagaagcct tggggtcaat ttgttgtata gctgaggttt
      661 taattacaac aagaacggct gctgataatt ttagcaccca gtatgtttta gatggcagtg
      721 gccacatact ttctcagaaa ccttcacatc ttggtcaagg tacaactgta actgctttaa
      781 gattatttaa gaatctacct gtaagaaagc agttttactc aactgcaaaa aaatgtaaag
      841 atgaaataaa aaagatccaa gatctcctca tgagctttgg tatccttaaa cctgacttaa
      901 ggattgtctt tgtacataac aaggcagtta tttggcagaa aagcagagta tcagatcaca
      961 agatggctct catgtcagtt ctggggactg ctgttatgaa caatatggaa tcctttcagt
     1021 accactctga agaatctcag atttatctca gtggatttct tccaaagtgt gatgcagacc
     1081 actctttcac tagtctttca acaccagaaa gaagtttcat cttcataaac agtcgaccag
     1141 tacatcaaaa agatatctta aagttaatcc gacatcatta caatctgaaa tgcctaaagg
     1201 aatctactcg tttgtatcct gttttctttc tgaaaatcga tgttcctaca gctgatgttg
     1261 atgtaaattt aacaccagat aaaagccaag tattattaca aaataaggaa tctgttttaa
     1321 ttgctcttga aaatctgatg acgacttgtt atggaccatt acctagtaca aattcttatg
     1381 aaaataataa aacagatgtt tccgcagctg acatcgttct tagtaaaaca gcagaaacag
     1441 atgtgctttt taataaagtg gaatcatctg gaaagaatta ttcaaatgtt gatacttcag
     1501 tcattccatt ccaaaatgat atgcataatg atgaatctgg aaaaaacact gatgattgtt
     1561 taaatcacca gataagtatt ggtgactttg gttatggtca ttgtagtagt gaaatttcta
     1621 acattgataa aaacactaag aatgcatttc aggacatttc aatgagtaat gtatcatggg
     1681 agaactctca gacggaatat agtaaaactt gttttataag ttccgttaag cacacccagt
     1741 cagaaaatgg caataaagac catatagatg agagtgggga aaatgaggaa gaagcaggtc
     1801 ttgaaaactc ttcggaaatt tctgcagatg agtggagcag gggaaatata cttaaaaatt
     1861 cagtgggaga gaatattgaa cctgtgaaaa ttttagtgcc tgaaaaaagt ttaccatgta
     1921 aagtaagtaa taataattat ccaatccctg aacaaatgaa tcttaatgaa gattcatgta
     1981 acaaaaaatc aaatgtaata gataataaat ctggaaaagt tacagcttat gatttactta
     2041 gcaatcgagt aatcaagaaa cccatgtcag caagtgctct ttttgttcaa gatcatcgtc
     2101 ctcagtttct catagaaaat cctaagacta gtttagagga tgcaacacta caaattgaag
     2161 aactgtggaa gacattgagt gaagaggaaa aactgaatct ttttaatgga tctcattatt
     2221 tagacgtttt atataaaatg acagcagatg accaaagata cagtggatca acttacctgt
     2281 ctgatcctcg tcttacagcg aatggtttca agataaaatt gataccagga gtttcaatta
     2341 ctgaaaatta cttggaaata gaaggaatgg ctaattgtct cccattctat ggagtagcag
     2401 atttaaaaga aattcttaat gctatattaa acagaaatgc aaaggaagtt tatgaatgta
     2461 gacctcgcaa agtgataagt tatttagagg gagaagcagt gcgtctatcc agacaattac
     2521 ccatgtactt atcaaaagag gacatccaag acattatcta cagaatgaag caccagtttg
     2581 gaaatgaaat taaagagtgt gttcatggtc gcccattttt tcatcattta acctatcttc
     2641 cagaaactac atgattaaat atgtttaaga agattagtta ccattgaaat tggttctgtc
     2701 ataaaacagc atgagtctgg ttttaaatta tctttgtatt atgtgtcaca tggttatttt
     2761 ttaaatgagg attcactgac ttgtttttat attgaaaaaa gttccacgta ttgtagaaaa
     2821 cgtaaataaa ctaatataga ctattca
//
