LOCUS       XM_017004347            2856 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens PMS1 homolog 1, mismatch repair system
            component (PMS1), transcript variant X5, mRNA.
ACCESSION   XM_017004347
VERSION     XM_017004347.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017004347.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..2856
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /note="PMS1 homolog 1, mismatch repair system component;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 31 ESTs, 437 long SRA reads, 1 Protein, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 30 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
     CDS             165..2663
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /codon_start=1
                     /product="PMS1 protein homolog 1 isoform X2"
                     /protein_id="XP_016859836.1"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
                     /translation="MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKL
                     VLITTRTAADNFSTQYVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAK
                     KCKDEIKKIQDLLMSFGILKPDLRIVFVHNKIYLSGFLPKCDADHSFTSLSTPERSFI
                     FINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVL
                     LQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESS
                     GKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKN
                     AFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSE
                     ISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCNKKS
                     NVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEEL
                     WKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKH
                     KLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEEKDEP
                     CLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESL
                     FNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN
                     CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQ
                     DIIYRMKHQFGNEIKECVHGRPFFHHLTYLPETT"
ORIGIN      
        1 agtgccgcgc tctctgcacc cgctctgccg cgcgcgtgcg tgctgggtgc gggtgcgggt
       61 gcggggttgg gcctgcgcat cgggtgagac gctggctgct tgcggctagt ggatggtaat
      121 tgcctgcctc gcgctagcag gaagctgctc tgttaaaagc gaaaatgaaa caattgcctg
      181 cggcaacagt tcgactcctt tcaagttctc agatcatcac ttcggtggtc agtgttgtaa
      241 aagagcttat tgaaaactcc ttggatgctg gtgccacaag cgtagatgtt aaactggttt
      301 taattacaac aagaacggct gctgataatt ttagcaccca gtatgtttta gatggcagtg
      361 gccacatact ttctcagaaa ccttcacatc ttggtcaagg tacaactgta actgctttaa
      421 gattatttaa gaatctacct gtaagaaagc agttttactc aactgcaaaa aaatgtaaag
      481 atgaaataaa aaagatccaa gatctcctca tgagctttgg tatccttaaa cctgacttaa
      541 ggattgtctt tgtacataac aagatttatc tcagtggatt tcttccaaag tgtgatgcag
      601 accactcttt cactagtctt tcaacaccag aaagaagttt catcttcata aacagtcgac
      661 cagtacatca aaaagatatc ttaaagttaa tccgacatca ttacaatctg aaatgcctaa
      721 aggaatctac tcgtttgtat cctgttttct ttctgaaaat cgatgttcct acagctgatg
      781 ttgatgtaaa tttaacacca gataaaagcc aagtattatt acaaaataag gaatctgttt
      841 taattgctct tgaaaatctg atgacgactt gttatggacc attacctagt acaaattctt
      901 atgaaaataa taaaacagat gtttccgcag ctgacatcgt tcttagtaaa acagcagaaa
      961 cagatgtgct ttttaataaa gtggaatcat ctggaaagaa ttattcaaat gttgatactt
     1021 cagtcattcc attccaaaat gatatgcata atgatgaatc tggaaaaaac actgatgatt
     1081 gtttaaatca ccagataagt attggtgact ttggttatgg tcattgtagt agtgaaattt
     1141 ctaacattga taaaaacact aagaatgcat ttcaggacat ttcaatgagt aatgtatcat
     1201 gggagaactc tcagacggaa tatagtaaaa cttgttttat aagttccgtt aagcacaccc
     1261 agtcagaaaa tggcaataaa gaccatatag atgagagtgg ggaaaatgag gaagaagcag
     1321 gtcttgaaaa ctcttcggaa atttctgcag atgagtggag caggggaaat atacttaaaa
     1381 attcagtggg agagaatatt gaacctgtga aaattttagt gcctgaaaaa agtttaccat
     1441 gtaaagtaag taataataat tatccaatcc ctgaacaaat gaatcttaat gaagattcat
     1501 gtaacaaaaa atcaaatgta atagataata aatctggaaa agttacagct tatgatttac
     1561 ttagcaatcg agtaatcaag aaacccatgt cagcaagtgc tctttttgtt caagatcatc
     1621 gtcctcagtt tctcatagaa aatcctaaga ctagtttaga ggatgcaaca ctacaaattg
     1681 aagaactgtg gaagacattg agtgaagagg aaaaactgaa atatgaagag aaggctacta
     1741 aagacttgga acgatacaat agtcaaatga agagagccat tgaacaggag tcacaaatgt
     1801 cactaaaaga tggcagaaaa aagataaaac ccaccagcgc atggaatttg gcccagaagc
     1861 acaagttaaa aacctcatta tctaatcaac caaaacttga tgaactcctt cagtcccaaa
     1921 ttgaaaaaag aaggagtcaa aatattaaaa tggtacagat ccccttttct atgaaaaact
     1981 taaaaataaa ttttaagaaa caaaacaaag ttgacttaga agagaaggat gaaccttgct
     2041 tgatccacaa tctcaggttt cctgatgcat ggctaatgac atccaaaaca gaggtaatgt
     2101 tattaaatcc atatagagta gaagaagccc tgctatttaa aagacttctt gagaatcata
     2161 aacttcctgc agagccactg gaaaagccaa ttatgttaac agagagtctt tttaatggat
     2221 ctcattattt agacgtttta tataaaatga cagcagatga ccaaagatac agtggatcaa
     2281 cttacctgtc tgatcctcgt cttacagcga atggtttcaa gataaaattg ataccaggag
     2341 tttcaattac tgaaaattac ttggaaatag aaggaatggc taattgtctc ccattctatg
     2401 gagtagcaga tttaaaagaa attcttaatg ctatattaaa cagaaatgca aaggaagttt
     2461 atgaatgtag acctcgcaaa gtgataagtt atttagaggg agaagcagtg cgtctatcca
     2521 gacaattacc catgtactta tcaaaagagg acatccaaga cattatctac agaatgaagc
     2581 accagtttgg aaatgaaatt aaagagtgtg ttcatggtcg cccatttttt catcatttaa
     2641 cctatcttcc agaaactaca tgattaaata tgtttaagaa gattagttac cattgaaatt
     2701 ggttctgtca taaaacagca tgagtctggt tttaaattat ctttgtatta tgtgtcacat
     2761 ggttattttt taaatgagga ttcactgact tgtttttata ttgaaaaaag ttccacgtat
     2821 tgtagaaaac gtaaataaac taatatagac tattca
//
