LOCUS       XM_017004344            3165 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens PMS1 homolog 1, mismatch repair system
            component (PMS1), transcript variant X3, mRNA.
ACCESSION   XM_017004344
VERSION     XM_017004344.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017004344.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3165
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..3165
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /note="PMS1 homolog 1, mismatch repair system component;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 3 mRNAs, 30 ESTs, 463 long SRA reads, 6
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 17 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
     CDS             291..2972
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /codon_start=1
                     /product="PMS1 protein homolog 1 isoform X1"
                     /protein_id="XP_016859833.1"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
                     /translation="MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKL
                     ENYGFDKIEVRDNGEGIKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICC
                     IAEVLITTRTAADNFSTQYVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYS
                     TAKKCKDEIKKIQDLLMSFGILKPDLRIVFVHNKIYLSGFLPKCDADHSFTSLSTPER
                     SFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKS
                     QVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKV
                     ESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKN
                     TKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLEN
                     SSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCN
                     KKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQI
                     EELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLA
                     QKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEEK
                     DEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLT
                     ESLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEG
                     MANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKE
                     DIQDIIYRMKHQFGNEIKECVHGRPFFHHLTYLPETT"
ORIGIN      
        1 agtgccgcgc tctctgcacc cgctctgccg cgcgcgtgcg tgctgggtgc gggtgcgggt
       61 gcggggttgg gcctgcgcat cgggtgagac gctggctgct tgcggctagt ggatggtaat
      121 tgcctgcctc gcgctagcag gaaggcacac ctgttgtcct taactgactt tccgggtcat
      181 cagcacttct tcagaagtgt tccttttccc tcccagcaaa tatggaagac tgactatcct
      241 gatattccca gacattcttt gctgtgattt ctgctctgtt aaaagcgaaa atgaaacaat
      301 tgcctgcggc aacagttcga ctcctttcaa gttctcagat catcacttcg gtggtcagtg
      361 ttgtaaaaga gcttattgaa aactccttgg atgctggtgc cacaagcgta gatgttaaac
      421 tggagaacta tggatttgat aaaattgagg tgcgagataa cggggagggt atcaaggctg
      481 ttgatgcacc tgtaatggca atgaagtact acacctcaaa aataaatagt catgaagatc
      541 ttgaaaattt gacaacttac ggttttcgtg gagaagcctt ggggtcaatt tgttgtatag
      601 ctgaggtttt aattacaaca agaacggctg ctgataattt tagcacccag tatgttttag
      661 atggcagtgg ccacatactt tctcagaaac cttcacatct tggtcaaggt acaactgtaa
      721 ctgctttaag attatttaag aatctacctg taagaaagca gttttactca actgcaaaaa
      781 aatgtaaaga tgaaataaaa aagatccaag atctcctcat gagctttggt atccttaaac
      841 ctgacttaag gattgtcttt gtacataaca agatttatct cagtggattt cttccaaagt
      901 gtgatgcaga ccactctttc actagtcttt caacaccaga aagaagtttc atcttcataa
      961 acagtcgacc agtacatcaa aaagatatct taaagttaat ccgacatcat tacaatctga
     1021 aatgcctaaa ggaatctact cgtttgtatc ctgttttctt tctgaaaatc gatgttccta
     1081 cagctgatgt tgatgtaaat ttaacaccag ataaaagcca agtattatta caaaataagg
     1141 aatctgtttt aattgctctt gaaaatctga tgacgacttg ttatggacca ttacctagta
     1201 caaattctta tgaaaataat aaaacagatg tttccgcagc tgacatcgtt cttagtaaaa
     1261 cagcagaaac agatgtgctt tttaataaag tggaatcatc tggaaagaat tattcaaatg
     1321 ttgatacttc agtcattcca ttccaaaatg atatgcataa tgatgaatct ggaaaaaaca
     1381 ctgatgattg tttaaatcac cagataagta ttggtgactt tggttatggt cattgtagta
     1441 gtgaaatttc taacattgat aaaaacacta agaatgcatt tcaggacatt tcaatgagta
     1501 atgtatcatg ggagaactct cagacggaat atagtaaaac ttgttttata agttccgtta
     1561 agcacaccca gtcagaaaat ggcaataaag accatataga tgagagtggg gaaaatgagg
     1621 aagaagcagg tcttgaaaac tcttcggaaa tttctgcaga tgagtggagc aggggaaata
     1681 tacttaaaaa ttcagtggga gagaatattg aacctgtgaa aattttagtg cctgaaaaaa
     1741 gtttaccatg taaagtaagt aataataatt atccaatccc tgaacaaatg aatcttaatg
     1801 aagattcatg taacaaaaaa tcaaatgtaa tagataataa atctggaaaa gttacagctt
     1861 atgatttact tagcaatcga gtaatcaaga aacccatgtc agcaagtgct ctttttgttc
     1921 aagatcatcg tcctcagttt ctcatagaaa atcctaagac tagtttagag gatgcaacac
     1981 tacaaattga agaactgtgg aagacattga gtgaagagga aaaactgaaa tatgaagaga
     2041 aggctactaa agacttggaa cgatacaata gtcaaatgaa gagagccatt gaacaggagt
     2101 cacaaatgtc actaaaagat ggcagaaaaa agataaaacc caccagcgca tggaatttgg
     2161 cccagaagca caagttaaaa acctcattat ctaatcaacc aaaacttgat gaactccttc
     2221 agtcccaaat tgaaaaaaga aggagtcaaa atattaaaat ggtacagatc cccttttcta
     2281 tgaaaaactt aaaaataaat tttaagaaac aaaacaaagt tgacttagaa gagaaggatg
     2341 aaccttgctt gatccacaat ctcaggtttc ctgatgcatg gctaatgaca tccaaaacag
     2401 aggtaatgtt attaaatcca tatagagtag aagaagccct gctatttaaa agacttcttg
     2461 agaatcataa acttcctgca gagccactgg aaaagccaat tatgttaaca gagagtcttt
     2521 ttaatggatc tcattattta gacgttttat ataaaatgac agcagatgac caaagataca
     2581 gtggatcaac ttacctgtct gatcctcgtc ttacagcgaa tggtttcaag ataaaattga
     2641 taccaggagt ttcaattact gaaaattact tggaaataga aggaatggct aattgtctcc
     2701 cattctatgg agtagcagat ttaaaagaaa ttcttaatgc tatattaaac agaaatgcaa
     2761 aggaagttta tgaatgtaga cctcgcaaag tgataagtta tttagaggga gaagcagtgc
     2821 gtctatccag acaattaccc atgtacttat caaaagagga catccaagac attatctaca
     2881 gaatgaagca ccagtttgga aatgaaatta aagagtgtgt tcatggtcgc ccattttttc
     2941 atcatttaac ctatcttcca gaaactacat gattaaatat gtttaagaag attagttacc
     3001 attgaaattg gttctgtcat aaaacagcat gagtctggtt ttaaattatc tttgtattat
     3061 gtgtcacatg gttatttttt aaatgaggat tcactgactt gtttttatat tgaaaaaagt
     3121 tccacgtatt gtagaaaacg taaataaact aatatagact attca
//
