LOCUS       XM_006712596            2981 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens PMS1 homolog 1, mismatch repair system
            component (PMS1), transcript variant X9, mRNA.
ACCESSION   XM_006712596
VERSION     XM_006712596.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_006712596.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2981
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..2981
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /note="PMS1 homolog 1, mismatch repair system component;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 32 ESTs, 467 long SRA reads, 3 Proteins,
                     and 100% coverage of the annotated genomic feature by
                     RNAseq alignments, including 7 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
     CDS             545..2788
                     /gene="PMS1"
                     /gene_synonym="HNPCC3; hPMS1; MLH2; PMSL1"
                     /codon_start=1
                     /product="PMS1 protein homolog 1 isoform X5"
                     /protein_id="XP_006712659.1"
                     /db_xref="GeneID:5378"
                     /db_xref="HGNC:HGNC:9121"
                     /db_xref="MIM:600258"
                     /translation="MQRKAARLIAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHS
                     EESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKE
                     STRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNS
                     YENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNT
                     DDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISS
                     VKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILV
                     PEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSA
                     SALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQM
                     KRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQN
                     IKMVQIPFSMKNLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVMLLNPYR
                     VEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYLDVLYKMTADDQRYSGSTYLS
                     DPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYE
                     CRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNEIKECVHGRPFFHHL
                     TYLPETT"
ORIGIN      
        1 catgtgggcc gcggttgccg actgtggcgc gggcagtgga ggaggaggcg gggctggcgc
       61 tgaagtcgga tccggatccg ttgctgtgca ccctggtcgg ggagagtccg atgcgcctgg
      121 gtaggagcac cgactgcggg gcctctaccg accttactag aaagatgaaa cctgatgaaa
      181 ctcttatgtt tgacccaagt ctactcgaag aagtggactg gaggcagaat acagctacat
      241 tttctccagc catttcccca acacatcctg gagaaggctt gattttgtgg cctctttgta
      301 ctgctgactt aaatagaggg ttttttttta aggtattggg tcagctgatc gagactggag
      361 ttgtcagccc tgaacagttt atgaaatctt ttgagtatat gaagaaatct ggggattatg
      421 ttacagttgt agaagatgtg actctaggac agattgttgc tacagcaact ctgataatag
      481 aacataaatt catccattcc tgtgctaaga gagtaagagt agaagatgtt gtcgttagtg
      541 atgaatgcag aggaaagcag ctcggctaat tgcagttatt tggcagaaaa gcagagtatc
      601 agatcacaag atggctctca tgtcagttct ggggactgct gttatgaaca atatggaatc
      661 ctttcagtac cactctgaag aatctcagat ttatctcagt ggatttcttc caaagtgtga
      721 tgcagaccac tctttcacta gtctttcaac accagaaaga agtttcatct tcataaacag
      781 tcgaccagta catcaaaaag atatcttaaa gttaatccga catcattaca atctgaaatg
      841 cctaaaggaa tctactcgtt tgtatcctgt tttctttctg aaaatcgatg ttcctacagc
      901 tgatgttgat gtaaatttaa caccagataa aagccaagta ttattacaaa ataaggaatc
      961 tgttttaatt gctcttgaaa atctgatgac gacttgttat ggaccattac ctagtacaaa
     1021 ttcttatgaa aataataaaa cagatgtttc cgcagctgac atcgttctta gtaaaacagc
     1081 agaaacagat gtgcttttta ataaagtgga atcatctgga aagaattatt caaatgttga
     1141 tacttcagtc attccattcc aaaatgatat gcataatgat gaatctggaa aaaacactga
     1201 tgattgttta aatcaccaga taagtattgg tgactttggt tatggtcatt gtagtagtga
     1261 aatttctaac attgataaaa acactaagaa tgcatttcag gacatttcaa tgagtaatgt
     1321 atcatgggag aactctcaga cggaatatag taaaacttgt tttataagtt ccgttaagca
     1381 cacccagtca gaaaatggca ataaagacca tatagatgag agtggggaaa atgaggaaga
     1441 agcaggtctt gaaaactctt cggaaatttc tgcagatgag tggagcaggg gaaatatact
     1501 taaaaattca gtgggagaga atattgaacc tgtgaaaatt ttagtgcctg aaaaaagttt
     1561 accatgtaaa gtaagtaata ataattatcc aatccctgaa caaatgaatc ttaatgaaga
     1621 ttcatgtaac aaaaaatcaa atgtaataga taataaatct ggaaaagtta cagcttatga
     1681 tttacttagc aatcgagtaa tcaagaaacc catgtcagca agtgctcttt ttgttcaaga
     1741 tcatcgtcct cagtttctca tagaaaatcc taagactagt ttagaggatg caacactaca
     1801 aattgaagaa ctgtggaaga cattgagtga agaggaaaaa ctgaaatatg aagagaaggc
     1861 tactaaagac ttggaacgat acaatagtca aatgaagaga gccattgaac aggagtcaca
     1921 aatgtcacta aaagatggca gaaaaaagat aaaacccacc agcgcatgga atttggccca
     1981 gaagcacaag ttaaaaacct cattatctaa tcaaccaaaa cttgatgaac tccttcagtc
     2041 ccaaattgaa aaaagaagga gtcaaaatat taaaatggta cagatcccct tttctatgaa
     2101 aaacttaaaa ataaatttta agaaacaaaa caaagttgac ttagaagaga aggatgaacc
     2161 ttgcttgatc cacaatctca ggtttcctga tgcatggcta atgacatcca aaacagaggt
     2221 aatgttatta aatccatata gagtagaaga agccctgcta tttaaaagac ttcttgagaa
     2281 tcataaactt cctgcagagc cactggaaaa gccaattatg ttaacagaga gtctttttaa
     2341 tggatctcat tatttagacg ttttatataa aatgacagca gatgaccaaa gatacagtgg
     2401 atcaacttac ctgtctgatc ctcgtcttac agcgaatggt ttcaagataa aattgatacc
     2461 aggagtttca attactgaaa attacttgga aatagaagga atggctaatt gtctcccatt
     2521 ctatggagta gcagatttaa aagaaattct taatgctata ttaaacagaa atgcaaagga
     2581 agtttatgaa tgtagacctc gcaaagtgat aagttattta gagggagaag cagtgcgtct
     2641 atccagacaa ttacccatgt acttatcaaa agaggacatc caagacatta tctacagaat
     2701 gaagcaccag tttggaaatg aaattaaaga gtgtgttcat ggtcgcccat tttttcatca
     2761 tttaacctat cttccagaaa ctacatgatt aaatatgttt aagaagatta gttaccattg
     2821 aaattggttc tgtcataaaa cagcatgagt ctggttttaa attatctttg tattatgtgt
     2881 cacatggtta ttttttaaat gaggattcac tgacttgttt ttatattgaa aaaagttcca
     2941 cgtattgtag aaaacgtaaa taaactaata tagactattc a
//
