LOCUS       NM_033250               2886 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens PML nuclear body scaffold (PML), transcript variant
            11, mRNA.
ACCESSION   NM_033250
VERSION     NM_033250.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2886)
  AUTHORS   Ni,Y., Chen,H., Zhan,Q. and Zhuang,Z.
  TITLE     Nuclear export of PML promotes p53-mediated apoptosis and
            ferroptosis
  JOURNAL   Cell Signal 121, 111278 (2024)
   PUBMED   38944257
  REMARK    GeneRIF: Nuclear export of PML promotes p53-mediated apoptosis and
            ferroptosis.
REFERENCE   2  (bases 1 to 2886)
  AUTHORS   Katerndahl,C.D.S., Rogers,O.R.S., Day,R.B., Xu,Z., Helton,N.M.,
            Ramakrishnan,S.M., Miller,C.A. and Ley,T.J.
  TITLE     PML::RARA and GATA2 proteins interact via DNA templates to induce
            aberrant self-renewal in mouse and human hematopoietic cells
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2317690121 (2024)
   PUBMED   38648485
  REMARK    GeneRIF: PML::RARA and GATA2 proteins interact via DNA templates to
            induce aberrant self-renewal in mouse and human hematopoietic
            cells.
REFERENCE   3  (bases 1 to 2886)
  AUTHORS   Dubey,S., Mishra,N., Shelke,R. and Varma,A.K.
  TITLE     Mutations at proximal cysteine residues in PML impair ATO binding
            by destabilizing the RBCC domain
  JOURNAL   FEBS J 291 (7), 1422-1438 (2024)
   PUBMED   38129745
  REMARK    GeneRIF: Mutations at proximal cysteine residues in PML impair ATO
            binding by destabilizing the RBCC domain.
REFERENCE   4  (bases 1 to 2886)
  AUTHORS   Chu,Y., Jiang,Z., Gong,Z., Ji,X., Zhu,M., Shang,Q., Gong,P.,
            Cao,L., Chen,Y., Li,P., Shao,C. and Shi,Y.
  TITLE     PML-mediated nuclear loosening permits immunomodulation of
            mesenchymal stem/stromal cells under inflammatory conditions
  JOURNAL   Cell Prolif 57 (4), e13566 (2024)
   PUBMED   37864298
  REMARK    GeneRIF: PML-mediated nuclear loosening permits immunomodulation of
            mesenchymal stem/stromal cells under inflammatory conditions.
REFERENCE   5  (bases 1 to 2886)
  AUTHORS   Fracassi,C., Ugge',M., Abdelhalim,M., Zapparoli,E., Simoni,M.,
            Magliulo,D., Mazza,D., Lazarevic,D., Morelli,M.J., Collas,P. and
            Bernardi,R.
  TITLE     PML modulates epigenetic composition of chromatin to regulate
            expression of pro-metastatic genes in triple-negative breast cancer
  JOURNAL   Nucleic Acids Res 51 (20), 11024-11039 (2023)
   PUBMED   37823593
  REMARK    GeneRIF: PML modulates epigenetic composition of chromatin to
            regulate expression of pro-metastatic genes in triple-negative
            breast cancer.
REFERENCE   6  (bases 1 to 2886)
  AUTHORS   Borden,K.L., Boddy,M.N., Lally,J., O'Reilly,N.J., Martin,S.,
            Howe,K., Solomon,E. and Freemont,P.S.
  TITLE     The solution structure of the RING finger domain from the acute
            promyelocytic leukaemia proto-oncoprotein PML
  JOURNAL   EMBO J 14 (7), 1532-1541 (1995)
   PUBMED   7729428
REFERENCE   7  (bases 1 to 2886)
  AUTHORS   Fagioli,M., Alcalay,M., Pandolfi,P.P., Venturini,L., Mencarelli,A.,
            Simeone,A., Acampora,D., Grignani,F. and Pelicci,P.G.
  TITLE     Alternative splicing of PML transcripts predicts coexpression of
            several carboxy-terminally different protein isoforms
  JOURNAL   Oncogene 7 (6), 1083-1091 (1992)
   PUBMED   1594241
REFERENCE   8  (bases 1 to 2886)
  AUTHORS   Tong,J.H., Dong,S., Geng,J.P., Huang,W., Wang,Z.Y., Sun,G.L.,
            Chen,S.J., Chen,Z., Larsen,C.J. and Berger,R.
  TITLE     Molecular rearrangements of the MYL gene in acute promyelocytic
            leukemia (APL, M3) define a breakpoint cluster region as well as
            some molecular variants
  JOURNAL   Oncogene 7 (2), 311-316 (1992)
   PUBMED   1312695
REFERENCE   9  (bases 1 to 2886)
  AUTHORS   Goddard,A.D., Borrow,J., Freemont,P.S. and Solomon,E.
  TITLE     Characterization of a zinc finger gene disrupted by the t(15;17) in
            acute promyelocytic leukemia
  JOURNAL   Science 254 (5036), 1371-1374 (1991)
   PUBMED   1720570
REFERENCE   10 (bases 1 to 2886)
  AUTHORS   Kakizuka,A., Miller,W.H. Jr., Umesono,K., Warrell,R.P. Jr.,
            Frankel,S.R., Murty,V.V., Dmitrovsky,E. and Evans,R.M.
  TITLE     Chromosomal translocation t(15;17) in human acute promyelocytic
            leukemia fuses RAR alpha with a novel putative transcription
            factor, PML
  JOURNAL   Cell 66 (4), 663-674 (1991)
   PUBMED   1652368
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X63131.1 and BC034251.1.
            
            On May 31, 2019 this sequence version replaced NM_033250.2.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. This phosphoprotein localizes to nuclear
            bodies where it functions as a transcription factor and tumor
            suppressor. Its expression is cell-cycle related and it regulates
            the p53 response to oncogenic signals. The gene is often involved
            in the translocation with the retinoic acid receptor alpha gene
            associated with acute promyelocytic leukemia (APL). Extensive
            alternative splicing of this gene results in several variations of
            the protein's central and C-terminal regions; all variants encode
            the same N-terminus. Alternatively spliced transcript variants
            encoding different isoforms have been identified. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (11) has multiple differences in
            the coding region compared to variant 1, one of which results in
            translational frame-shift. The resulting isoform (11, also known as
            PML-2A and PML-IIA) has a distinct C-terminus and is shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000080.2, BT009911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1351              X63131.1           45-1395
            1352-1663           X63131.1           1540-1851
            1664-2886           BC034251.1         820-2042
FEATURES             Location/Qualifiers
     source          1..2886
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..2886
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /note="PML nuclear body scaffold"
                     /db_xref="GeneID:5371"
                     /db_xref="HGNC:HGNC:9113"
                     /db_xref="MIM:102578"
     exon            1..226
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2443
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /note="isoform 11 is encoded by transcript variant 11;
                     promyelocytic leukemia, inducer of; tripartite motif
                     protein TRIM19; PML/RARA fusion; probable transcription
                     factor PML; protein PML; promyelocytic leukemia protein;
                     RING finger protein 71; tripartite motif-containing
                     protein 19; E3 SUMO-protein ligase PML; RING-type E3 SUMO
                     transferase PML"
                     /codon_start=1
                     /product="protein PML isoform 11"
                     /protein_id="NP_150253.2"
                     /db_xref="CCDS:CCDS10258.1"
                     /db_xref="GeneID:5371"
                     /db_xref="HGNC:HGNC:9113"
                     /db_xref="MIM:102578"
                     /translation="MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTER
                     APASEEEFQFLRCQQCQAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTP
                     ALDNVFFESLQRRLSVYRQIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLK
                     HEARPLAELRNQSVREFLDGTRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALL
                     DSSHSELKCDISAEIQQRQEELDAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETE
                     ELIRERVRQVVAHVRAQERELLEAVDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQ
                     RMKCYASDQEVLDMHGFLRQALCRLRQEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQ
                     GKDAAVSKKASPEAASTPRDPIDVDLDVSNTTTAQKRKCSQTQCPRKVIKMESEEGKE
                     ARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLPNSNHVASGAGEAEERV
                     VVISSSEDSDAENSCMEPMETAEPQSSPAHSSPAHSSPAHSSPVQSLLRAQGASSLPC
                     GTYHPPAWPPHQPAEQAATPDAEPHSEPPDHQERPAVHRGIRYLLYRAQRAIRLRHAL
                     RLHPQLHRAPIRTWSPHVVQASTPAITGPLNHPANAQEHPAQLQRGISPPHRIRGAVR
                     SRSRSLRGSSHLSQWLNNFFALPFSSMASQLDMSSVVGAGESRAQTLGAGVPPGDSVR
                     GSMEASQVQVPLEASPITFPPPCAPERPPISPVPGARQAGL"
     exon            227..699
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     exon            700..1280
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1351
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1610
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1663
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..2886
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2864..2869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /note="hexamer: AATAAA"
     polyA_site      2886
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /note="major polyA site"
ORIGIN      
        1 agctcaaggg actcagccaa ctggctcacg cctccccttc agcttctctt cacgcactcc
       61 aagatctaaa ccgagaatcg aaactaagct ggggtccatg gagcctgcac ccgcccgatc
      121 tccgaggccc cagcaggacc ccgcccggcc ccaggagccc accatgcctc cccccgagac
      181 cccctctgaa ggccgccagc ccagccccag ccccagccct acagagcgag cccccgcttc
      241 ggaggaggag ttccagtttc tgcgctgcca gcaatgccag gcggaagcca agtgcccgaa
      301 gctgctgcct tgtctgcaca cgctgtgctc aggatgcctg gaggcgtcgg gcatgcagtg
      361 ccccatctgc caggcgccct ggcccctagg tgcagacaca cccgccctgg ataacgtctt
      421 tttcgagagt ctgcagcggc gcctgtcggt gtaccggcag attgtggatg cgcaggctgt
      481 gtgcacccgc tgcaaagagt cggccgactt ctggtgcttt gagtgcgagc agctcctctg
      541 cgccaagtgc ttcgaggcac accagtggtt cctcaagcac gaggcccggc ccctagcaga
      601 gctgcgcaac cagtcggtgc gtgagttcct ggacggcacc cgcaagacca acaacatctt
      661 ctgctccaac cccaaccacc gcacccctac gctgaccagc atctactgcc gaggatgttc
      721 caagccgctg tgctgctcgt gcgcgctcct tgacagcagc cacagtgagc tcaagtgcga
      781 catcagcgca gagatccagc agcgacagga ggagctggac gccatgacgc aggcgctgca
      841 ggagcaggat agtgcctttg gcgcggttca cgcgcagatg cacgcggccg tcggccagct
      901 gggccgcgcg cgtgccgaga ccgaggagct gatccgcgag cgcgtgcgcc aggtggtagc
      961 tcacgtgcgg gctcaggagc gcgagctgct ggaggctgtg gacgcgcggt accagcgcga
     1021 ctacgaggag atggccagtc ggctgggccg cctggatgct gtgctgcagc gcatccgcac
     1081 gggcagcgcg ctggtgcaga ggatgaagtg ctacgcctcg gaccaggagg tgctggacat
     1141 gcacggtttc ctgcgccagg cgctctgccg cctgcgccag gaggagcccc agagcctgca
     1201 agctgccgtg cgcaccgatg gcttcgacga gttcaaggtg cgcctgcagg acctcagctc
     1261 ttgcatcacc caggggaaag atgcagctgt atccaagaaa gccagcccag aggctgccag
     1321 cactcccagg gaccctattg acgttgacct ggatgtctcc aatacaacga cagcccagaa
     1381 gaggaagtgc agccagaccc agtgccccag gaaggtcatc aagatggagt ctgaggaggg
     1441 gaaggaggca aggttggctc ggagctcccc ggagcagccc aggcccagca cctccaaggc
     1501 agtctcacca ccccacctgg atggaccgcc tagccccagg agccccgtca taggaagtga
     1561 ggtcttcctg cccaacagca accacgtggc cagtggcgcc ggggaggcag aggaacgcgt
     1621 tgtggtgatc agcagctcgg aagactcaga tgccgaaaac tcgtgcatgg agcccatgga
     1681 gaccgccgag ccacagtcct cgccagccca ctcctcgcca gcccactcct cgccagccca
     1741 ctcctcgcca gtccagtctc tgctgagagc acaaggagcc tccagcctgc cctgtggcac
     1801 ataccacccc ccagcttggc ctccccacca gcccgctgag caggctgcca cccccgatgc
     1861 tgagcctcac agcgagcctc ctgatcacca ggagcgccct gccgtccacc gtgggatccg
     1921 ctacctgttg tacagagcac agagagccat ccgccttcgc catgccctcc gcttgcaccc
     1981 tcaattgcat cgggccccta ttcggacttg gtctccccat gtggtccaag ccagcactcc
     2041 tgccatcaca gggcccctca accatcctgc caatgcccag gaacatcctg cccagctgca
     2101 aaggggcatc agcccacccc accggatacg aggggctgtg cgatcccgca gccgctccct
     2161 ccggggctcc tcccatttat cccagtggct caacaacttt tttgccctcc ccttctcctc
     2221 catggcttcc cagcttgaca tgtcttccgt ggtgggggca ggggaaagca gagcccagac
     2281 tcttggagca ggtgttcccc ctggggactc tgtcagaggc tccatggagg cctctcaagt
     2341 ccaagtgcct ctggaagcct ctccaattac attcccacca ccctgtgccc cagaaaggcc
     2401 ccccatcagc ccagtcccag gcgcccgtca agcaggcctc tgagagtgct acccttctct
     2461 tgtaaccttg cagccaacac ccctgcccgg cccctgagct gcctcctcca gcccatgctc
     2521 ttacaggccc tgcacagagt agcactcatt aattcttggt taaggaatga atcaacgaat
     2581 gaatggctat gcatggacct ctgggcaggg agacctgggt cttctctggc tgagagggga
     2641 aggctaaggc atggctgaga ttcaagccac cattccaggc ctctttgccc aagaaagaaa
     2701 cttctgtcac ccttgcactc tcctgtattc tgagtccctg gccaatagca cagccttcca
     2761 tgccccgacc cccaccccaa gcctctccac taggcctctg ccaggatcta agcccatgag
     2821 cacagggact ggctatccca agacctggca gatgtggctg ctcaataaac acttgttgaa
     2881 ccatca
//
