LOCUS       NM_033238               5565 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens PML nuclear body scaffold (PML), transcript variant 1,
            mRNA.
ACCESSION   NM_033238
VERSION     NM_033238.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5565)
  AUTHORS   Ni,Y., Chen,H., Zhan,Q. and Zhuang,Z.
  TITLE     Nuclear export of PML promotes p53-mediated apoptosis and
            ferroptosis
  JOURNAL   Cell Signal 121, 111278 (2024)
   PUBMED   38944257
  REMARK    GeneRIF: Nuclear export of PML promotes p53-mediated apoptosis and
            ferroptosis.
REFERENCE   2  (bases 1 to 5565)
  AUTHORS   Katerndahl,C.D.S., Rogers,O.R.S., Day,R.B., Xu,Z., Helton,N.M.,
            Ramakrishnan,S.M., Miller,C.A. and Ley,T.J.
  TITLE     PML::RARA and GATA2 proteins interact via DNA templates to induce
            aberrant self-renewal in mouse and human hematopoietic cells
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2317690121 (2024)
   PUBMED   38648485
  REMARK    GeneRIF: PML::RARA and GATA2 proteins interact via DNA templates to
            induce aberrant self-renewal in mouse and human hematopoietic
            cells.
REFERENCE   3  (bases 1 to 5565)
  AUTHORS   Dubey,S., Mishra,N., Shelke,R. and Varma,A.K.
  TITLE     Mutations at proximal cysteine residues in PML impair ATO binding
            by destabilizing the RBCC domain
  JOURNAL   FEBS J 291 (7), 1422-1438 (2024)
   PUBMED   38129745
  REMARK    GeneRIF: Mutations at proximal cysteine residues in PML impair ATO
            binding by destabilizing the RBCC domain.
REFERENCE   4  (bases 1 to 5565)
  AUTHORS   Chu,Y., Jiang,Z., Gong,Z., Ji,X., Zhu,M., Shang,Q., Gong,P.,
            Cao,L., Chen,Y., Li,P., Shao,C. and Shi,Y.
  TITLE     PML-mediated nuclear loosening permits immunomodulation of
            mesenchymal stem/stromal cells under inflammatory conditions
  JOURNAL   Cell Prolif 57 (4), e13566 (2024)
   PUBMED   37864298
  REMARK    GeneRIF: PML-mediated nuclear loosening permits immunomodulation of
            mesenchymal stem/stromal cells under inflammatory conditions.
REFERENCE   5  (bases 1 to 5565)
  AUTHORS   Fracassi,C., Ugge',M., Abdelhalim,M., Zapparoli,E., Simoni,M.,
            Magliulo,D., Mazza,D., Lazarevic,D., Morelli,M.J., Collas,P. and
            Bernardi,R.
  TITLE     PML modulates epigenetic composition of chromatin to regulate
            expression of pro-metastatic genes in triple-negative breast cancer
  JOURNAL   Nucleic Acids Res 51 (20), 11024-11039 (2023)
   PUBMED   37823593
  REMARK    GeneRIF: PML modulates epigenetic composition of chromatin to
            regulate expression of pro-metastatic genes in triple-negative
            breast cancer.
REFERENCE   6  (bases 1 to 5565)
  AUTHORS   Borden,K.L., Boddy,M.N., Lally,J., O'Reilly,N.J., Martin,S.,
            Howe,K., Solomon,E. and Freemont,P.S.
  TITLE     The solution structure of the RING finger domain from the acute
            promyelocytic leukaemia proto-oncoprotein PML
  JOURNAL   EMBO J 14 (7), 1532-1541 (1995)
   PUBMED   7729428
REFERENCE   7  (bases 1 to 5565)
  AUTHORS   Fagioli,M., Alcalay,M., Pandolfi,P.P., Venturini,L., Mencarelli,A.,
            Simeone,A., Acampora,D., Grignani,F. and Pelicci,P.G.
  TITLE     Alternative splicing of PML transcripts predicts coexpression of
            several carboxy-terminally different protein isoforms
  JOURNAL   Oncogene 7 (6), 1083-1091 (1992)
   PUBMED   1594241
REFERENCE   8  (bases 1 to 5565)
  AUTHORS   Tong,J.H., Dong,S., Geng,J.P., Huang,W., Wang,Z.Y., Sun,G.L.,
            Chen,S.J., Chen,Z., Larsen,C.J. and Berger,R.
  TITLE     Molecular rearrangements of the MYL gene in acute promyelocytic
            leukemia (APL, M3) define a breakpoint cluster region as well as
            some molecular variants
  JOURNAL   Oncogene 7 (2), 311-316 (1992)
   PUBMED   1312695
REFERENCE   9  (bases 1 to 5565)
  AUTHORS   Goddard,A.D., Borrow,J., Freemont,P.S. and Solomon,E.
  TITLE     Characterization of a zinc finger gene disrupted by the t(15;17) in
            acute promyelocytic leukemia
  JOURNAL   Science 254 (5036), 1371-1374 (1991)
   PUBMED   1720570
REFERENCE   10 (bases 1 to 5565)
  AUTHORS   Kakizuka,A., Miller,W.H. Jr., Umesono,K., Warrell,R.P. Jr.,
            Frankel,S.R., Murty,V.V., Dmitrovsky,E. and Evans,R.M.
  TITLE     Chromosomal translocation t(15;17) in human acute promyelocytic
            leukemia fuses RAR alpha with a novel putative transcription
            factor, PML
  JOURNAL   Cell 66 (4), 663-674 (1991)
   PUBMED   1652368
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X63131.1, AB209411.1, M79462.1
            and AC013486.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_033238.2.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. This phosphoprotein localizes to nuclear
            bodies where it functions as a transcription factor and tumor
            suppressor. Its expression is cell-cycle related and it regulates
            the p53 response to oncogenic signals. The gene is often involved
            in the translocation with the retinoic acid receptor alpha gene
            associated with acute promyelocytic leukemia (APL). Extensive
            alternative splicing of this gene results in several variations of
            the protein's central and C-terminal regions; all variants encode
            the same N-terminus. Alternatively spliced transcript variants
            encoding different isoforms have been identified. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript, and encodes the longest isoform (1, also known as
            TRIM19alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M79462.1, AF230401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268058.8/ ENSP00000268058.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1958              X63131.1           45-2002
            1959-3858           AB209411.1         1802-3701
            3859-3884           M79462.1           3774-3799
            3885-4335           AB209411.1         3728-4178
            4336-4357           M79462.1           4243-4264
            4358-4509           AB209411.1         4201-4352
            4510-5557           AC013486.12        37014-38061         c
            5558-5565           AC013486.12        37006-37013         c
FEATURES             Location/Qualifiers
     source          1..5565
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..5565
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /note="PML nuclear body scaffold"
                     /db_xref="GeneID:5371"
                     /db_xref="HGNC:HGNC:9113"
                     /db_xref="MIM:102578"
     exon            1..226
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2746
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /note="isoform 1 is encoded by transcript variant 1;
                     promyelocytic leukemia, inducer of; tripartite motif
                     protein TRIM19; PML/RARA fusion; probable transcription
                     factor PML; protein PML; promyelocytic leukemia protein;
                     RING finger protein 71; tripartite motif-containing
                     protein 19; E3 SUMO-protein ligase PML; RING-type E3 SUMO
                     transferase PML"
                     /codon_start=1
                     /product="protein PML isoform 1"
                     /protein_id="NP_150241.2"
                     /db_xref="CCDS:CCDS10255.1"
                     /db_xref="GeneID:5371"
                     /db_xref="HGNC:HGNC:9113"
                     /db_xref="MIM:102578"
                     /translation="MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTER
                     APASEEEFQFLRCQQCQAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTP
                     ALDNVFFESLQRRLSVYRQIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLK
                     HEARPLAELRNQSVREFLDGTRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALL
                     DSSHSELKCDISAEIQQRQEELDAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETE
                     ELIRERVRQVVAHVRAQERELLEAVDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQ
                     RMKCYASDQEVLDMHGFLRQALCRLRQEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQ
                     GKDAAVSKKASPEAASTPRDPIDVDLPEEAERVKAQVQALGLAEAQPMAVVQSVPGAH
                     PVPVYAFSIKGPSYGEDVSNTTTAQKRKCSQTQCPRKVIKMESEEGKEARLARSSPEQ
                     PRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLPNSNHVASGAGEAEERVVVISSSEDSD
                     AENSSSRELDDSSSESSDLQLEGPSTLRVLDENLADPQAEDRPLVFFDLKIDNETQKI
                     SQLAAVNRESKFRVVIQPEAFFSIYSKAVSLEVGLQHFLSFLSSMRRPILACYKLWGP
                     GLPNFFRALEDINRLWEFQEAISGFLAALPLIRERVPGASSFKLKNLAQTYLARNMSE
                     RSAMAAVLAMRDLCRLLEVSPGPQLAQHVYPFSSLQCFASLQPLVQAAVLPRAEARLL
                     ALHNVSFMELLSAHRRDRQGGLKKYSRYLSLQTTTLPPAQPAFNLQALGTYFEGLLEG
                     PALARAEGVSTPLAGRGLAERASQQS"
     exon            227..699
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     exon            700..1280
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1351
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1495
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1754
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1807
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1958
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..5565
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4488..4493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /note="hexamer: AATAAA"
     polyA_site      4509
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /note="major polyA site"
     regulatory      5528..5533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
                     /note="hexamer: AATAAA"
     polyA_site      5565
                     /gene="PML"
                     /gene_synonym="MYL; PP8675; RNF71; TRIM19"
ORIGIN      
        1 agctcaaggg actcagccaa ctggctcacg cctccccttc agcttctctt cacgcactcc
       61 aagatctaaa ccgagaatcg aaactaagct ggggtccatg gagcctgcac ccgcccgatc
      121 tccgaggccc cagcaggacc ccgcccggcc ccaggagccc accatgcctc cccccgagac
      181 cccctctgaa ggccgccagc ccagccccag ccccagccct acagagcgag cccccgcttc
      241 ggaggaggag ttccagtttc tgcgctgcca gcaatgccag gcggaagcca agtgcccgaa
      301 gctgctgcct tgtctgcaca cgctgtgctc aggatgcctg gaggcgtcgg gcatgcagtg
      361 ccccatctgc caggcgccct ggcccctagg tgcagacaca cccgccctgg ataacgtctt
      421 tttcgagagt ctgcagcggc gcctgtcggt gtaccggcag attgtggatg cgcaggctgt
      481 gtgcacccgc tgcaaagagt cggccgactt ctggtgcttt gagtgcgagc agctcctctg
      541 cgccaagtgc ttcgaggcac accagtggtt cctcaagcac gaggcccggc ccctagcaga
      601 gctgcgcaac cagtcggtgc gtgagttcct ggacggcacc cgcaagacca acaacatctt
      661 ctgctccaac cccaaccacc gcacccctac gctgaccagc atctactgcc gaggatgttc
      721 caagccgctg tgctgctcgt gcgcgctcct tgacagcagc cacagtgagc tcaagtgcga
      781 catcagcgca gagatccagc agcgacagga ggagctggac gccatgacgc aggcgctgca
      841 ggagcaggat agtgcctttg gcgcggttca cgcgcagatg cacgcggccg tcggccagct
      901 gggccgcgcg cgtgccgaga ccgaggagct gatccgcgag cgcgtgcgcc aggtggtagc
      961 tcacgtgcgg gctcaggagc gcgagctgct ggaggctgtg gacgcgcggt accagcgcga
     1021 ctacgaggag atggccagtc ggctgggccg cctggatgct gtgctgcagc gcatccgcac
     1081 gggcagcgcg ctggtgcaga ggatgaagtg ctacgcctcg gaccaggagg tgctggacat
     1141 gcacggtttc ctgcgccagg cgctctgccg cctgcgccag gaggagcccc agagcctgca
     1201 agctgccgtg cgcaccgatg gcttcgacga gttcaaggtg cgcctgcagg acctcagctc
     1261 ttgcatcacc caggggaaag atgcagctgt atccaagaaa gccagcccag aggctgccag
     1321 cactcccagg gaccctattg acgttgacct gcccgaggag gcagagagag tgaaggccca
     1381 ggttcaggcc ctggggctgg ctgaagccca gcctatggct gtggtacagt cagtgcccgg
     1441 ggcacacccc gtgccagtgt acgccttctc catcaaaggc ccttcctatg gagaggatgt
     1501 ctccaataca acgacagccc agaagaggaa gtgcagccag acccagtgcc ccaggaaggt
     1561 catcaagatg gagtctgagg aggggaagga ggcaaggttg gctcggagct ccccggagca
     1621 gcccaggccc agcacctcca aggcagtctc accaccccac ctggatggac cgcctagccc
     1681 caggagcccc gtcataggaa gtgaggtctt cctgcccaac agcaaccacg tggccagtgg
     1741 cgccggggag gcagaggaac gcgttgtggt gatcagcagc tcggaagact cagatgccga
     1801 aaactcgtcc tcccgagagc tggatgacag cagcagtgag tccagtgacc tccagctgga
     1861 aggccccagc accctcaggg tcctggacga gaaccttgct gacccccaag cagaagacag
     1921 acctctggtt ttctttgacc tcaagattga caatgaaacc cagaagatta gccagctggc
     1981 tgcggtgaac cgggaaagca agttccgcgt ggtcatccag cctgaagcct tcttcagcat
     2041 ctactccaag gccgtgtccc tggaggtggg gctgcagcac ttcctcagct ttctgagctc
     2101 catgcgccgc cctatcttgg cctgctacaa gctgtggggg cctggcctcc caaacttctt
     2161 ccgggccctg gaggacatta acaggctgtg ggaattccag gaggccatct cgggcttcct
     2221 ggctgccctg cctctcatcc gggagcgtgt gcccggggcc agcagcttca aactcaagaa
     2281 cctggcccag acctacctgg cgagaaacat gagcgagcgc agcgccatgg ctgccgtgct
     2341 ggccatgcgt gacctgtgcc gcctcctcga ggtctccccg ggcccccagc tggcccagca
     2401 tgtctacccc ttcagtagcc tgcagtgctt tgcctccctg cagcccctgg tgcaggcagc
     2461 tgtgctgccc cgggctgagg cccgcctcct ggccctacac aacgtgagct tcatggagct
     2521 gctgagtgca caccgccgtg accggcaggg gggcctgaag aagtacagcc gctatctaag
     2581 cctgcagacc accacgttgc cccctgccca gcctgctttc aacctgcagg ctctgggcac
     2641 ctactttgaa ggcctgttgg agggtccggc gctggcacgg gcagaaggag tctccacccc
     2701 acttgctggc cgtggcttgg cagagagggc ctcccagcag agctgagagg agggggtgac
     2761 cagcttggag tctctggtgg gcagagaggg atggggtccc tgagccaggc cccacccatc
     2821 acagcattcc caggtcctgg tacccagccc tcagttgtca tttggttcag aatcagttcc
     2881 ctttctctgg gaccaaattt cccttctcta aacatcctac agagaaggtt ccaaagctga
     2941 gcacccatca ccctaggtgt gcaccagact cctattagcc cctccttcca ggagctagaa
     3001 ccagggaggt cctgagtgag gaaggcatga cctctgggct ctctaggtgg ccctggtctt
     3061 gccccatcca tcccacctgc cactaccttg ggtgtcctta cagctctgcc ctgaccccag
     3121 cccctgcccc tggacacctg ctgacagctc ccacacagaa cagtctgagg tgatgctggc
     3181 tacagccctg gcagcccatg gcaactcaaa gtgccttcca aaccaaactg cccctcatga
     3241 ggttagggtc ccccaccctc cacctgccca gaggccaact ctgttccctt ctcctttcat
     3301 cccagagggg cctcatcagc aaagacagaa actgatgttc catgcatgtc cctgcttcca
     3361 aagcctgacc ttccaaagct tgcttccttc ctcctggctg cacagacacc tctgcttggc
     3421 cacagctttg ctctttggtc ctcaggccac cagacccctc acagcatggc ccttggctct
     3481 tcctgcactg ccctcaccct cagccgtccc aaggagtgcc cagcactact cagcatgtag
     3541 tccaggacct gcggcatcag catcccctgg gagcttctta gaaatgcaga cctgtgggct
     3601 ctaccacagg cctctggaat cagaatcttc agggtggggc ccagcagtct gtgttttaac
     3661 aggttctccc ggtgatgctg gtgcatgctc aagtttgaga accgctgctc tcatagactg
     3721 ctcctccaag gggaagcagt gtggaacagc agagaaagtc ccgtccctat ctctgactgt
     3781 gcagtgagtg tggcctagga acaggtccct tcctaagctc tagtgtcccc atctgtaaaa
     3841 tgggctgatt ggcctccacg gtcagagcgg ccatctggct gtgccatcct gcatttttag
     3901 gaatggaaag caggcctctg aggcagtgga caggaagact tctcatcctt gaattctagc
     3961 tcccattcca aactgttagt ccccaacctt gtggtcacat cagaggtcaa cagcagaaca
     4021 gaggcaggtc agggttgtcc gctctgatta gcagaacgac agccccttcc tcctcctccc
     4081 tccttcccat ccctactcat tagctccctg ctcctgggat gcttcccaag cagcccaggc
     4141 ctctagcctc catggctgat gacctcagct ttcacactgg tgaagtctgt gtacccatac
     4201 tgcagcccca tcccatgggg cccctgaaga cccactgagg aattccgtag ggtcttgttc
     4261 ccacgaccgg agtgctggct ctcacagtga attttgatgc atttaaaata agattctgat
     4321 gccagactgt taaaacaggc gctggttctg aagcaccgat ggaaacagat tgatgcagat
     4381 ggaaggagga agggagactg ggcccactga tttccagccc caccatgtgt gctgttttca
     4441 gatgtgattg aggggtgttc tgccctgcct ccactgtcac agcctttaat aaagatgtga
     4501 atcttgaaag cctgatgctc caatcacaga ctctgctcag catccccaga ggaaccactg
     4561 agaagccttt tgcctggata ggagggggct ctcccaggca taggcttgtg gccacttgcc
     4621 cagcacaact gtgttttgtg gggcgtcttt taggacttag cagagctgag agccctttgt
     4681 tgctcaatgc tgtgagcctt aagcatgtga atccccccac atgacaagtg gggagaccca
     4741 gggtaggctt tcctttggat catctccaaa tgggagtgcc atgtggcagg aaagaagcac
     4801 cgatttcaag aattacttcc tagagaaagt caggaactag agaccagagt ctgcaggaac
     4861 tttgccactg cccttcactg gctaatcctg tacttctctc tgtgttcctt gagtgacagg
     4921 tggtaaaacc cttaaaaagg gaggtgtggg aggcccagga ctttggtaac aggtgatgaa
     4981 tgtgttgtct tggccatcac aggtggagct tcagttagta cccgagggat tcccctggca
     5041 caagcattat aggaattagt ccaccactgg cgtgggtgag cagccaggta atgggaattg
     5101 atcagtgcca ccacccttga ccccaactac catcccagat gcccagattc cagtcctgga
     5161 gttttattct ctcagcttga tcctttgacc aagaagatcc agtcccaata tgtcacctgt
     5221 gcttcatctt tggactatat ctcaggtgtt tacgtgtcaa ctaatgggag cttactgggt
     5281 tagaagtcag gacactgagt ttcaatcctc acttagtagt ctgtggccct ctttggcaca
     5341 ttaacctccc tccttgatcc tcaggctgca cctctggcaa atgggagaat gcggctcctt
     5401 ttgacttcaa gggatctttg tgggaaccaa tgagaaaatg tgtgtgaaga tagctttttg
     5461 gtatatttta aaagtgcaca aatttaagat cttactgctt tataaagtgc tttatgaatt
     5521 ataggaaaat aaacacattt tagatcttag aaaaaaacaa aaaaa
//
