LOCUS       NM_007221               1068 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens polyamine modulated factor 1 (PMF1), transcript
            variant 2, mRNA.
ACCESSION   NM_007221
VERSION     NM_007221.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1068)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1068)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1068)
  AUTHORS   Poh,J., Ponsford,A.H., Boyd,J., Woodsmith,J., Stelzl,U., Wanker,E.,
            Harper,N., MacEwan,D. and Sanderson,C.M.
  TITLE     A functionally defined high-density NRF2 interactome reveals new
            conditional regulators of ARE transactivation
  JOURNAL   Redox Biol 37, 101686 (2020)
   PUBMED   32911434
REFERENCE   4  (bases 1 to 1068)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1068)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1068)
  AUTHORS   Obuse,C., Iwasaki,O., Kiyomitsu,T., Goshima,G., Toyoda,Y. and
            Yanagida,M.
  TITLE     A conserved Mis12 centromere complex is linked to heterochromatic
            HP1 and outer kinetochore protein Zwint-1
  JOURNAL   Nat Cell Biol 6 (11), 1135-1141 (2004)
   PUBMED   15502821
REFERENCE   7  (bases 1 to 1068)
  AUTHORS   Cheeseman,I.M., Niessen,S., Anderson,S., Hyndman,F., Yates,J.R.
            3rd, Oegema,K. and Desai,A.
  TITLE     A conserved protein network controls assembly of the outer
            kinetochore and its ability to sustain tension
  JOURNAL   Genes Dev 18 (18), 2255-2268 (2004)
   PUBMED   15371340
REFERENCE   8  (bases 1 to 1068)
  AUTHORS   Wang,Y., Devereux,W., Stewart,T.M. and Casero,R.A. Jr.
  TITLE     Polyamine-modulated factor 1 binds to the human homologue of the 7a
            subunit of the Arabidopsis COP9 signalosome: implications in gene
            expression
  JOURNAL   Biochem J 366 (Pt 1), 79-86 (2002)
   PUBMED   12020345
  REMARK    GeneRIF: Polyamine-modulated factor 1 binds to CSN7.
REFERENCE   9  (bases 1 to 1068)
  AUTHORS   Wang,Y., Devereux,W., Stewart,T.M. and Casero,R.A. Jr.
  TITLE     Characterization of the interaction between the transcription
            factors human polyamine modulated factor (PMF-1) and NF-E2-related
            factor 2 (Nrf-2) in the transcriptional regulation of the
            spermidine/spermine N1-acetyltransferase (SSAT) gene
  JOURNAL   Biochem J 355 (Pt 1), 45-49 (2001)
   PUBMED   11256947
REFERENCE   10 (bases 1 to 1068)
  AUTHORS   Wang,Y., Devereux,W., Stewart,T.M. and Casero,R.A. Jr.
  TITLE     Cloning and characterization of human polyamine-modulated factor-1,
            a transcriptional cofactor that regulates the transcription of the
            spermidine/spermine N(1)-acetyltransferase gene
  JOURNAL   J Biol Chem 274 (31), 22095-22101 (1999)
   PUBMED   10419538
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL135927.14.
            
            On Mar 22, 2021 this sequence version replaced NM_007221.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056417.1, AK289490.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368277.3/ ENSP00000357260.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AL135927.14        100695-100864
            171-276             AL135927.14        120008-120113
            277-377             AL135927.14        121316-121416
            378-573             AL135927.14        123976-124171
            574-1068            AL135927.14        127236-127730
FEATURES             Location/Qualifiers
     source          1..1068
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1068
                     /gene="PMF1"
                     /note="polyamine modulated factor 1"
                     /db_xref="GeneID:11243"
                     /db_xref="HGNC:HGNC:9112"
                     /db_xref="MIM:609176"
     exon            1..170
                     /gene="PMF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..627
                     /gene="PMF1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Est1p-like protein B (EST1B)"
                     /codon_start=1
                     /product="polyamine-modulated factor 1 isoform 2"
                     /protein_id="NP_009152.2"
                     /db_xref="CCDS:CCDS30886.1"
                     /db_xref="GeneID:11243"
                     /db_xref="HGNC:HGNC:9112"
                     /db_xref="MIM:609176"
                     /translation="MAEASSANLGSGCEEKRHEGSSSESVPPGTTISRVKLLDTMVDT
                     FLQKLVAAGSYQRFTDCYKCFYQLQPAMTQQIYDKFIAQLQTSIREEISDIKEEGNLE
                     AVLNALDKIVEEGKVRKEPAWRPSGIPEKDLHSVMAPYFLQQRDTLRRHVQKQEAENQ
                     QLADAVLAGRRQVEELQLQVQAQQQAWQALHREQRELVAVLREPE"
     exon            171..276
                     /gene="PMF1"
                     /inference="alignment:Splign:2.1.0"
     exon            277..377
                     /gene="PMF1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..573
                     /gene="PMF1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..1068
                     /gene="PMF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1043..1048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PMF1"
                     /note="hexamer: AATAAA"
     polyA_site      1068
                     /gene="PMF1"
                     /note="major polyA site"
ORIGIN      
        1 aacttcaaca tggccgaagc aagtagcgcc aatctaggca gcggctgtga ggaaaaaagg
       61 catgaggggt cgtcttcgga atctgtgcca cccggcacta ccatttcgag ggtgaagctc
      121 ctcgacacca tggtggacac ttttcttcag aagctggtcg ccgccggcag ctaccagaga
      181 ttcactgact gctataagtg cttctaccag ttgcagcctg cgatgacaca gcaaatctat
      241 gacaagttta tagctcagtt gcagacatct atccgggagg aaatctctga catcaaagag
      301 gaggggaacc tagaagctgt cttgaatgcc ttggataaaa ttgtggaaga aggcaaagtc
      361 cgcaaagagc cagcctggcg ccccagcggg atcccagaga aggatctgca cagtgttatg
      421 gcaccctact tcctgcagca acgggacacc ctgcggcgcc atgtgcagaa acaggaggcc
      481 gagaaccagc agctggcaga tgccgtcctg gcagggcgga ggcaggtgga ggagctgcag
      541 ctacaggtcc aggcccagca gcaggcctgg caggctctac acagagaaca gagggagctg
      601 gttgctgtgc tgagggagcc tgagtgagga gaccgccagc cccagaagca gagggcagtc
      661 aaggtcaaga gcctgtggtc cagcatgcct ggcctgggcg ggctacctct gagaacggct
      721 gaaatggtgc ccagtccatc agcagtgatg gaatttgctg gaggactagg ccagagcaag
      781 cctcactgcc actgtgcctt tggggcaccc ttggggttgg acatacaccc cctttagatt
      841 cctctgtttc ttctacctgg ataattcttg gccatgttct ctcttctcta ggttcaggtc
      901 agctctgccc ctccgccccc ctcctgctgg ttccccagcc cttttccctg gccctggctt
      961 ggagaatctg ttttcaatct ccactgattg cccccttgct ggccagccca ggggccttta
     1021 ccatgttctc tccacatccg taaataaact tccttcacta cactgtaa
//
