LOCUS       NM_020182               4954 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens prostate transmembrane protein, androgen induced 1
            (PMEPA1), transcript variant 1, mRNA.
ACCESSION   NM_020182
VERSION     NM_020182.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4954)
  AUTHORS   Yu,H., Zhuang,J., Zhou,Z., Song,Q., Lv,J., Yang,X., Yang,H. and
            Lu,Q.
  TITLE     METTL16 suppressed the proliferation and cisplatin-chemoresistance
            of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through
            autophagy pathway
  JOURNAL   Int J Biol Sci 20 (4), 1471-1491 (2024)
   PUBMED   38385084
  REMARK    GeneRIF: METTL16 suppressed the proliferation and
            cisplatin-chemoresistance of bladder cancer by degrading PMEPA1
            mRNA in a m6A manner through autophagy pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4954)
  AUTHORS   Wen,F., Yang,S., Cai,W., Zhao,M., Qin,L. and Jiao,Z.
  TITLE     Exploring the role of PMEPA1 in gastric cancer
  JOURNAL   Mol Cell Probes 72, 101931 (2023)
   PUBMED   37683830
  REMARK    GeneRIF: Exploring the role of PMEPA1 in gastric cancer.
REFERENCE   3  (bases 1 to 4954)
  AUTHORS   Li,J. and Kong,W.M.
  TITLE     PMEPA1 Serves as a Prognostic Biomarker and Correlates with Immune
            Infiltrates in Cervical Cancer
  JOURNAL   J Immunol Res 2022, 4510462 (2022)
   PUBMED   35497877
  REMARK    GeneRIF: PMEPA1 Serves as a Prognostic Biomarker and Correlates
            with Immune Infiltrates in Cervical Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4954)
  AUTHORS   Qiu,D., Hu,J., Hu,J., Yu,A., Othmane,B., He,T., Ding,J., Cheng,X.,
            Ren,W., Tan,X., Yu,Q., Chen,J. and Zu,X.
  TITLE     PMEPA1 Is a Prognostic Biomarker That Correlates With Cell
            Malignancy and the Tumor Microenvironment in Bladder Cancer
  JOURNAL   Front Immunol 12, 705086 (2021)
   PUBMED   34777336
  REMARK    GeneRIF: PMEPA1 Is a Prognostic Biomarker That Correlates With Cell
            Malignancy and the Tumor Microenvironment in Bladder Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4954)
  AUTHORS   Giannini,G., Ambrosini,M.I., Di Marcotullio,L., Cerignoli,F.,
            Zani,M., MacKay,A.R., Screpanti,I., Frati,L. and Gulino,A.
  TITLE     EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a
            conserved gene family and is overexpressed and amplified in breast
            and ovarian cancer
  JOURNAL   Mol Carcinog 38 (4), 188-200 (2003)
   PUBMED   14639658
REFERENCE   6  (bases 1 to 4954)
  AUTHORS   Xu,L.L., Shi,Y., Petrovics,G., Sun,C., Makarem,M., Zhang,W.,
            Sesterhenn,I.A., McLeod,D.G., Sun,L., Moul,J.W. and Srivastava,S.
  TITLE     PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell
            growth inhibitory function and decreased expression during prostate
            cancer progression
  JOURNAL   Cancer Res 63 (15), 4299-4304 (2003)
   PUBMED   12907594
  REMARK    GeneRIF: PMEPA1 negatively regulates growth of androgen responsive
            or refractory prostate cancer cells, and these functions may be
            mediated through the interaction of PMEPA1 with the NEDD4 protein.
REFERENCE   7  (bases 1 to 4954)
  AUTHORS   Brunschwig,E.B., Wilson,K., Mack,D., Dawson,D., Lawrence,E.,
            Willson,J.K., Lu,S., Nosrati,A., Rerko,R.M., Swinler,S., Beard,L.,
            Lutterbaugh,J.D., Willis,J., Platzer,P. and Markowitz,S.
  TITLE     PMEPA1, a transforming growth factor-beta-induced marker of
            terminal colonocyte differentiation whose expression is maintained
            in primary and metastatic colon cancer
  JOURNAL   Cancer Res 63 (7), 1568-1575 (2003)
   PUBMED   12670906
  REMARK    GeneRIF: Expression of PMEPA1 was well maintained both in colon
            cancer primary tumors and in colon cancer liver metastases.
REFERENCE   8  (bases 1 to 4954)
  AUTHORS   Rae,F.K., Hooper,J.D., Nicol,D.L. and Clements,J.A.
  TITLE     Characterization of a novel gene, STAG1/PMEPA1, upregulated in
            renal cell carcinoma and other solid tumors
  JOURNAL   Mol Carcinog 32 (1), 44-53 (2001)
   PUBMED   11568975
REFERENCE   9  (bases 1 to 4954)
  AUTHORS   Jolliffe,C.N., Harvey,K.F., Haines,B.P., Parasivam,G. and Kumar,S.
  TITLE     Identification of multiple proteins expressed in murine embryos as
            binding partners for the WW domains of the ubiquitin-protein ligase
            Nedd4
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 557-565 (2000)
   PUBMED   11042109
REFERENCE   10 (bases 1 to 4954)
  AUTHORS   Xu,L.L., Shanmugam,N., Segawa,T., Sesterhenn,I.A., McLeod,D.G.,
            Moul,J.W. and Srivastava,S.
  TITLE     A novel androgen-regulated gene, PMEPA1, located on chromosome
            20q13 exhibits high level expression in prostate
  JOURNAL   Genomics 66 (3), 257-263 (2000)
   PUBMED   10873380
  REMARK    Erratum:[Genomics 2000 Dec 15;70(3):407]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121913.4, BM846677.1,
            AF305616.1 and BQ008707.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020182.4.
            
            Summary: This gene encodes a transmembrane protein that contains a
            Smad interacting motif (SIM). Expression of this gene is induced by
            androgens and transforming growth factor beta, and the encoded
            protein suppresses the androgen receptor and transforming growth
            factor beta signaling pathways though interactions with Smad
            proteins. Overexpression of this gene may play a role in multiple
            types of cancer. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.117985.1, AF305616.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154125, SAMEA2162946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341744.8/ ENSP00000345826.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AL121913.4         52878-52917         c
            41-113              BM846677.1         2-74
            114-4952            AF305616.1         1-4839
            4953-4954           BQ008707.1         21-22               c
FEATURES             Location/Qualifiers
     source          1..4954
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.31"
     gene            1..4954
                     /gene="PMEPA1"
                     /gene_synonym="STAG1; TMEPAI"
                     /note="prostate transmembrane protein, androgen induced 1"
                     /db_xref="GeneID:56937"
                     /db_xref="HGNC:HGNC:14107"
                     /db_xref="MIM:606564"
     exon            1..542
                     /gene="PMEPA1"
                     /gene_synonym="STAG1; TMEPAI"
                     /inference="alignment:Splign:2.1.0"
     CDS             434..1297
                     /gene="PMEPA1"
                     /gene_synonym="STAG1; TMEPAI"
                     /note="isoform a is encoded by transcript variant 1;
                     transmembrane, prostate androgen induced RNA; solid
                     tumor-associated 1 protein; protein TMEPAI; solid
                     tumor-associated gene 1"
                     /codon_start=1
                     /product="protein TMEPAI isoform a"
                     /protein_id="NP_064567.2"
                     /db_xref="CCDS:CCDS13463.1"
                     /db_xref="GeneID:56937"
                     /db_xref="HGNC:HGNC:14107"
                     /db_xref="MIM:606564"
                     /translation="MHRLMGVNSTAAAAAGQPNVSCTCNCKRSLFQSMEITELEFVQI
                     IIIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGN
                     GIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPP
                     YQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATC
                     YGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWS
                     KEKDKQKGHPL"
     exon            543..697
                     /gene="PMEPA1"
                     /gene_synonym="STAG1; TMEPAI"
                     /inference="alignment:Splign:2.1.0"
     exon            698..751
                     /gene="PMEPA1"
                     /gene_synonym="STAG1; TMEPAI"
                     /inference="alignment:Splign:2.1.0"
     exon            752..4954
                     /gene="PMEPA1"
                     /gene_synonym="STAG1; TMEPAI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2271..2276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PMEPA1"
                     /gene_synonym="STAG1; TMEPAI"
                     /note="hexamer: AATAAA"
     polyA_site      2291
                     /gene="PMEPA1"
                     /gene_synonym="STAG1; TMEPAI"
                     /note="major polyA site"
     regulatory      4931..4936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PMEPA1"
                     /gene_synonym="STAG1; TMEPAI"
                     /note="hexamer: AATAAA"
     polyA_site      4954
                     /gene="PMEPA1"
                     /gene_synonym="STAG1; TMEPAI"
                     /note="major polyA site"
ORIGIN      
        1 gtcagaccgt ctgcctgcct ccgaccgcgg tctcggagcg aaacccgatc tccttggact
       61 tgaatgagga ggaggaggcg gcggcggcgg cggcggcgga ggcgctcggc tggggaaagc
      121 tagcggcaga ggctcagccc cggcggcagc gcgcgccccg ctgccagccc attttccgga
      181 cgccacccgc gggcactgcc gacgcccccg gggctgccga ggggaggccg ggggggcgca
      241 gcggagcgcg gtcccgcgca ctgagccccg cggcgccccg ggaacttggc ggcgacccga
      301 gcccggcgag ccggggcgcg cctcccccgc cgcgcgcctc ctgcatgcgg ggccccagct
      361 ccgggcgccg gccggagccc cccccggccg cccccgagcc ccccgcgccc cgcgccgcgc
      421 cgccgcgccg tccatgcacc gcttgatggg ggtcaacagc accgccgccg ccgccgccgg
      481 gcagcccaat gtctcctgca cgtgcaactg caaacgctct ttgttccaga gcatggagat
      541 cacggagctg gagtttgttc agatcatcat catcgtggtg gtgatgatgg tgatggtggt
      601 ggtgatcacg tgcctgctga gccactacaa gctgtctgca cggtccttca tcagccggca
      661 cagccagggg cggaggagag aagatgccct gtcctcagaa ggatgcctgt ggccctcgga
      721 gagcacagtg tcaggcaacg gaatcccaga gccgcaggtc tacgccccgc ctcggcccac
      781 cgaccgcctg gccgtgccgc ccttcgccca gcgggagcgc ttccaccgct tccagcccac
      841 ctatccgtac ctgcagcacg agatcgacct gccacccacc atctcgctgt cagacgggga
      901 ggagccccca ccctaccagg gcccctgcac cctccagctt cgggaccccg agcagcagct
      961 ggaactgaac cgggagtcgg tgcgcgcacc cccaaacaga accatcttcg acagtgacct
     1021 gatggatagt gccaggctgg gcggcccctg cccccccagc agtaactcgg gcatcagcgc
     1081 cacgtgctac ggcagcggcg ggcgcatgga ggggccgccg cccacctaca gcgaggtcat
     1141 cggccactac ccggggtcct ccttccagca ccagcagagc agtgggccgc cctccttgct
     1201 ggaggggacc cggctccacc acacacacat cgcgccccta gagagcgcag ccatctggag
     1261 caaagagaag gataaacaga aaggacaccc tctctagggt ccccaggggg gccgggctgg
     1321 ggctgcgtag gtgaaaaggc agaacactcc gcgcttctta gaagaggagt gagaggaagg
     1381 cggggggcgc agcaacgcat cgtgtggccc tcccctccca cctccctgtg tataaatatt
     1441 tacatgtgat gtctggtctg aatgcacaag ctaagagagc ttgcaaaaaa aaaaagaaaa
     1501 aagaaaaaaa aaaaccacgt ttctttgttg agctgtgtct tgaaggcaaa agaaaaaaaa
     1561 tttctacagt agtctttctt gtttctagtt gagctgcgtg cgtgaatgct tattttcttt
     1621 tgtttatgat aatttcactt aactttaaag acatatttgc acaaaacctt tgtttaaaga
     1681 tctgcaatat tatatatata aatatatata agataagaga aactgtatgt gcgagggcag
     1741 gagtattttt gtattagaag aggcctatta aaaaaaaaag ttgttttctg aactagaaga
     1801 ggaaaaaaat ggcaattttt gagtgccaag tcagaaagtg tgtattacct tgtaaagaaa
     1861 aaaattacaa agcaggggtt tagagttatt tatataaatg ttgagatttt gcactatttt
     1921 ttaatataaa tatgtcagtg cttgcttgat ggaaacttct cttgtgtctg ttgagacttt
     1981 aagggagaaa tgtcggaatt tcagagtcgc ctgacggcag agggtgagcc cccgtggagt
     2041 ctgcagagag gccttggcca ggagcggcgg gctttcccga ggggccactg tccctgcaga
     2101 gtggatgctt ctgcctagtg acaggttatc accacgttat atattcccta ccgaaggaga
     2161 caccttttcc cccctgaccc agaacagcct ttaaatcaca agcaaaatag gaaagttaac
     2221 cacggaggca ccgagttcca ggtagtggtt ttgcctttcc caaaaatgaa aataaactgt
     2281 taccgaagga attagttttt cctcttcttt tttccaactg tgaaggtccc cgtggggtgg
     2341 agcatggtgc ccctcacaag ccgcagcggc tggtgcccgg gctaccaggg acatgccaga
     2401 gggctcgatg acttgtctct gcagggcgct ttggtggttg ttcagctggc taaaggttca
     2461 ccggtgaagg caggtgcggt aactgccgca ctggacccta ggaagcccca ggtattcgca
     2521 atctgacctc ctcctgtctg tttcccttca cggatcaatt ctcacttaag aggccaataa
     2581 acaacccaac atgaaaaggt gacaagcctg ggtttctccc aggataggtg aaagggttaa
     2641 aatgagtaaa gcagttgagc aaacaccaac ccgagcttcg ggcgcagaat tcttcacctt
     2701 ctcttcccct ttccatctcc tttccccgcg gaaacaacgc ttcccttctg gtgtgtctgt
     2761 tgatctgtgt tttcatttac atctctctta gactccgctc ttgttctcca ggttttcacc
     2821 agatagattt ggggttggcg ggacctgctg gtgacgtgca ggtgaaggac aggaaggggc
     2881 atgtgagcgt aaatagaggt gaccagagga gagcatgagg ggtggggctt tgggacccac
     2941 cggggccagt ggctggagct tgacgtcttt cctccccatg ggggtgggag ggcccccagc
     3001 tggaagagca gactcccagc tgctaccccc tcccttccca tgggagtggc tttccatttt
     3061 gggcagaatg ctgactagta gactaacata aaagatataa aaggcaataa ctattgtttg
     3121 tgagcaactt ttttataact tccaaaacaa aaacctgagc acagttttga agttctagcc
     3181 actcgagctc atgcatgtga aacgtgtgct ttacgaaggt ggcagctgac agacgtgggc
     3241 tctgcatgcc gccagcctag tagaaagttc tcgttcattg gcaacagcag aacctgcctc
     3301 tccgtgaagt cgtcagccta aaatttgttt ctctcttgaa gaggattctt tgaaaaggtc
     3361 ctgcagagaa atcagtacag gttatcccga aaggtacaag gacgcacttg taaagatgat
     3421 taaaacgtat ctttccttta tgtgacgcgt ctctagtgcc ttactgaaga agcagtgaca
     3481 ctcccgtcgc tcggtgagga cgttcccgga cagtgcctca ctcacctggg actggtatcc
     3541 cctcccaggg tccaccaagg gctcctgctt ttcagacacc ccatcatcct cgcgcgtcct
     3601 caccctgtct ctaccaggga ggtgcctagc ttggtgaggt tactcctgct cctccaacct
     3661 ttttttgcca aggtttgtac acgactccca tctaggctga aaacctagaa gtggaccttg
     3721 tgtgtgtgca tggtgtcagc ccaaagccag gctgagacag tcctcatatc ctcttgagcc
     3781 aaactgtttg ggtctcgttg cttcatggta tggtctggat ttgtgggaat ggctttgcgt
     3841 gagaaagggg aggagagtgg ttgctgccct cagccggctt gaggacagag cctgtccctc
     3901 tcatgacaac tcagtgttga agcccagtgt cctcagcttc atgtccagtg gatggcagaa
     3961 gttcatgggg tagtggcctc tcaaaggctg ggcgcatccc aagacagcca gcaggttgtc
     4021 tctggaaacg accagagtta agctctcggc ttctctgctg agggtgcacc ctttcctcta
     4081 gatggtagtt gtcacgttat ctttgaaaac tcttggactg ctcctgagga ggccctcttt
     4141 tccagtagga agttagatgg gggttctcag aagtggctga ttggaagggg acaagcttcg
     4201 tttcaggggt ctgccgttcc atcctggttc agagaaggcc gagcgtggct ttctctagcc
     4261 ttgtcactgt ctccctgcct gtcaatcacc acctttcctc cagaggagga aaattatctc
     4321 ccctgcaaag cccggttcta cacagatttc acaaattgtg ctaagaaccg tccgtgttct
     4381 cagaaagccc agtgtttttg caaagaatga aaagggaccc catatgtagc aaaaatcagg
     4441 gctgggggag agccgggttc attccctgtc ctcattggtc gtccctatga attgtacgtt
     4501 tcagagaaat tttttttcct atgtgcaaca cgaagcttcc agaaccataa aatatcccgt
     4561 cgataaggaa agaaaatgtc gttgttgttg tttttctgga aactgcttga aatcttgctg
     4621 tactatagag ctcagaagga cacagcccgt cctcccctgc ctgcctgatt ccatggctgt
     4681 tgtgctgatt ccaatgcttt cacgttggtt cctggcgtgg gaactgctct cctttgcagc
     4741 cccatttccc aagctctgtt caagttaaac ttatgtaagc tttccgtggc atgcggggcg
     4801 cgcacccacg tccccgctgc gtaagactct gtatttggat gccaatccac aggcctgaag
     4861 aaactgcttg ttgtgtatca gtaatcatta gtggcaatga tgacattctg aaaagctgca
     4921 atacttatac aataaatttt acaattcttt ggaa
//
