LOCUS       NM_002674                754 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens pro-melanin concentrating hormone (PMCH), mRNA.
ACCESSION   NM_002674
VERSION     NM_002674.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 754)
  AUTHORS   Gao,Y., Zhou,Q., Li,H., Zhao,Y., Zhu,H., Zhang,X. and Li,Y.
  TITLE     Melanin-Concentrating Hormone Is Associated With Delayed
            Neurocognitive Recovery in Older Adult Patients With Preoperative
            Sleep Disorders Undergoing Spinal Anesthesia
  JOURNAL   Anesth Analg 138 (3), 579-588 (2024)
   PUBMED   38051670
  REMARK    GeneRIF: Melanin-Concentrating Hormone Is Associated With Delayed
            Neurocognitive Recovery in Older Adult Patients With Preoperative
            Sleep Disorders Undergoing Spinal Anesthesia.
REFERENCE   2  (bases 1 to 754)
  AUTHORS   Lord,M.N., Subramanian,K., Kanoski,S.E. and Noble,E.E.
  TITLE     Melanin-concentrating hormone and food intake control: Sites of
            action, peptide interactions, and appetition
  JOURNAL   Peptides 137, 170476 (2021)
   PUBMED   33370567
  REMARK    GeneRIF: Melanin-concentrating hormone and food intake control:
            Sites of action, peptide interactions, and appetition.
            Review article
REFERENCE   3  (bases 1 to 754)
  AUTHORS   Takahashi,K., Ohba,K. and Kaneko,K.
  TITLE     Ubiquitous expression and multiple functions of biologically active
            peptides
  JOURNAL   Peptides 72, 184-191 (2015)
   PUBMED   25868673
  REMARK    Review article
REFERENCE   4  (bases 1 to 754)
  AUTHORS   Naufahu,J., Cunliffe,A.D. and Murray,J.F.
  TITLE     The roles of melanin-concentrating hormone in energy balance and
            reproductive function: Are they connected?
  JOURNAL   Reproduction 146 (5), R141-R150 (2013)
   PUBMED   23884861
  REMARK    GeneRIF: MCH is an anabolic neuropeptide with multiple and diverse
            physiological functions including a key role in energy
            homoeostasis; evidence suggests that, in the reproductive context,
            MCH is a modulator rather than a primary regulator.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 754)
  AUTHORS   Schmidt,F.M., Kratzsch,J., Gertz,H.J., Tittmann,M., Jahn,I.,
            Pietsch,U.C., Kaisers,U.X., Thiery,J., Hegerl,U. and Schonknecht,P.
  TITLE     Cerebrospinal fluid melanin-concentrating hormone (MCH) and
            hypocretin-1 (HCRT-1, orexin-A) in Alzheimer's disease
  JOURNAL   PLoS One 8 (5), e63136 (2013)
   PUBMED   23667582
  REMARK    GeneRIF: Cerebrospinal fluid (CSF) levels were measured in 33
            patients with Alzheimer's disease (AD) and 33 healthy subjects, to
            investigate the role of MCH and HCRT-1 in AD.
            Erratum:[PLoS One. 2013;8(6).
            doi:10.1371/annotation/7a79c40c-c1c2-41eb-a894-614c12e8c056]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 754)
  AUTHORS   Nahon,J.L., Joly,C., Levan,G., Szpirer,J. and Szpirer,C.
  TITLE     Pro-melanin-concentrating hormone gene (PMCH) is localized on human
            chromosome 12q and rat chromosome 7
  JOURNAL   Genomics 12 (4), 846-848 (1992)
   PUBMED   1572663
REFERENCE   7  (bases 1 to 754)
  AUTHORS   Presse,F., Nahon,J.L., Fischer,W.H. and Vale,W.
  TITLE     Structure of the human melanin concentrating hormone mRNA
  JOURNAL   Mol Endocrinol 4 (4), 632-637 (1990)
   PUBMED   2149166
REFERENCE   8  (bases 1 to 754)
  AUTHORS   Bresson,J.L., Clavequin,M.C., Fellmann,D. and Bugnon,C.
  TITLE     Human hypothalamic neuronal system revealed with a salmon
            melanin-concentrating hormone (MCH) antiserum
  JOURNAL   Neurosci Lett 102 (1), 39-43 (1989)
   PUBMED   2779843
REFERENCE   9  (bases 1 to 754)
  AUTHORS   Sekiya,K., Ghatei,M.A., Lacoumenta,S., Burnet,P.W., Zamir,N.,
            Burrin,J.M., Polak,J.M. and Bloom,S.R.
  TITLE     The distribution of melanin-concentrating hormone-like
            immunoreactivity in the central nervous system of rat, guinea-pig,
            pig and man
  JOURNAL   Neuroscience 25 (3), 925-930 (1988)
   PUBMED   3405434
REFERENCE   10 (bases 1 to 754)
  AUTHORS   Pelletier,G., Guy,J., Desy,L., Li,S., Eberle,A.N. and Vaudry,H.
  TITLE     Melanin-concentrating hormone (MCH) is colocalized with
            alpha-melanocyte-stimulating hormone (alpha-MSH) in the rat but not
            in the human hypothalamus
  JOURNAL   Brain Res 423 (1-2), 247-253 (1987)
   PUBMED   2823986
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB047053.1 and CB047052.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002674.3.
            
            Summary: This gene encodes a preproprotein that is proteolytically
            processed to generate multiple protein products. These products
            include melanin-concentrating hormone (MCH), neuropeptide-glutamic
            acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid
            (NGE). Melanin-concentrating hormone is a 19-amino acid
            neuropeptide that stimulates hunger and may additionally regulate
            energy homeostasis, reproductive function, and sleep. Pseudogenes
            of this gene have been identified on chromosome 5. [provided by
            RefSeq, Jul 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018048.1, BG706895.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329406.5/ ENSP00000332225.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               CB047053.1         22-526
            506-754             CB047052.1         25-273              c
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.2"
     gene            1..754
                     /gene="PMCH"
                     /gene_synonym="MCH; ppMCH"
                     /note="pro-melanin concentrating hormone"
                     /db_xref="GeneID:5367"
                     /db_xref="HGNC:HGNC:9109"
                     /db_xref="MIM:176795"
     exon            1..312
                     /gene="PMCH"
                     /gene_synonym="MCH; ppMCH"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..561
                     /gene="PMCH"
                     /gene_synonym="MCH; ppMCH"
                     /note="pro-MCH; prepro-MCH; prepro-melanin-concentrating
                     hormone"
                     /codon_start=1
                     /product="pro-MCH preproprotein"
                     /protein_id="NP_002665.2"
                     /db_xref="CCDS:CCDS31885.1"
                     /db_xref="GeneID:5367"
                     /db_xref="HGNC:HGNC:9109"
                     /db_xref="MIM:176795"
                     /translation="MAKMNLSSYILILTFSLFSQGILLSASKSIRNLDDDMVFNTFRL
                     GKGFQKEDTAEKSVIAPSLEQYKNDESSFMNEEENKVSKNTGSKHNFLNHGLPLNLAI
                     KPYLALKGSVAFPAENGVQNTESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYR
                     PCWQV"
     exon            313..511
                     /gene="PMCH"
                     /gene_synonym="MCH; ppMCH"
                     /inference="alignment:Splign:2.1.0"
     exon            512..754
                     /gene="PMCH"
                     /gene_synonym="MCH; ppMCH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      728..733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PMCH"
                     /gene_synonym="MCH; ppMCH"
                     /note="hexamer: ATTAAA"
     polyA_site      754
                     /gene="PMCH"
                     /gene_synonym="MCH; ppMCH"
                     /note="major polyA site"
ORIGIN      
        1 aggctgacag agaaattttt cattttcttt cttgtttgac tgtatgcaaa catcaaacta
       61 agaatggcaa aaatgaatct ctcttcctat atattaatac taactttttc tttgttttct
      121 caaggtattt tactttcagc atccaagtcc ataagaaatt tagatgatga catggtattt
      181 aatacattca ggttggggaa aggctttcag aaggaagaca ctgcagaaaa atcagttatt
      241 gctccttccc tggaacaata taaaaatgat gagagcagtt tcatgaacga agaggaaaat
      301 aaagtttcaa agaacacagg ctccaaacat aatttcttaa atcatggtct gccactgaat
      361 ctggctataa aaccttatct tgcactaaaa ggatctgtag ctttcccagc tgagaatgga
      421 gttcagaata ctgaatcaac acaagaaaag agagaaattg gggatgaaga aaactcagct
      481 aaatttccta taggaaggag agattttgac atgctcagat gtatgctggg aagagtctac
      541 cgaccttgtt ggcaagtctg atacctgttg gtccacatca tcttttcaga agaaaataaa
      601 agcatttaat tgccaatggg aggagaagcc catactgcta ctataacttg tgtatgttaa
      661 atgtctgttt taaaagaaag tagtgttaag atgtatcagt aactgaaatg atatgctttc
      721 tctgtgcatt aaactttgtg aaaattctgc ataa
//
