LOCUS       NM_021127               1899 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens phorbol-12-myristate-13-acetate-induced protein 1
            (PMAIP1), transcript variant 6, mRNA.
ACCESSION   NM_021127
VERSION     NM_021127.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1899)
  AUTHORS   Ling,Y., Hu,L., Chen,J., Zhao,M. and Dai,X.
  TITLE     The mechanism of mitochondrial metabolic gene PMAIP1 involved in
            Alzheimer's disease process based on bioinformatics analysis and
            experimental validation
  JOURNAL   Clinics (Sao Paulo) 79, 100373 (2024)
   PUBMED   38692009
  REMARK    GeneRIF: The mechanism of mitochondrial metabolic gene PMAIP1
            involved in Alzheimer's disease process based on bioinformatics
            analysis and experimental validation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1899)
  AUTHORS   Shi,J., Ding,F., Dai,D., Song,X., Wu,X., Yan,D., Han,X., Tao,G. and
            Dai,W.
  TITLE     Noxa inhibits oncogenesis through ZNF519 in gastric cancer and is
            suppressed by hsa-miR-200b-3p
  JOURNAL   Sci Rep 14 (1), 6568 (2024)
   PUBMED   38503887
  REMARK    GeneRIF: Noxa inhibits oncogenesis through ZNF519 in gastric cancer
            and is suppressed by hsa-miR-200b-3p.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1899)
  AUTHORS   Al Shboul,S., El-Sadoni,M., Alhesa,A., Abu Shahin,N.,
            Abuquteish,D., Abu Al Karsaneh,O., Alsharaiah,E., Ismail,M.A.,
            Tyutyunyk-Massey,L., Alotaibi,M.R., Neely,V., Harada,H. and
            Saleh,T.
  TITLE     NOXA expression is downregulated in human breast cancer undergoing
            incomplete pathological response and senescence after neoadjuvant
            chemotherapy
  JOURNAL   Sci Rep 13 (1), 15903 (2023)
   PUBMED   37741850
  REMARK    GeneRIF: NOXA expression is downregulated in human breast cancer
            undergoing incomplete pathological response and senescence after
            neoadjuvant chemotherapy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1899)
  AUTHORS   Voss,A.K. and Strasser,A.
  TITLE     The essentials of developmental apoptosis
  JOURNAL   F1000Res 9 (2020)
   PUBMED   32148779
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1899)
  AUTHORS   Morsi,R.Z., Hage-Sleiman,R., Kobeissy,H. and Dbaibo,G.
  TITLE     Noxa: Role in Cancer Pathogenesis and Treatment
  JOURNAL   Curr Cancer Drug Targets 18 (10), 914-928 (2018)
   PUBMED   29521234
  REMARK    Review article
REFERENCE   6  (bases 1 to 1899)
  AUTHORS   Guikema,J.E., Amiot,M. and Eldering,E.
  TITLE     Exploiting the pro-apoptotic function of NOXA as a therapeutic
            modality in cancer
  JOURNAL   Expert Opin Ther Targets 21 (8), 767-779 (2017)
   PUBMED   28670929
  REMARK    Review article
REFERENCE   7  (bases 1 to 1899)
  AUTHORS   Czabotar,P.E., Lessene,G., Strasser,A. and Adams,J.M.
  TITLE     Control of apoptosis by the BCL-2 protein family: implications for
            physiology and therapy
  JOURNAL   Nat Rev Mol Cell Biol 15 (1), 49-63 (2014)
   PUBMED   24355989
  REMARK    Review article
REFERENCE   8  (bases 1 to 1899)
  AUTHORS   Wang,Z. and Sun,Y.
  TITLE     Identification and characterization of two splicing variants of
            human Noxa
  JOURNAL   Anticancer Res 28 (3A), 1667-1674 (2008)
   PUBMED   18630524
  REMARK    GeneRIF: Two splicing variants of the human Noxa geneare
            identified, which consists of three exons and two introns.
            Alternative splicing of exon 2 yields three transcripts.
            Transcript-1 joins exons 1 and 3 to encode Noxa of 54 amino acids.
REFERENCE   9  (bases 1 to 1899)
  AUTHORS   Oda,E., Ohki,R., Murasawa,H., Nemoto,J., Shibue,T., Yamashita,T.,
            Tokino,T., Taniguchi,T. and Tanaka,N.
  TITLE     Noxa, a BH3-only member of the Bcl-2 family and candidate mediator
            of p53-induced apoptosis
  JOURNAL   Science 288 (5468), 1053-1058 (2000)
   PUBMED   10807576
REFERENCE   10 (bases 1 to 1899)
  AUTHORS   Hijikata,M., Kato,N., Sato,T., Kagami,Y. and Shimotohno,K.
  TITLE     Molecular cloning and characterization of a cDNA for a novel
            phorbol-12-myristate-13-acetate-responsive gene that is highly
            expressed in an adult T-cell leukemia cell line
  JOURNAL   J Virol 64 (10), 4632-4639 (1990)
   PUBMED   2398525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF667112.1, BC013120.1, BC032663.1 and BM999509.1.
            
            On Jun 2, 2019 this sequence version replaced NM_021127.2.
            
            Summary: This gene belongs to a pro-apoptotic subfamily within the
            BCL-2 protein family, referred to as the BCL-2 homology domain 3
            (BH3)-only subfamily, which determine whether a cell commits to
            apoptosis. In response to death-inducing stimuli, BH3-only members
            inhibit the anti-apoptotic BCL-2 family members, which under
            steady-state conditions keep the multi-BH domain proteins BAX and
            BAK, in an inactive state. [provided by RefSeq, Aug 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.218718.1,
                                           SRR3476690.195483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316660.7/ ENSP00000326119.7
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BF667112.1         38-78
            42-663              BC013120.1         1-622
            664-1131            BC032663.1         806-1273
            1132-1614           BC013120.1         1092-1574
            1615-1899           BM999509.1         20-304              c
FEATURES             Location/Qualifiers
     source          1..1899
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.32"
     gene            1..1899
                     /gene="PMAIP1"
                     /gene_synonym="APR; NOXA"
                     /note="phorbol-12-myristate-13-acetate-induced protein 1"
                     /db_xref="GeneID:5366"
                     /db_xref="HGNC:HGNC:9108"
                     /db_xref="MIM:604959"
     exon            1..240
                     /gene="PMAIP1"
                     /gene_synonym="APR; NOXA"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..347
                     /gene="PMAIP1"
                     /gene_synonym="APR; NOXA"
                     /note="isoform 6 is encoded by transcript variant 6; adult
                     T cell leukemia-derived PMA-responsive; protein Noxa;
                     PMA-induced protein 1; immediate-early-response protein
                     APR"
                     /codon_start=1
                     /product="phorbol-12-myristate-13-acetate-induced protein
                     1 isoform 6"
                     /protein_id="NP_066950.1"
                     /db_xref="CCDS:CCDS11975.1"
                     /db_xref="GeneID:5366"
                     /db_xref="HGNC:HGNC:9108"
                     /db_xref="MIM:604959"
                     /translation="MPGKKARKNAQPSPARAPAELEVECATQLRRFGDKLNFRQKLLN
                     LISKLFCSGT"
     exon            241..1899
                     /gene="PMAIP1"
                     /gene_synonym="APR; NOXA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1881..1886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PMAIP1"
                     /gene_synonym="APR; NOXA"
                     /note="hexamer: ATTAAA"
     polyA_site      1899
                     /gene="PMAIP1"
                     /gene_synonym="APR; NOXA"
                     /note="major polyA site"
ORIGIN      
        1 agagtttccc gggcactcac cgtgtgtagt tggcatctcc gcgcgtccgg acacccgatc
       61 ccagcatccc tgcctgcagg actgttcgtg ttcagctcgc gtcctgcagc tgtccgaggt
      121 gctccagttg gaggctgagg ttcccgggct ctgtagctga gtgggcggcg gcaccggcgg
      181 agatgcctgg gaagaaggcg cgcaagaacg ctcaaccgag ccccgcgcgg gctccagcag
      241 agctggaagt cgagtgtgct actcaactca ggagatttgg agacaaactg aacttccggc
      301 agaaacttct gaatctgata tccaaactct tctgctcagg aacctgactg catcaaaaac
      361 ttgcatgagg ggactccttc aaaagagttt tctcaggagg tgcacgtttc atcaatttga
      421 agaaagactg cattgtaatt gagaggaatg tgaaggtgca ttcatgggtg cccttggaaa
      481 cggaagatgg aatacatcaa agtgaatttc tgttcaagtt ttcccagatt atcattcttt
      541 gggatgagag aacattataa aaccactttg tttattttaa agcaagaatg gaagaccctt
      601 gaaaataaag aagtaattat tgacacattt cttttttact tagagaatcg ttctagtgtt
      661 tttgccgaag attaccgctg gcctactgtg aagggagatg acctgtgatt agactgggcg
      721 gctggggaga aacagttcag tgcattgttg ttgttgctgt ttttggtgtt ttgcttttca
      781 gtgccaactc agcacattgt atatgattcg gtttatacat attaccttgt tataatgaaa
      841 aaactcattc tgagaacact gaaatgttat actcagtgtt gatttcttcg gtcactacac
      901 aacgtaaaat catttgtttc ttttgactca aattgtattg cttctgttca gatgatcttt
      961 cattcaatgt gttcctgttg ggcgttacta gaaactatgg aaaactggaa aataactttg
     1021 aaaaaattgg ataaagtata ggagggttac ttggggccag taaatcagta gactgaacat
     1081 tcaatataat aaaagaacat ggggattttg tataaccagg gataataaaa agaaaaaaga
     1141 agttaatttt taattgatgt ttttgaaact tagtagaaca aatattcaga agtaacttga
     1201 taagatatga atgtttctaa agaagtttct aaaggttcgg aaaatgctcc ttgtcacatt
     1261 agtgtgcatc ctacaaaaag tgatctctta atgtaaatta agaatatttt cataattgga
     1321 atatactttt cttaaaaaaa aggaacagtt agttctcatc tagaatgaaa gttccatata
     1381 tgcattggtg aatatatatg tatacacata cttacatact tatatgggta tctgtataga
     1441 taatttgtat tagagtatta tatagcttct tagtagggtc tcaagtaagt ttcatttttt
     1501 ttatctgggc tatatacagt cctcaaataa ataatgtctt gattttattt cagcaggaat
     1561 aattttattt attttgccta tttataatta aagtattttt ctttagtttg aaaatgtgta
     1621 ttaaagttac atttttgagt tacaagagtc ttataactac ttgaattttt agttaaaatg
     1681 tcttaatgta ggttgtagtc actttagatg gaaaattacc tcacatctgt tttcttcagt
     1741 attacttaag attgtttatt tagtggtaga gagttttttt tttcagccta gaggcagcta
     1801 ttttaccatc tggtatttat ggtctaattt gtatttaaac atatgcacac atataaaagt
     1861 tgatactgtg gcagtaaact attaaaagtt ttcactgtt
//
