LOCUS       NM_001010853            4703 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens peptidase M20 domain containing 2 (PM20D2), mRNA.
ACCESSION   NM_001010853 XM_072402
VERSION     NM_001010853.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4703)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4703)
  AUTHORS   Veiga-da-Cunha,M., Chevalier,N., Stroobant,V., Vertommen,D. and Van
            Schaftingen,E.
  TITLE     Metabolite proofreading in carnosine and homocarnosine synthesis:
            molecular identification of PM20D2 as beta-alanyl-lysine
            dipeptidase
  JOURNAL   J Biol Chem 289 (28), 19726-19736 (2014)
   PUBMED   24891507
  REMARK    GeneRIF: PM20D2 hydrolyzed beta-alanyl-lysine,
            beta-alanyl-ornithine, gamma-aminobutyryl-lysine, and
            gamma-aminobutyryl-ornithine as its best substrates.
REFERENCE   3  (bases 1 to 4703)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC035036.1, AK302464.1, AL353135.32 and AA503266.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001010853.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035036.1, SRR1660807.66389.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275072.5/ ENSP00000275072.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BC035036.1         9-43
            36-1529             AK302464.1         1-1494
            1530-4350           AL353135.32        90759-93579
            4351-4703           AA503266.1         13-365              c
FEATURES             Location/Qualifiers
     source          1..4703
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..4703
                     /gene="PM20D2"
                     /gene_synonym="ACY1L2"
                     /note="peptidase M20 domain containing 2"
                     /db_xref="GeneID:135293"
                     /db_xref="HGNC:HGNC:21408"
                     /db_xref="MIM:615913"
     exon            1..555
                     /gene="PM20D2"
                     /gene_synonym="ACY1L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1401
                     /gene="PM20D2"
                     /gene_synonym="ACY1L2"
                     /EC_number="3.4.13.4"
                     /note="aminoacylase-1-like protein 2; I(2)-alanyl-lysine
                     dipeptidase; beta-alanyl-lysine dipeptidase; beta-Ala-Lys
                     dipeptidase"
                     /codon_start=1
                     /product="xaa-Arg dipeptidase"
                     /protein_id="NP_001010853.1"
                     /db_xref="CCDS:CCDS34499.1"
                     /db_xref="GeneID:135293"
                     /db_xref="HGNC:HGNC:21408"
                     /db_xref="MIM:615913"
                     /translation="MRPGGERPVEGGACNGRSELELLKLRSAECIDEAAERLGALSRA
                     IWSQPELAYEEHHAHRVLTHFFEREPPAASWAVQPHYQLPTAFRAEWEPPEARAPSAT
                     PRPLHLGFLCEYDALPGIGHACGHNLIAEVGAAAALGVRGALEGLPRPPPPVKVVVLG
                     TPAEEDGGGKIDLIEAGAFTNLDVVFMAHPSQENAAYLPDMAEHDVTVKYYGKASHSA
                     SYPWEGLNALDAAVLAYNNLSVFRQQMKPTWRVHGIIKNGGVKPNIIPSYSELIYYFR
                     APSMKELQVLTKKAEDCFRAAALASGCTVEIKGGAHDYYNVLPNKSLWKAYMENGRKL
                     GIEFISEDTMLNGPSGSTDFGNVSFVVPGIHPYFHIGSNALNHTEQYTEAAGSQEAQF
                     YTLRTAKALAMTALDVIFKPELLEGIREDFKLKLQEEQFVNAVE"
     exon            556..704
                     /gene="PM20D2"
                     /gene_synonym="ACY1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            705..847
                     /gene="PM20D2"
                     /gene_synonym="ACY1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1002
                     /gene="PM20D2"
                     /gene_synonym="ACY1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1138
                     /gene="PM20D2"
                     /gene_synonym="ACY1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1246
                     /gene="PM20D2"
                     /gene_synonym="ACY1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..4703
                     /gene="PM20D2"
                     /gene_synonym="ACY1L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4683..4688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PM20D2"
                     /gene_synonym="ACY1L2"
                     /note="hexamer: AATAAA"
     polyA_site      4703
                     /gene="PM20D2"
                     /gene_synonym="ACY1L2"
                     /note="major polyA site"
ORIGIN      
        1 ctggaggcct ctgggcgcgt gcgcgggcgg tcgctacctg cggccgagcc agggagcgag
       61 agggcgcaga gggcagcggg cttgggcagc atgaggcccg gaggggagcg gcccgtggaa
      121 gggggcgcgt gcaatggccg ctccgagctg gagctactga agctgcgctc ggcggagtgc
      181 atcgacgagg cggccgagcg gctgggggcc ctgagccgcg cgatctggag ccagcccgag
      241 ctggcctacg aggagcacca tgcccaccgc gtgctgacgc acttcttcga gcgggagccg
      301 cccgcggcct cctgggcagt gcagccgcac taccagctgc ccacggcctt ccgcgccgag
      361 tgggagccgc cggaggcccg ggcaccgagc gccacgccac gcccgctgca cctgggcttc
      421 ctctgcgagt acgacgcgct gcccggcatc ggccacgcct gcggccacaa cctcatcgct
      481 gaggtcgggg cggcggccgc gctgggcgtg aggggggcct tagagggcct ccccaggccg
      541 cctccgcccg tgaaggtagt tgtcctggga acccctgcag aagaagatgg tggtggcaaa
      601 attgatttaa ttgaagcagg ggcttttaca aatcttgatg ttgtttttat ggcccaccca
      661 tcacaagaga atgctgctta tctaccagat atggctgaac atgatgtgac tgtgaaatac
      721 tatggaaaag catctcattc tgcttcttat ccctgggaag gattaaatgc attagatgct
      781 gctgtgctgg cctataacaa tctgtctgtg ttcagacagc aaatgaaacc aacctggaga
      841 gttcatggta taataaaaaa tggtggtgta aaacccaata tcattccctc ttattctgaa
      901 ttaatctatt acttccgtgc accctcaatg aaagaacttc aagttttgac caaaaaggca
      961 gaagattgct tcagagctgc agctttggct tcagggtgca cagtggaaat taaaggtgga
     1021 gcacatgatt attacaatgt tcttcccaat aagagcctat ggaaagccta tatggaaaat
     1081 ggaagaaagc taggaataga gttcatttca gaagatacaa tgttgaatgg cccttcagga
     1141 tctacggatt ttggaaatgt tagttttgtg gttcctggaa ttcatccata ttttcacatt
     1201 ggatctaatg ccttgaatca tactgaacag tacactgaag ctgctgggtc acaggaagct
     1261 cagttctaca ctctgcggac ggccaaagct ctggcaatga cggcactgga tgttattttt
     1321 aaaccagagt tactggaagg aatcagagag gactttaaac tgaaacttca agaagaacag
     1381 tttgtaaatg cagtagaata aaagacttag gggccactta taaatcaaga agacgtgatg
     1441 atttttttct tttaatctct tttaatgaag gcatgcttgt tttttaatct taaaggagta
     1501 aaattctttt tacctgataa gtgaggacag ggtgtggaga aaacatatta attacctcat
     1561 atctaaagtg aaaatttttg caaatccgta cttgatagga ttatgatatt acaggagctg
     1621 gtatgtgatg ccattctttc ttttttttta ccccgcaacc actcaccttc acagtagtga
     1681 taccatttct taacctggag gatacatggc atcattttta taaaatatgt tagtaaacct
     1741 ttttgtaagc cttaaatgtt atgtgtattt ttaaaagctt aagagatttc aaaccttata
     1801 ttcagaattg acacccatga gagtgttttg tggtataggg tggtaaactt gttctctaat
     1861 cgtatattaa ttcctctacc agattgtata tttgaagcca gtgtctttcc tttttttgtt
     1921 ttaagataga gcctcgctct gttgcccagg ctgaagtgta gtggcacaat ctcggctcac
     1981 tgcaacctct gcctcccagg ttcaagtgat tctcctgcct cagcctacca agtagctggg
     2041 attacaggtg tgtggcacca tgcccagcta atttttgtat ttttagtaga gacggcattt
     2101 caccatgttg gccaggctgg tctcgaactc ctgacctcag gtgatgcacc tgcctcggcc
     2161 tcctaaagtg ctgggattac aggcatgagc caccgcaccc ggcctgccag tgtcttttta
     2221 atacacatgt gtgttggtat ttttaaattg ttacagtatc tagcatattg cttactctga
     2281 atattcagta ctttttgaat aagcaaatat tgcttccttg cttggaatca tcagagttta
     2341 aagtagcttc gtggatggac catgatccta agatgagttt taattttgtg tttacagtca
     2401 tctcttgtac aacgtggaga agaaaagata tacttactac tttgcttcag gtacacataa
     2461 gaaaacctct tttttaaaaa aatttttatt tttttacata atagagacag gggctcgctg
     2521 tagcttccag gctggcctca aactcctggg ctcaagcaat cctcctgtct tggcctccca
     2581 aagtgttggg atttcaggta tgagacacca cacctgccca tttttgtttg gttttttaat
     2641 gggcaggttc ttgctctccc aggctggagt gcagtggtgt aatcacagct cactgcagtc
     2701 tcgaactcct ggactcaagc agtcctccca cctcagcctc ctaaagcact gggattacag
     2761 gcttgaggca ctgcacctgg ccctgaccat tttttaaaaa ggttaggctt agtgcaaagt
     2821 ttaaaattat atgattctta aaatactgaa ttagtttcta aactaaacta gaggtatagg
     2881 tggacctgct tgaggtatct ttgtttttat ggaacatttt tattacatgc ctttataatt
     2941 tttcattgtt cacaccctgt actgaaacct ttttctcaaa taccaactct tggctatgtt
     3001 aaatttgtag actttaaaag atgttatcta aattaatggt ttaaatatac aaattgaaaa
     3061 tattttcttt ttagtggcaa ttttaaaagc aggccttaat atgggacctg cttttaaagt
     3121 aaaatatgtg gtactatgaa ttactaaatt gctatatacc atgtaatagt gagtatagct
     3181 aatatttagt atgcctttta aaaattttgg actgcttttc ggttttaaca aattctccac
     3241 atgtgaacta ctcaagaaat tttccctttt taattgcctc tatagcactc ataagagcta
     3301 gggcattagg ataaactaga atattttatg tttatgaata cttgtataaa cttaaaagtg
     3361 ttttgatttc ccacaatttc ccaaaggaat gtttatttat taagagttgt gttgataatt
     3421 taactgttac aatttcagca gttgaattca gtgaacactg gttgaggagt gcctatttct
     3481 aagcactggg tgtaagaaga aaagacactt gcaaaggaag agctaagatt aacataattt
     3541 ctttggtttt tctattgctt gttattatta tgtaaaaact gggtggcagt tcacaaggaa
     3601 gattgttgta acagaagagt gacaaccaat agttttttga tcattaaatc aaattttgta
     3661 aacagtggca ggagcgtgga cttaaaacaa ggcttgctta tttggttttg tcaaagtttt
     3721 acgaaaatat atgatatata tttatactaa aactatataa tccttagatt taggaaagca
     3781 atcagttaat gtctttagca cactaaagca gtattaaaca caggtacaag ttggaaattg
     3841 tagaaaactg aaagaaaaca agacaaaatg tctatggtag ggaataaaag agtttaagat
     3901 attatgtaaa attatgtgta ttttcttctc ttttacataa attgtttgtg aaaagtgtgc
     3961 tcaacttttt tacaagagtg atattaactt ggatttattt ttcaatataa tttggagacc
     4021 ctttgttatc caaataaaat tgatgagttt ctgtgcctgt aaaaaaaaaa aaaaaaaaaa
     4081 gaaaagaaaa gacactgttg catgccccag aaagcttgtg gtgggtggta agttctcacg
     4141 agatttattt atctgagcaa cattgggact gagggaacat ctgaaagcta ccatcttgaa
     4201 aatttttgag gaagtgtttc tgaaatattt aaaaatactt aagtcagtca ttttgaacaa
     4261 aagaaattga tacaataagt tttttttttt aaggatgatt gtctaatttt gtaatatgtt
     4321 gttttttaaa aacctgtctg atggtgtttt atacatttct aactttttac ctgagttatc
     4381 tctttagtct tttggaaaat accctacaca atactaacct ttaaaactat caaatttttg
     4441 ttataagata aatgttatct ttgtactaga tagcaaccct ttataaggtt gtaaggtata
     4501 ataaactgct tattttttta catacttcat atcaagcatt ttgcagtcca attatatagt
     4561 tgaggatggt gtattttgat atgtatgaag ttaatatttt caagtaagca atcagtctac
     4621 taccatcaga ttataagctt ttttgtaata ataggtacat aaaatgtgta tgaaaaatct
     4681 acaataaaca tgtttatctg ata
//
