LOCUS       NM_015103               6913 bp    mRNA    linear   PRI 24-MAR-2024
DEFINITION  Homo sapiens plexin D1 (PLXND1), mRNA.
ACCESSION   NM_015103
VERSION     NM_015103.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6913)
  AUTHORS   Wu,J., Liu,C. and Yu,G.
  TITLE     Downregulation of circ_PLXND1 inhibits tumorigenesis of non-small
            cell lung carcinoma via miR-1287-5p/ERBB3 axis
  JOURNAL   Thorac Cancer 14 (17), 1543-1555 (2023)
   PUBMED   37073425
  REMARK    GeneRIF: Downregulation of circ_PLXND1 inhibits tumorigenesis of
            non-small cell lung carcinoma via miR-1287-5p/ERBB3 axis.
REFERENCE   2  (bases 1 to 6913)
  AUTHORS   Guimier,A., de Pontual,L., Braddock,S.R., Torti,E.,
            Perez-Jurado,L.A., Munoz-Cabello,P., Arumi,M., Monaghan,K.G.,
            Lee,H., Wang,L.K., Pluym,I.D., Lynch,S.A., Stals,K., Ellard,S.,
            Muller,C., Houyel,L., Cohen,L., Lyonnet,S., Bajolle,F., Amiel,J.
            and Gordon,C.T.
  TITLE     Biallelic alterations in PLXND1 cause common arterial trunk and
            other cardiac malformations in humans
  JOURNAL   Hum Mol Genet 32 (3), 353-356 (2023)
   PUBMED   35396997
  REMARK    GeneRIF: Biallelic alterations in PLXND1 cause common arterial
            trunk and other cardiac malformations in humans.
REFERENCE   3  (bases 1 to 6913)
  AUTHORS   Hagihara,K., Haraguchi,N., Nishimura,J., Yasueda,A., Fujino,S.,
            Ogino,T., Takahashi,H., Miyoshi,N., Uemura,M., Matsuda,C.,
            Mizushima,T., Yamamoto,H., Mori,M., Doki,Y. and Eguchi,H.
  TITLE     PLXND1/SEMA3E Promotes Epithelial-Mesenchymal Transition Partly via
            the PI3K/AKT-Signaling Pathway and Induces Heterogenity in
            Colorectal Cancer
  JOURNAL   Ann Surg Oncol 29 (12), 7435-7445 (2022)
   PUBMED   35917012
  REMARK    GeneRIF: PLXND1/SEMA3E Promotes Epithelial-Mesenchymal Transition
            Partly via the PI3K/AKT-Signaling Pathway and Induces Heterogenity
            in Colorectal Cancer.
REFERENCE   4  (bases 1 to 6913)
  AUTHORS   Zhou,W.Z., Zeng,Z., Shen,H., Chen,W., Li,T., Ma,B., Sun,Y.,
            Yang,F., Zhang,Y., Li,W., Han,B., Liu,X., Yuan,M., Zhang,G.,
            Yang,Y., Liu,X., Pang,K.J., Li,S.J. and Zhou,Z.
  TITLE     Association of PLXND1 with a novel subtype of anomalous pulmonary
            venous return
  JOURNAL   Hum Mol Genet 31 (9), 1443-1452 (2022)
   PUBMED   34791216
  REMARK    GeneRIF: Association of PLXND1 with a novel subtype of anomalous
            pulmonary venous return.
REFERENCE   5  (bases 1 to 6913)
  AUTHORS   Uto,K., Ueda,K., Okano,T., Akashi,K., Takahashi,S., Nakamachi,Y.,
            Imanishi,T., Awano,H., Morinobu,A., Kawano,S. and Saegusa,J.
  TITLE     Identification of plexin D1 on circulating extracellular vesicles
            as a potential biomarker of polymyositis and dermatomyositis
  JOURNAL   Rheumatology (Oxford) 61 (4), 1669-1679 (2022)
   PUBMED   34297034
  REMARK    GeneRIF: Identification of plexin D1 on circulating extracellular
            vesicles as a potential biomarker of polymyositis and
            dermatomyositis.
REFERENCE   6  (bases 1 to 6913)
  AUTHORS   Gu,C., Yoshida,Y., Livet,J., Reimert,D.V., Mann,F., Merte,J.,
            Henderson,C.E., Jessell,T.M., Kolodkin,A.L. and Ginty,D.D.
  TITLE     Semaphorin 3E and plexin-D1 control vascular pattern independently
            of neuropilins
  JOURNAL   Science 307 (5707), 265-268 (2005)
   PUBMED   15550623
REFERENCE   7  (bases 1 to 6913)
  AUTHORS   van der Zwaag,B., Verzijl,H.T., Wichers,K.H., Beltran-Valero de
            Bernabe,D., Brunner,H.G., van Bokhoven,H. and Padberg,G.W.
  TITLE     Sequence analysis of the PLEXIN-D1 gene in Mobius syndrome patients
  JOURNAL   Pediatr Neurol 31 (2), 114-118 (2004)
   PUBMED   15301830
  REMARK    GeneRIF: Results of extensive mutational analysis leads to the
            exclusion of the PLEXIN-D1 gene as the causative gene in Mobius
            syndrome 2, and in isolated Mobius syndrome.
REFERENCE   8  (bases 1 to 6913)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   9  (bases 1 to 6913)
  AUTHORS   van der Zwaag,B., Hellemons,A.J., Leenders,W.P., Burbach,J.P.,
            Brunner,H.G., Padberg,G.W. and Van Bokhoven,H.
  TITLE     PLEXIN-D1, a novel plexin family member, is expressed in vascular
            endothelium and the central nervous system during mouse
            embryogenesis
  JOURNAL   Dev Dyn 225 (3), 336-343 (2002)
   PUBMED   12412018
REFERENCE   10 (bases 1 to 6913)
  AUTHORS   Tamagnone,L., Artigiani,S., Chen,H., He,Z., Ming,G.I., Song,H.,
            Chedotal,A., Winberg,M.L., Goodman,C.S., Poo,M., Tessier-Lavigne,M.
            and Comoglio,P.M.
  TITLE     Plexins are a large family of receptors for transmembrane,
            secreted, and GPI-anchored semaphorins in vertebrates
  JOURNAL   Cell 99 (1), 71-80 (1999)
   PUBMED   10520995
  REMARK    Erratum:[Cell 2001 Jan 26;104(2):following 320]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023162.41 and AC080007.26.
            
            On Feb 7, 2020 this sequence version replaced NM_015103.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY116661.1, BC150280.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324093.9/ ENSP00000317128.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1348              AC023162.41        53702-55049
            1349-1525           AC023162.41        70851-71027
            1526-1657           AC023162.41        73659-73790
            1658-1758           AC023162.41        74106-74206
            1759-1888           AC023162.41        74297-74426
            1889-2066           AC023162.41        75816-75993
            2067-2175           AC023162.41        76145-76253
            2176-2278           AC023162.41        76709-76811
            2279-2383           AC023162.41        81945-82049
            2384-2473           AC023162.41        84523-84612
            2474-2567           AC023162.41        84816-84909
            2568-2722           AC023162.41        85888-86042
            2723-2874           AC023162.41        86633-86784
            2875-2974           AC023162.41        87437-87536
            2975-3114           AC023162.41        87630-87769
            3115-3282           AC023162.41        88534-88701
            3283-3373           AC023162.41        88779-88869
            3374-3637           AC023162.41        89075-89338
            3638-3787           AC023162.41        89443-89592
            3788-3902           AC023162.41        90421-90535
            3903-4010           AC023162.41        92573-92680
            4011-4123           AC023162.41        92774-92886
            4124-4228           AC080007.26        167-271
            4229-4359           AC080007.26        781-911
            4360-4558           AC080007.26        1260-1458
            4559-4705           AC080007.26        3558-3704
            4706-4862           AC080007.26        3855-4011
            4863-4966           AC080007.26        4895-4998
            4967-5030           AC080007.26        5089-5152
            5031-5065           AC080007.26        6075-6109
            5066-5170           AC080007.26        6364-6468
            5171-5334           AC080007.26        7015-7178
            5335-5482           AC080007.26        8223-8370
            5483-5623           AC080007.26        9575-9715
            5624-5698           AC080007.26        10107-10181
            5699-6913           AC080007.26        10370-11584
FEATURES             Location/Qualifiers
     source          1..6913
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..6913
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /note="plexin D1"
                     /db_xref="GeneID:23129"
                     /db_xref="HGNC:HGNC:9107"
                     /db_xref="MIM:604282"
     exon            1..1348
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..5815
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /codon_start=1
                     /product="plexin-D1 precursor"
                     /protein_id="NP_055918.3"
                     /db_xref="CCDS:CCDS33854.1"
                     /db_xref="GeneID:23129"
                     /db_xref="HGNC:HGNC:9107"
                     /db_xref="MIM:604282"
                     /translation="MAPRAAGGAPLSARAAAASPPPFQTPPRCPVPLLLLLLLGAARA
                     GALEIQRRFPSPTPTNNFALDGAAGTVYLAAVNRLYQLSGANLSLEAEAAVGPVPDSP
                     LCHAPQLPQASCEHPRRLTDNYNKILQLDPGQGLVVVCGSIYQGFCQLRRRGNISAVA
                     VRFPPAAPPAEPVTVFPSMLNVAANHPNASTVGLVLPPAAGAGGSRLLVGATYTGYGS
                     SFFPRNRSLEDHRFENTPEIAIRSLDTRGDLAKLFTFDLNPSDDNILKIKQGAKEQHK
                     LGFVSAFLHPSDPPPGAQSYAYLALNSEARAGDKESQARSLLARICLPHGAGGDAKKL
                     TESYIQLGLQCAGGAGRGDLYSRLVSVFPARERLFAVFERPQGSPAARAAPAALCAFR
                     FADVRAAIRAARTACFVEPAPDVVAVLDSVVQGTGPACERKLNIQLQPEQLDCGAAHL
                     QHPLSILQPLKATPVFRAPGLTSVAVASVNNYTAVFLGTVNGRLLKINLNESMQVVSR
                     RVVTVAYGEPVHHVMQFDPADSGYLYLMTSHQMARVKVAACNVHSTCGDCVGAADAYC
                     GWCALETRCTLQQDCTNSSQQHFWTSASEGPSRCPAMTVLPSEIDVRQEYPGMILQIS
                     GSLPSLSGMEMACDYGNNIRTVARVPGPAFGHQIAYCNLLPRDQFPPFPPNQDHVTVE
                     MSVRVNGRNIVKANFTIYDCSRTAQVYPHTACTSCLSAQWPCFWCSQQHSCVSNQSRC
                     EASPNPTSPQDCPRTLLSPLAPVPTGGSQNILVPLANTAFFQGAALECSFGLEEIFEA
                     VWVNESVVRCDQVVLHTTRKSQVFPLSLQLKGRPARFLDSPEPMTVMVYNCAMGSPDC
                     SQCLGREDLGHLCMWSDGCRLRGPLQPMAGTCPAPEIHAIEPLSGPLDGGTLLTIRGR
                     NLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVCVTGPAPGPLSGVVTVNASKEGKS
                     RDRFSYVLPLVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDTDPCTELMRTDT
                     SIACTMPEGALPAPVPVCVRFERRGCVHGNLTFWYMQNPVITAISPRRSPVSGGRTIT
                     VAGERFHMVQNVSMAVHHIGREPTLCKVLNSTLITCPSPGALSNASAPVDFFINGRAY
                     ADEVAVAEELLDPEEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEPLTLVIHKEQD
                     SLGLQSHEYRVKIGQVSCDIQIVSDRIIHCSVNESLGAAVGQLPITIQVGNFNQTIAT
                     LQLGGSETAIIVSIVICSVLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIRE
                     EIRKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQTL
                     NSQGSSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFLIVFVHALEQQKDF
                     AVRDRCSLASLLTIALHGKLEYYTSIMKELLVDLIDASAAKNPKLMLRRTESVVEKML
                     TNWMSICMYSCLRETVGEPFFLLLCAIKQQINKGSIDAITGKARYTLSEEWLLRENIE
                     AKPRNLNVSFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDLEW
                     FASSTQSYILRDLDDTSVVEDGRKKLNTLAHYKIPEGASLAMSLIDKKDNTLGRVKDL
                     DTEKYFHLVLPTDELAEPKKSHRQSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAIL
                     SIREDKPPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVFD
                     IDKTDHIDACLSVIAQAFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYKQI
                     QDMTPLSEQEMNAHLAEESRKYQNEFNTNVAMAEIYKYAKRYRPQIMAALEANPTARR
                     TQLQHKFEQVVALMEDNIYECYSEA"
     exon            1349..1525
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1657
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1758
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1888
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2066
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2175
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2278
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2383
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2473
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2567
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2722
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2874
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..2974
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3114
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3282
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3373
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3637
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3638..3787
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3788..3902
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3903..4010
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4011..4123
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4124..4228
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4229..4359
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4360..4558
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4559..4705
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4706..4862
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4863..4966
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4967..5030
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5031..5065
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5066..5170
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5171..5334
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5335..5482
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5483..5623
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5624..5698
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5699..6913
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6889..6894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /note="hexamer: AATAAA"
     polyA_site      6913
                     /gene="PLXND1"
                     /gene_synonym="CHTD9; PLEXD1"
                     /note="major polyA site"
ORIGIN      
        1 atgcactcgc cgcgccgcgc agcccgcgca cgcccggatg gctcctcgcg ccgcgggcgg
       61 cgcacccctt agcgcccggg ccgccgccgc cagccccccg ccgttccaga cgccgccgcg
      121 gtgcccggtg ccgctgctgt tgctgctgct cctgggggcg gcgcgggccg gcgccctgga
      181 gatccagcgt cggttcccct cgcccacgcc caccaacaac ttcgccctgg acggcgcggc
      241 ggggaccgtg tacctggcgg ccgtcaaccg cctctatcag ctgtcgggcg ccaacctgag
      301 cctggaggcc gaggcggccg tgggcccggt gcccgacagc ccgctgtgtc acgctccgca
      361 gctgccgcag gcctcgtgcg agcacccgcg gcgcctcacg gacaactaca acaagatcct
      421 gcagctggac cccggccagg gcctggtagt cgtgtgcggg tccatctacc agggcttctg
      481 ccagctgcgg cgccggggca acatctcggc cgtggccgtg cgcttcccgc ccgccgcgcc
      541 gcccgccgag cccgtcacgg tgttccccag catgctgaac gtggcggcca accacccgaa
      601 cgcgtccacc gtggggctag ttctgcctcc cgccgcgggc gcggggggca gccgcctgct
      661 cgtgggcgcc acgtacaccg gttacggcag ctccttcttc ccgcgcaacc gcagcctgga
      721 ggaccaccgc ttcgagaaca cgcccgagat cgccatccgc tccctggaca cgcgcggcga
      781 cctggccaag ctcttcacct tcgacctcaa cccctccgac gacaacatcc tcaagatcaa
      841 gcagggcgcc aaggagcagc acaagctggg cttcgtgagc gccttcctgc acccgtccga
      901 cccgccgccg ggtgcacagt cctacgcgta cctggcgctc aacagcgagg cgcgcgcggg
      961 cgacaaggag agccaggcgc ggagcctgct ggcgcgcatc tgcctgcccc acggcgccgg
     1021 cggcgacgcc aagaagctca ccgagtccta catccagttg ggcttgcagt gcgcgggcgg
     1081 cgcgggccgc ggcgacctct acagccgcct ggtgtcggtc ttcccagccc gggagcggct
     1141 ctttgctgtc ttcgagcggc cccaggggtc ccccgcggcc cgcgctgctc cggccgcact
     1201 ctgcgccttc cgcttcgccg acgtgcgagc cgccatccga gctgcgcgca ccgcctgctt
     1261 cgtggaaccg gcgcccgacg tggtggcggt gctcgacagc gtggtgcagg gcacgggacc
     1321 ggcctgtgag cgcaagctca acatccagct ccagccagag cagctggact gtggagctgc
     1381 tcacctgcag cacccgctgt ccatcctgca gcccctgaag gccacgcccg tgttccgcgc
     1441 cccgggcctc acctccgtgg ccgtggccag cgtcaacaac tacacagcgg tcttcctggg
     1501 cacggtcaac gggaggcttc tcaagatcaa cctgaacgag agcatgcagg tggtgagcag
     1561 gcgggtggtg actgtggcct atggggagcc cgtgcaccat gtcatgcagt ttgacccagc
     1621 agactccggt tacctttacc tgatgacgtc ccaccagatg gccagggtga aggtcgccgc
     1681 ctgcaacgtg cactccacct gtggggactg cgtgggtgcg gcggacgcct actgcggctg
     1741 gtgtgccctg gagacgcggt gcaccttgca gcaggactgc accaattcca gccagcagca
     1801 tttctggacc agtgccagcg agggccccag ccgctgtcct gccatgaccg tcctgccttc
     1861 cgagatcgat gtgcgccagg agtacccagg catgatcctg cagatctcgg gcagcctgcc
     1921 cagcctcagt ggcatggaga tggcctgtga ctatgggaac aacatccgca ctgtggctcg
     1981 ggtcccaggc cctgcctttg gtcaccagat tgcctactgc aacctcctgc cgagggacca
     2041 gtttccgccc ttccccccca accaggacca cgtgactgtt gagatgtctg tgagggtcaa
     2101 tgggcggaac atcgtcaagg ccaatttcac catctacgac tgcagccgca ctgcacaagt
     2161 gtacccccac acagcctgta ccagctgcct gtcggcacag tggccctgtt tctggtgcag
     2221 ccagcagcac tcctgtgttt ccaaccagtc tcggtgcgag gcctcaccaa accccacgag
     2281 ccctcaggac tgcccccgga ccctgctctc acccctggca cccgtgccta cgggtggctc
     2341 ccagaacatc ctggtgcctc tggccaacac tgcctttttc cagggtgcag ccctggagtg
     2401 tagttttggg ctggaggaga tcttcgaggc tgtgtgggtg aatgagtctg ttgtacgctg
     2461 tgaccaggtg gtgctgcaca cgacccggaa gagccaggtg ttcccgctca gcctccaact
     2521 aaaggggcgg ccagcccgat tcctggacag ccctgagccc atgacagtca tggtctataa
     2581 ctgtgccatg ggcagccccg actgttccca gtgcctgggc cgcgaagacc tgggtcacct
     2641 gtgcatgtgg agtgatggct gccgcctgcg ggggcctctg cagcccatgg ctggcacctg
     2701 ccccgccccc gagatccacg cgattgagcc cctgagtggc ccgttggacg gtgggaccct
     2761 gctgaccatc cgaggaagga acctgggccg gcggctcagt gacgtggccc acggcgtgtg
     2821 gattggtggt gtggcctgtg agccactgcc tgacagatac acggtgtcgg aggagatcgt
     2881 gtgtgtcaca gggccagccc caggaccact ctcaggtgtg gtgaccgtga acgcctctaa
     2941 ggagggcaag tcccgggacc gcttctccta cgtgctgccc ctggtccact ccctggagcc
     3001 taccatgggc cccaaggccg ggggcaccag gatcaccatc catgggaatg acctccatgt
     3061 aggctccgag ctccaggtcc tggtgaacga cacagacccc tgcacggagc tgatgcgcac
     3121 agataccagc atcgcctgca ccatgcctga gggggccctg ccggctccgg tgcctgtgtg
     3181 tgtgcgcttc gagcgtcggg gctgcgtgca cggcaacctc accttctggt acatgcagaa
     3241 cccggtcatc acggccatca gtccccgccg cagccctgtc agtggcggca ggaccatcac
     3301 agtggctggt gagcgtttcc acatggtgca gaatgtgtcc atggccgtcc accacattgg
     3361 ccgggagccc acgctctgca aggttctcaa ctccaccctc atcacctgcc cgtcccccgg
     3421 ggccctgagc aacgcatcag cgccagtgga cttcttcatc aatgggcggg cctacgcaga
     3481 cgaggtggct gtggctgagg agctactgga ccccgaggag gcacagcggg gcagcaggtt
     3541 ccgcctggac tacctcccca acccacagtt ctctacggcc aagagggaga agtggatcaa
     3601 gcaccacccc ggggagcctc tcaccctcgt tatccacaag gagcaggaca gcctggggct
     3661 ccagagtcac gagtaccggg tcaagatagg ccaagtaagc tgcgacatcc agattgtctc
     3721 tgacagaatc atccactgct cggtcaacga gtccctgggc gcggccgtgg ggcagctgcc
     3781 catcacaatc caggtaggga acttcaacca gaccatcgcc acactgcagc tggggggcag
     3841 cgagacggcc atcatcgtgt ccatcgtcat ctgcagcgtc ctgctgctgc tctccgtggt
     3901 ggccctgttc gtcttctgta ccaagagccg acgtgctgag cgttactggc agaagacgct
     3961 gctgcagatg gaggagatgg aatctcagat ccgagaggaa atccgcaaag gcttcgctga
     4021 gctgcagaca gacatgacag atctcaccaa ggagctgaac cgcagccagg gcatcccctt
     4081 cctggagtat aagcacttcg tgacccgcac cttcttcccc aagtgttcct ccctttatga
     4141 agagcgttac gtgctgccct cccagaccct caactcccag ggcagctccc aggcacagga
     4201 aacccaccca ctgctgggag agtggaagat tcctgagagc tgccggccca acatggaaga
     4261 gggaattagc ttgttctcct cactactcaa caacaagcac ttcctcatcg tctttgtcca
     4321 cgcgctggag cagcagaagg actttgcggt gcgcgacagg tgcagcctgg cctcgctgct
     4381 gaccatcgcg ctgcacggca agctggagta ctacaccagc atcatgaagg agctgctggt
     4441 ggacctcatt gacgcctcgg ccgccaagaa ccccaagctc atgctgcggc gcacagagtc
     4501 tgtggtggag aagatgctca ccaactggat gtccatctgc atgtacagct gtctgcggga
     4561 gacggtgggg gagccattct tcctgctgct gtgtgccatc aagcagcaaa tcaacaaggg
     4621 ctccatcgac gccatcacag gcaaggcccg ctacacactc agtgaggagt ggctgctgcg
     4681 ggagaacatc gaggccaagc cccggaacct gaacgtgtcc ttccagggct gtggcatgga
     4741 ctcgctgagc gtgcgggcca tggacaccga cacgctgaca caggtcaagg agaagatcct
     4801 ggaggccttc tgcaagaatg tgccctactc ccagtggccg cgtgcagagg acgtcgacct
     4861 tgagtggttc gcctccagca cacagagcta catccttcgg gacctggacg acacctcagt
     4921 ggtggaagac ggccgcaaga agcttaacac gctggcccat tacaagatcc ctgaaggtgc
     4981 ctccctggcc atgagtctca tagacaagaa ggacaacaca ctgggccgag tgaaagactt
     5041 ggacacagag aagtatttcc atttggtgct gcctacggac gagctggcgg agcccaagaa
     5101 gtctcaccgg cagagccatc gcaagaaggt gctcccggaa atctacctga cccgcctgct
     5161 ctccaccaag ggcacgttgc agaagtttct ggatgacctg ttcaaggcca ttctgagtat
     5221 ccgtgaagac aagcccccac tggctgtcaa gtactttttc gacttcctgg aggagcaggc
     5281 tgagaagagg ggaatctccg accccgacac cctacacatc tggaagacca acagccttcc
     5341 tctccggttc tgggtgaaca tcctgaagaa cccccagttt gtctttgaca tcgacaagac
     5401 agaccacatc gacgcctgcc tttcagtcat cgcgcaggcc ttcatcgacg cctgctccat
     5461 ctctgacctg cagctgggca aggattcgcc aaccaacaag ctcctctacg ccaaggagat
     5521 tcctgagtac cggaagatcg tgcagcgcta ctacaagcag atccaggaca tgacgccgct
     5581 cagcgagcaa gagatgaatg cccatctggc cgaggagtcg aggaaatacc agaatgagtt
     5641 caacaccaat gtggccatgg cagagattta taagtacgcc aagaggtatc ggccgcagat
     5701 catggccgcg ctggaggcca accccacggc ccggaggaca caactgcagc acaagtttga
     5761 gcaggtggtg gctttgatgg aggacaacat ctacgagtgc tacagtgagg cctgagacac
     5821 atggagagtt ggtcaggctg ctgctgggag aaatggacgc ccactgggcc tcaacttgat
     5881 cttctacccc gtgcctgtga ctcagactgg gaaatactga gcagagacgg ctggggcggg
     5941 ggcaggagga ggggctgctc tctgagacag gggcgccccc gccttgaccc ctgggcacct
     6001 ccatcccctc ccacctgtcc ccagatcagt ctctgggatg gaggccagag agctggtcag
     6061 gctcccccat ctgcccagca cggcctgcac tgtgcccacc cacttgctcc acaacgtcca
     6121 gttggtcctg ctgccaagag ccccgtgcat ccaggcggcc aagcacaaac tgggggagag
     6181 gaggccgcca gcccggaggc tgcagcccag aaactctacc tcatccacac tggtgcaggg
     6241 agccctcctt gaactgacct ttgattggtt tctgcttcaa ctaccaaaat gttatctcca
     6301 cttccccctc acccgtagag gatcctggcc acagacagtt tcaagtagtg tcagattttt
     6361 gttgcttggg cggctgttgg tagagtgggc agtgcccgcg ccatggggtg ctctgtgggc
     6421 ttctccagga gcagggaggg tggaggggag ggatgggggg cacaggagct gggagccccg
     6481 tctccaggaa aaggagaggg gttaagatgc accgaggctg tagctgggct acttgatctt
     6541 gctgaaagtg tttctaaaga tagcaccact ttttttttta aagcttttat atattaaaaa
     6601 acgtatcatg caccaactgt gaatagctgc cgcttgcgca gaggacccgg ggaggggtcc
     6661 cgagaggctc cccatgcaac actggaaatg actgttccag agagcgggca gacctggcag
     6721 agcgcccctg gcgcctgaga ctaccaccca ctccgttcct gccagaaacg accctctgtg
     6781 gccgatgggc catgcgggcc cctcgcagcc aactcagcca gtgttgggac tggctcagag
     6841 cccatggggg ctggaggggg gcagctggga ctctggaatc ttctttataa taaaagcctt
     6901 acggacaaac cta
//
