LOCUS       NM_005761               7492 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens plexin C1 (PLXNC1), transcript variant 1, mRNA.
ACCESSION   NM_005761
VERSION     NM_005761.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7492)
  AUTHORS   Huang,J., Zhao,C. and Zhang,S.
  TITLE     Semaphorin 7A promotes endothelial permeability and inflammation
            via plexin C1 and integrin beta1 in Kawasaki disease
  JOURNAL   BMC Pediatr 24 (1), 285 (2024)
   PUBMED   38678170
  REMARK    GeneRIF: Semaphorin 7A promotes endothelial permeability and
            inflammation via plexin C1 and integrin beta1 in Kawasaki disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7492)
  AUTHORS   Meng,N., Mao,L., Jiang,Q., Yuan,J., Liu,L. and Wang,L.
  TITLE     PLXNC1 interference alleviates the inflammatory injury, apoptosis
            and extracellular matrix degradation of IL-1beta-exposed
            chondrocytes via suppressing GRP78 expression
  JOURNAL   J Orthop Surg Res 18 (1), 784 (2023)
   PUBMED   37853395
  REMARK    GeneRIF: PLXNC1 interference alleviates the inflammatory injury,
            apoptosis and extracellular matrix degradation of IL-1beta-exposed
            chondrocytes via suppressing GRP78 expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7492)
  AUTHORS   NazimTurhal,S., Dogan,M., Esendagli,G., Artac,M., Korkmaz,L.,
            Coskun,H.S., Goker,E., PerranYumuk,F., Bilgetekin,I., Kose,F.,
            Uncu,D., Kavgaci,H., Akyol,G., Ozet,A. and Yagci,T.
  TITLE     The Relationship Between Plexin C1 Overexpression and Survival in
            Hepatocellular Carcinoma: a Turkish Oncology Group (TOG) Study
  JOURNAL   J Gastrointest Cancer 53 (2), 356-362 (2022)
   PUBMED   33656690
  REMARK    GeneRIF: The Relationship Between Plexin C1 Overexpression and
            Survival in Hepatocellular Carcinoma: a Turkish Oncology Group
            (TOG) Study.
REFERENCE   4  (bases 1 to 7492)
  AUTHORS   Li,R., Teng,X., Zhu,H., Han,T. and Liu,Q.
  TITLE     MiR-4500 Regulates PLXNC1 and Inhibits Papillary Thyroid Cancer
            Progression
  JOURNAL   Horm Cancer 10 (4-6), 150-160 (2019)
   PUBMED   31317324
  REMARK    GeneRIF: Results indicated that PLXNC1 was a direct target of
            miR-4500. Its knockdown inhibits proliferation and invasion of
            papillary thyroid cancer (PTC) cells. On the contrary, its
            overexpression of impairs miR-4500-induced inhibition of PTC
            malignancy.
REFERENCE   5  (bases 1 to 7492)
  AUTHORS   Wang,Z., Wang,X., Zhou,H., Dan,X., Jiang,L. and Wu,Y.
  TITLE     Long non-coding RNA CASC2 inhibits tumorigenesis via the
            miR-181a/PLXNC1 axis in melanoma
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 50 (3), 263-272 (2018)
   PUBMED   29514220
  REMARK    GeneRIF: Results indicate that long non-coding RNA (lncRNA) CASC2
            can promote PLXNC1 expression by sponging miR-181a, thereby
            inhibiting the proliferation and invasion of melanoma cells.
REFERENCE   6  (bases 1 to 7492)
  AUTHORS   Stirewalt,D.L., Meshinchi,S., Kopecky,K.J., Fan,W.,
            Pogosova-Agadjanyan,E.L., Engel,J.H., Cronk,M.R., Dorcy,K.S.,
            McQuary,A.R., Hockenbery,D., Wood,B., Heimfeld,S. and Radich,J.P.
  TITLE     Identification of genes with abnormal expression changes in acute
            myeloid leukemia
  JOURNAL   Genes Chromosomes Cancer 47 (1), 8-20 (2008)
   PUBMED   17910043
REFERENCE   7  (bases 1 to 7492)
  AUTHORS   Scott,G.A., McClelland,L.A. and Fricke,A.F.
  TITLE     Semaphorin 7a promotes spreading and dendricity in human
            melanocytes through beta1-integrins
  JOURNAL   J Invest Dermatol 128 (1), 151-161 (2008)
   PUBMED   17671519
  REMARK    GeneRIF: GTP-bound form of Rab7 promotes melanogenesis through the
            regulation of gp100 maturation in melanoma cells.
REFERENCE   8  (bases 1 to 7492)
  AUTHORS   Chabbert-de Ponnat,I., Marie-Cardine,A., Pasterkamp,R.J.,
            Schiavon,V., Tamagnone,L., Thomasset,N., Bensussan,A. and
            Boumsell,L.
  TITLE     Soluble CD100 functions on human monocytes and immature dendritic
            cells require plexin C1 and plexin B1, respectively
  JOURNAL   Int Immunol 17 (4), 439-447 (2005)
   PUBMED   15746246
REFERENCE   9  (bases 1 to 7492)
  AUTHORS   Tamagnone,L., Artigiani,S., Chen,H., He,Z., Ming,G.I., Song,H.,
            Chedotal,A., Winberg,M.L., Goodman,C.S., Poo,M., Tessier-Lavigne,M.
            and Comoglio,P.M.
  TITLE     Plexins are a large family of receptors for transmembrane,
            secreted, and GPI-anchored semaphorins in vertebrates
  JOURNAL   Cell 99 (1), 71-80 (1999)
   PUBMED   10520995
  REMARK    Erratum:[Cell 2001 Jan 26;104(2):following 320]
REFERENCE   10 (bases 1 to 7492)
  AUTHORS   Comeau,M.R., Johnson,R., DuBose,R.F., Petersen,M., Gearing,P.,
            VandenBos,T., Park,L., Farrah,T., Buller,R.M., Cohen,J.I.,
            Strockbine,L.D., Rauch,C. and Spriggs,M.K.
  TITLE     A poxvirus-encoded semaphorin induces cytokine production from
            monocytes and binds to a novel cellular semaphorin receptor, VESPR
  JOURNAL   Immunity 8 (4), 473-482 (1998)
   PUBMED   9586637
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC123567.8 and AC073655.26.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005761.2.
            
            Summary: This gene encodes a member of the plexin family. Plexins
            are transmembrane receptors for semaphorins, a large family of
            proteins that regulate axon guidance, cell motility and migration,
            and the immune response. The encoded protein and its ligand
            regulate melanocyte adhesion, and viral semaphorins may modulate
            the immune response by binding to this receptor. The encoded
            protein may be a tumor suppressor protein for melanoma.
            Alternatively spliced transcript variants have been observed for
            this gene. [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.120141.1,
                                           SRR1803613.122834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258526.9/ ENSP00000258526.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1457              AC123567.8         20351-21807
            1458-1598           AC123567.8         40927-41067
            1599-1733           AC123567.8         53220-53354
            1734-1834           AC123567.8         58147-58247
            1835-1949           AC123567.8         81364-81478
            1950-2097           AC123567.8         91790-91937
            2098-2185           AC123567.8         96002-96089
            2186-2288           AC123567.8         98379-98481
            2289-2375           AC123567.8         98923-99009
            2376-2515           AC123567.8         109438-109577
            2516-2695           AC123567.8         112259-112438
            2696-2783           AC073655.26        2901-2988
            2784-2987           AC073655.26        6866-7069
            2988-3173           AC073655.26        7190-7375
            3174-3276           AC073655.26        10389-10491
            3277-3378           AC073655.26        13750-13851
            3379-3482           AC073655.26        14156-14259
            3483-3521           AC073655.26        18300-18338
            3522-3646           AC073655.26        18573-18697
            3647-3845           AC073655.26        19605-19803
            3846-3992           AC073655.26        24042-24188
            3993-4170           AC073655.26        38435-38612
            4171-4274           AC073655.26        41261-41364
            4275-4329           AC073655.26        53449-53503
            4330-4361           AC073655.26        56152-56183
            4362-4469           AC073655.26        56279-56386
            4470-4633           AC073655.26        57595-57758
            4634-4781           AC073655.26        59873-60020
            4782-4922           AC073655.26        62719-62859
            4923-4997           AC073655.26        62940-63014
            4998-7492           AC073655.26        64144-66638
FEATURES             Location/Qualifiers
     source          1..7492
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q22"
     gene            1..7492
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /note="plexin C1"
                     /db_xref="GeneID:10154"
                     /db_xref="HGNC:HGNC:9106"
                     /db_xref="MIM:604259"
     exon            1..1457
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..5102
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /note="receptor for virally-encoded semaphorin; plexin
                     (semaphorin receptor); receptor for viral semaphorin
                     protein; virus-encoded semaphorin protein receptor"
                     /codon_start=1
                     /product="plexin-C1 precursor"
                     /protein_id="NP_005752.1"
                     /db_xref="CCDS:CCDS9049.1"
                     /db_xref="GeneID:10154"
                     /db_xref="HGNC:HGNC:9106"
                     /db_xref="MIM:604259"
                     /translation="MEVSRRKAPPRPPRPAAPLPLLAYLLALAAPGRGADEPVWRSEQ
                     AIGAIAASQEDGVFVASGSCLDQLDYSLEHSLSRLYRDQAGNCTEPVSLAPPARPRPG
                     SSFSKLLLPYREGAAGLGGLLLTGWTFDRGACEVRPLGNLSRNSLRNGTEVVSCHPQG
                     STAGVVYRAGRNNRWYLAVAATYVLPEPETASRCNPAASDHDTAIALKDTEGRSLATQ
                     ELGRLKLCEGAGSLHFVDAFLWNGSIYFPYYPYNYTSGAATGWPSMARIAQSTEVLFQ
                     GQASLDCGHGHPDGRRLLLSSSLVEALDVWAGVFSAAAGEGQERRSPTTTALCLFRMS
                     EIQARAKRVSWDFKTAESHCKEGDQPERVQPIASSTLIHSDLTSVYGTVVMNRTVLFL
                     GTGDGQLLKVILGENLTSNCPEVIYEIKEETPVFYKLVPDPVKNIYIYLTAGKEVRRI
                     RVANCNKHKSCSECLTATDPHCGWCHSLQRCTFQGDCVHSENLENWLDISSGAKKCPK
                     IQIIRSSKEKTTVTMVGSFSPRHSKCMVKNVDSSRELCQNKSQPNRTCTCSIPTRATY
                     KDVSVVNVMFSFGSWNLSDRFNFTNCSSLKECPACVETGCAWCKSARRCIHPFTACDP
                     SDYERNQEQCPVAVEKTSGGGRPKENKGNRTNQALQVFYIKSIEPQKVSTLGKSNVIV
                     TGANFTRASNITMILKGTSTCDKDVIQVSHVLNDTHMKFSLPSSRKEMKDVCIQFDGG
                     NCSSVGSLSYIALPHCSLIFPATTWISGGQNITMMGRNFDVIDNLIISHELKGNINVS
                     EYCVATYCGFLAPSLKSSKVRTNVTVKLRVQDTYLDCGTLQYREDPRFTGYRVESEVD
                     TELEVKIQKENDNFNISKKDIEITLFHGENGQLNCSFENITRNQDLTTILCKIKGIKT
                     ASTIANSSKKVRVKLGNLELYVEQESVPSTWYFLIVLPVLLVIVIFAAVGVTRHKSKE
                     LSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSFGTVPFLDYKHFALRTFFPES
                     GGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFA
                     SFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLS
                     GFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFSTVALNVV
                     FEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLELQM
                     GTRQKELLDIDSSSVILEDGITKLNTIGHYEISNGSTIKVFKKIANFTSDVEYSDDHC
                     HLILPDSEAFQDVQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNS
                     RAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQFVFDIKKTP
                     HIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDLPP
                     LSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQKQL
                     LHVKVLFDEKKKCKWM"
     exon            1458..1598
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1733
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1834
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1949
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2097
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2185
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2288
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2375
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2515
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2695
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2783
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2987
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3173
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..3276
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3378
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3482
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            3483..3521
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            3522..3646
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..3845
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..3992
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            3993..4170
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            4171..4274
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            4275..4329
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            4330..4361
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            4362..4469
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            4470..4633
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            4634..4781
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            4782..4922
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            4923..4997
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     exon            4998..7492
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7469..7474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /note="hexamer: AATAAA"
     polyA_site      7492
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /note="major polyA site"
ORIGIN      
        1 acaatgggaa agtgaaacgc acaagcgcac ccaacctctc cagccctccc cgcccgcctc
       61 gctcctctcc gcccgtcccc tcccttcccc tccgcgcctc cccgcgagcg ccagcgctgc
      121 acacaggaac tctccggcga aggagggcga ggaggaaacg gtgccggagc gcgcagggct
      181 tgctgccgcc accgccgctg cacaggctgc cggagcgagc ctgccgcgcg ccgccctccc
      241 cgctctcctt cctgggcgag ctgcggggat ggggcggccg cgggagcccg agcgcgcgca
      301 ggaaccgccg ccgccgccgc ccgcgtctcc gttgccgcgc gcctgagccg ccgtcgccgc
      361 cgcgcgccct gcccgggggc ggccccccca gccccatgga ggtctcccgg aggaaggcgc
      421 cgccgcgccc cccgcgcccc gcagcgccac tgcccctgct cgcctatctg ctggcactgg
      481 cggctcccgg ccggggcgcg gacgagcccg tgtggcggtc ggagcaagcc atcggagcca
      541 tcgcggcgag ccaggaggac ggcgtgtttg tggcgagcgg cagctgcctg gaccagctgg
      601 actacagcct ggagcacagc ctctcgcgcc tgtaccggga ccaagcgggc aactgcacag
      661 agccggtctc gctggcgccc cccgcgcggc cccggcccgg gagcagcttc agcaagctgc
      721 tgctgcccta ccgcgagggg gcggccggcc tcggggggct gctgctcacc ggctggacct
      781 tcgaccgggg cgcctgcgag gtgcggcccc tgggcaacct gagccgcaac tccctgcgca
      841 acggcaccga ggtggtgtcg tgccacccgc agggctcgac ggccggcgtg gtgtaccgcg
      901 cgggccggaa caaccgctgg tacctggcgg tggccgccac ctacgtgctg cctgagccgg
      961 agacggcgag ccgctgcaac cccgcggcat ccgaccacga cacggccatc gcgctcaagg
     1021 acacggaggg gcgcagcctg gccacgcagg agctggggcg cctcaagctg tgcgagggcg
     1081 cgggcagcct gcacttcgtg gacgcctttc tctggaacgg cagcatctac ttcccctact
     1141 acccctacaa ctacacgagc ggcgctgcca ccggctggcc cagcatggcg cgcatcgcgc
     1201 agagcaccga ggtgctgttc cagggccagg catccctcga ctgcggccac ggccaccccg
     1261 acggccgccg cctgctcctc tcctccagcc tagtggaggc cctggacgtc tgggcgggag
     1321 tgttcagcgc ggccgctgga gagggccagg agcggcgctc ccccaccacc acggcgctct
     1381 gcctcttcag aatgagtgag atccaggcgc gcgccaagag ggtcagctgg gacttcaaga
     1441 cggccgagag ccactgcaaa gaaggggatc aacctgaaag agtccaacca atcgcatcat
     1501 ctaccttgat ccattccgac ctgacatccg tttatggcac cgtggtaatg aacaggactg
     1561 ttttattctt ggggactgga gatggccagt tacttaaggt tattcttggt gagaatttga
     1621 cttcaaattg tccagaggtt atctatgaaa ttaaagaaga gacacctgtt ttctacaaac
     1681 tcgttcctga tcctgtgaag aatatctaca tttatctaac agctgggaaa gaggtgagga
     1741 gaattcgtgt tgcaaactgc aataaacata aatcctgttc ggagtgttta acagccacag
     1801 accctcactg cggttggtgc cattcgctac aaaggtgcac ttttcaagga gattgtgtac
     1861 attcagagaa cttagaaaac tggctggata tttcgtctgg agcaaaaaag tgccctaaaa
     1921 ttcagataat tcgaagcagt aaagaaaaga ctacagtgac tatggtggga agcttctctc
     1981 caagacactc aaagtgcatg gtgaagaatg tggactctag cagggagctc tgccagaata
     2041 aaagtcagcc caaccggacc tgcacctgta gcatcccaac cagagcaacc tacaaagatg
     2101 tttcagttgt caacgtgatg ttctccttcg gttcttggaa tttatcagac agattcaact
     2161 ttaccaactg ctcatcatta aaagaatgcc cagcatgcgt agaaactggc tgcgcgtggt
     2221 gtaaaagtgc aagaaggtgt atccacccct tcacagcttg cgacccttct gattatgaga
     2281 gaaaccagga acagtgtcca gtggctgtcg agaagacatc aggaggagga agacccaagg
     2341 agaacaaggg gaacagaacc aaccaggctt tacaggtctt ctacattaag tccattgagc
     2401 cacagaaagt atcgacatta gggaaaagca acgtgatagt aacgggagca aactttaccc
     2461 gggcatcgaa catcacaatg atcctgaaag gaaccagtac ctgtgataag gatgtgatac
     2521 aggttagcca tgtgctaaat gacacccaca tgaaattctc tcttccatca agccggaaag
     2581 aaatgaagga tgtgtgtatc cagtttgatg gtgggaactg ctcttctgtg ggatccttat
     2641 cctacattgc tctgccacat tgttccctta tatttcctgc taccacctgg atcagtggtg
     2701 gtcaaaatat aaccatgatg ggcagaaatt ttgatgtaat tgacaactta atcatttcac
     2761 atgaattaaa aggaaacata aatgtctctg aatattgtgt ggcgacttac tgcgggtttt
     2821 tagcccccag tttaaagagt tcaaaagtgc gcacgaatgt cactgtgaag ctgagagtac
     2881 aagacaccta cttggattgt ggaaccctgc agtatcggga ggaccccaga ttcacggggt
     2941 atcgggtgga atccgaggtg gacacagaac tggaagtgaa aattcaaaaa gaaaatgaca
     3001 acttcaacat ttccaaaaaa gacattgaaa ttactctctt ccatggggaa aatgggcaat
     3061 taaattgcag ttttgaaaat attactagaa atcaagatct taccaccatc ctttgcaaaa
     3121 ttaaaggcat caagactgca agcaccattg ccaactcttc taagaaagtt cgggtcaagc
     3181 tgggaaacct ggagctctac gtcgagcagg agtcagttcc ttccacatgg tattttctga
     3241 ttgtgctccc tgtcttgcta gtgattgtca tttttgcggc cgtgggggtg accaggcaca
     3301 aatcgaagga gctgagtcgc aaacagagtc aacaactaga attgctggaa agcgagctcc
     3361 ggaaagagat acgtgacggc tttgctgagc tgcagatgga taaattggat gtggttgata
     3421 gttttggaac tgttcccttc cttgactaca aacattttgc tctgagaact ttcttccctg
     3481 agtcaggtgg cttcacccac atcttcactg aagatatgca taacagagac gccaacgaca
     3541 agaatgaaag tctcacagct ttggatgccc taatctgtaa taaaagcttt cttgttactg
     3601 tcatccacac ccttgaaaag cagaagaact tttctgtgaa ggacaggtgt ctgtttgcct
     3661 ccttcctaac cattgcactg caaaccaagc tggtctacct gaccagcatc ctagaggtgc
     3721 tgaccaggga cttgatggaa cagtgtagta acatgcagcc gaaactcatg ctgagacgca
     3781 cggagtccgt cgtcgaaaaa ctcctcacaa actggatgtc cgtctgcctt tctggatttc
     3841 tccgggagac tgtcggagag cccttctatt tgctggtgac gactctgaac cagaaaatta
     3901 acaagggtcc cgtggatgta atcacttgca aagccctgta cacacttaat gaagactggc
     3961 tgttgtggca ggttccggaa ttcagtactg tggcattaaa cgtcgtcttt gaaaaaatcc
     4021 cggaaaacga gagtgcagat gtctgtcgga atatttcagt caatgttctc gactgtgaca
     4081 ccattggcca agccaaagaa aagattttcc aagcattctt aagcaaaaat ggctctcctt
     4141 atggacttca gcttaatgaa attggtcttg agcttcaaat gggcacacga cagaaagaac
     4201 ttctggacat cgacagttcc tccgtgattc ttgaagatgg aatcaccaag ctaaacacca
     4261 ttggccacta tgagatatca aatggatcca ctataaaagt ctttaagaag atagcaaatt
     4321 ttacttcaga tgtggagtac tcggatgacc actgccattt gattttacca gattcggaag
     4381 cattccaaga tgtgcaagga aagagacatc gagggaagca caagttcaaa gtaaaagaaa
     4441 tgtatctgac aaagctgctg tcgaccaagg tggcaattca ttctgtgctt gaaaaacttt
     4501 ttagaagcat ttggagttta cccaacagca gagctccatt tgctataaaa tacttttttg
     4561 actttttgga cgcccaggct gaaaacaaaa aaatcacaga tcctgacgtc gtacatattt
     4621 ggaaaacaaa cagccttcct cttcgcttct gggtaaacat cctgaagaac cctcagtttg
     4681 tctttgacat taagaagaca ccacatatag acggctgttt gtcagtgatt gcccaggcat
     4741 tcatggatgc attttctctc acagagcagc aactagggaa ggaagcacca actaataagc
     4801 ttctctatgc caaggatatc ccaacctaca aagaagaagt aaaatcttat tacaaagcaa
     4861 tcagggattt gcctccattg tcatcctcag aaatggaaga atttttaact caggaatcta
     4921 agaaacatga aaatgaattt aatgaagaag tggccttgac agaaatttac aaatacatcg
     4981 taaaatattt tgatgagatt ctaaataaac tagaaagaga acgagggctg gaagaagctc
     5041 agaaacaact cttgcatgta aaagtcttat ttgatgaaaa gaagaaatgc aagtggatgt
     5101 aagcactctg gggcctggct taatctggca aagttcttca gacgacttgg gagcaaaatg
     5161 gctgcttgag ctactctgtg tcgttaattt gttgtttgca cataggttcc actttgggca
     5221 ctgtcttttt aagagaccaa ggcacatgca cagcttttag aaagcatacc aacccttgtg
     5281 cctgtgtgta taccgtggga acccttctgt aaatagagtt gaagtggttg ttgcaaacag
     5341 cctccttgtt tacagagaat acaaggccag taagcgaatg tcagtattgt aactacagtc
     5401 tccacttaag cacaatgata taagtggttt tgtttgaaaa ctacagctat gtagcacttg
     5461 tgctacactg cacctctgca ttgtaaaggg atactgccag tgctcaaaac aaaatgtgaa
     5521 atgagtcatt tggaaacaag gtgggggtgt tagggcaacc tcgaggattt gcagcattga
     5581 aactttcccc agtagttctt ggaaaagctg accgcagaat ttggtagtgt acacttagca
     5641 tttgtgagtg tgtgtgtgtg tttaaaccaa aaactaacag tgttgcaaca ttgttgaaag
     5701 ggctcgtgtt tttcagtggt catcaactgc actccatcaa actcacctcc atttcaccaa
     5761 ggagctctaa agtaaggaga gtgggcttta tttaaatgaa cagcatttta accagatact
     5821 ttgtcctaat gtatgttcct tttcttcatc tgttttttca tactaaatgt atttgatagt
     5881 ggacatgttg gatattatac aaaaaaatca ttaattcatt tctgttccaa aacctttgat
     5941 cagaacgatc tgtggaagag taactccatt tctatatgag tgagtgtctc cttgctttag
     6001 atttctggtg aaccctgtgg ttatgaatac ttgtgtgtga tttaaaaaaa aaaagataca
     6061 ttttacattt tatcgaattg ctgttcacac tggagtatta tatataaata tatatatttg
     6121 aggcccaagg cctgaaaaat attagtatac aacttggtat cttagtctta ctatgtactt
     6181 tttgaaagta ttcctcgcag gagaaagaat ttaaaatacc cattttattc atgcctttct
     6241 ttttaaagaa ttctctatcc agttatactg tagtcttttt agtgctgatt ttttaattcc
     6301 tgaatttttg ctgctcatga ccagttttaa taccactgtg ttttccttct attaaaccag
     6361 aagaagtaaa cagcataatt ggcaactctt gagcttttct tgtggcaggc accttttacc
     6421 cttggtgctc caaatccccc atctaggaaa gaaaattttt tcaagtcaaa taacattgat
     6481 cacatattcc ttgaaatcat ttaccaacac tgtatggagc attaggattt aaatatgaat
     6541 ttgtcttaaa ggcaattcct ttttgcttct gtattatctg gaaaagcatg agagaggtga
     6601 cacctcaaca aactgatcag agaaaataag cagttactac cctgataggc accttcccaa
     6661 tcctgttgct tttgaccatt gtctgtccaa cggacacacc tcaaacaaac aaaactacca
     6721 aatagatgac agatcagaat aaaggtgaga ggtctggtcc ccattgaagg ctgctacagt
     6781 cttcaaagag gtgaaggagt tcataagaga acaacagtag gaaagttgag agccaagggt
     6841 aggagagttg cccaaaagac ttcccctact actttagggt actgaaaact caaaggatca
     6901 gctacagctt tatctaagta tttactaaat gctacatgag ggtgtccctg tccagctttc
     6961 tggcacatga gtcctgtgtg gagagttacc tcctcttcca gggactgtgc tgttgggaac
     7021 tttgggcaag tcacttacct ctttgtgcct caatttctgt ataatatttc taagctacct
     7081 cactgaggtg gtatgaagat tcactaatgt atgtagcgtg tttgtcaatc ctccagtgaa
     7141 aagcactatc tagatcacat tttggatcac attagccaaa tgcagtaaat ggccaaatta
     7201 gatgtgtgct gaagacaatc agtcactggg tctatattaa acagcaacca gagcaacaaa
     7261 tggcaaacaa tttctatttt caagtttctt tgcatatttt tttggtgcaa aaccatttat
     7321 aaactttttt ttctaacact agtgtctaca gcagcattca aaaaaattct gttacctttt
     7381 ctgtattagg atttaaagtc tatttcttat tgtatacctg attgaagctg ttcttggaga
     7441 tgaatgtttt aaatgtctat atccaaaaaa taaacatttt gatgtaactg tg
//
