LOCUS       NM_005393               6153 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens plexin B3 (PLXNB3), transcript variant 1, mRNA.
ACCESSION   NM_005393
VERSION     NM_005393.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6153)
  AUTHORS   Zuo,Q., Yang,Y., Lyu,Y., Yang,C., Chen,C., Salman,S., Huang,T.Y.,
            Wicks,E.E., Jackson,W. 3rd, Datan,E., Qin,W. and Semenza,G.L.
  TITLE     Plexin-B3 expression stimulates MET signaling, breast cancer stem
            cell specification, and lung metastasis
  JOURNAL   Cell Rep 42 (3), 112164 (2023)
   PUBMED   36857181
  REMARK    GeneRIF: Plexin-B3 expression stimulates MET signaling, breast
            cancer stem cell specification, and lung metastasis.
REFERENCE   2  (bases 1 to 6153)
  AUTHORS   Wang,K., He,M., Fan,X., Zhou,J., Yang,J., Wang,L., Zhao,Z., Dai,C.
            and Zhang,Z.
  TITLE     SEMA5A-PLXNB3 Axis Promotes PDAC Liver Metastasis Outgrowth through
            Enhancing the Warburg Effect
  JOURNAL   J Immunol Res 2023, 3274467 (2023)
   PUBMED   36741230
  REMARK    GeneRIF: SEMA5A-PLXNB3 Axis Promotes PDAC Liver Metastasis
            Outgrowth through Enhancing the Warburg Effect.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6153)
  AUTHORS   Kuhlmann,L., Govindarajan,M., Mejia-Guerrero,S., Ignatchenko,V.,
            Liu,L.Y., Grunwald,B.T., Cruickshank,J., Berman,H., Khokha,R. and
            Kislinger,T.
  TITLE     Glycoproteomics Identifies Plexin-B3 as a Targetable Cell Surface
            Protein Required for the Growth and Invasion of Triple-Negative
            Breast Cancer Cells
  JOURNAL   J Proteome Res 21 (9), 2224-2236 (2022)
   PUBMED   35981243
  REMARK    GeneRIF: Glycoproteomics Identifies Plexin-B3 as a Targetable Cell
            Surface Protein Required for the Growth and Invasion of
            Triple-Negative Breast Cancer Cells.
REFERENCE   4  (bases 1 to 6153)
  AUTHORS   Nihonmatsu-Kikuchi,N., Yu,X.J., Matsuda,Y., Ozawa,N., Ito,T.,
            Satou,K., Kaname,T., Iwasaki,Y., Akagi,A., Yoshida,M., Toru,S.,
            Hirokawa,K., Takashima,A., Hasegawa,M., Uchihara,T. and
            Tatebayashi,Y.
  TITLE     Essential roles of plexin-B3+ oligodendrocyte precursor cells in
            the pathogenesis of Alzheimer's disease
  JOURNAL   Commun Biol 4 (1), 870 (2021)
   PUBMED   34267322
  REMARK    GeneRIF: Essential roles of plexin-B3(+) oligodendrocyte precursor
            cells in the pathogenesis of Alzheimer's disease.
            Erratum:[Commun Biol. 2021 Dec 2;4(1):1372. doi:
            10.1038/s42003-021-02905-5.. PMID: 34857866]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6153)
  AUTHORS   Li,X., Law,J.W. and Lee,A.Y.
  TITLE     Semaphorin 5A and plexin-B3 regulate human glioma cell motility and
            morphology through Rac1 and the actin cytoskeleton
  JOURNAL   Oncogene 31 (5), 595-610 (2012)
   PUBMED   21706053
  REMARK    GeneRIF: Data show that Semaphorin 5A (Sema5A) and plexin-B3
            inhibit glioma cell invasion through Rac1 inactivation.
REFERENCE   6  (bases 1 to 6153)
  AUTHORS   Conrotto,P., Corso,S., Gamberini,S., Comoglio,P.M. and Giordano,S.
  TITLE     Interplay between scatter factor receptors and B plexins controls
            invasive growth
  JOURNAL   Oncogene 23 (30), 5131-5137 (2004)
   PUBMED   15184888
REFERENCE   7  (bases 1 to 6153)
  AUTHORS   Artigiani,S., Conrotto,P., Fazzari,P., Gilestro,G.F., Barberis,D.,
            Giordano,S., Comoglio,P.M. and Tamagnone,L.
  TITLE     Plexin-B3 is a functional receptor for semaphorin 5A
  JOURNAL   EMBO Rep 5 (7), 710-714 (2004)
   PUBMED   15218527
  REMARK    GeneRIF: Plexin-B3 is a functional receptor for semaphorin 5A
REFERENCE   8  (bases 1 to 6153)
  AUTHORS   Perrot,V., Vazquez-Prado,J. and Gutkind,J.S.
  TITLE     Plexin B regulates Rho through the guanine nucleotide exchange
            factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF
  JOURNAL   J Biol Chem 277 (45), 43115-43120 (2002)
   PUBMED   12183458
REFERENCE   9  (bases 1 to 6153)
  AUTHORS   Tamagnone,L., Artigiani,S., Chen,H., He,Z., Ming,G.I., Song,H.,
            Chedotal,A., Winberg,M.L., Goodman,C.S., Poo,M., Tessier-Lavigne,M.
            and Comoglio,P.M.
  TITLE     Plexins are a large family of receptors for transmembrane,
            secreted, and GPI-anchored semaphorins in vertebrates
  JOURNAL   Cell 99 (1), 71-80 (1999)
   PUBMED   10520995
  REMARK    Erratum:[Cell 2001 Jan 26;104(2):following 320]
REFERENCE   10 (bases 1 to 6153)
  AUTHORS   Sandoval,N., Bauer,D., Brenner,V., Coy,J.F., Drescher,B.,
            Kioschis,P., Korn,B., Nyakatura,G., Poustka,A., Reichwald,K.,
            Rosenthal,A. and Platzer,M.
  TITLE     The genomic organization of a human creatine transporter (CRTR)
            gene located in Xq28
  JOURNAL   Genomics 35 (2), 383-385 (1996)
   PUBMED   8661155
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292535.1, AF149019.1 and
            AK295762.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005393.2.
            
            Summary: The protein encoded by this gene is a member of the plexin
            family. It functions as a receptor for semaphorin 5A, and plays a
            role in axon guidance, invasive growth and cell migration.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Sep
            2009].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292535.1, AB033032.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361971.10/ ENSP00000355378.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1082              AK292535.1         54-1135
            1083-6152           AF149019.1         1076-6145
            6153-6153           AK295762.1         6226-6226
FEATURES             Location/Qualifiers
     source          1..6153
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..6153
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /note="plexin B3"
                     /db_xref="GeneID:5365"
                     /db_xref="HGNC:HGNC:9105"
                     /db_xref="MIM:300214"
     exon            1..56
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            57..166
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..5851
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; plexin 6"
                     /codon_start=1
                     /product="plexin-B3 isoform 1 precursor"
                     /protein_id="NP_005384.2"
                     /db_xref="CCDS:CCDS14729.1"
                     /db_xref="GeneID:5365"
                     /db_xref="HGNC:HGNC:9105"
                     /db_xref="MIM:300214"
                     /translation="MCHAAQETPLLHHFMAPVMARWPPFGLCLLLLLLSPPPLPLTGA
                     HRFSAPNTTLNHLALAPGRGTLYVGAVNRLFQLSPELQLEAVAVTGPVIDSPDCVPFR
                     DPAECPQAQLTDNANQLLLVSSRAQELVACGQVRQGVCETRRLGDVAEVLYQAEDPGD
                     GQFVAANTPGVATVGLVVPLPGRDLLLVARGLAGKLSAGVPPLAIRQLAGSQPFSSEG
                     LGRLVVGDFSDYNNSYVGAFADARSAYFVFRRRGARAQAEYRSYVARVCLGDTNLYSY
                     VEVPLACQGQGLIQAAFLAPGTLLGVFAAGPRGTQAALCAFPMVELGASMEQARRLCY
                     TAGGRGPSGAEEATVEYGVTSRCVTLPLDSPESYPCGDEHTPSPIAGRQPLEVQPLLK
                     LGQPVSAVAALQADGHMIAFLGDTQGQLYKVFLHGSQGQVYHSQQVGPPGSAISPDLL
                     LDSSGSHLYVLTAHQVDRIPVAACPQFPDCASCLQAQDPLCGWCVLQGRCTRKGQCGR
                     AGQLNQWLWSYEEDSHCLHIQSLLPGHHPRQEQGQVTLSVPRLPILDADEYFHCAFGD
                     YDSLAHVEGPHVACVTPPQDQVPLNPPGTDHVTVPLALMFEDVTVAATNFSFYDCSAV
                     QALEAAAPCRACVGSIWRCHWCPQSSHCVYGEHCPEGERTIYSAQEVDIQVRGPGACP
                     QVEGLAGPHLVPVGWESHLALRVRNLQHFRGLPASFHCWLELPGELRGLPATLEETAG
                     DSGLIHCQAHQFYPSMSQRELPVPIYVTQGEAQRLDNTHALYVILYDCAMGHPDCSHC
                     QAANRSLGCLWCADGQPACRYGPLCPPGAVELLCPAPSIDAVEPLTGPPEGGLALTIL
                     GSNLGRAFADVQYAVSVASRPCNPEPSLYRTSARIVCVTSPAPNGTTGPVRVAIKSQP
                     PGISSQHFTYQDPVLLSLSPRWGPQAGGTQLTIRGQHLQTGGNTSAFVGGQPCPILEP
                     VCPEAIVCRTRPQAAPGEAAVLVVFGHAQRTLLASPFRYTANPQLVAAEPSASFRGGG
                     RLIRVRGTGLDVVQRPLLSVWLEADAEVQASRAQPQDPQPRRSCGAPAADPQACIQLG
                     GGLLQCSTVCSVNSSSLLLCRSPAVPDRAHPQRVFFTLDNVQVDFASASGGQGFLYQP
                     NPRLAPLSREGPARPYRLKPGHVLDVEGEGLNLGISKEEVRVHIGRGECLVKTLTRTH
                     LYCEPPAHAPQPANGSGLPQFVVQMGNVQLALGPVQYEAEPPLSAFPVEAQAGVGMGA
                     AVLIAAVLLLTLMYRHKSKQALRDYQKVLVQLESLETGVGDQCRKEFTDLMTEMTDLS
                     SDLEGSGIPFLDYRTYAERAFFPGHGGCPLQPKPEGPGEDGHCATVRQGLTQLSNLLN
                     SKLFLLTLIHTLEEQPSFSQRDRCHVASLLSLALHGKLEYLTDIMRTLLGDLAAHYVH
                     RNPKLMLRRTETMVEKLLTNWLSICLYAFLREVAGEPLYMLFRAIQYQVDKGPVDAVT
                     GKAKRTLNDSRLLREDVEFQPLTLMVLVGPGAGGAAGSSEMQRVPARVLDTDTITQVK
                     EKVLDQVYKGTPFSQRPSVHALDLEWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHY
                     KVPDGATVGLVPQLHRGSTISQSLAQRCPLGENIPTLEDGEEGGVCLWHLVKATEEPE
                     GAKVRCSSLREREPARAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNRPIPIAVK
                     YLFDLLDELAEKHGIEDPGTLHIWKTNSLLLRFWVNALKNPQLIFDVRVSDNVDAILA
                     VIAQTFIDSCTTSEHKVGRDSPVNKLLYAREIPRYKQMVERYYADIRQSSPASYQEMN
                     SALAELSGNYTSAPHCLEALQELYNHIHRYYDQIISALEEDPVGQKLQLACRLQQVAA
                     LVENKVTDL"
     exon            167..1207
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1387
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1516
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1617
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1750
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1907
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2016
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2131
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2257
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2374
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2468
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2638
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2790
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2896
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..3027
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3204
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3400
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            3401..3640
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            3641..3799
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            3800..3951
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4052
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            4053..4276
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            4277..4455
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            4456..4522
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            4523..4850
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            4851..4954
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            4955..5048
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            5049..5221
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            5222..5382
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            5383..5530
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            5531..5595
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            5596..5671
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            5672..5746
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     exon            5747..6153
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6129..6134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /note="hexamer: AATAGA"
     polyA_site      6153
                     /gene="PLXNB3"
                     /gene_synonym="PLEXB3; PLEXR; PLXN6"
                     /note="major polyA site"
ORIGIN      
        1 gagacgtgct cctggcaccg ccagctgcta cttggccctc gccggtggcc caccaggaca
       61 atgccccccc gcagccatct catgcccatc gccactgccc tggggcagct gaactgagcg
      121 tatgtgccac gccgcccagg agacccctct gctgcaccac ttcatggccc ccgtgatggc
      181 tcgctggcct cccttcggcc tctgcctcct cctgctgctg ctgtccccac cgccactgcc
      241 cttgacaggg gcccatcgct tctccgcacc taataccact ctcaaccact tggcactggc
      301 acctggccga ggcacactct atgtcggcgc agtgaaccgc ctcttccagc tcagccccga
      361 gctgcagctc gaggccgtgg ctgtcactgg ccctgtaatc gacagccctg actgcgtgcc
      421 cttccgtgac ccagccgagt gcccacaggc ccagctcact gacaatgcca accagctgct
      481 gctggtgagc agccgcgccc aggagctggt ggcctgcggg caggtgcggc agggcgtgtg
      541 tgagacacgg cgccttgggg atgtggccga ggtgctgtac caggctgagg accctggtga
      601 cgggcagttt gtggctgcca ataccccggg agtggcaacg gtggggctgg tggtgccctt
      661 gcccggccgg gacctcctgc ttgtggccag aggcctggcg ggcaagctgt cggcaggggt
      721 gccacccctg gccatccgcc agctggccgg gtctcagccc ttctccagcg agggcctggg
      781 ccgcctggtg gtgggcgact tctccgacta caacaacagc tacgtcgggg cctttgccga
      841 cgcccgctcc gcctacttcg tgttccgccg ccgcggggcc cgggcccagg ctgagtaccg
      901 ctcctacgtg gcccgcgtct gcctggggga caccaacctg tactcctacg tggaggtccc
      961 cctcgcctgc cagggccagg gcctcatcca ggccgccttc cttgccccgg gcaccttgct
     1021 aggggtgttt gccgcgggcc caaggggcac ccaggcggcg ctctgtgcct tccccatggt
     1081 ggagctgggt gccagcatgg agcaggcccg gagactctgc tacacggcgg gcggccgggg
     1141 ccccagcggc gcagaggaag ccaccgtgga gtacggcgtc acgtcgcgct gcgtcaccct
     1201 gccccttgat tcccccgagt cgtacccctg tggcgacgag cacaccccca gccccattgc
     1261 tggccgccag cccctggagg tccagcctct gctgaagctc gggcagccgg tcagcgccgt
     1321 ggcagctctc caggcagatg ggcacatgat agccttcctg ggggacaccc agggccagct
     1381 gtacaaggtc tttctccacg gctcccaggg ccaggtttac cactcccagc aagtggggcc
     1441 tccaggctca gccatcagcc cagacctgct gctggacagc agtggcagtc acctctatgt
     1501 cctgactgcc caccaggtgg accggatacc tgtggcagcc tgcccccagt tccctgactg
     1561 tgccagctgc ctccaggccc aggacccgct gtgtggctgg tgtgtcctcc agggcaggtg
     1621 tacccggaag ggccagtgcg ggcgggcagg ccagctgaac cagtggctgt ggagttatga
     1681 ggaggacagc cactgcctgc acatccagag cctgctgccg ggccaccacc cccgccagga
     1741 gcagggccag gtcactttgt ctgtcccccg gctgcccatc ctggatgcag atgaatactt
     1801 ccattgtgcg ttcggggact atgacagctt ggctcatgtg gaagggcccc acgtggcctg
     1861 tgtcacccct ccccaagacc aggtgccact taaccctcca ggcacagacc acgtcactgt
     1921 gcccctggcc ctgatgttcg aggacgtgac tgtggctgcc accaacttct ccttttatga
     1981 ctgcagtgcc gtccaggcct tggaggcggc tgccccgtgt cgcgcttgcg tgggcagcat
     2041 ctggcggtgt cactggtgcc cgcagagtag ccactgcgtg tacggagagc actgcccaga
     2101 gggcgagagg accatctaca gcgcccagga ggtggacatc caggtgcgtg gcccaggggc
     2161 ttgcccacag gtcgaaggcc tggcaggtcc ccacctggtg cctgtgggct gggagagcca
     2221 tttggcccta cgcgtgcgga accttcaaca tttccgaggc ctgcctgcct ccttccactg
     2281 ctggctggag ctgcctggag aacttcgggg actgccggcc accctggagg agacagcagg
     2341 ggattcaggc ctcatccact gccaggccca ccagttttat ccctccatgt cccagcggga
     2401 gctcccagtg cccatctacg tcacccaggg tgaagcccag aggctggaca acacccatgc
     2461 tctttatgtg atcctgtacg actgcgccat gggccacccg gactgcagcc actgccaagc
     2521 ggccaacagg agcctgggct gcctgtggtg tgctgacggc cagcctgcct gtcgctatgg
     2581 gcccttgtgc ccgccggggg ctgtggagct gctgtgtcct gcgcccagca ttgatgcagt
     2641 cgagcccctg accggtcccc ctgagggagg cttggccctc accatcctgg gctccaacct
     2701 gggccgggcc ttcgccgatg tgcagtacgc cgtgagcgtg gccagccggc cctgcaaccc
     2761 tgagccctct ctctaccgca cgtcggcccg gattgtgtgt gtgacatctc ctgcccccaa
     2821 tggcaccact gggcccgtcc gggtggccat taagagccag ccaccaggca tctcaagcca
     2881 gcacttcacc taccaggacc ctgtcctgct gagcctgagt cctcgctggg gcccccaggc
     2941 agggggcacc cagctcacca tccgaggtca gcacctccag acaggtggca acaccagtgc
     3001 cttcgtgggt ggccaaccct gtcccatcct ggagccagtg tgtccggagg ccatcgtgtg
     3061 ccgtaccagg ccccaggctg ccccaggaga agcagcggtc cttgtggtct ttggccatgc
     3121 ccagcgcaca ctgctcgcca gccccttccg ctacaccgcc aacccccagc ttgtagcggc
     3181 ggagcccagt gccagcttcc gggggggtgg gcgactgatc cgtgtcaggg gcaccggcct
     3241 agacgtggtg cagcggcccc tactgtctgt gtggctggag gctgacgcag aggtgcaggc
     3301 ttccagggcc cagccccagg acccacagcc aaggaggagc tgtggagccc ctgctgcgga
     3361 cccccaggct tgtatccagc tcggtggggg gctgctgcag tgctccaccg tctgctccgt
     3421 caactcgtcc agcctcctcc tgtgccggag ccctgctgta ccagacagag cccacccgca
     3481 gcgggtcttc ttcaccctag acaacgtgca agtggacttc gccagtgcca gtgggggcca
     3541 gggcttcctg taccagccca acccccgcct ggcacccctc agccgcgagg ggcctgcccg
     3601 cccctaccgc ctcaagccag gccatgtcct ggatgtggag ggcgagggcc tcaacctggg
     3661 catcagcaag gaggaggtgc gcgtgcacat cggccgcggc gagtgcctgg tgaagacgct
     3721 cacgcgcacc cacctgtact gcgagccgcc tgcgcacgcc ccgcagcctg ccaatggctc
     3781 cggcctgcca cagttcgtgg tgcagatggg caatgtgcag ctggccctgg gccctgtgca
     3841 gtacgaggct gaacccccgc tgtctgcctt tcccgtggag gcccaggcag gcgtgggcat
     3901 gggtgctgca gtgctgattg ccgccgtgct cctcctcacc ctcatgtaca ggcacaagag
     3961 caagcaggcc ctgcgggact accagaaggt gctagtgcag ctggagagcc tggagaccgg
     4021 cgtgggagac cagtgccgca aggagttcac agacctcatg acggagatga ccgacctcag
     4081 cagcgacctg gagggcagcg ggatcccctt cctggactac cgcacctacg ccgagcgcgc
     4141 cttcttccct ggccatggcg gttgcccgct gcagcccaag cctgaggggc caggggagga
     4201 cggccactgt gccactgtgc gccagggcct cacgcagctc tccaacctgc tcaacagcaa
     4261 gctcttcctc ctcacgctca tccacaccct ggaggagcag cccagctttt cccagaggga
     4321 tcgctgccat gtggcttcgc tgctgtcgct agcgctacac ggcaagctgg agtacctgac
     4381 ggacatcatg aggaccctgc tgggtgacct ggcggcccat tacgtgcaca ggaaccccaa
     4441 gctcatgcta cgcaggacag agaccatggt ggagaaactg ctcaccaact ggctgtccat
     4501 ctgcctgtac gccttcctga gggaggtggc tggtgaacca ctgtacatgc tcttccgggc
     4561 catccagtac caggtggaca aaggccccgt ggacgccgtg acaggcaagg ccaaacggac
     4621 cctgaatgat agccgcttgc tgcgggagga cgtggagttc cagcccctga cgctgatggt
     4681 gctggtgggg cccggggctg gcggggccgc aggcagcagc gagatgcagc gcgtgccagc
     4741 ccgggtgctc gacacggaca ccatcaccca ggtcaaggag aaggtgttgg accaagtcta
     4801 caagggcacc cccttctccc agaggccctc agtgcatgcc ctagaccttg agtggcgctc
     4861 aggcctggct ggtcacctga ccctatcgga cgaagacttg acctccgtga cccaaaacca
     4921 ctggaagaga ctcaacacct tgcaacacta caaggtccca gatggagcaa cagtggggct
     4981 cgtccctcag ctgcaccgtg gcagcaccat ctcccagagc ctggcccaga ggtgcccctt
     5041 gggagagaac atacccacgc tggaggatgg cgaggagggg ggggtgtgcc tctggcacct
     5101 ggtgaaagcc accgaggagc cagaaggggc caaggtgcgg tgcagcagcc tgcgggagcg
     5161 cgagccagca agggccaagg ccattccgga aatctacctc acccgtctgc tgtccatgaa
     5221 gggcacgctg cagaagtttg tggacgacac cttccaggcc attctcagcg tgaaccggcc
     5281 catccccatc gccgtcaagt acctgtttga ccttctggat gagctagcag agaagcacgg
     5341 catcgaggac ccagggaccc tgcacatctg gaagaccaac agtctgctgc tgcggttctg
     5401 ggtgaatgcc ttgaagaacc cacagctcat ctttgatgta cgggtgtcgg acaatgtgga
     5461 cgccatcctt gctgtcatcg cccagacctt cattgactcc tgtaccacct cggagcataa
     5521 agtgggccgg gattccccag tgaacaaact gctctacgcc cgggagatcc cacgctacaa
     5581 gcagatggtg gagaggtact atgcggacat tcgccagagc tctccggcga gctaccagga
     5641 gatgaactct gctttggctg agctctccgg gaactacact tctgctcccc actgtctgga
     5701 ggctctgcaa gaactctaca accacatcca caggtactat gatcagatta tcagtgccct
     5761 ggaggaggac cctgtgggcc agaagctgca gctggcctgc cgcctgcagc aggtcgccgc
     5821 cctggtggaa aacaaagtga ctgacctgtg agctctggct cagacagcag caagccggat
     5881 ccaccaacac cgcagcgcct tatgaccccg gaaccgagcc agccactgag gggagctggc
     5941 agagcctggg ggcacagggt gcaaagccag gcactgtgcc cagcagtggg ctccctgcct
     6001 gccacctccc ctgccagccc acccaccttc cccccacctg agattgtttc taatttataa
     6061 ggatccccct ccttccccct ctccccattg tatttatttg cctgctggaa aatcacatcc
     6121 ggaaataaaa tagaaatatg tctttttatt tta
//
