LOCUS       NM_012401               6409 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens plexin B2 (PLXNB2), transcript variant 3, mRNA.
ACCESSION   NM_012401 XM_371474 XM_938245
VERSION     NM_012401.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6409)
  AUTHORS   Borrelli,C., Roberts,M., Eletto,D., Hussherr,M.D., Fazilaty,H.,
            Valenta,T., Lafzi,A., Kretz,J.A., Guido Vinzoni,E., Karakatsani,A.,
            Adivarahan,S., Mannhart,A., Kimura,S., Meijs,A., Baccouche
            Mhamedi,F., Acar,I.E., Handler,K., Ficht,X., Platt,R.J.,
            Piscuoglio,S. and Moor,A.E.
  TITLE     In vivo interaction screening reveals liver-derived constraints to
            metastasis
  JOURNAL   Nature 632 (8024), 411-418 (2024)
   PUBMED   39048831
  REMARK    GeneRIF: In vivo interaction screening reveals liver-derived
            constraints to metastasis.
REFERENCE   2  (bases 1 to 6409)
  AUTHORS   Smith,C.E.L., Laugel-Haushalter,V., Hany,U., Best,S., Taylor,R.L.,
            Poulter,J.A., Wortmann,S.B., Feichtinger,R.G., Mayr,J.A., Al
            Bahlani,S., Nikolopoulos,G., Rigby,A., Black,G.C., Watson,C.M.,
            Mansour,S., Inglehearn,C.F., Mighell,A.J. and Bloch-Zupan,A.
  CONSRTM   UK Inherited Retinal Disease Consortium, Genomics England Research
            Consortium
  TITLE     Biallelic variants in Plexin B2 (PLXNB2) cause amelogenesis
            imperfecta, hearing loss and intellectual disability
  JOURNAL   J Med Genet 61 (7), 689-698 (2024)
   PUBMED   38458752
  REMARK    GeneRIF: Biallelic variants in Plexin B2 (PLXNB2) cause
            amelogenesis imperfecta, hearing loss and intellectual disability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6409)
  AUTHORS   Hu,A., Nussbaum,Y.I., Mitchem,J. and Yoo,J.
  TITLE     Colorectal Cancer-Associated Myofibroblasts Exhibit Enhanced
            Angiogenin Expression and Signaling via the PLXNB2 Receptor
  JOURNAL   J Surg Res 296, 273-280 (2024)
   PUBMED   38295715
  REMARK    GeneRIF: Colorectal Cancer-Associated Myofibroblasts Exhibit
            Enhanced Angiogenin Expression and Signaling via the PLXNB2
            Receptor.
REFERENCE   4  (bases 1 to 6409)
  AUTHORS   Wang,J., Wu,C. and Zhou,W.
  TITLE     CircPLXNB2 regulates acute myeloid leukemia progression through
            miR-654-3p/CCND1 axis
  JOURNAL   Hematology 28 (1), 2220522 (2023)
   PUBMED   37272581
  REMARK    GeneRIF: CircPLXNB2 regulates acute myeloid leukemia progression
            through miR-654-3p/CCND1 axis.
REFERENCE   5  (bases 1 to 6409)
  AUTHORS   Guo,Z., Guo,D., Kong,D., Bian,S., Zhao,L., Li,Q., Lin,L., Hao,J.,
            Sun,L. and Li,Y.
  TITLE     Expression analysis, clinical significance and potential function
            of PLXNB2 in acute myeloid leukaemia
  JOURNAL   Mol Biol Rep 50 (10), 8445-8457 (2023)
   PUBMED   37632633
  REMARK    GeneRIF: Expression analysis, clinical significance and potential
            function of PLXNB2 in acute myeloid leukaemia.
REFERENCE   6  (bases 1 to 6409)
  AUTHORS   Perrot,V., Vazquez-Prado,J. and Gutkind,J.S.
  TITLE     Plexin B regulates Rho through the guanine nucleotide exchange
            factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF
  JOURNAL   J Biol Chem 277 (45), 43115-43120 (2002)
   PUBMED   12183458
  REMARK    GeneRIF: Plexin B2 associates directly with two members of a
            recently identified family of Dbl homology/pleckstrin homology
            containing guanine nucleotide exchange factors for Rho, PDZ-RhoGEF,
            and Leukemia-associated Rho GEF (LARG).
REFERENCE   7  (bases 1 to 6409)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   8  (bases 1 to 6409)
  AUTHORS   Tamagnone,L., Artigiani,S., Chen,H., He,Z., Ming,G.I., Song,H.,
            Chedotal,A., Winberg,M.L., Goodman,C.S., Poo,M., Tessier-Lavigne,M.
            and Comoglio,P.M.
  TITLE     Plexins are a large family of receptors for transmembrane,
            secreted, and GPI-anchored semaphorins in vertebrates
  JOURNAL   Cell 99 (1), 71-80 (1999)
   PUBMED   10520995
  REMARK    Erratum:[Cell 2001 Jan 26;104(2):following 320]
REFERENCE   9  (bases 1 to 6409)
  AUTHORS   Trofatter,J.A., Long,K.R., Murrell,J.R., Stotler,C.J., Gusella,J.F.
            and Buckler,A.J.
  TITLE     An expression-independent catalog of genes from human chromosome 22
  JOURNAL   Genome Res 5 (3), 214-224 (1995)
   PUBMED   8593609
REFERENCE   10 (bases 1 to 6409)
  AUTHORS   Shinoura,N., Shamraj,O.I., Hugenholz,H., Zhu,J.G., McBlack,P.,
            Warnick,R., Tew,J.J., Wani,M.A. and Menon,A.G.
  TITLE     Identification and partial sequence of a cDNA that is
            differentially expressed in human brain tumors
  JOURNAL   Cancer Lett 89 (2), 215-221 (1995)
   PUBMED   7889532
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010163.2, BX649592.2, AB002313.1, AL022328.21 and BC000221.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012401.3.
            
            Summary: Members of the B class of plexins, such as PLXNB2 are
            transmembrane receptors that participate in axon guidance and cell
            migration in response to semaphorins (Perrot et al. (2002) [PubMed
            12183458]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2839192.1,
                                           SRR1660805.70948.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359337.9/ ENSP00000352288.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                CT010163.2         805-898             c
            95-154              BX649592.2         18474-18533         c
            155-157             BX649592.2         14350-14352         c
            158-5950            AB002313.1         1-5793
            5951-6391           AL022328.21        175152-175592       c
            6392-6409           BC000221.1         4515-4532
FEATURES             Location/Qualifiers
     source          1..6409
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..6409
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /note="plexin B2"
                     /db_xref="GeneID:23654"
                     /db_xref="HGNC:HGNC:9104"
                     /db_xref="MIM:604293"
     exon            1..94
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            95..154
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            155..1235
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..5684
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; ferroptosis-associated lncRNA"
                     /codon_start=1
                     /product="plexin-B2 isoform 3 precursor"
                     /protein_id="NP_036533.2"
                     /db_xref="CCDS:CCDS43035.1"
                     /db_xref="GeneID:23654"
                     /db_xref="HGNC:HGNC:9104"
                     /db_xref="MIM:604293"
                     /translation="MALQLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASG
                     VVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLL
                     DPPRKRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSST
                     GPGGDRVLFVGKGNGPHDNGIIVSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQF
                     VAAFEDGPYVFFVFNQQDKHPARNRTLLARMCREDPNYYSYLEMDLQCRDPDIHAAAF
                     GTCLAASVAAPGSGRVLYAVFSRDSRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGT
                     REARDIFYKPFHGDIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNL
                     TAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLVLSGDL
                     GSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEAS
                     HWLWSRSKSCVAVTSAQPQNMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPPHPAR
                     VEGEAVICNSPSSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQAMSLEEN
                     LPCISCVSNRWTCQWDLRYHECREASPNPEDGIVRAHMEDSCPQFLGPSPLVIPMNHE
                     TDVNFQGKNLDTVKGSSLHVGSDLLKFMEPVTMQESGTFAFRTPKLSHDANETLPLHL
                     YVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCAWCGGQSRCVYEALCNTTS
                     ECPPPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERYSVST
                     RIVCVIEAAETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPLSVEPQQGPQAGGTTLT
                     IHGTHLDTGSQEDVRVTLNGVPCKVTKFGAQLQCVTGPQATRGQMLLEVSYGGSPVPN
                     PGIFFTYRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVVIAEPLQSWQPPR
                     EAESLQPMTVVGTDYVFHNDTKVVFLSPAVPEEPEAYNLTVLIEMDGHRALLRTEAGA
                     FEYVPDPTFENFTGGVKKQVNKLIHARGTNLNKAMTLQEAEAFVGAERCTMKTLTETD
                     LYCEPPEVQPPPKRRQKRDTTHNLPEFIVKFGSREWVLGRVEYDTRVSDVPLSLILPL
                     VIVPMVVVIAVSVYCYWRKSQQAEREYEKIKSQLEGLEESVRDRCKKEFTDLMIEMED
                     QTNDVHEAGIPVLDYKTYTDRVFFLPSKDGDKDVMITGKLDIPEPRRPVVEQALYQFS
                     NLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTDIMHTLFLELLE
                     QYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKHQVEKGP
                     VDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGVDAIPVKVLNCDTISQVKEKI
                     IDQVYRGQPCSCWPRPDSVVLEWRPGSTAQILSDLDLTSQREGRWKRVNTLMHYNVRD
                     GATLILSKVGVSQQPEDSQQDLPGERHALLEEENRVWHLVRPTDEVDEGKSKRGSVKE
                     KERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKH
                     NIQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRT
                     EHKLSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDS
                     LNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAALENKVTDL"
     exon            1236..1418
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1547
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1648
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1775
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1929
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2044
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2153
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2255
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2348
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2430
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2588
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2737
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2846
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2983
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3154
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3284
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3512
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            3513..3689
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            3690..3829
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..3930
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            3931..4160
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            4161..4342
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4409
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            4410..4556
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            4557..4713
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            4714..4814
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            4815..4899
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            4900..5054
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            5055..5215
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            5216..5363
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            5364..5428
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            5429..5504
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            5505..5579
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            5580..6409
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6387..6392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /note="hexamer: AATACA"
     polyA_site      6409
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /note="major polyA site"
ORIGIN      
        1 acacaaaggc cccgtctcca tggcagcagc gcgggccaga gcgcagcgcc gagcgcggcc
       61 cgggcgccat cgagccttgg cggcggacgt gcagagaatc tcgatgctgg cctggagcag
      121 aaactgagct ggaccactgg agcctcggtg agggggtgcg gggggcaatg gcactgcagc
      181 tctgggccct gaccctgctg ggcctgctgg gcgcaggtgc cagcctgagg ccccgcaagc
      241 tggacttctt ccgcagcgag aaagagctga accacctggc tgtggatgag gcctcaggcg
      301 tggtgtacct gggggcggtg aatgccctct accagctgga tgcgaagctg cagctggagc
      361 agcaggtggc cacgggcccg gccctggaca acaagaagtg cacgccgccc atcgaggcca
      421 gccagtgcca tgaggctgag atgactgaca atgtcaacca gctgctgctg ctcgaccctc
      481 ccaggaagcg cctggtggag tgcggcagcc tcttcaaggg catctgcgct ctgcgcgccc
      541 tgagcaacat ctccctccgc ctgttctacg aggacggcag cggggagaag tctttcgtgg
      601 ccagcaatga tgagggcgtg gccacagtgg ggctggtgag ctccacgggt cctggtggtg
      661 accgcgtgct gtttgtgggc aaaggcaatg ggccacacga caacggcatc atcgtgagca
      721 ctcggctgtt ggaccggact gacagcaggg aggcctttga agcctacacg gaccacgcca
      781 cctacaaggc cggctacctg tccaccaaca cacagcagtt cgtggcggcc ttcgaggacg
      841 gcccctacgt cttctttgtc ttcaaccagc aggacaagca cccggcccgg aaccgcacgc
      901 tgctggcacg catgtgcaga gaagacccca actactactc ctacctggag atggacctgc
      961 agtgccggga ccccgacatc cacgccgctg cctttggcac ctgcctggcc gcctccgtgg
     1021 ctgcgcctgg ctctggcagg gtgctatatg ctgtcttcag cagagacagc cggagcagtg
     1081 gggggcccgg tgcgggcctc tgcctgttcc cgctggacaa ggtgcacgcc aagatggagg
     1141 ccaaccgcaa cgcctgttac acaggcaccc gggaggcccg tgacatcttc tacaagccct
     1201 tccacggcga tatccagtgc ggcggccacg cgccgggctc cagcaagagc ttcccatgtg
     1261 gctcggagca cctgccctac ccgctgggca gccgcgacgg gctcagaggc acagccgtgc
     1321 tgcagcgtgg aggcctgaac ctcacggccg tgacggtcgc cgccgagaac aaccacactg
     1381 ttgcttttct gggcacctct gatggccgga tcctcaaggt gtacctcacc ccagatggca
     1441 cctcctcaga gtacgactct atccttgtgg agataaacaa gagagtcaag cgcgacctgg
     1501 tactgtctgg agacctgggc agcctgtacg ccatgaccca ggacaaggtg ttccggctgc
     1561 cggtgcagga gtgcctgagc tacccgacct gcacccagtg ccgcgactcc caggacccct
     1621 actgcggctg gtgcgtcgtc gagggacgat gcacccggaa ggccgagtgt ccgcgggccg
     1681 aggaggccag ccactggctg tggagccgaa gcaagtcctg cgtggccgtc accagcgccc
     1741 agccacagaa catgagccgg cgggcccagg gggaggtgca gctgaccgtc agccccctcc
     1801 ctgccctgag cgaggaggac gagttgctgt gcctttttgg ggagtcgccg ccacaccccg
     1861 cccgcgtgga gggcgaggcc gtcatctgca actccccaag cagcatcccc gtcacaccgc
     1921 caggccagga ccacgtggcc gtgaccatcc agctcctcct tagacgaggc aacatcttcc
     1981 tcacgtccta ccagtacccc ttctacgact gccgccaggc catgagcctg gaggagaacc
     2041 tgccgtgcat ctcctgcgtg agcaaccgct ggacctgcca gtgggacctg cgctaccacg
     2101 agtgccggga ggcttcgccc aaccctgagg acggcatcgt ccgtgcccac atggaggaca
     2161 gctgtcccca gttcctggga cccagccccc tggtgatccc catgaaccac gagacagatg
     2221 tgaacttcca gggcaagaac ctggacaccg tgaagggttc ctccctgcac gtgggcagtg
     2281 acttgctcaa gttcatggag ccggtgacca tgcaggaatc tgggaccttc gcctttcgga
     2341 ccccaaagct gtcccacgat gccaacgaga cgctgcccct gcacctctac gtcaagtctt
     2401 acggcaagaa tatcgacagc aagctccatg tgaccctcta caactgctcc tttggccgca
     2461 gcgactgcag cctgtgccgg gccgctaacc ccgactacag gtgtgcgtgg tgcgggggcc
     2521 agagcaggtg cgtgtatgag gccctgtgca acaccacctc cgagtgcccg ccgcccgtca
     2581 tcaccaggat ccagcctgag acgggccccc tgggtggggg catccgcatc accatcctgg
     2641 ggtccaattt gggcgtccaa gcaggggaca tccagaggat ctctgtggcc ggccggaact
     2701 gctcctttca gccggaacgt tactccgtgt ccacccggat cgtgtgtgtg atcgaggctg
     2761 cggagacgcc tttcacgggg ggtgtcgagg tggacgtctt cgggaaactg ggccgttcgc
     2821 ctcccaatgt ccagttcacc ttccaacagc ccaagcctct cagtgtggag ccgcagcagg
     2881 gaccgcaggc gggcggcacc acactgacca tccacggcac ccacctggac acgggctccc
     2941 aggaggacgt gcgggtgacc ctcaacggcg tcccgtgtaa agtgacgaag tttggggcgc
     3001 agctccagtg tgtcactggc ccccaggcga cacggggcca gatgcttctg gaggtctcct
     3061 acggggggtc ccccgtgccc aaccccggca tcttcttcac ctaccgcgaa aaccccgtac
     3121 tgcgagcctt cgagccgcta cgaagctttg ccagtggtgg ccgcagcatc aacgtcacgg
     3181 gtcagggctt cagcctgatc cagaggtttg ccatggtggt catcgcggag cccctgcagt
     3241 cctggcagcc gccgcgggag gctgaatccc tgcagcccat gacggtggtg ggtacagact
     3301 acgtgttcca caatgacacc aaggtcgtct tcctgtcccc ggctgtgcct gaggagccag
     3361 aggcctacaa cctcacggtg ctgatcgaga tggacgggca ccgtgccctg ctcagaacag
     3421 aggccggggc cttcgagtac gtgcctgacc ccacctttga gaacttcaca ggtggcgtca
     3481 agaagcaggt caacaagctc atccacgccc ggggcaccaa tctgaacaag gcgatgacgc
     3541 tgcaggaggc cgaggccttc gtgggtgccg agcgctgcac catgaagacg ctgacggaga
     3601 ccgacctgta ctgtgagccc ccggaggtgc agcccccgcc caagcggcgg cagaaacgag
     3661 acaccacaca caacctgccc gagttcattg tgaagttcgg ctctcgcgag tgggtgctgg
     3721 gccgcgtgga gtacgacaca cgggtgagcg acgtgccgct cagcctcatc ttgccgctgg
     3781 tcatcgtgcc catggtggtc gtcatcgcgg tgtctgtcta ctgctactgg aggaagagcc
     3841 agcaggccga acgagagtat gagaagatca agtcccagct ggagggcctg gaggagagcg
     3901 tgcgggaccg ctgcaagaag gaattcacag acctgatgat cgagatggag gaccagacca
     3961 acgacgtgca cgaggccggc atccccgtgc tggactacaa gacctacacc gaccgcgtct
     4021 tcttcctgcc ctccaaggac ggcgacaagg acgtgatgat caccggcaag ctggacatcc
     4081 ctgagccgcg gcggccggtg gtggagcagg ccctctacca gttctccaac ctgctgaaca
     4141 gcaagtcttt cctcatcaat ttcatccaca ccctggagaa ccagcgggag ttctcggccc
     4201 gcgccaaggt ctacttcgcg tccctgctga cggtggcgct gcacgggaaa ctggagtact
     4261 acacggacat catgcacacg ctcttcctgg agctcctgga gcagtacgtg gtggccaaga
     4321 accccaagct gatgctgcgc aggtctgaga ctgtggtgga gaggatgctg tccaactgga
     4381 tgtccatctg cctgtaccag tacctcaagg acagtgccgg ggagcccctg tacaagctct
     4441 tcaaggccat caaacatcag gtggaaaagg gcccggtgga tgcggtacag aagaaggcca
     4501 agtacactct caacgacacg gggctgctgg gggatgatgt ggagtacgca cccctgacgg
     4561 tgagcgtgat cgtgcaggac gagggagtgg acgccatccc ggtgaaggtc ctcaactgtg
     4621 acaccatctc ccaggtcaag gagaagatca ttgaccaggt gtaccgtggg cagccctgct
     4681 cctgctggcc caggccagac agcgtggtcc tggagtggcg tccgggctcc acagcgcaga
     4741 tcctgtcgga cctggacctg acgtcacagc gggagggccg gtggaagcgc gtcaacaccc
     4801 ttatgcacta caatgtccgg gatggagcca ccctcatcct gtccaaggtg ggggtctccc
     4861 agcagccgga ggacagccag caggacctgc ctggggagcg ccatgccctc ctggaggagg
     4921 agaaccgggt gtggcacctg gtgcggccga ccgacgaggt ggacgagggc aagtccaaga
     4981 gaggcagcgt gaaagagaag gagcggacga aggccatcac cgagatctac ctgacgcggc
     5041 tgctctcagt caagggcaca ctgcagcagt ttgtggacaa cttcttccag agcgtgctgg
     5101 cgcctgggca cgcggtgcca cctgcagtca agtacttctt cgacttcctg gacgagcagg
     5161 cagagaagca caacatccag gatgaagaca ccatccacat ctggaagacg aacagcttac
     5221 cgctccggtt ctgggtgaac atcctcaaga acccccactt catctttgac gtgcatgtcc
     5281 acgaggtggt ggacgcctcg ctgtcagtca tcgcgcagac cttcatggat gcctgcacgc
     5341 gcacggagca taagctgagc cgcgattctc ccagcaacaa gctgctgtac gccaaggaga
     5401 tctccaccta caagaagatg gtggaggatt actacaaggg gatccggcag atggtgcagg
     5461 tcagcgacca ggacatgaac acacacctgg cagagatttc ccgggcgcac acggactcct
     5521 tgaacaccct cgtggcactc caccagctct accaatacac gcagaagtac tatgacgaga
     5581 tcatcaatgc cttggaggag gatcctgccg cccagaagat gcagctggcc ttccgcctgc
     5641 agcagattgc cgctgcactg gagaacaagg tcactgacct ctgacctaca atctccagtg
     5701 ctgccttggg acataggtac ctgaggtacc tgagagcccc tcaggggagg aggccgagtg
     5761 gctgtggctg aggcccccac cctcccctgg aacgcgcccc aagccggagt gggtgcagcc
     5821 ggaacccgcc cagcgtctag actgtagcat cttcctctga gcaataccgc cgggcaccgc
     5881 accagcacca gccccagccc cagctccctc cggccgcaga accagcatcg ggtgttcact
     5941 gtcgagtctc cagtgatttg aaaatgtgcc ttacgctgcc acgctggggg cagctggcct
     6001 ccgcctccgc ccacgcacca gcagccgcct ccatgcccta ggttgggccc ctgggggatc
     6061 tgagggcctg tggcccccag ggcaagttcc cagatcctat gtctgtctgt ccaccacgag
     6121 atgggaggag gagaaaaagc ggtacgatgc cttcctgacc tcaccggcct ccccaagggt
     6181 gccggcactc tgggtggact cacggctgct gggccccacg tcaaaggtca agtgagacgt
     6241 aggtcaagtc ctacgtcggg gcccagacat cctggggtcc tggtctgtca gacaggctgc
     6301 cctagagccc cacccagtcc ggggggactg ggagcagttc caagaccacc ccaccccttt
     6361 ttgtaaatct tgttcattgt aaatcaaata cagcgtcttt ttcactctg
//
