LOCUS       NM_001376870            6374 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens plexin B2 (PLXNB2), transcript variant 9, mRNA.
ACCESSION   NM_001376870 XM_005261910
VERSION     NM_001376870.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6374)
  AUTHORS   Borrelli,C., Roberts,M., Eletto,D., Hussherr,M.D., Fazilaty,H.,
            Valenta,T., Lafzi,A., Kretz,J.A., Guido Vinzoni,E., Karakatsani,A.,
            Adivarahan,S., Mannhart,A., Kimura,S., Meijs,A., Baccouche
            Mhamedi,F., Acar,I.E., Handler,K., Ficht,X., Platt,R.J.,
            Piscuoglio,S. and Moor,A.E.
  TITLE     In vivo interaction screening reveals liver-derived constraints to
            metastasis
  JOURNAL   Nature 632 (8024), 411-418 (2024)
   PUBMED   39048831
  REMARK    GeneRIF: In vivo interaction screening reveals liver-derived
            constraints to metastasis.
REFERENCE   2  (bases 1 to 6374)
  AUTHORS   Smith,C.E.L., Laugel-Haushalter,V., Hany,U., Best,S., Taylor,R.L.,
            Poulter,J.A., Wortmann,S.B., Feichtinger,R.G., Mayr,J.A., Al
            Bahlani,S., Nikolopoulos,G., Rigby,A., Black,G.C., Watson,C.M.,
            Mansour,S., Inglehearn,C.F., Mighell,A.J. and Bloch-Zupan,A.
  CONSRTM   UK Inherited Retinal Disease Consortium, Genomics England Research
            Consortium
  TITLE     Biallelic variants in Plexin B2 (PLXNB2) cause amelogenesis
            imperfecta, hearing loss and intellectual disability
  JOURNAL   J Med Genet 61 (7), 689-698 (2024)
   PUBMED   38458752
  REMARK    GeneRIF: Biallelic variants in Plexin B2 (PLXNB2) cause
            amelogenesis imperfecta, hearing loss and intellectual disability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6374)
  AUTHORS   Hu,A., Nussbaum,Y.I., Mitchem,J. and Yoo,J.
  TITLE     Colorectal Cancer-Associated Myofibroblasts Exhibit Enhanced
            Angiogenin Expression and Signaling via the PLXNB2 Receptor
  JOURNAL   J Surg Res 296, 273-280 (2024)
   PUBMED   38295715
  REMARK    GeneRIF: Colorectal Cancer-Associated Myofibroblasts Exhibit
            Enhanced Angiogenin Expression and Signaling via the PLXNB2
            Receptor.
REFERENCE   4  (bases 1 to 6374)
  AUTHORS   Wang,J., Wu,C. and Zhou,W.
  TITLE     CircPLXNB2 regulates acute myeloid leukemia progression through
            miR-654-3p/CCND1 axis
  JOURNAL   Hematology 28 (1), 2220522 (2023)
   PUBMED   37272581
  REMARK    GeneRIF: CircPLXNB2 regulates acute myeloid leukemia progression
            through miR-654-3p/CCND1 axis.
REFERENCE   5  (bases 1 to 6374)
  AUTHORS   Guo,Z., Guo,D., Kong,D., Bian,S., Zhao,L., Li,Q., Lin,L., Hao,J.,
            Sun,L. and Li,Y.
  TITLE     Expression analysis, clinical significance and potential function
            of PLXNB2 in acute myeloid leukaemia
  JOURNAL   Mol Biol Rep 50 (10), 8445-8457 (2023)
   PUBMED   37632633
  REMARK    GeneRIF: Expression analysis, clinical significance and potential
            function of PLXNB2 in acute myeloid leukaemia.
REFERENCE   6  (bases 1 to 6374)
  AUTHORS   Perrot,V., Vazquez-Prado,J. and Gutkind,J.S.
  TITLE     Plexin B regulates Rho through the guanine nucleotide exchange
            factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF
  JOURNAL   J Biol Chem 277 (45), 43115-43120 (2002)
   PUBMED   12183458
  REMARK    GeneRIF: Plexin B2 associates directly with two members of a
            recently identified family of Dbl homology/pleckstrin homology
            containing guanine nucleotide exchange factors for Rho, PDZ-RhoGEF,
            and Leukemia-associated Rho GEF (LARG).
REFERENCE   7  (bases 1 to 6374)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   8  (bases 1 to 6374)
  AUTHORS   Tamagnone,L., Artigiani,S., Chen,H., He,Z., Ming,G.I., Song,H.,
            Chedotal,A., Winberg,M.L., Goodman,C.S., Poo,M., Tessier-Lavigne,M.
            and Comoglio,P.M.
  TITLE     Plexins are a large family of receptors for transmembrane,
            secreted, and GPI-anchored semaphorins in vertebrates
  JOURNAL   Cell 99 (1), 71-80 (1999)
   PUBMED   10520995
  REMARK    Erratum:[Cell 2001 Jan 26;104(2):following 320]
REFERENCE   9  (bases 1 to 6374)
  AUTHORS   Trofatter,J.A., Long,K.R., Murrell,J.R., Stotler,C.J., Gusella,J.F.
            and Buckler,A.J.
  TITLE     An expression-independent catalog of genes from human chromosome 22
  JOURNAL   Genome Res 5 (3), 214-224 (1995)
   PUBMED   8593609
REFERENCE   10 (bases 1 to 6374)
  AUTHORS   Shinoura,N., Shamraj,O.I., Hugenholz,H., Zhu,J.G., McBlack,P.,
            Warnick,R., Tew,J.J., Wani,M.A. and Menon,A.G.
  TITLE     Identification and partial sequence of a cDNA that is
            differentially expressed in human brain tumors
  JOURNAL   Cancer Lett 89 (2), 215-221 (1995)
   PUBMED   7889532
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX649592.2 and AL022328.21.
            
            On Nov 20, 2019 this sequence version replaced XM_005261910.3.
            
            Summary: Members of the B class of plexins, such as PLXNB2 are
            transmembrane receptors that participate in axon guidance and cell
            migration in response to semaphorins (Perrot et al. (2002) [PubMed
            12183458]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.22392.1,
                                           SRR7346977.2647003.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BX649592.2         24032-24090         c
            60-119              BX649592.2         18474-18533         c
            120-1200            BX649592.2         13272-14352         c
            1201-1383           BX649592.2         12715-12897         c
            1384-1512           BX649592.2         12498-12626         c
            1513-1613           BX649592.2         11692-11792         c
            1614-1740           BX649592.2         11422-11548         c
            1741-1894           BX649592.2         10866-11019         c
            1895-2009           BX649592.2         9928-10042          c
            2010-2118           BX649592.2         9745-9853           c
            2119-2220           BX649592.2         9555-9656           c
            2221-2313           BX649592.2         8328-8420           c
            2314-2395           BX649592.2         7887-7968           c
            2396-2553           BX649592.2         7588-7745           c
            2554-2702           BX649592.2         7357-7505           c
            2703-2811           BX649592.2         7092-7200           c
            2812-2948           BX649592.2         6805-6941           c
            2949-3119           BX649592.2         6466-6636           c
            3120-3249           BX649592.2         5939-6068           c
            3250-3477           BX649592.2         5609-5836           c
            3478-3654           BX649592.2         5321-5497           c
            3655-3794           BX649592.2         5115-5254           c
            3795-3895           BX649592.2         4844-4944           c
            3896-4125           BX649592.2         4499-4728           c
            4126-4307           BX649592.2         4244-4425           c
            4308-4374           BX649592.2         3760-3826           c
            4375-4521           BX649592.2         3385-3531           c
            4522-4678           BX649592.2         2610-2766           c
            4679-4779           BX649592.2         2351-2451           c
            4780-4864           BX649592.2         2190-2274           c
            4865-5019           BX649592.2         1872-2026           c
            5020-5180           BX649592.2         1608-1768           c
            5181-5328           BX649592.2         1346-1493           c
            5329-5393           AL022328.21        176997-177061       c
            5394-5469           AL022328.21        176784-176859       c
            5470-5544           AL022328.21        176044-176118       c
            5545-6374           AL022328.21        175134-175963       c
FEATURES             Location/Qualifiers
     source          1..6374
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..6374
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /note="plexin B2"
                     /db_xref="GeneID:23654"
                     /db_xref="HGNC:HGNC:9104"
                     /db_xref="MIM:604293"
     exon            1..59
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            60..119
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            120..1200
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..5649
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 9; ferroptosis-associated lncRNA"
                     /codon_start=1
                     /product="plexin-B2 isoform 3 precursor"
                     /protein_id="NP_001363799.1"
                     /db_xref="CCDS:CCDS43035.1"
                     /db_xref="GeneID:23654"
                     /db_xref="HGNC:HGNC:9104"
                     /db_xref="MIM:604293"
                     /translation="MALQLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASG
                     VVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLL
                     DPPRKRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSST
                     GPGGDRVLFVGKGNGPHDNGIIVSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQF
                     VAAFEDGPYVFFVFNQQDKHPARNRTLLARMCREDPNYYSYLEMDLQCRDPDIHAAAF
                     GTCLAASVAAPGSGRVLYAVFSRDSRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGT
                     REARDIFYKPFHGDIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNL
                     TAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLVLSGDL
                     GSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEAS
                     HWLWSRSKSCVAVTSAQPQNMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPPHPAR
                     VEGEAVICNSPSSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQAMSLEEN
                     LPCISCVSNRWTCQWDLRYHECREASPNPEDGIVRAHMEDSCPQFLGPSPLVIPMNHE
                     TDVNFQGKNLDTVKGSSLHVGSDLLKFMEPVTMQESGTFAFRTPKLSHDANETLPLHL
                     YVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCAWCGGQSRCVYEALCNTTS
                     ECPPPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERYSVST
                     RIVCVIEAAETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPLSVEPQQGPQAGGTTLT
                     IHGTHLDTGSQEDVRVTLNGVPCKVTKFGAQLQCVTGPQATRGQMLLEVSYGGSPVPN
                     PGIFFTYRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVVIAEPLQSWQPPR
                     EAESLQPMTVVGTDYVFHNDTKVVFLSPAVPEEPEAYNLTVLIEMDGHRALLRTEAGA
                     FEYVPDPTFENFTGGVKKQVNKLIHARGTNLNKAMTLQEAEAFVGAERCTMKTLTETD
                     LYCEPPEVQPPPKRRQKRDTTHNLPEFIVKFGSREWVLGRVEYDTRVSDVPLSLILPL
                     VIVPMVVVIAVSVYCYWRKSQQAEREYEKIKSQLEGLEESVRDRCKKEFTDLMIEMED
                     QTNDVHEAGIPVLDYKTYTDRVFFLPSKDGDKDVMITGKLDIPEPRRPVVEQALYQFS
                     NLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTDIMHTLFLELLE
                     QYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKHQVEKGP
                     VDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGVDAIPVKVLNCDTISQVKEKI
                     IDQVYRGQPCSCWPRPDSVVLEWRPGSTAQILSDLDLTSQREGRWKRVNTLMHYNVRD
                     GATLILSKVGVSQQPEDSQQDLPGERHALLEEENRVWHLVRPTDEVDEGKSKRGSVKE
                     KERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKH
                     NIQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRT
                     EHKLSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDS
                     LNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAALENKVTDL"
     exon            1201..1383
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1512
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1613
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1740
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1894
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2009
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2118
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2220
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2313
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2395
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2553
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2702
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2811
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2948
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3119
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3249
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3477
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3654
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            3655..3794
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..3895
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..4125
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            4126..4307
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            4308..4374
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            4375..4521
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            4522..4678
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            4679..4779
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            4780..4864
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            4865..5019
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            5020..5180
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            5181..5328
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            5329..5393
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            5394..5469
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            5470..5544
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            5545..6374
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6352..6357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /note="hexamer: AATACA"
     polyA_site      6374
                     /gene="PLXNB2"
                     /gene_synonym="dJ402G11.3; lncFAL; MM1; Nbla00445; PLEXB2"
                     /note="major polyA site"
ORIGIN      
        1 ccacggctcg gaggacttag gtaatggccg gctgtgcgat ccgatgtgcc cgacgccaga
       61 gaatctcgat gctggcctgg agcagaaact gagctggacc actggagcct cggtgagggg
      121 gtgcgggggg caatggcact gcagctctgg gccctgaccc tgctgggcct gctgggcgca
      181 ggtgccagcc tgaggccccg caagctggac ttcttccgca gcgagaaaga gctgaaccac
      241 ctggctgtgg atgaggcctc aggcgtggtg tacctggggg cggtgaatgc cctctaccag
      301 ctggatgcga agctgcagct ggagcagcag gtggccacgg gcccggccct ggacaacaag
      361 aagtgcacgc cgcccatcga ggccagccag tgccatgagg ctgagatgac tgacaatgtc
      421 aaccagctgc tgctgctcga ccctcccagg aagcgcctgg tggagtgcgg cagcctcttc
      481 aagggcatct gcgctctgcg cgccctgagc aacatctccc tccgcctgtt ctacgaggac
      541 ggcagcgggg agaagtcttt cgtggccagc aatgatgagg gcgtggccac agtggggctg
      601 gtgagctcca cgggtcctgg tggtgaccgc gtgctgtttg tgggcaaagg caatgggcca
      661 cacgacaacg gcatcatcgt gagcactcgg ctgttggacc ggactgacag cagggaggcc
      721 tttgaagcct acacggacca cgccacctac aaggccggct acctgtccac caacacacag
      781 cagttcgtgg cggccttcga ggacggcccc tacgtcttct ttgtcttcaa ccagcaggac
      841 aagcacccgg cccggaaccg cacgctgctg gcacgcatgt gcagagaaga ccccaactac
      901 tactcctacc tggagatgga cctgcagtgc cgggaccccg acatccacgc cgctgccttt
      961 ggcacctgcc tggccgcctc cgtggctgcg cctggctctg gcagggtgct atatgctgtc
     1021 ttcagcagag acagccggag cagtgggggg cccggtgcgg gcctctgcct gttcccgctg
     1081 gacaaggtgc acgccaagat ggaggccaac cgcaacgcct gttacacagg cacccgggag
     1141 gcccgtgaca tcttctacaa gcccttccac ggcgatatcc agtgcggcgg ccacgcgccg
     1201 ggctccagca agagcttccc atgtggctcg gagcacctgc cctacccgct gggcagccgc
     1261 gacgggctca gaggcacagc cgtgctgcag cgtggaggcc tgaacctcac ggccgtgacg
     1321 gtcgccgccg agaacaacca cactgttgct tttctgggca cctctgatgg ccggatcctc
     1381 aaggtgtacc tcaccccaga tggcacctcc tcagagtacg actctatcct tgtggagata
     1441 aacaagagag tcaagcgcga cctggtactg tctggagacc tgggcagcct gtacgccatg
     1501 acccaggaca aggtgttccg gctgccggtg caggagtgcc tgagctaccc gacctgcacc
     1561 cagtgccgcg actcccagga cccctactgc ggctggtgcg tcgtcgaggg acgatgcacc
     1621 cggaaggccg agtgtccgcg ggccgaggag gccagccact ggctgtggag ccgaagcaag
     1681 tcctgcgtgg ccgtcaccag cgcccagcca cagaacatga gccggcgggc ccagggggag
     1741 gtgcagctga ccgtcagccc cctccctgcc ctgagcgagg aggacgagtt gctgtgcctt
     1801 tttggggagt cgccgccaca ccccgcccgc gtggagggcg aggccgtcat ctgcaactcc
     1861 ccaagcagca tccccgtcac accgccaggc caggaccacg tggccgtgac catccagctc
     1921 ctccttagac gaggcaacat cttcctcacg tcctaccagt accccttcta cgactgccgc
     1981 caggccatga gcctggagga gaacctgccg tgcatctcct gcgtgagcaa ccgctggacc
     2041 tgccagtggg acctgcgcta ccacgagtgc cgggaggctt cgcccaaccc tgaggacggc
     2101 atcgtccgtg cccacatgga ggacagctgt ccccagttcc tgggacccag ccccctggtg
     2161 atccccatga accacgagac agatgtgaac ttccagggca agaacctgga caccgtgaag
     2221 ggttcctccc tgcacgtggg cagtgacttg ctcaagttca tggagccggt gaccatgcag
     2281 gaatctggga ccttcgcctt tcggacccca aagctgtccc acgatgccaa cgagacgctg
     2341 cccctgcacc tctacgtcaa gtcttacggc aagaatatcg acagcaagct ccatgtgacc
     2401 ctctacaact gctcctttgg ccgcagcgac tgcagcctgt gccgggccgc taaccccgac
     2461 tacaggtgtg cgtggtgcgg gggccagagc aggtgcgtgt atgaggccct gtgcaacacc
     2521 acctccgagt gcccgccgcc cgtcatcacc aggatccagc ctgagacggg ccccctgggt
     2581 gggggcatcc gcatcaccat cctggggtcc aatttgggcg tccaagcagg ggacatccag
     2641 aggatctctg tggccggccg gaactgctcc tttcagccgg aacgttactc cgtgtccacc
     2701 cggatcgtgt gtgtgatcga ggctgcggag acgcctttca cggggggtgt cgaggtggac
     2761 gtcttcggga aactgggccg ttcgcctccc aatgtccagt tcaccttcca acagcccaag
     2821 cctctcagtg tggagccgca gcagggaccg caggcgggcg gcaccacact gaccatccac
     2881 ggcacccacc tggacacggg ctcccaggag gacgtgcggg tgaccctcaa cggcgtcccg
     2941 tgtaaagtga cgaagtttgg ggcgcagctc cagtgtgtca ctggccccca ggcgacacgg
     3001 ggccagatgc ttctggaggt ctcctacggg gggtcccccg tgcccaaccc cggcatcttc
     3061 ttcacctacc gcgaaaaccc cgtactgcga gccttcgagc cgctacgaag ctttgccagt
     3121 ggtggccgca gcatcaacgt cacgggtcag ggcttcagcc tgatccagag gtttgccatg
     3181 gtggtcatcg cggagcccct gcagtcctgg cagccgccgc gggaggctga atccctgcag
     3241 cccatgacgg tggtgggtac agactacgtg ttccacaatg acaccaaggt cgtcttcctg
     3301 tccccggctg tgcctgagga gccagaggcc tacaacctca cggtgctgat cgagatggac
     3361 gggcaccgtg ccctgctcag aacagaggcc ggggccttcg agtacgtgcc tgaccccacc
     3421 tttgagaact tcacaggtgg cgtcaagaag caggtcaaca agctcatcca cgcccggggc
     3481 accaatctga acaaggcgat gacgctgcag gaggccgagg ccttcgtggg tgccgagcgc
     3541 tgcaccatga agacgctgac ggagaccgac ctgtactgtg agcccccgga ggtgcagccc
     3601 ccgcccaagc ggcggcagaa acgagacacc acacacaacc tgcccgagtt cattgtgaag
     3661 ttcggctctc gcgagtgggt gctgggccgc gtggagtacg acacacgggt gagcgacgtg
     3721 ccgctcagcc tcatcttgcc gctggtcatc gtgcccatgg tggtcgtcat cgcggtgtct
     3781 gtctactgct actggaggaa gagccagcag gccgaacgag agtatgagaa gatcaagtcc
     3841 cagctggagg gcctggagga gagcgtgcgg gaccgctgca agaaggaatt cacagacctg
     3901 atgatcgaga tggaggacca gaccaacgac gtgcacgagg ccggcatccc cgtgctggac
     3961 tacaagacct acaccgaccg cgtcttcttc ctgccctcca aggacggcga caaggacgtg
     4021 atgatcaccg gcaagctgga catccctgag ccgcggcggc cggtggtgga gcaggccctc
     4081 taccagttct ccaacctgct gaacagcaag tctttcctca tcaatttcat ccacaccctg
     4141 gagaaccagc gggagttctc ggcccgcgcc aaggtctact tcgcgtccct gctgacggtg
     4201 gcgctgcacg ggaaactgga gtactacacg gacatcatgc acacgctctt cctggagctc
     4261 ctggagcagt acgtggtggc caagaacccc aagctgatgc tgcgcaggtc tgagactgtg
     4321 gtggagagga tgctgtccaa ctggatgtcc atctgcctgt accagtacct caaggacagt
     4381 gccggggagc ccctgtacaa gctcttcaag gccatcaaac atcaggtgga aaagggcccg
     4441 gtggatgcgg tacagaagaa ggccaagtac actctcaacg acacggggct gctgggggat
     4501 gatgtggagt acgcacccct gacggtgagc gtgatcgtgc aggacgaggg agtggacgcc
     4561 atcccggtga aggtcctcaa ctgtgacacc atctcccagg tcaaggagaa gatcattgac
     4621 caggtgtacc gtgggcagcc ctgctcctgc tggcccaggc cagacagcgt ggtcctggag
     4681 tggcgtccgg gctccacagc gcagatcctg tcggacctgg acctgacgtc acagcgggag
     4741 ggccggtgga agcgcgtcaa cacccttatg cactacaatg tccgggatgg agccaccctc
     4801 atcctgtcca aggtgggggt ctcccagcag ccggaggaca gccagcagga cctgcctggg
     4861 gagcgccatg ccctcctgga ggaggagaac cgggtgtggc acctggtgcg gccgaccgac
     4921 gaggtggacg agggcaagtc caagagaggc agcgtgaaag agaaggagcg gacgaaggcc
     4981 atcaccgaga tctacctgac gcggctgctc tcagtcaagg gcacactgca gcagtttgtg
     5041 gacaacttct tccagagcgt gctggcgcct gggcacgcgg tgccacctgc agtcaagtac
     5101 ttcttcgact tcctggacga gcaggcagag aagcacaaca tccaggatga agacaccatc
     5161 cacatctgga agacgaacag cttaccgctc cggttctggg tgaacatcct caagaacccc
     5221 cacttcatct ttgacgtgca tgtccacgag gtggtggacg cctcgctgtc agtcatcgcg
     5281 cagaccttca tggatgcctg cacgcgcacg gagcataagc tgagccgcga ttctcccagc
     5341 aacaagctgc tgtacgccaa ggagatctcc acctacaaga agatggtgga ggattactac
     5401 aaggggatcc ggcagatggt gcaggtcagc gaccaggaca tgaacacaca cctggcagag
     5461 atttcccggg cgcacacgga ctccttgaac accctcgtgg cactccacca gctctaccaa
     5521 tacacgcaga agtactatga cgagatcatc aatgccttgg aggaggatcc tgccgcccag
     5581 aagatgcagc tggccttccg cctgcagcag attgccgctg cactggagaa caaggtcact
     5641 gacctctgac ctacaatctc cagtgctgcc ttgggacata ggtacctgag gtacctgaga
     5701 gcccctcagg ggaggaggcc gagtggctgt ggctgaggcc cccaccctcc cctggaacgc
     5761 gccccaagcc ggagtgggtg cagccggaac ccgcccagcg tctagactgt agcatcttcc
     5821 tctgagcaat accgccgggc accgcaccag caccagcccc agccccagct ccctccggcc
     5881 gcagaaccag catcgggtgt tcactgtcga gtctccagtg atttgaaaat gtgccttacg
     5941 ctgccacgct gggggcagct ggcctccgcc tccgcccacg caccagcagc cgcctccatg
     6001 ccctaggttg ggcccctggg ggatctgagg gcctgtggcc cccagggcaa gttcccagat
     6061 cctatgtctg tctgtccacc acgagatggg aggaggagaa aaagcggtac gatgccttcc
     6121 tgacctcacc ggcctcccca agggtgccgg cactctgggt ggactcacgg ctgctgggcc
     6181 ccacgtcaaa ggtcaagtga gacgtaggtc aagtcctacg tcggggccca gacatcctgg
     6241 ggtcctggtc tgtcagacag gctgccctag agccccaccc agtccggggg gactgggagc
     6301 agttccaaga ccaccccacc cctttttgta aatcttgttc attgtaaatc aaatacagcg
     6361 tctttttcac tctg
//
